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Bain Capital Life Sciences Investors, LLC — 13F Portfolio Breakdown & Top Holdings (Q2 2026)
Bain Capital Life Sciences Investors, LLCCIK: 0001703031
Sector-focusedContrarianQuality / disciplined sizing
Total reported value
$1.7B
Reporting period: 2026-06-30 · Number of holdings: 21
Bain Capital Life Sciences Investors, LLC disclosed 21 holdings in its latest 13F filing for the period ending 2026-06-30, with total reported value of $1.7B and a quarterly turnover rate of 66.2%.
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Personality snowflake
- Concentration
- 54.54
- Portfolio Stability
- 66.18
- Momentum
- 0
- Sector conviction
- 100
- Diversification
- 42
- Sizing Uniformity
- 86.01
Bain Capital Life Sciences Investors, LLC's disclosed holdings carry a Herfindahl concentration index of 0.136 — mathematically equivalent to about 7 equally-sized positions, well below its 21 actual disclosed holdings. That gap points to a strategy built around a small core of high-conviction bets rather than broad diversification.
Position sizes vary widely across the portfolio (a coefficient of variation of 1.40), with a handful of outsized bets alongside many smaller positions.
Recent activity leans toward initiating meaningfully larger new positions than it adds to existing ones (a 14.4 percentage-point tilt) — a pattern consistent with a more contrarian, new-idea-driven approach.
Sector classification currently covers about 6% of this portfolio's disclosed value; the remainder includes holdings (e.g. unmapped tickers, options, or other security types) not yet covered by our sector mapping.
Source and citation information
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Recent moves
View source Form 13F filing on SEC.govNew buy 482931102
Trim NAMS
-47.9% -$104.9M
Trim HTFL
-19.1% -$6.3M
Trim OLMA
-5.2% -$22.8M
Add ALKS
+217.7% $80.0M
New buy 423494103
Holdings Map
New buyAddUnchangedTrim
Top 10 holdings by weight
Full holdings list this quarter
| # | Ticker | Issuer | Asset Subclass | Weight | Weight Change | Shares Change | 4Q Trend |
|---|---|---|---|---|---|---|---|
| 1 | ✓ | Stock-Other | 29.58% | +29.58% | NEW | ||
| 2 | HTFL | Heartflow Inc | Stock-Other | 14.74% | -8.19% | -19.14% | |
| 3 | NAMS | NewAmsterdam Pharma Company N.V. | Stock-Other | 7.67% | -13.42% | -47.90% | |
| 4 | SVRA | Savara Inc | Stock-Other | 6.45% | -2.22% | — | |
| 5 | ALKS | Alkermes plc | Stock-Healthcare | 6.04% | +4.09% | +217.69% | |
| 6 | SLDB | Solid Biosciences Inc | Stock-Other | 5.83% | -0.54% | — | |
| 7 | PHVS | Pharvaris N.V. | Stock-Other | 5.50% | -1.32% | — | |
| 8 | OLMA | Olema Pharmaceuticals Inc | Stock-Other | 5.27% | -4.78% | -5.19% | |
| 9 | ✓ | Stock-Other | 3.60% | +3.60% | NEW | ||
| 10 | CABA | Cabaletta Bio Inc | Stock-Other | 3.19% | +0.84% | +78.17% | |
| 11 | XFOR | X4 Pharmaceuticals Inc | Stock-Other | 2.21% | -0.76% | — | |
| 12 | DNTH | Dianthus Therapeutics Inc | Stock-Other | 2.10% | -0.64% | — | |
