CIK: 0001335325
Total reported value
$362.2M
Reporting period: 2026-03-31 · Number of holdings: 156
HighVista Strategies LLC disclosed 156 holdings in its latest 13F filing for the period ending 2026-03-31, with total reported value of $362.2M and a quarterly turnover rate of 62.7%.
Browse other institutions with $100M to $1B AUMBrowse other institutions starting with "H"
HighVista Strategies LLC's disclosed holdings carry a Herfindahl concentration index of 0.017 — mathematically equivalent to about 60 equally-sized positions, well below its 156 actual disclosed holdings. That gap points to a strategy built around a small core of high-conviction bets rather than broad diversification.
Position sizes vary widely across the portfolio (a coefficient of variation of 1.26), with a handful of outsized bets alongside many smaller positions.
No strong tilt toward either adding to existing winners or initiating outsized new positions was observed in the latest reported quarter.
Sector classification currently covers about 33% of this portfolio's disclosed value; the remainder includes holdings (e.g. unmapped tickers, options, or other security types) not yet covered by our sector mapping.
Add DBC
0.0% $7.0M
Trim VRDN
-64.0% -$9.0M
Trim GPCR
-35.8% -$7.5M
Add TYRA
+274.2% $4.1M
Trim OLMA
-51.3% -$4.3M
Trim MAZE
-41.4% -$4.1M
| # | Ticker | Issuer | Asset Subclass | Weight | Weight Change | Shares Change | 4Q Trend |
|---|---|---|---|---|---|---|---|
| 1 | DBC | Invesco Db Commodity Index T | ETF-Commodities | 8.45% | +2.36% | — | |
| 2 | ABVX | Abivax Sa-adr | Stock-Other | 3.48% | +0.97% | +56.89% | |
| 3 | PRAX | Praxis Precision Medicines I | Stock-Other | 2.34% | — | +1.87% | |
| 4 | COGT | Cogent Biosciences INC | Stock-Other | 2.09% | -0.99% | -41.47% | |
| 5 | SYRE | Spyre Therapeutics INC | Stock-Other | 2.04% | — | -22.29% | |
| 6 | PCVX | Vaxcyte INC | Stock-Other | 2.00% | +0.64% | +9.29% | |
| 7 | RVMD | Revolution Medicines INC | Stock-Healthcare | 1.86% | -0.61% | -42.36% | |
| 8 | 430 | Terns Pharmaceuticals INC | Stock-Other | 1.66% | — | -34.85% | |
| 9 | GPCR | Structure Therapeutics INC | Stock-Other | 1.65% | -1.81% | -35.80% | |
| 10 | NUVL | Nuvalent Inc-a | Stock-Other | 1.60% | -0.30% | -22.77% | |
| 11 | IMVT | Immunovant INC | Stock-Other | 1.54% | — | +1.47% | |
| 12 | SLNOEUR | Soleno Therapeutics INC | Stock-Other | 1.53% | — | +22.33% | |
| 13 | TYRA | Tyra Biosciences INC | Stock-Other | 1.39% | +1.15% | +274.23% | |
| 14 | AMLX | Amylyx Pharmaceuticals INC | Stock-Other | 1.35% | +0.61% | +47.43% | |
| 15 | AMZN | Amazon.com INC | Stock-Consumer Disc | 1.29% | — | +28.74% | |
| 16 | LBRX | Lb Pharmaceuticals INC | Stock-Other | 1.18% | — | +23.90% | |
| 17 | RLAY | Relay Therapeutics INC | Stock-Other | 1.16% | — | -22.60% | |
| 18 | INSM | Insmed INC | Stock-Healthcare | 1.10% | -0.67% | -38.28% | |
