EA
Exome Asset Management LLC 13F Holdings & Recent Stock Buys (Q2 2026)
Exome Asset Management LLCCIK: 0002011932
Diversified strategySector-focusedContrarian
Total reported value
$162.1M
Reporting period: 2026-06-30 · Number of holdings: 52
Exome Asset Management LLC disclosed 52 holdings in its latest 13F filing for the period ending 2026-06-30, with total reported value of $162.1M and a quarterly turnover rate of 66.0%.
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Personality snowflake
- Concentration
- 12.01
- Portfolio Stability
- 66.01
- Momentum
- 0
- Sector conviction
- 100
- Diversification
- 100
- Sizing Uniformity
- 92.43
Exome Asset Management LLC's disclosed holdings carry a Herfindahl concentration index of 0.030 — mathematically equivalent to about 33 equally-sized positions, close to its 52 actual disclosed holdings. Value is spread relatively evenly across the portfolio rather than concentrated in a handful of names.
Position sizes are fairly uniform across the portfolio (a coefficient of variation of 0.76), suggesting a disciplined, rules-based approach to how much capital goes into each idea.
No strong tilt toward either adding to existing winners or initiating outsized new positions was observed in the latest reported quarter.
Sector classification currently covers about 43% of this portfolio's disclosed value; the remainder includes holdings (e.g. unmapped tickers, options, or other security types) not yet covered by our sector mapping.
Source and citation information
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Recent moves
View source Form 13F filing on SEC.govNew buy TGTX
Sold out XBI
New buy ABVX
New buy QURE
Add GH
-18.4% $2.5M
Sold out ELV
Holdings Map
New buyAddUnchangedTrim
Top 10 holdings by weight
Full holdings list this quarter
| # | Ticker | Issuer | Asset Subclass | Weight | Weight Change | Shares Change | 4Q Trend |
|---|---|---|---|---|---|---|---|
| 1 | GH | Guardant Health Inc | Stock-Healthcare | 6.25% | +2.30% | -18.42% | |
| 2 | PRAX | Praxis Precision Medicines I | Stock-Other | 5.62% | -1.96% | -40.17% | |
| 3 | TGTX | Tg Therapeutics Inc | Stock-Healthcare | 5.59% | +5.59% | NEW | |
| 4 | COGT | Cogent Biosciences Inc | Stock-Other | 5.03% | -0.51% | -24.42% | |
| 5 | IONS | Ionis Pharmaceuticals Inc | Stock-Healthcare | 4.31% | +0.04% | -19.89% | |
| 6 | LLY | Eli Lilly & Co | Stock-Healthcare | 4.06% | +0.72% | -21.68% | |
| 7 | ABVX | Abivax Sa-adr | Stock-Other | 3.85% | +3.85% | NEW | |
| 8 | ALMS | Alumis Inc | Stock-Other | 3.55% | +0.37% | -26.78% | |
| 9 | CYTK | Cytokinetics Inc | Stock-Healthcare | 3.16% | -0.38% | -42.10% | |
| 10 | ELVN | Enliven Therapeutics Inc | Stock-Other | 3.14% | -1.32% | -54.47% | |
| 11 | VERA | Vera Therapeutics Inc | Stock-Other | 2.57% | +0.19% | -15.41% | |
| 12 | UNH | Unitedhealth Group Inc | Stock-Healthcare | 2.46% | +0.66% | -25.27% | |
| 13 | TXG | 10x Genomics Inc-class A | Stock-Other | 2.43% | +0.74% | -33.44% | |
| 14 | NTRA | Natera Inc | Stock-Healthcare | 2.31% | +0.38% | -26.01% | |
