AC
Asymmetry Capital Management, L.P. Historical SEC 13F Holdings & Archive (Q4 2021)
Asymmetry Capital Management, L.P.CIK: 0001657134
Sector-focusedQuality / disciplined sizingLong-term holder
Total reported value
$188.4M
Reporting period: 2021-12-31 · Number of holdings: 24
Asymmetry Capital Management, L.P. disclosed 24 holdings in its latest 13F filing for the period ending 2021-12-31, with total reported value of $188.4M and a quarterly turnover rate of 0.0%.
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Personality snowflake
- Concentration
- 21.55
- Portfolio Stability
- 0
- Momentum
- 50
- Sector conviction
- 100
- Diversification
- 48
- Sizing Uniformity
- 94.47
Asymmetry Capital Management, L.P.'s disclosed holdings carry a Herfindahl concentration index of 0.054 — mathematically equivalent to about 19 equally-sized positions, close to its 24 actual disclosed holdings. Value is spread relatively evenly across the portfolio rather than concentrated in a handful of names.
Position sizes are fairly uniform across the portfolio (a coefficient of variation of 0.55), suggesting a disciplined, rules-based approach to how much capital goes into each idea.
No strong tilt toward either adding to existing winners or initiating outsized new positions was observed in the latest reported quarter.
Sector classification currently covers about 19% of this portfolio's disclosed value; the remainder includes holdings (e.g. unmapped tickers, options, or other security types) not yet covered by our sector mapping.
Source and citation information
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Recent moves
View source Form 13F filing on SEC.govNo holding changes this quarter
Holdings Map
New buyAddUnchangedTrim
Top 10 holdings by weight
Full holdings list this quarter
| # | Ticker | Issuer | Asset Subclass | Weight | Weight Change | Shares Change | 4Q Trend |
|---|---|---|---|---|---|---|---|
| 1 | BMRN | Biomarin Pharmaceutical Inc | Stock-Healthcare | 8.34% | — | — | |
| 2 | ✓ | Horizon Therapeutics PLC | Stock-Other | 7.87% | — | +451.57% | |
| 3 | UNH | Unitedhealth Group Inc | Stock-Healthcare | 7.16% | — | — | |
| 4 | ABBV | Abbvie Inc | Stock-Healthcare | 6.79% | — | — | |
| 5 | IQV | Iqvia Holdings Inc | Stock-Healthcare | 6.64% | — | — | |
| 6 | CNC | Centene CORP | Stock-Healthcare | 6.48% | — | — | |
| 7 | BLU | Bellus Health Inc | Stock-Other | 5.47% | — | +19.40% | |
| 8 | CYTK | Cytokinetics Inc | Stock-Healthcare | 5.44% | — | -8.65% | |
| 9 | JNJ | Johnson & Johnson | Stock-Healthcare | 5.06% | — | — | |
| 10 | NTRA | Natera Inc | Stock-Healthcare | 5.04% | — | — | |
| 11 | AM6 | Amicus Therapeutics Inc | Stock-Other | 4.39% | — | +9.59% | |
| 12 | ARGX | Argenx Se - Adr | Stock-Healthcare | 3.88% | — | — | |
| 13 | KURA | Kura Oncology Inc | Stock-Other | 3.73% | — | +158.49% | |
| 14 | APLSUSD | Apellis Pharmaceuticals Inc | Stock-Other | 3.50% | — | — | |
| 15 | MRTXEUR | Mirati Therapeutics Inc | Stock-Other | 3.42% | — | +4.49% | |
| 16 | OPHTEUR | Iveric Bio Inc | Stock-Other | 3.34% | — | +5.79% | |
| 17 | QTRX | Quanterix CORP | Stock-Other | 3.22% | — | -11.57% | |
| 18 | 2662247D | Iteos Therapeutics Inc | Stock-Other | 2.59% | — | +82.86% | |
| 19 | ✓ | DICE Therapeutics Inc | Stock-Other | 2.49% | — | -32.69% | |