| 19 | NVDA | Nvidia CORP | Stock-Tech | 1.08% | — | +57.67% | |
| 20 | ORKA | Oruka Therapeutics INC | Stock-Other | 1.07% | +1.07% | NEW | |
| 21 | CYTK | Cytokinetics INC | Stock-Healthcare | 1.07% | -0.80% | -48.81% | |
| 22 | LQDA | Liquidia CORP | Stock-Other | 1.04% | -0.35% | -36.06% | |
| 23 | OCUL | Ocular Therapeutix INC | Stock-Other | 1.03% | — | +28.34% | |
| 24 | TARS | Tarsus Pharmaceuticals INC | Stock-Other | 1.02% | — | -2.05% | |
| 25 | BBIO | Bridgebio Pharma INC | Stock-Healthcare | 1.02% | -0.56% | -38.21% | |
| 26 | MLTX | Moonlake Immunotherapeutics | Stock-Other | 1.00% | +1.00% | NEW | |
| 27 | ARGX | Argenx Se - Adr | Stock-Healthcare | 0.99% | — | +37.07% | |
| 28 | PTGX | Protagonist Therapeutics INC | Stock-Other | 0.99% | -0.66% | -53.97% | |
| 29 | PALI | Palisade Bio INC | Stock-Other | 0.98% | — | +55.33% | |
| 30 | DFTX | Definium Therapeutics INC | Stock-Other | 0.97% | +0.97% | NEW | |
| 31 | NRIX | Nurix Therapeutics INC | Stock-Other | 0.97% | +0.97% | NEW | |
| 32 | AXSM | Axsome Therapeutics INC | Stock-Healthcare | 0.95% | — | +83.60% | |
| 33 | IVA | Inventiva SA - Adr | Stock-Other | 0.94% | +0.94% | NEW | |
| 34 | DYN | Dyne Therapeutics INC | Stock-Other | 0.92% | +0.62% | +206.71% | |
| 35 | APGE | Apogee Therapeutics INC | Stock-Other | 0.83% | -0.90% | -59.92% | |
| 36 | GHRS | GH Research PLC | Stock-Other | 0.83% | — | -11.36% | |
| 37 | DNTH | Dianthus Therapeutics INC | Stock-Other | 0.82% | — | -26.60% | |
| 38 | MAZE | Maze Therapeutics INC | Stock-Other | 0.82% | -1.00% | -41.39% | |
| 39 | ERAS | Erasca INC | Stock-Other | 0.81% | +0.81% | NEW | |
| 40 | EWTX | Edgewise Therapeutics INC | Stock-Other | 0.80% | — | -46.28% | |
| 41 | ELVN | Enliven Therapeutics INC | Stock-Other | 0.79% | +0.46% | -11.43% | |
| 42 | XENE | Xenon Pharmaceuticals INC | Stock-Other | 0.79% | +0.79% | NEW | |
| 43 | CLDX | Celldex Therapeutics INC | Stock-Other | 0.78% | — | +72.56% | |
| 44 | VERA | Vera Therapeutics INC | Stock-Other | 0.77% | +0.77% | NEW | |
| 45 | PHVS | Pharvaris N.V. | Stock-Other | 0.76% | -0.40% | -39.73% | |
| 46 | VRDN | Viridian Therapeutics INC | Stock-Other | 0.72% | -2.27% | -63.96% | |
| 47 | ALKS | Alkermes plc | Stock-Healthcare | 0.71% | +0.52% | +177.22% | |
| 48 | ALMS | Alumis INC | Stock-Other | 0.69% | +0.69% | NEW | |
| 49 | MSFT | Microsoft CORP | Stock-Tech | 0.66% | — | -1.22% | |
| 50 | EYPT | Eyepoint INC | Stock-Other | 0.65% | +0.65% | NEW |
Performance for Q3 2026
+13.1%
Performance Last 4 Quarters
+75.7%
Based on 81% of reported portfolio value with available pricing
| Period | Holdings | Total value | Stability | Top holdings |
|---|---|---|---|---|
| 2026-03-31 | 156 | $362.2M | 63 | |
| 2025-12-31 | 145 | $388.3M | 66 | |
| 2025-09-30 | 148 | $408.0M | 91 | |
| 2025-06-30 | 146 | $272.1M | 0 | |
| 2025-03-31 | 148 | $259.5M | 100 | |
| 2024-12-31 | 137 | $268.8M | 0 | |
| 2024-09-30 | 142 | $290.0M | 0 | |
