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Blue Water Life Science Advisors, LP SEC 13F Filing (Q2 2026) — Holdings & Portfolio
Blue Water Life Science Advisors, LPCIK: 0001789778
Sector-focusedMomentum followerQuality / disciplined sizing
Total reported value
$158.8M
Reporting period: 2026-06-30 · Number of holdings: 9
Blue Water Life Science Advisors, LP disclosed 9 holdings in its latest 13F filing for the period ending 2026-06-30, with total reported value of $158.8M and a quarterly turnover rate of 51.2%.
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Personality snowflake
- Concentration
- 54.71
- Portfolio Stability
- 51.17
- Momentum
- 100
- Sector conviction
- 100
- Diversification
- 18
- Sizing Uniformity
- 94.9
Blue Water Life Science Advisors, LP's disclosed holdings carry a Herfindahl concentration index of 0.137 — mathematically equivalent to about 7 equally-sized positions, close to its 9 actual disclosed holdings. Value is spread relatively evenly across the portfolio rather than concentrated in a handful of names.
Position sizes are fairly uniform across the portfolio (a coefficient of variation of 0.51), suggesting a disciplined, rules-based approach to how much capital goes into each idea.
Recent activity leans toward adding more aggressively to already-large existing positions than to newly initiated ones (a 6.8 percentage-point tilt) — a pattern consistent with a momentum-following approach.
Sector classification currently covers about 21% of this portfolio's disclosed value; the remainder includes holdings (e.g. unmapped tickers, options, or other security types) not yet covered by our sector mapping.
Source and citation information
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Recent moves
View source Form 13F filing on SEC.govSold out TWST
Add CDNA
+27.3% $17.7M
Trim GH
-52.6% -$5.2M
Add PSNL
0.0% $11.8M
Add BLLN
+250.0% $6.8M
Add QTRX
+62.2% $7.5M
Holdings Map
New buyAddUnchangedTrim
Top 10 holdings by weight
Full holdings list this quarter
| # | Ticker | Issuer | Asset Subclass | Weight | Weight Change | Shares Change | 4Q Trend |
|---|---|---|---|---|---|---|---|
| 1 | CDNA | Caredx Inc | Stock-Other | 21.36% | +8.34% | +27.27% | |
| 2 | TXG | 10x Genomics Inc-class A | Stock-Other | 15.50% | -3.06% | -41.10% | |
| 3 | PSNL | Personalis Inc | Stock-Other | 14.15% | +5.59% | — | |
| 4 | ADPT | Adaptive Biotechnologies | Stock-Other | 13.65% | +2.41% | — | |
| 5 | GH | Guardant Health Inc | Stock-Healthcare | 10.84% | -7.10% | -52.63% | |
| 6 | QTRX | Quanterix CORP | Stock-Other | 9.45% | +3.40% | +62.18% | |
| 7 | NTRA | Natera Inc | Stock-Healthcare | 5.90% | -1.28% | -22.99% | |
| 8 | BLLN | Billiontoone Inc Cl A | Stock-Other | 5.29% | +4.02% | +250.00% | |
| 9 | TEM | Tempus Ai Inc-cl A | Stock-Healthcare | 3.85% | -1.82% | -32.61% |
Portfolio Performance
Performance for Q3 2026
+70.6%
Performance Last 4 Quarters
+152.3%
- Stdev
- +52.5%
- Beta
- +2.2
- Alpha
- +21.4%
- Max Drawdown
- -23.9%
- Annualized Perf
- +67.6%
- Batting Avg vs S&P
- +52.8%
- Sortino
- +2.66
- Stutzer
- +0.37
- Treynor
- +0.3
- Sterling
- +2.33
- Calmar
- +2.82
- Information Ratio
- +0.97
- Tracking Error
- +46.7%
- Stdev Down
- +24.7%
- Winning Months %
- +63.9%
- Losing Months %
- +36.1%
- Best 12 Months
- +177.7%
- Worst 12 Months
- +16.4%
- Efficiency Ratio
- +0.8
- Sharpe
- +1.25
- Stdev Sectors
- 0%
- Skewness
- +0.16
- Kurtosis
- -0.89
- Upside Potential
- +4.47
Reported value over time
Sector allocation
Sector allocation over time
Quarterly history
| Period | Holdings | Total value | Stability | Top holdings | |
|---|---|---|---|---|---|
| 2026 Q2 | 9 | $158.8M | 51 | ||
| 2026 Q1 | 10 | $124.7M | 73 | ||
| 2025 Q4 | 9 | $159.3M | 43 | ||
| 2025 Q3 | 7 | $109.6M | 46 | ||
| 2025 Q2 | 8 | $126.3M | 0 | ||
| 2025 Q1 | 7 | $100.9M | 100 | ||
| 2024 Q4 | 9 | $112.9M | 0 | ||
| 2024 Q3 | 8 | $113.7M | 0 | ||
| 2024 Q2 | 8 | $102.8M | 0 | ||
| 2024 Q1 | 8 | $106.3M | 0 | ||
| 2023 Q4 | 9 | $114.2M | 0 | ||
| 2023 Q3 | 7 | $105.9M | 0 | ||
| 2023 Q2 | 7 | $148.2M | 0 | ||
| 2023 Q1 | 8 | $151.2M | 0 | ||
| 2022 Q4 | 8 | $148.9M | 0 | ||
| 2022 Q3 | 9 | $247.8M | 0 | ||
| 2022 Q2 | 9 | $184.1M | 0 | ||
| 2022 Q1 | 10 | $210.7M | 0 | ||
| 2021 Q4 | 13 | $326.9M | 0 | ||
| 2021 Q3 | 24 | $307.4M | 0 | ||
| 2021 Q2 | 22 | $265.8M | 87 | ||
| 2021 Q1 | 24 | $204.7M | 49 | ||
| 2020 Q4 | 21 | $170.4M | 0 |
Holding changes this quarter
Blue Water Life Science Advisors, LP's most significant position changes for 2026-06-30: Sold out: Twist Bioscience CORP (TWST); Add: Caredx Inc (CDNA) — shares +27.27%; Trim: Guardant Health Inc (GH) — shares -52.63%; Add: Billiontoone Inc Cl A (BLLN) — shares +250.00%; Add: Quanterix CORP (QTRX) — shares +62.18%.
