目前共有 24 家機構持有 ACOG，以下依持股市值由高至低排序。
| 主要持有機構 | 總市值 | 平均佔比 |
|---|---|---|
| Opaleye Management Inc. | US$1406.5萬 | 1.85% |
| Solas Capital Management, LLC | US$1056.6萬 | 6.08% |
| AWM Investment Company, Inc. | US$918.0萬 | 1.02% |
| Cable Car Capital, LP | US$758.9萬 | 2.62% |
| Ikarian Capital, LLC | US$579.9萬 | 0.47% |
| SPHERA FUNDS MANAGEMENT LTD. | US$311.6萬 | 0.49% |
| Alyeska Investment Group, L.P. | US$200.4萬 | 0.01% |
| BOOTHBAY FUND MANAGEMENT, LLC | US$140.8萬 | 0.02% |
| Aristides Capital LLC | US$120.0萬 | 0.26% |
| CANTOR FITZGERALD, L. P. | US$103.6萬 | 0.02% |
| CITADEL ADVISORS LLC | US$49.2萬 | 0.00% |
| VILLERE ST DENIS J & CO LLC | US$39.1萬 | 0.04% |
| TUDOR INVESTMENT CORP ET AL | US$33.8萬 | 0.00% |
| ACT CAPITAL MANAGEMENT, LLC | US$28.3萬 | 0.22% |
| TWO SIGMA INVESTMENTS, LP | US$8.7萬 | 0.00% |
| GEODE CAPITAL MANAGEMENT, LLC | US$6.6萬 | 0.00% |
| RAYMOND JAMES FINANCIAL INC | US$5.5萬 | 0.00% |
| NATIONAL BANK OF CANADA /FI/ | US$2.8萬 | 0.00% |
| Allworth Financial LP | US$4118.0 | 0.00% |
| ROYAL BANK OF CANADA | US$4000.0 | 0.00% |
| UBS Group AG | US$2405.0 | 0.00% |
| Steward Partners Investment Advisory, LLC | US$1098.0 | 0.00% |
| JONES FINANCIAL COMPANIES LLLP | US$508.0 | 0.00% |
| HARBOUR INVESTMENTS, INC. | US$25.0 | 0.00% |