| 15 | QURE | uniQure N.V. | Stock-Other | 2.30% | +2.30% | NEW | |
| 16 | RYTM | Rhythm Pharmaceuticals Inc | Stock-Other | 2.21% | +0.38% | -20.63% | |
| 17 | MAZE | Maze Therapeutics Inc | Stock-Other | 2.11% | +0.74% | +29.58% | |
| 18 | GLUE | Monte Rosa Therapeutics Inc | Stock-Other | 2.05% | +0.52% | -23.61% | |
| 19 | MLTX | Moonlake Immunotherapeutics | Stock-Other | 2.00% | -0.08% | -22.70% | |
| 20 | ALKS | Alkermes plc | Stock-Healthcare | 1.98% | +0.44% | -27.07% | |
| 21 | LQDA | Liquidia CORP | Stock-Other | 1.93% | +1.04% | -14.35% | |
| 22 | UTHR | United Therapeutics CORP | Stock-Healthcare | 1.81% | -0.35% | -23.30% | |
| 23 | GKOS | Glaukos CORP | Stock-Healthcare | 1.71% | +0.55% | -4.85% | |
| 24 | ARWR | Arrowhead Pharmaceuticals In | Stock-Healthcare | 1.62% | +0.14% | -29.54% | |
| 25 | AGIO | Agios Pharmaceuticals Inc | Stock-Other | 1.61% | -0.58% | -43.63% | |
| 26 | ✓ | Crescent Biopharma Inc. | Stock-Other | 1.42% | -0.04% | -16.59% | |
| 27 | AZN | AstraZeneca PLC | Stock-Healthcare | 1.39% | +1.39% | NEW | |
| 28 | BSX | Boston Scientific CORP | Stock-Healthcare | 1.27% | -0.30% | — | |
| 29 | ADAG | Adagene Inc-adr | Stock-Other | 1.27% | -0.22% | -33.73% | |
| 30 | PEN | Penumbra Inc | Stock-Healthcare | 1.23% | +0.16% | — | |
| 31 | ISRG | Intuitive Surgical Inc | Stock-Healthcare | 1.20% | -0.32% | -22.81% | |
| 32 | VKTX | Viking Therapeutics Inc | Stock-Healthcare | 1.15% | +1.15% | NEW | |
| 33 | OCUL | Ocular Therapeutix Inc | Stock-Other | 1.10% | +1.10% | NEW | |
| 34 | EQ | Equillium Inc | Stock-Other | 1.09% | +1.09% | NEW | |
| 35 | ✓ | Ascendis Pharma A/s | Stock-Other | 1.08% | +1.08% | NEW | |
| 36 | CRBP | Corbus Pharmaceuticals Holdi | Stock-Other | 1.07% | -0.07% | -21.02% | |
| 37 | CTMX | Cytomx Therapeutics Inc | Stock-Other | 1.06% | -0.21% | -11.77% | |
| 38 | VSTM | Verastem Inc | Stock-Other | 1.01% | -0.74% | -32.61% | |
| 39 | NKTR | Nektar Therapeutics | Stock-Other | 0.97% | +0.97% | NEW | |
| 40 | CLPT | Clearpoint Neuro Inc | Stock-Other | 0.92% | +0.92% | NEW | |
| 41 | INSM | Insmed Inc | Stock-Healthcare | 0.91% | -1.34% | -47.95% | |
| 42 | CAI | Caris Life Sciences Inc | Stock-Other | 0.86% | +0.86% | NEW | |
| 43 | BBIO | Bridgebio Pharma Inc | Stock-Healthcare | 0.84% | -1.75% | -72.80% | |
| 44 | ZBIO | Zenas Biopharma Inc | Stock-Other | 0.82% | — | -35.04% | |
| 45 | NBP | Novabridge Biosciences | Stock-Other | 0.69% | -0.04% | — | |
| 46 | ✓ | Establishment Labs Holdings In | Stock-Other | 0.69% | +0.31% | — | |
| 47 | RLAY | Relay Therapeutics Inc | Stock-Other | 0.55% | -0.88% | -82.92% | |
| 48 | GERN | Geron CORP | Stock-Other | 0.49% | +0.49% | NEW | |
| 49 | DRUG | Bright Minds Biosciences Inc | Stock-Other | 0.44% | +0.44% | NEW | |
| 50 | CMPX | Compass Therapeutics Inc | Stock-Other | 0.37% | +0.37% | NEW |
1–50 of 52
💡
Data Source Notice: AlphaSMO is the web's most authoritative 13F / Inside Trader database. Institutional holdings and insider trades presented here are precisely computed to deliver accurate portfolio reporting.