| 2024-06-30 | 138 | $273.8M | 0 | |
| 2024-03-31 | 131 | $280.4M | 0 | |
| 2023-12-31 | 126 | $275.6M | 0 | |
| 2023-09-30 | 132 | $216.1M | 0 | |
| 2023-06-30 | 134 | $218.6M | 0 | |
| 2023-03-31 | 108 | $122.8M | 0 | |
| 2022-12-31 | 105 | $168.5M | 0 | |
| 2022-09-30 | 113 | $175.1M | 0 | |
| 2022-06-30 | 110 | $165.6M | 0 | |
| 2022-03-31 | 86 | $157.3M | 0 | |
| 2021-12-31 | 69 | $125.6M | 0 | |
| 2021-09-30 | 127 | $151.1M | 0 | |
| 2021-06-30 | 116 | $141.0M | 98 | |
| 2021-03-31 | 125 | $134.6M | 62 | |
| 2020-12-31 | 117 | $156.6M | 54 | |
| 2020-09-30 | 113 | $137.2M | 53 | |
| 2020-06-30 | 100 | $120.8M | 91 | |
| 2020-03-31 | 65 | $108.0M | 99 | |
| 2019-12-31 | 119 | $131.8M | 53 | |
| 2019-09-30 | 126 | $146.5M | 59 | |
| 2019-06-30 | 108 | $195.4M | 93 | |
| 2019-03-31 | 112 | $122.6M | 99 | |
| 2018-12-31 | 113 | $115.6M | 97 | |
| 2018-09-30 | 133 | $214.4M | 44 | |
| 2018-06-30 | 143 | $221.5M | 73 | |
| 2018-03-31 | 161 | $234.5M | 85 | |
| 2017-12-31 | 215 | $358.9M | 73 | |
| 2017-09-30 | 231 | $439.9M | 53 | |
| 2017-06-30 | 222 | $438.5M | 87 | |
| 2017-03-31 | 145 | $446.7M | 85 | |
| 2016-12-31 | 166 | $510.0M | 77 | |
| 2016-09-30 | 167 | $539.0M | 70 | |
| 2016-06-30 | 167 | $523.3M | 92 | |
| 2016-03-31 | 166 | $532.7M | 90 | |
| 2015-12-31 | 193 | $538.2M | 100 | |
| 2015-09-30 | 180 | $529.4M | 69 | |
| 2015-06-30 | 164 | $586.1M | 56 | |
| 2015-03-31 | 179 | $625.4M | 86 | |
| 2014-12-31 | 148 | $763.2M | 67 | |
| 2014-09-30 | 162 | $742.6M | 52 | |
| 2014-06-30 | 151 | $704.3M | 44 | |
| 2014-03-31 | 147 | $749.4M | 100 | |
| 2013-12-31 | 136 | $555.4M | 83 | |
| 2013-09-30 | 74 | $508.4M | 69 | |
| 2013-06-30 | 77 | $417.4M | 0 |
HighVista Strategies LLC's most significant position changes for 2026-03-31: Sold out: Cidara Therapeutics INC (CDTX); Sold out: Arcellx INC (ACLXGBX); Sold out: Agios Pharmaceuticals INC (AGIO); New buy: Oruka Therapeutics INC (ORKA); Sold out: Apellis Pharmaceuticals INC (APLSUSD).
| # | Ticker | Issuer | Weight Change | Shares Change | Action |
|---|---|---|---|---|---|
| 1 | DBC | Invesco Db Commodity Index T | +2.4% | — | Unchanged |
| 2 | TYRA | Tyra Biosciences INC | +1.2% | +274.23% | Add |
| 3 | ABVX | Abivax Sa-adr | +1% | +56.89% | Add |
| 4 | PCVX | Vaxcyte INC | +0.6% | +9.29% | Add |
| 5 | DYN | Dyne Therapeutics INC | +0.6% | +206.71% | Add |
| 6 | AMLX | Amylyx Pharmaceuticals INC | +0.6% | +47.43% | Add |
| 7 | ALKS | Alkermes plc | +0.5% | +177.22% | Add |
| 8 | ELVN | Enliven Therapeutics INC | +0.5% | -11.43% | Trim |
| 9 | NUVL | Nuvalent Inc-a | -0.3% | -22.77% | Trim |
| 10 | LQDA | Liquidia CORP | -0.4% | -36.06% | Trim |
| 11 | GH | Guardant Health INC | -0.4% | -36.46% | Trim |
| 12 | STOK | Stoke Therapeutics INC | -0.4% | -45.80% | Trim |
| 13 | PHVS | Pharvaris N.V. | -0.4% | -39.73% | Trim |
| 14 | BBOT | Bridgebio Oncology Therapeut | -0.6% | -65.90% | Trim |
