CIK: 0001306923
Total reported value
$653.9M
| # | Ticker | Issuer | Asset Subclass | Weight | Weight Change | Shares Change | 4Q Trend |
|---|---|---|---|---|---|---|---|
| 1 | INSM | Insmed INC | Stock-Healthcare | 14.34% | -1.47% | -38.44% | |
| 2 | BMRN | Biomarin Pharmaceutical INC | Stock-Healthcare | 13.34% | -0.25% | -7.13% | |
| 3 | AM6 | Amicus Therapeutics INC | Stock-Other | 11.41% | -7.86% | -4.14% | |
| 4 | ACAD | Acadia Pharmaceuticals INC | Stock-Healthcare | 8.43% | +0.54% | -3.08% | |
| 5 | UTHR | United Therapeutics CORP | Stock-Healthcare | 6.18% | +1.75% | -32.42% | |
| 6 | BIIB | Biogen INC | Stock-Healthcare | 5.34% | -0.55% | +7.77% | |
| 7 | ALNY | Alnylam Pharmaceuticals INC | Stock-Healthcare | 4.29% | — | -40.65% | |
| 8 | PTCT | Ptc Therapeutics INC | Stock-Healthcare | 3.92% | +0.04% | +4.60% | |
| 9 | PRTA | Prothena Corporation plc | Stock-Other | 3.91% | +0.04% | -4.50% | |
| 10 | ANAB | Anaptysbio INC | Stock-Other | 3.61% | +0.75% | +20.94% | |
| 11 | NVCR | NovoCure Limited | Stock-Healthcare | 3.40% | -0.21% | +23.07% | |
| 12 | SRPT | Sarepta Therapeutics INC | Stock-Healthcare | 2.56% | — | — | |
| 13 | EHTH | Ehealth INC | Stock-Other | 2.14% | -0.69% | -10.32% | |
| 14 | IOVA | Iovance Biotherapeutics INC | Stock-Other | 2.04% | +0.71% | +5.58% | |
| 15 | STAA | Staar Surgical Co | Stock-Other | 1.76% | — | +4.84% | |
| 16 | AGIO | Agios Pharmaceuticals INC | Stock-Other | 1.54% | +0.30% | — | |
| 17 | ALKS | Alkermes plc | Stock-Healthcare | 1.39% | +0.37% | -23.43% | |
| 18 | GOSS | Gossamer Bio INC | Stock-Other | 1.31% | -1.93% | EXIT | |
| 19 | ALGN | Align Technology INC | Stock-Healthcare | 1.14% | +0.19% | — | |
| 20 | SNDX | Syndax Pharmaceuticals INC | Stock-Other | 1.04% | +0.77% | +9.67% | |
| 21 | ✓ | Acelyrin INC | Stock-Other | 0.84% | — | — | |
| 22 | DYN | Dyne Therapeutics INC | Stock-Other | 0.66% | +0.57% | — | |
| 23 | MIRM | Mirum Pharmaceuticals INC | Stock-Other | 0.56% | +2.87% | — | |
| 24 | EW | Edwards Lifesciences CORP | Stock-Healthcare | 0.54% | +0.01% | — | |
| 25 | ✓ | Verve Therapeutics INC | Stock-Other | 0.50% | — | — | |
| 26 | BNTX | Biontech Se-adr | Stock-Other | 0.44% | +0.01% | — | |
| 27 | BCYC | Bicycle Therapeutics Plc-adr | Stock-Other | 0.40% | -0.08% | — | |
| 28 | TVTX | Travere Therapeutics INC | Stock-Other | 0.38% | +0.46% | — | |
| 29 | TSHA | Taysha Gene Therapies INC | Stock-Other | 0.38% | +0.04% | +74.97% | |
| 30 | NBIX | Neurocrine Biosciences INC | Stock-Healthcare | 0.28% | — | — | |
| 31 | NUVB | Nuvation Bio INC | Stock-Other | 0.26% | -0.34% | — | |
| 32 | ALDX | Aldeyra Therapeutics INC | Stock-Other | 0.25% | -0.12% | — | |
| 33 | KPTIEUR | Karyopharm Therapeutics INC | Stock-Other | 0.23% | — | -93.40% | |
| 34 | ACRS | Aclaris Therapeutics INC | Stock-Other | 0.23% | +0.27% | +36.19% | |
| 35 | HUM | Humana INC | Stock-Healthcare | 0.20% | -0.03% | — | |
| 36 | PYXS | Pyxis Oncology INC | Stock-Other | 0.19% | +0.06% | — | |
| 37 | STOK | Stoke Therapeutics INC | Stock-Other | 0.16% | +0.10% | — | |
| 38 | VYNE | Vyne Therapeutics INC | Stock-Other | 0.13% | — | — | |
| 39 | ABEO | Abeona Therapeutics INC | Stock-Other | 0.10% | — | — | |
| 40 | URGN | UroGen Pharma Ltd. | Stock-Other | 0.05% | -0.01% | — | |
