| Frazier Life Sciences Management, L.P. | $542.4M | 13.96% |
| Capital World Investors | $355.6M | 0.05% |
| RA CAPITAL MANAGEMENT, L.P. | $305.7M | 3.24% |
| FCPM III SERVICES B.V. | $294.5M | 40.77% |
| FMR LLC | $280.6M | 0.01% |
| Bain Capital Life Sciences Investors, LLC | $233.9M | 21.09% |
| WELLINGTON MANAGEMENT GROUP LLP | $163.8M | 0.03% |
| DEERFIELD MANAGEMENT COMPANY, L.P. | $136.5M | 1.61% |
| VIKING GLOBAL INVESTORS LP | $134.6M | 0.38% |
| Duquesne Family Office LLC | $98.3M | 2.91% |
| Polar Capital Holdings Plc | $90.6M | 0.32% |
| JENNISON ASSOCIATES LLC | $88.0M | 0.06% |
| Medicxi Ventures Management (Jersey) Ltd | $85.6M | 8.72% |
| JANUS HENDERSON GROUP PLC | $72.3M | 0.03% |
| WESTFIELD CAPITAL MANAGEMENT CO LP | $70.5M | 0.30% |
| MAVERICK CAPITAL LTD | $70.0M | 0.81% |
| GOLDMAN SACHS GROUP INC | $62.3M | 0.01% |
| Capital International Investors | $46.1M | 0.01% |
| ALLIANCEBERNSTEIN L.P. | $42.1M | 0.01% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | $35.4M | 0.05% |
| Castle Hook Partners LP | $33.4M | 0.65% |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | $30.6M | 0.04% |
| Cormorant Asset Management, LP | $30.4M | 1.53% |
| BlackRock, Inc. | $28.4M | 0.00% |
| BANK OF AMERICA CORP /DE/ | $27.1M | 0.00% |
| Aberdeen Group plc | $26.8M | 0.04% |
| JPMORGAN CHASE & CO | $25.9M | 0.00% |
| UBS Group AG | $25.4M | 0.00% |
| FRANKLIN RESOURCES INC | $24.7M | 0.01% |
| CITADEL ADVISORS LLC | $24.6M | 0.00% |
| AMERIPRISE FINANCIAL INC | $24.1M | 0.01% |
| Woodline Partners LP | $24.1M | 0.09% |
| TimesSquare Capital Management, LLC | $24.1M | 0.41% |
| Logos Global Management LP | $19.2M | 0.96% |
| Rock Springs Capital Management LP | $18.8M | 1.11% |
| First Turn Management, LLC | $17.9M | 2.00% |
| MORGAN STANLEY | $17.8M | 0.00% |
| AMERICAN CENTURY COMPANIES INC | $16.6M | 0.01% |
| Artia Global Partners LP | $16.1M | 3.23% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $14.9M | 0.00% |
| Handelsbanken Fonder AB | $13.4M | 0.04% |
| KENNEDY CAPITAL MANAGEMENT LLC | $13.1M | 0.28% |
| Bank of New York Mellon Corp | $12.1M | 0.00% |
| Decheng Capital LLC | $10.4M | 1.57% |
| Slate Path Capital LP | $10.2M | 0.15% |
| MILLENNIUM MANAGEMENT LLC | $9.7M | 0.00% |
| Eversept Partners, LP | $9.1M | 0.48% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | $9.1M | 0.00% |
| Affinity Asset Advisors, LLC | $8.8M | 0.45% |
| SEB Asset Management AB | $8.7M | 0.04% |
| FIRST TRUST ADVISORS LP | $8.6M | 0.01% |
| MARSHALL WACE, LLP | $8.5M | 0.01% |
| ArrowMark Colorado Holdings LLC | $8.3M | 0.22% |
| Ensign Peak Advisors, Inc | $8.0M | 0.01% |
| GILDER GAGNON HOWE & CO LLC | $7.7M | 0.09% |
| JANE STREET GROUP, LLC | $7.2M | 0.00% |
| LORD, ABBETT & CO. LLC | $6.3M | 0.02% |
| STEMPOINT CAPITAL LP | $5.8M | 1.11% |
| PEREGRINE CAPITAL MANAGEMENT LLC | $5.7M | 0.21% |
| VICTORY CAPITAL MANAGEMENT INC | $5.5M | 0.00% |
| Atle Fund Management AB | $5.5M | 1.78% |
| DCF Advisers, LLC | $5.1M | 1.37% |
| XTX Topco Ltd | $4.6M | 0.08% |
| LMR Partners LLP | $4.4M | 0.01% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $4.3M | 0.00% |
| Nicholas Investment Partners, LP | $4.0M | 0.29% |
| DEUTSCHE BANK AG\ | $4.0M | 0.00% |
| ADAR1 Capital Management, LLC | $3.8M | 0.22% |
| MOODY ALDRICH PARTNERS LLC | $3.7M | 0.66% |
| GEODE CAPITAL MANAGEMENT, LLC | $3.3M | 0.00% |
| Swedbank AB | $3.2M | 0.00% |
| Caption Management, LLC | $3.0M | 0.02% |
| ALPS ADVISORS INC | $3.0M | 0.01% |
| Swiss National Bank | $2.8M | 0.00% |
| Russell Investments Group, Ltd. | $2.7M | 0.00% |
| Catalio Capital Management, LP | $2.7M | 0.56% |
| STATE STREET CORP | $2.0M | 0.00% |