| 13 | CCCC | C4 Therapeutics Inc | Stock-Other | 1.99% | +0.29% | — | |
| 14 | KYTX | Kyverna Therapeutics Inc | Stock-Other | 1.53% | -0.89% | -7.23% | |
| 15 | ANNX | Annexon Inc | Stock-Other | 1.51% | -1.09% | -14.87% | |
| 16 | RPID | Rapid Micro Biosystems Inc-a | Stock-Other | 0.87% | -0.86% | — | |
| 17 | IRON | Disc Medicine Inc | Stock-Other | 0.61% | -0.20% | — | |
| 18 | AVIR | Atea Pharmaceuticals Inc | Stock-Other | 0.57% | -0.58% | -12.07% | |
| 19 | XLO | Xilio Therapeutics Inc | Stock-Other | 0.38% | -0.12% | — | |
| 20 | UPB | Upstream Bio Inc | Stock-Other | 0.25% | -0.45% | -30.70% | |
| 21 | ✓ | Newamsterdam Pharma Company | Stock-Other | 0.13% | -0.05% | — |
Portfolio Performance
Performance for Q3 2026
+10.7%
Performance Last 4 Quarters
+79.8%
- Stdev
- +37.9%
- Beta
- +1.1
- Alpha
- +17.7%
- Max Drawdown
- -31.9%
- Annualized Perf
- +38.7%
- Batting Avg vs S&P
- +50%
- Sortino
- +2.37
- Stutzer
- +0.32
- Treynor
- +0.36
- Sterling
- +1.27
- Calmar
- +1.21
- Information Ratio
- +0.56
- Tracking Error
- +35.2%
- Stdev Down
- +16.7%
- Winning Months %
- +58.3%
- Losing Months %
- +41.7%
- Best 12 Months
- +115%
- Worst 12 Months
- -30%
- Efficiency Ratio
- +0.53
- Sharpe
- +1.05
- Stdev Sectors
- 0%
- Skewness
- +0.65
- Kurtosis
- -0.26
- Upside Potential
- +4.3
Reported value over time
Sector allocation
Sector allocation over time
Quarterly history
| Period | Holdings | Total value | Stability | Top holdings | |
|---|---|---|---|---|---|
| 2026 Q2 | 21 | $1.7B | 66 | ||
| 2026 Q1 | 20 | $1.1B | 34 | ||
| 2025 Q4 | 19 | $1.3B | 50 | ||
| 2025 Q3 | 21 | $1.5B | 100 | ||
| 2025 Q2 | 23 | $799.3M | 0 | ||
| 2025 Q1 | 24 | $675.9M | 100 | ||
| 2024 Q4 | 26 | $850.1M | 0 | ||
| 2024 Q3 | 24 | $961.2M | 0 | ||
| 2024 Q2 | 25 | $910.8M | 0 | ||
| 2024 Q1 | 26 | $1.2B | 0 | ||
| 2023 Q4 | 27 | $1.0B | 0 | ||
| 2023 Q3 | 31 | $894.2M | 0 | ||
| 2023 Q2 | 32 | $971.0M | 0 | ||
| 2023 Q1 | 34 | $800.1M | 0 | ||
| 2022 Q4 | 33 | $894.8M | 0 | ||
| 2022 Q3 | 33 | $837.8M | 0 | ||
| 2022 Q2 | 35 | $852.7M | 0 | ||
| 2022 Q1 | 34 | $1.0B | 0 | ||
| 2021 Q4 | 34 | $1.3B | 0 | ||
| 2021 Q3 | 33 | $1.6B | 0 | ||
| 2021 Q2 | 30 | $1.5B | 33 | ||
| 2021 Q1 | 31 | $1.8B | 41 | ||
| 2020 Q4 | 26 | $1.6B | 66 | ||
| 2020 Q3 | 22 | $1.1B | 39 | ||
| 2020 Q2 | 15 | $954.8M | 54 | ||
| 2020 Q1 | 11 | $591.3M | 52 | ||
| 2019 Q4 | 10 | $670.5M | 68 | ||
| 2019 Q3 | 7 | $388.4M | 83 | ||
| 2019 Q2 | 5 | $196.9M | 24 | ||
| 2019 Q1 | 6 | $250.1M | 58 | ||
| 2018 Q4 | 6 | $292.6M | 42 | ||
| 2018 Q3 | 6 | $440.6M | 32 | ||
| 2018 Q2 | 5 | $319.1M | 61 | ||
| 2018 Q1 | 4 | $169.6M | 32 | ||
| 2017 Q4 | 3 | $152.4M | 0 |
Holding changes this quarter
Bain Capital Life Sciences Investors, LLC's most significant position changes for 2026-06-30: New buy: ; New buy: ; Sold out: Centessa Pharmaceuticals-adr (260); Trim: NewAmsterdam Pharma Company N.V. (NAMS) — shares -47.90%; Trim: Heartflow Inc (HTFL) — shares -19.14%.