| 41 | TIL | Instil Bio INC | Stock-Other | 0.04% | — | — | |
| 42 | ✓ | Akari Therapeutics PLC | Stock-Other | 0.03% | — | — | |
| 43 | RLMD | Relmada Therapeutics INC | Stock-Other | 0.03% | — | — | |
| 44 | GBIOGBX | Generation Bio Co | Stock-Other | 0.01% | — | — |
| # | Ticker | Issuer | Weight Change | Shares Change | Action |
|---|---|---|---|---|---|
| 1 | AM6 | Amicus Therapeutics INC | +6.1% | -4.14% | Trim |
| 2 | ACAD | Acadia Pharmaceuticals INC | +5.3% | -3.08% | Add |
| 3 | INSM | Insmed INC | +4.9% | -38.44% | Trim |
| 4 | BMRN | Biomarin Pharmaceutical INC | +3.2% | -7.13% | Trim |
| 5 | ANAB | Anaptysbio INC | +3% | +20.94% | Add |
| 6 | ALKS | Alkermes plc | +0.7% | -23.43% | Trim |
| 7 | SNDX | Syndax Pharmaceuticals INC | +0.7% | +9.67% | Add |
| 8 | GOSS | Gossamer Bio INC | +0.5% | -0.00% | Add |
| 9 | UTHR | United Therapeutics CORP | -0.6% | -32.42% | Trim |
| 10 | ALGN | Align Technology INC | -0.7% | — | Trim |
| 11 | PRTA | Prothena Corporation plc | -1% | -4.50% | Trim |
| 12 | EHTH | Ehealth INC | -1.6% | -10.32% | Add |
| 13 | BIIB | Biogen INC | -1.6% | +7.77% | Trim |
| 14 | KPTIEUR | Karyopharm Therapeutics INC | -2.8% | -93.40% | Trim |
| 15 | STAA | Staar Surgical Co | -8.9% | +4.84% | Trim |
| 16 | ABMDEUR | Abiomed INC | — | EXIT | Sold out |
| 17 | RVNCEUR | Revance Therapeutics INC | — | EXIT | Sold out |
| 18 | VNDA | Vanda Pharmaceuticals INC | — | EXIT | Sold out |
| 19 | EPZMEUR | Epizyme INC | — | EXIT | Sold out |
| 20 | SG7 | Sage Therapeutics INC | — | EXIT | Sold out |
| 21 | CLVSEUR | Clovis Oncology INC | — | EXIT | Sold out |
| 22 | ALNY | Alnylam Pharmaceuticals INC | — | NEW | New buy |
| 23 | 2JQ | Gritstone Bio INC | — | EXIT | Sold out |
| 24 | PTCT | Ptc Therapeutics INC | — | NEW | New buy |
| 25 | NVCR | NovoCure Limited | — | NEW | New buy |
| 26 | ALXN | Alexion Pharmaceuticals INC | — | EXIT | Sold out |
| 27 | SRPT | Sarepta Therapeutics INC | — | NEW | New buy |
| 28 | PBYI | Puma Biotechnology INC | — | EXIT | Sold out |
| 29 | DRNAUSD | Dicerna Pharmaceuticals INC | — | EXIT | Sold out |
| 30 | IOVA | Iovance Biotherapeutics INC | — | NEW | New buy |
| 31 | AGIO | Agios Pharmaceuticals INC | — | NEW | New buy |
| 32 | KLDO | Kaleido Biosciences INC | — | EXIT | Sold out |
| 33 | ✓ | Acelyrin INC | — | NEW | New buy |
| 34 | ✓ | Magenta Therapeutics INC | — | EXIT | Sold out |
| 35 | ZGNXEUR | Zogenix INC | — | EXIT | Sold out |
| 36 | ✓ | — | EXIT | Sold out | |
| 37 | DYN | Dyne Therapeutics INC | — | NEW | New buy |
| 38 | MIRM | Mirum Pharmaceuticals INC | — | NEW | New buy |
| 39 | EW | Edwards Lifesciences CORP | — | NEW | New buy |
| 40 | RIGLUSD | Rigel Pharmaceuticals INC | — | EXIT | Sold out |
| 41 | ✓ | Verve Therapeutics INC | — | NEW | New buy |
| 42 | CYTK | Cytokinetics INC | — | EXIT | Sold out |
| 43 | BNTX | Biontech Se-adr | — | NEW | New buy |
| 44 | BCYC | Bicycle Therapeutics Plc-adr | — | NEW | New buy |
| 45 | TSHA | Taysha Gene Therapies INC | — | NEW | New buy |
| 46 | ✓ | Alimera Sciences INC | — | EXIT | Sold out |
| 47 | NBIX | Neurocrine Biosciences INC | — | NEW | New buy |
| 48 | ATNXEUR | Athenex INC | — | EXIT | Sold out |
| 49 | TCMD | Tactile Systems Technology I | — | EXIT | Sold out |
| 50 | NUVB | Nuvation Bio INC | — | NEW | New buy |