| Walleye Capital LLC | $1.9M | 0.01% |
| SEI INVESTMENTS CO | $1.8M | 0.00% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | $1.7M | 0.00% |
| FRED ALGER MANAGEMENT, LLC | $1.7M | 0.01% |
| Mizuho Markets Cayman LP | $1.7M | 0.09% |
| DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main | $1.5M | 0.00% |
| Tidal Investments LLC | $1.4M | 0.00% |
| China Universal Asset Management Co., Ltd. | $1.4M | 0.11% |
| Squarepoint Ops LLC | $1.4M | 0.00% |
| Ishara Investments LP | $1.2M | 1.12% |
| Point72 Asset Management, L.P. | $1.2M | 0.00% |
| Knights of Columbus Asset Advisors LLC | $1.2M | 0.07% |
| Legal & General Group Plc | $1.1M | 0.00% |
| NORTHERN TRUST CORP | $1.0M | 0.00% |
| STIFEL FINANCIAL CORP | $935.2K | 0.00% |
| VANGUARD ASSET MANAGEMENT, Ltd | $901.0K | 0.00% |
| Headlands Technologies LLC | $885.9K | 0.10% |
| Bellevue Group AG | $885.4K | 0.02% |
| BOOTHBAY FUND MANAGEMENT, LLC | $875.0K | 0.01% |
| VOYA INVESTMENT MANAGEMENT LLC | $865.9K | 0.00% |
| Eleva Capital SAS | $823.3K | 0.24% |
| Lifetime Wealth Management P.C. | $752.2K | 0.43% |
| CenterBook Partners LP | $712.4K | 0.04% |
| BARCLAYS PLC | $697.2K | 0.00% |
| DNB Asset Management AS | $690.1K | 0.00% |
| Zurcher Kantonalbank (Zurich Cantonalbank) | $669.7K | 0.00% |
| STATE OF WISCONSIN INVESTMENT BOARD | $657.7K | 0.00% |
| HighVista Strategies LLC | $642.3K | 0.18% |
| DAFNA Capital Management LLC | $640.2K | 0.15% |
| Aquatic Capital Management LLC | $628.4K | 0.02% |
| GLENMEDE TRUST CO NA | $594.6K | 0.00% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | $571.9K | 0.00% |
| NEW YORK STATE COMMON RETIREMENT FUND | $569.8K | 0.00% |
| Brevan Howard Capital Management LP | $527.9K | 0.00% |
| ENVESTNET ASSET MANAGEMENT INC | $497.8K | 0.00% |
| Mesirow Financial Investment Management, Inc. | $493.9K | 0.01% |
| State of New Jersey Common Pension Fund D | $492.9K | 0.00% |
| PSP Research LLC | $480.2K | 0.34% |
| AlphaCentric Advisors LLC | $469.1K | 0.47% |
| ALTFEST L J & CO INC | $446.0K | 0.05% |
| PTM WEALTH MANAGEMENT, LLC | $440.1K | 0.23% |
| SBI Okasan Asset Management Co.Ltd. | $437.0K | 0.02% |
| KEYBANK NATIONAL ASSOCIATION/OH | $399.5K | 0.00% |
| ARIZONA STATE RETIREMENT SYSTEM | $396.1K | 0.00% |
| LETKO, BROSSEAU & ASSOCIATES INC | $376.9K | 0.01% |
| ROYAL BANK OF CANADA | $362.0K | 0.00% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | $361.8K | 0.00% |
| TWINBEECH CAPITAL LP | $339.3K | 0.04% |
| AQR CAPITAL MANAGEMENT LLC | $332.4K | 0.00% |
| Vanguard Investments Australia, Ltd. | $321.0K | 0.00% |
| KLP KAPITALFORVALTNING AS | $316.9K | 0.00% |
| PNC FINANCIAL SERVICES GROUP, INC. | $291.9K | 0.00% |
| Creative Planning | $267.5K | 0.00% |
| Virtus Investment Advisers, LLC | $234.3K | 0.06% |
| Invesco Ltd. | $233.4K | 0.00% |
| Allianz Asset Management GmbH | $211.3K | 0.00% |
| Pictet Asset Management Holding SA | $209.1K | 0.00% |
| GUGGENHEIM CAPITAL LLC | $206.7K | 0.00% |
| Mirae Asset Global Investments Co., Ltd. | $192.0K | 0.00% |
| US BANCORP \DE\ | $175.2K | 0.00% |
| CITIGROUP INC | $152.6K | 0.00% |
| Quarry LP | $144.0K | 0.03% |
| Caitong International Asset Management Co., Ltd | $120.9K | 0.02% |
| Freestone Grove Partners LP | $96.0K | 0.00% |
| AdvisorNet Financial, Inc | $82.1K | 0.00% |
| GF FUND MANAGEMENT CO. LTD. | $81.5K | 0.00% |
| NATIONAL BANK OF CANADA /FI/ | $64.5K | 0.00% |
| Parallel Advisors, LLC | $45.1K | 0.00% |
| Tower Research Capital LLC (TRC) | $38.3K | 0.00% |
| KBC Group NV | $37.0K | 0.00% |
| THURSTON, SPRINGER, MILLER, HERD & TITAK, INC. | $34.2K | 0.01% |
| Farther Finance Advisors, LLC | $33.4K | 0.00% |
| CWM, LLC | $32.6K | 0.00% |