| 20 | ✓ | Avadel Pharmaceuticals PLC ADR | Stock-Other | 1.58% | — | -22.18% | |
| 21 | ACRS | Aclaris Therapeutics Inc | Stock-Other | 1.53% | — | -17.88% | |
| 22 | PMVP | Pmv Pharmaceuticals Inc | Stock-Other | 1.20% | — | -3.17% | |
| 23 | RGLSUSD | Regulus Therapeutics Inc | Stock-Other | 0.46% | — | +94.87% | |
| 24 | ✓ | Bcls Acquisition CORP | Stock-Other | 0.37% | — | -2.64% |
Reported value over time
Sector allocation
Sector allocation over time
Quarterly history
| Period | Holdings | Total value | Stability | Top holdings | |
|---|---|---|---|---|---|
| 2021 Q4 | 24 | $188.4M | 0 | ||
| 2021 Q3 | 29 | $166.3M | 0 | ||
| 2021 Q2 | 30 | $145.5M | 100 | ||
| 2021 Q1 | 29 | $193.3M | 100 | ||
| 2020 Q4 | 33 | $219.3M | 100 | ||
| 2020 Q3 | 34 | $155.6M | 98 | ||
| 2020 Q2 | 32 | $130.5M | 88 | ||
| 2020 Q1 | 29 | $91.4M | 100 | ||
| 2019 Q4 | 33 | $55.8M | 100 | ||
| 2019 Q3 | 22 | $46.7M | 100 | ||
| 2019 Q2 | 30 | $184.7M | 100 | ||
| 2019 Q1 | 25 | $59.8M | 81 | ||
| 2018 Q4 | 23 | $36.2M | 100 | ||
| 2018 Q3 | 35 | $108.2M | 83 | ||
| 2018 Q2 | 36 | $101.7M | 78 | ||
| 2018 Q1 | 36 | $79.9M | 56 | ||
| 2017 Q4 | 31 | $73.7M | 68 | ||
| 2017 Q3 | 32 | $86.2M | 73 | ||
| 2017 Q2 | 28 | $84.3M | 81 | ||
| 2017 Q1 | 27 | $71.7M | 51 | ||
| 2016 Q4 | 20 | $53.8M | 82 | ||
| 2016 Q3 | 20 | $57.5M | 77 | ||
| 2016 Q2 | 19 | $54.6M | 94 | ||
| 2016 Q1 | 16 | $38.4M | 87 | ||
| 2015 Q4 | 17 | $66.1M | 100 | ||
| 2015 Q3 | 22 | $44.9M | 0 |
Holding changes this quarter
| # | Ticker | Issuer | Weight Change | Shares Change | Action |
|---|
Filing History
FAQ
What is Asymmetry Capital Management, L.P. and what type of investor is it?
Asymmetry Capital Management, L.P. is an investment manager that files SEC Form 13F quarterly, disclosing its U.S. public equity holdings to regulators. As of the most recent reporting period (2021-12-31), the firm manages a tracked equity portfolio valued at approximately $188.4M, spread across 24 disclosed positions.
What are Asymmetry Capital Management, L.P.'s largest equity positions?
Based on the latest 13F filing, Asymmetry Capital Management, L.P.'s top holdings by market value are:
1. Biomarin Pharmaceutical Inc (BMRN) — $15.7M (8.3%)
2. Horizon Therapeutics PLC — $14.8M (7.9%)
3. Unitedhealth Group Inc (UNH) — $13.5M (7.2%)
4. Abbvie Inc (ABBV) — $12.8M (6.8%)
5. Iqvia Holdings Inc (IQV) — $12.5M (6.6%)
What changes did Asymmetry Capital Management, L.P. make in its most recent portfolio filing?
No notable portfolio changes were recorded for Asymmetry Capital Management, L.P. in the most recent quarter. Holdings appear to have remained relatively stable.
What sectors does Asymmetry Capital Management, L.P. focus on?
Asymmetry Capital Management, L.P. is concentrated in the following sectors based on its current disclosed equity portfolio:
• Health Care: 100.0%
Investment Profile
Asymmetry Capital Management, L.P.'s portfolio is broadly diversified and long-term-holding, with 100.0% of the portfolio concentrated in Health Care.
Its turnover score has fallen from 100 to 0 over the past 4 quarters — a shift toward longer holding periods.
It has added to its AM6 position over the past two quarters (+$5.4M, now $8.3M), while trimming MRTXEUR over the same stretch (-$2.9M, still holding $6.4M).
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