| 15 | BBIO | Bridgebio Pharma INC | -0.6% | -38.21% | Trim |
| 16 | RVMD | Revolution Medicines INC | -0.6% | -42.36% | Trim |
| 17 | PTGX | Protagonist Therapeutics INC | -0.7% | -53.97% | Trim |
| 18 | INSM | Insmed INC | -0.7% | -38.28% | Trim |
| 19 | RYTM | Rhythm Pharmaceuticals INC | -0.8% | -60.82% | Trim |
| 20 | CYTK | Cytokinetics INC | -0.8% | -48.81% | Trim |
| 21 | MLYS | Mineralys Therapeutics INC | -0.8% | -62.44% | Trim |
| 22 | APGE | Apogee Therapeutics INC | -0.9% | -59.92% | Trim |
| 23 | COGT | Cogent Biosciences INC | -1% | -41.47% | Trim |
| 24 | MAZE | Maze Therapeutics INC | -1% | -41.39% | Trim |
| 25 | OLMA | Olema Pharmaceuticals INC | -1.1% | -51.30% | Trim |
| 26 | GPCR | Structure Therapeutics INC | -1.8% | -35.80% | Trim |
| 27 | VRDN | Viridian Therapeutics INC | -2.3% | -63.96% | Trim |
| 28 | CDTX | Cidara Therapeutics INC | — | EXIT | Sold out |
| 29 | ACLXGBX | Arcellx INC | — | EXIT | Sold out |
| 30 | AGIO | Agios Pharmaceuticals INC | — | EXIT | Sold out |
| 31 | ORKA | Oruka Therapeutics INC | — | NEW | New buy |
| 32 | APLSUSD | Apellis Pharmaceuticals INC | — | EXIT | Sold out |
| 33 | MLTX | Moonlake Immunotherapeutics | — | NEW | New buy |
| 34 | DFTX | Definium Therapeutics INC | — | NEW | New buy |
| 35 | NRIX | Nurix Therapeutics INC | — | NEW | New buy |
| 36 | IVA | Inventiva SA - Adr | — | NEW | New buy |
| 37 | ERAS | Erasca INC | — | NEW | New buy |
| 38 | RNAGBP | Avidity Biosciences INC | — | EXIT | Sold out |
| 39 | XENE | Xenon Pharmaceuticals INC | — | NEW | New buy |
| 40 | VERA | Vera Therapeutics INC | — | NEW | New buy |
| 41 | ALMS | Alumis INC | — | NEW | New buy |
| 42 | EYPT | Eyepoint INC | — | NEW | New buy |
| 43 | SEPN | Septerna INC | — | EXIT | Sold out |
| 44 | TNGX | Tango Therapeutics INC | — | NEW | New buy |
| 45 | ASMB | Assembly Biosciences INC | — | NEW | New buy |
| 46 | JAZZ | Jazz Pharmaceuticals plc | — | NEW | New buy |
| 47 | NATL | Ncr Atleos CORP | — | NEW | New buy |
| 48 | ON | On Semiconductor | — | NEW | New buy |
| 49 | APP | Applovin Corp-class A | — | EXIT | Sold out |
| 50 | KOD | Kodiak Sciences INC | — | NEW | New buy |
| Period | Filed | Type | EDGAR |
|---|---|---|---|
| 2026-03-31 | 2026-05-15 | 13F-HR | View on EDGAR |
| 2025-12-31 | 2026-02-17 | 13F-HR | View on EDGAR |
| 2025-09-30 | 2025-11-14 | 13F-HR | View on EDGAR |
| 2025-06-30 | 2025-08-14 | 13F-HR | View on EDGAR |
| 2025-03-31 | 2025-05-15 | 13F-HR | View on EDGAR |
| 2024-12-31 | 2025-02-14 | 13F-HR | View on EDGAR |
| 2024-09-30 | 2024-11-14 | 13F-HR | View on EDGAR |
| 2024-06-30 | 2024-08-14 | 13F-HR | View on EDGAR |
| 2024-03-31 | 2024-05-15 | 13F-HR | View on EDGAR |
| 2023-12-31 | 2024-02-14 | 13F-HR | View on EDGAR |
| 2023-09-30 | 2023-11-14 | 13F-HR | View on EDGAR |
| 2023-06-30 | 2023-08-14 | 13F-HR | View on EDGAR |
| 2023-03-31 | 2023-05-15 | 13F-HR | View on EDGAR |