| # | Ticker | Issuer | Weight Change | Shares Change | Action |
|---|---|---|---|---|---|
| 1 | CDNA | Caredx Inc | +8.3% | +27.27% | Add |
| 2 | PSNL | Personalis Inc | +5.6% | — | Unchanged |
| 3 | BLLN | Billiontoone Inc Cl A | +4% | +250.00% | Add |
| 4 | QTRX | Quanterix CORP | +3.4% | +62.18% | Add |
| 5 | ADPT | Adaptive Biotechnologies | +2.4% | — | Unchanged |
| 6 | NTRA | Natera Inc | -1.3% | -22.99% | Trim |
| 7 | TEM | Tempus Ai Inc-cl A | -1.8% | -32.61% | Trim |
| 8 | TXG | 10x Genomics Inc-class A | -3.1% | -41.10% | Trim |
| 9 | GH | Guardant Health Inc | -7.1% | -52.63% | Trim |
| 10 | TWST | Twist Bioscience CORP | -10.5% | EXIT | Sold out |
Filing History
FAQ
What is Blue Water Life Science Advisors, LP and what type of investor is it?
Blue Water Life Science Advisors, LP is an investment manager that files SEC Form 13F quarterly, disclosing its U.S. public equity holdings to regulators. As of the most recent reporting period (2026-06-30), the firm manages a tracked equity portfolio valued at approximately $158.8M, spread across 9 disclosed positions.
What are Blue Water Life Science Advisors, LP's largest equity positions?
Based on the latest 13F filing, Blue Water Life Science Advisors, LP's top holdings by market value are:
1. Caredx Inc (CDNA) — $33.9M (21.4%)
2. 10x Genomics Inc-class A (TXG) — $24.6M (15.5%)
3. Personalis Inc (PSNL) — $22.5M (14.2%)
4. Adaptive Biotechnologies (ADPT) — $21.7M (13.7%)
5. Guardant Health Inc (GH) — $17.2M (10.8%)
What changes did Blue Water Life Science Advisors, LP make in its most recent portfolio filing?
In the latest reported quarter, Blue Water Life Science Advisors, LP made 8 notable position adjustments: 0 new positions were initiated, 3 existing holdings were added to, 4 positions were partially reduced, and 1 were completely exited. The largest of these moves: Sold out: Twist Bioscience CORP (TWST); Add: Caredx Inc (CDNA) — shares +27.27%; Trim: Guardant Health Inc (GH) — shares -52.63%; Add: Billiontoone Inc Cl A (BLLN) — shares +250.00%; Add: Quanterix CORP (QTRX) — shares +62.18%
What sectors does Blue Water Life Science Advisors, LP focus on?
Blue Water Life Science Advisors, LP is concentrated in the following sectors based on its current disclosed equity portfolio:
• Health Care: 100.0%
Investment Profile
Blue Water Life Science Advisors, LP returned an annualized 67.6% over the trailing 36 months — outperforming the S&P 500 by 21.4 points — based on a reconstructed track record of its disclosed 13F positions, with a beta of 2.20 (more volatile than the market) and a 53% quarterly batting average against the index.
Its portfolio is moderately concentrated and moderately active, with 100.0% of the portfolio concentrated in Health Care.
Its turnover score has risen from 0 to 51 over the past 4 quarters — a shift toward more active trading.
It has added to its CDNA position over the past two quarters (+$24.3M, now $33.9M), while trimming GH over the same stretch (-$19.0M, still holding $17.2M).
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