Portfolio Performance
Performance for Q3 2026
+12.2%
Performance Last 4 Quarters
+87.1%
Based on 87% of reported portfolio value with available pricing
- Stdev
- +25.5%
- Beta
- +0.72
- Alpha
- +18.7%
- Max Drawdown
- -21%
- Annualized Perf
- +33%
- Batting Avg vs S&P
- +63.3%
- Sortino
- +2.33
- Stutzer
- +0.37
- Treynor
- +0.45
- Sterling
- +1.44
- Calmar
- +1.57
- Information Ratio
- +0.56
- Tracking Error
- +24.2%
- Stdev Down
- +13.7%
- Winning Months %
- +70%
- Losing Months %
- +30%
- Best 12 Months
- +114.1%
- Worst 12 Months
- -6.3%
- Efficiency Ratio
- +0.54
- Sharpe
- +1.25
- Stdev Sectors
- 0%
- Skewness
- -0.08
- Kurtosis
- -0.1
- Upside Potential
- +3.95
Reported value over time
Sector allocation
Sector allocation over time
Quarterly history
Holding changes this quarter
Exome Asset Management LLC's most significant position changes for 2026-06-30: New buy: Tg Therapeutics Inc (TGTX); Sold out: Ss Spdr S&p Biotech ETF (XBI); New buy: Abivax Sa-adr (ABVX); Sold out: Elevance Health Inc (ELV); Sold out: Cytokinetics Inc.
| # | Ticker | Issuer | Weight Change | Shares Change | Action |
|---|---|---|---|---|---|
| 1 | TGTX | Tg Therapeutics Inc | +5.6% | NEW | New buy |
| 2 | ABVX | Abivax Sa-adr | +3.9% | NEW | New buy |
| 3 | QURE | uniQure N.V. | +2.3% | NEW | New buy |
| 4 | GH | Guardant Health Inc | +2.3% | -18.42% | Trim |
| 5 | AZN | AstraZeneca PLC | +1.4% | NEW | New buy |
| 6 | VKTX | Viking Therapeutics Inc | +1.2% | NEW | New buy |
| 7 | OCUL | Ocular Therapeutix Inc | +1.1% | NEW | New buy |
| 8 | EQ | Equillium Inc | +1.1% | NEW | New buy |
| 9 | ✓ | Ascendis Pharma A/s | +1.1% | NEW | New buy |
| 10 | LQDA | Liquidia CORP | +1% | -14.35% | Trim |
| 11 | NKTR | Nektar Therapeutics | +1% | NEW | New buy |
| 12 | CLPT | Clearpoint Neuro Inc | +0.9% | NEW | New buy |
| 13 | CAI | Caris Life Sciences Inc | +0.9% | NEW | New buy |
| 14 | MAZE | Maze Therapeutics Inc | +0.7% | +29.58% | Add |
| 15 | TXG | 10x Genomics Inc-class A | +0.7% | -33.44% | Trim |
| 16 | LLY | Eli Lilly & Co | +0.7% | -21.68% | Trim |
| 17 | UNH | Unitedhealth Group Inc | +0.7% | -25.27% | Trim |
| 18 | GKOS | Glaukos CORP | +0.6% | -4.85% | Trim |
| 19 | GLUE | Monte Rosa Therapeutics Inc | +0.5% | -23.61% | Trim |
| 20 | GERN | Geron CORP | +0.5% | NEW | New buy |
| 21 | DRUG | Bright Minds Biosciences Inc | +0.4% | NEW | New buy |
| 22 | ALKS | Alkermes plc | +0.4% | -27.07% | Trim |
| 23 | RYTM | Rhythm Pharmaceuticals Inc | +0.4% | -20.63% | Trim |
| 24 | NTRA | Natera Inc | +0.4% | -26.01% | Trim |
| 25 | CMPX | Compass Therapeutics Inc | +0.4% | NEW | New buy |
| 26 | ALMS | Alumis Inc | +0.4% | -26.78% | Trim |
| 27 | ✓ | Establishment Labs Holdings In | +0.3% | — | Unchanged |
| 28 | REPL | Replimune Group Inc | +0.3% | NEW | New buy |
| 29 | VERA | Vera Therapeutics Inc | +0.2% | -15.41% | Trim |
| 30 | PEN | Penumbra Inc | +0.2% | — | Unchanged |
| 31 | ARWR | Arrowhead Pharmaceuticals In | +0.1% | -29.54% | Trim |
| 32 | IONS | Ionis Pharmaceuticals Inc | 0% | -19.89% | Trim |
| 33 | ZBIO | Zenas Biopharma Inc | — | -35.04% | Trim |
| 34 | ABUS | Arbutus Biopharma CORP | 0% | -33.54% | Trim |
| 35 | ✓ | Crescent Biopharma Inc. | 0% | -16.59% | Trim |
| 36 | NBP | Novabridge Biosciences | 0% | — | Unchanged |