| 2022-12-31 | 2023-02-14 | 13F-HR | View on EDGAR |
| 2022-09-30 | 2022-11-14 | 13F-HR | View on EDGAR |
| 2022-06-30 | 2022-08-15 | 13F-HR | View on EDGAR |
| 2022-03-31 | 2022-05-16 | 13F-HR | View on EDGAR |
| 2021-12-31 | 2022-02-14 | 13F-HR | View on EDGAR |
| 2021-09-30 | 2021-11-15 | 13F-HR | View on EDGAR |
| 2021-06-30 | 2021-08-16 | 13F-HR | View on EDGAR |
| 2021-03-31 | 2021-05-17 | 13F-HR | View on EDGAR |
| 2020-12-31 | 2021-02-16 | 13F-HR | View on EDGAR |
| 2020-09-30 | 2020-11-16 | 13F-HR | View on EDGAR |
| 2020-06-30 | 2020-08-14 | 13F-HR | View on EDGAR |
| 2020-03-31 | 2020-05-15 | 13F-HR | View on EDGAR |
| 2019-12-31 | 2020-02-14 | 13F-HR | View on EDGAR |
| 2019-09-30 | 2019-11-14 | 13F-HR | View on EDGAR |
| 2019-06-30 | 2019-08-14 | 13F-HR | View on EDGAR |
| 2019-03-31 | 2019-05-15 | 13F-HR | View on EDGAR |
| 2018-12-31 | 2019-02-14 | 13F-HR | View on EDGAR |
| 2018-09-30 | 2018-11-14 | 13F-HR | View on EDGAR |
| 2018-06-30 | 2018-08-14 | 13F-HR | View on EDGAR |
| 2018-03-31 | 2018-05-15 | 13F-HR | View on EDGAR |
| 2017-12-31 | 2018-02-14 | 13F-HR | View on EDGAR |
| 2017-09-30 | 2017-11-14 | 13F-HR | View on EDGAR |
| 2017-06-30 | 2017-08-14 | 13F-HR | View on EDGAR |
| 2017-03-31 | 2017-05-15 | 13F-HR | View on EDGAR |
| 2016-12-31 | 2017-02-14 | 13F-HR | View on EDGAR |
| 2016-09-30 | 2016-11-14 | 13F-HR | View on EDGAR |
| 2016-06-30 | 2016-08-15 | 13F-HR | View on EDGAR |
| 2016-03-31 | 2016-05-16 | 13F-HR | View on EDGAR |
| 2015-12-31 | 2016-02-16 | 13F-HR | View on EDGAR |
| 2015-09-30 | 2015-11-16 | 13F-HR | View on EDGAR |
| 2015-06-30 | 2015-08-14 | 13F-HR | View on EDGAR |
| 2015-03-31 | 2015-05-15 | 13F-HR | View on EDGAR |
| 2014-12-31 | 2015-02-17 | 13F-HR | View on EDGAR |
| 2014-09-30 | 2014-11-14 | 13F-HR | View on EDGAR |
| 2014-06-30 | 2014-08-14 | 13F-HR | View on EDGAR |
| 2014-03-31 | 2014-05-15 | 13F-HR | View on EDGAR |
| 2013-12-31 | 2014-02-13 | 13F-HR | View on EDGAR |
| 2013-09-30 | 2013-11-14 | 13F-HR | View on EDGAR |
| 2013-06-30 | 2013-08-20 | Amendment | View on EDGAR |
| 2013-06-30 | 2013-08-14 | 13F-HR | View on EDGAR |
Institutions with a similar AUM
CIK 0001506796
Total reported value
$362.2M
425 stks
2022-09-30
Stale — no recent filing
AUM within 0.0% of this institution
CIK 0001887409
Total reported value
$362.1M
327 stks
2026-03-31
AUM within 0.0% of this institution
CIK 0001846711
Total reported value
$362.0M
143 stks
2026-03-31
AUM within 0.0% of this institution
Institutions with overlapping top holdings
CIK 0001009258
Total reported value
$8.5B
82 stks
2026-03-31
2 of the top 5 holdings overlap, including Cogent Biosciences INC
CIK 0001802528
Total reported value
$1.4B
12 stks
2026-03-31
2 of the top 5 holdings overlap, including Cogent Biosciences INC
CIK 0001831942
Total reported value
$1.7B
36 stks
2026-03-31
2 of the top 5 holdings overlap, including Cogent Biosciences INC