| # | Ticker | Issuer | Weight Change | Shares Change | Action |
|---|---|---|---|---|---|
| 1 | ✓ | +29.6% | NEW | New buy | |
| 2 | ALKS | Alkermes plc | +4.1% | +217.69% | Add |
| 3 | ✓ | +3.6% | NEW | New buy | |
| 4 | CABA | Cabaletta Bio Inc | +0.8% | +78.17% | Add |
| 5 | CCCC | C4 Therapeutics Inc | +0.3% | — | Unchanged |
| 6 | ✓ | Newamsterdam Pharma Company | -0.1% | — | Unchanged |
| 7 | XLO | Xilio Therapeutics Inc | -0.1% | — | Unchanged |
| 8 | IRON | Disc Medicine Inc | -0.2% | — | Unchanged |
| 9 | UPB | Upstream Bio Inc | -0.5% | -30.70% | Trim |
| 10 | SLDB | Solid Biosciences Inc | -0.5% | — | Unchanged |
| 11 | AVIR | Atea Pharmaceuticals Inc | -0.6% | -12.07% | Trim |
| 12 | DNTH | Dianthus Therapeutics Inc | -0.6% | — | Unchanged |
| 13 | XFOR | X4 Pharmaceuticals Inc | -0.8% | — | Unchanged |
| 14 | RPID | Rapid Micro Biosystems Inc-a | -0.9% | — | Unchanged |
| 15 | KYTX | Kyverna Therapeutics Inc | -0.9% | -7.23% | Trim |
| 16 | ANNX | Annexon Inc | -1.1% | -14.87% | Trim |
| 17 | PHVS | Pharvaris N.V. | -1.3% | — | Unchanged |
| 18 | SVRA | Savara Inc | -2.2% | — | Unchanged |
| 19 | 260 | Centessa Pharmaceuticals-adr | -2.3% | EXIT | Sold out |
| 20 | OLMA | Olema Pharmaceuticals Inc | -4.8% | -5.19% | Trim |
| 21 | HTFL | Heartflow Inc | -8.2% | -19.14% | Trim |
| 22 | NAMS | NewAmsterdam Pharma Company N.V. | -13.4% | -47.90% | Trim |
💡
Data Source Notice: AlphaSMO is the web's most authoritative 13F / Inside Trader database. Institutional holdings and insider trades presented here are precisely computed to deliver accurate portfolio reporting.
Filing History
FAQ
What is Bain Capital Life Sciences Investors, LLC and what type of investor is it?
Bain Capital Life Sciences Investors, LLC is an investment manager that files SEC Form 13F quarterly, disclosing its U.S. public equity holdings to regulators. As of the most recent reporting period (2026-06-30), the firm manages a tracked equity portfolio valued at approximately $1.7B, spread across 21 disclosed positions.
What are Bain Capital Life Sciences Investors, LLC's largest equity positions?
Based on the latest 13F filing, Bain Capital Life Sciences Investors, LLC's top holdings by market value are:
1. — $497.5M (29.6%)
2. Heartflow Inc (HTFL) — $247.9M (14.7%)
3. NewAmsterdam Pharma Company N.V. (NAMS) — $129.0M (7.7%)
4. Savara Inc (SVRA) — $108.4M (6.5%)
5. Alkermes plc (ALKS) — $101.5M (6.0%)
What changes did Bain Capital Life Sciences Investors, LLC make in its most recent portfolio filing?
In the latest reported quarter, Bain Capital Life Sciences Investors, LLC made 12 notable position adjustments: 2 new positions were initiated, 2 existing holdings were added to, 7 positions were partially reduced, and 1 were completely exited. The largest of these moves: New buy: ; New buy: ; Sold out: Centessa Pharmaceuticals-adr (260); Trim: NewAmsterdam Pharma Company N.V. (NAMS) — shares -47.90%; Trim: Heartflow Inc (HTFL) — shares -19.14%
What sectors does Bain Capital Life Sciences Investors, LLC focus on?
Bain Capital Life Sciences Investors, LLC is concentrated in the following sectors based on its current disclosed equity portfolio:
• Health Care: 100.0%
Investment Profile
Bain Capital Life Sciences Investors, LLC returned an annualized 38.7% over the trailing 36 months — outperforming the S&P 500 by 17.7 points — based on a reconstructed track record of its disclosed 13F positions, with a beta of 1.10 (roughly in line with the market) and a 50% quarterly batting average against the index.
Its portfolio is moderately concentrated and fast-trading, with 100.0% of the portfolio concentrated in Health Care.
Its turnover score has risen from 0 to 66 over the past 4 quarters — a shift toward more active trading.
It has added to its SLDB position over the past two quarters (+$53.4M, now $98.0M), while trimming NAMS over the same stretch (-$127.3M, still holding $129.0M).
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Developer Access
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