| 37 | CRBP | Corbus Pharmaceuticals Holdi | -0.1% | -21.02% | Trim |
| 38 | ✓ | Compass Therapeutics Inc | -0.1% | EXIT | Sold out |
| 39 | MLTX | Moonlake Immunotherapeutics | -0.1% | -22.70% | Trim |
| 40 | ✓ | Wave Life Sciences LTD | -0.1% | EXIT | Sold out |
| 41 | CTMX | Cytomx Therapeutics Inc | -0.2% | -11.77% | Trim |
| 42 | ADAG | Adagene Inc-adr | -0.2% | -33.73% | Trim |
| 43 | LPCN | Lipocine Inc | -0.3% | EXIT | Sold out |
| 44 | BSX | Boston Scientific CORP | -0.3% | — | Unchanged |
| 45 | ✓ | Travere Therapeutics Inc | -0.3% | EXIT | Sold out |
| 46 | ISRG | Intuitive Surgical Inc | -0.3% | -22.81% | Trim |
| 47 | UTHR | United Therapeutics CORP | -0.4% | -23.30% | Trim |
| 48 | CYTK | Cytokinetics Inc | -0.4% | -42.10% | Trim |
| 49 | COGT | Cogent Biosciences Inc | -0.5% | -24.42% | Trim |
| 50 | PALI | Palisade Bio Inc | -0.5% | EXIT | Sold out |
1–50 of 70
Filing History
FAQ
What is Exome Asset Management LLC and what type of investor is it?
Exome Asset Management LLC is an investment manager that files SEC Form 13F quarterly, disclosing its U.S. public equity holdings to regulators. As of the most recent reporting period (2026-06-30), the firm manages a tracked equity portfolio valued at approximately $162.1M, spread across 52 disclosed positions.
What are Exome Asset Management LLC's largest equity positions?
Based on the latest 13F filing, Exome Asset Management LLC's top holdings by market value are:
1. Guardant Health Inc (GH) — $10.1M (6.3%)
2. Praxis Precision Medicines I (PRAX) — $9.1M (5.6%)
3. Tg Therapeutics Inc (TGTX) — $9.1M (5.6%)
4. Cogent Biosciences Inc (COGT) — $8.1M (5.0%)
5. Ionis Pharmaceuticals Inc (IONS) — $7.0M (4.3%)
What changes did Exome Asset Management LLC make in its most recent portfolio filing?
In the latest reported quarter, Exome Asset Management LLC made 66 notable position adjustments: 15 new positions were initiated, 1 existing holdings were added to, 32 positions were partially reduced, and 18 were completely exited. The largest of these moves: New buy: Tg Therapeutics Inc (TGTX); Sold out: Ss Spdr S&p Biotech ETF (XBI); New buy: Abivax Sa-adr (ABVX); Sold out: Elevance Health Inc (ELV); Sold out: Cytokinetics Inc
What sectors does Exome Asset Management LLC focus on?
Exome Asset Management LLC is concentrated in the following sectors based on its current disclosed equity portfolio:
• Health Care: 100.0%
Investment Profile
Exome Asset Management LLC returned an annualized 33.0% over the trailing 30 months — outperforming the S&P 500 by 18.7 points — based on a reconstructed track record of its disclosed 13F positions, with a beta of 0.72 (less volatile than the market) and a 63% quarterly batting average against the index.
Its portfolio is broadly diversified and fast-trading, with 100.0% of the portfolio concentrated in Health Care.
Its turnover score has risen from 0 to 66 over the past 4 quarters — a shift toward more active trading.
It has added to its UNH position over the past two quarters (+$2.1M, now $4.0M), while trimming PRAX over the same stretch (-$8.0M, still holding $9.1M).
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Developer Access
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REST API
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npx alphasmo institutions get exome-asset-management-llc