| RTW INVESTMENTS, LP | $278.2M | 2.77% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | $268.0M | 0.41% |
| Boxer Capital Management, LLC | $227.5M | 29.87% |
| TCG Crossover Management, LLC | $220.3M | 6.30% |
| FMR LLC | $207.2M | 0.01% |
| FARALLON CAPITAL MANAGEMENT LLC | $190.3M | 1.08% |
| BlackRock, Inc. | $183.0M | 0.00% |
| Woodline Partners LP | $167.4M | 0.63% |
| Nextech Invest, Ltd. | $152.0M | 10.70% |
| TRV GP IV, LLC | $133.4M | 49.96% |
| Siren, L.L.C. | $118.3M | 3.28% |
| VANGUARD CAPITAL MANAGEMENT LLC | $108.0M | 0.00% |
| GOLDMAN SACHS GROUP INC | $106.2M | 0.01% |
| STATE STREET CORP | $97.3M | 0.00% |
| DEERFIELD MANAGEMENT COMPANY, L.P. | $86.8M | 1.02% |
| Paradigm Biocapital Advisors LP | $83.9M | 1.71% |
| Holocene Advisors, LP | $82.3M | 0.20% |
| Balyasny Asset Management L.P. | $80.1M | 0.10% |
| Logos Global Management LP | $62.8M | 3.13% |
| Deep Track Capital, LP | $57.5M | 0.94% |
| GEODE CAPITAL MANAGEMENT, LLC | $56.0M | 0.00% |
| Caligan Partners LP | $50.4M | 3.35% |
| Bellevue Group AG | $50.2M | 1.19% |
| JANUS HENDERSON GROUP PLC | $50.1M | 0.02% |
| Vivo Capital, LLC | $45.1M | 3.75% |
| MORGAN STANLEY | $30.9M | 0.00% |
| Cormorant Asset Management, LP | $29.8M | 1.50% |
| FRANKLIN RESOURCES INC | $27.1M | 0.01% |
| Candriam S.C.A. | $26.6M | 0.14% |
| Nantahala Capital Management, LLC | $26.2M | 0.96% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $18.9M | 0.00% |
| PRICE T ROWE ASSOCIATES INC /MD/ | $18.6M | 0.00% |
| NORTHERN TRUST CORP | $18.1M | 0.00% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $17.5M | 0.00% |
| PERCEPTIVE ADVISORS LLC | $16.9M | 0.33% |
| BESSEMER GROUP INC | $14.8M | 0.02% |
| ArrowMark Colorado Holdings LLC | $14.8M | 0.39% |
| UBS Group AG | $14.6M | 0.00% |
| VANGUARD FIDUCIARY TRUST CO | $13.9M | 0.00% |
| Invesco Ltd. | $12.1M | 0.00% |
| BOOTHBAY FUND MANAGEMENT, LLC | $12.0M | 0.16% |
| Point72 Asset Management, L.P. | $11.2M | 0.01% |
| AMERIPRISE FINANCIAL INC | $10.6M | 0.00% |
| Seven Fleet Capital Management LP | $10.5M | 3.33% |
| DIMENSIONAL FUND ADVISORS LP | $10.2M | 0.00% |
| Soleus Capital Management, L.P. | $9.4M | 0.38% |
| Integral Health Asset Management, LLC | $9.4M | 0.45% |
| ACUTA CAPITAL PARTNERS, LLC | $9.2M | 6.57% |
| T. Rowe Price Investment Management, Inc. | $9.2M | 0.01% |
| MILLENNIUM MANAGEMENT LLC | $8.9M | 0.00% |
| PFM Health Sciences, LP | $8.5M | 0.77% |
| Sofinnova Investments, Inc. | $8.3M | 0.31% |
| Rock Springs Capital Management LP | $8.1M | 0.48% |
| Nuveen, LLC | $7.5M | 0.00% |
| Connor, Clark & Lunn Investment Management Ltd. | $7.4M | 0.02% |
| Mass General Brigham, Inc | $7.4M | 1.58% |
| SPHERA FUNDS MANAGEMENT LTD. | $7.2M | 1.14% |
| CONGRESS ASSET MANAGEMENT CO | $7.1M | 0.05% |
| BANK OF AMERICA CORP /DE/ | $6.8M | 0.00% |
| Bank of New York Mellon Corp | $6.7M | 0.00% |
| DV Trading LLC | $6.3M | 0.15% |
| WELLINGTON MANAGEMENT GROUP LLP | $6.0M | 0.00% |
| Parkman Healthcare Partners LLC | $5.6M | 0.57% |
| CITADEL ADVISORS LLC | $5.2M | 0.00% |
| KVP Capital Advisors, LP | $4.8M | 3.60% |
| Cinctive Capital Management LP | $4.6M | 0.30% |
| STEMPOINT CAPITAL LP | $4.2M | 0.80% |
| TRV GP VI, LLC | $4.1M | 3.00% |
| SCHRODER INVESTMENT MANAGEMENT GROUP | $4.0M | 0.00% |
| Squarepoint Ops LLC | $3.7M | 0.00% |
| VOYA INVESTMENT MANAGEMENT LLC | $3.7M | 0.00% |
| Atle Fund Management AB | $3.6M | 1.17% |
| TWO SIGMA INVESTMENTS, LP | $3.6M | 0.00% |
| Informed Momentum Co LLC | $3.5M | 0.41% |
| Fisher Asset Management, LLC | $3.4M | 0.00% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $3.4M | 0.00% |
| FRED ALGER MANAGEMENT, LLC | $3.1M | 0.01% |
| ALGERT GLOBAL LLC | $3.0M | 0.05% |
| RHUMBLINE ADVISERS | $2.6M | 0.00% |
| Schonfeld Strategic Advisors LLC | $2.5M | 0.02% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | $2.3M | 0.00% |
| AQR CAPITAL MANAGEMENT LLC | $2.2M | 0.00% |
| Rafferty Asset Management, LLC | $2.2M | 0.01% |
| HighVista Strategies LLC | $2.2M | 0.60% |
| TD Asset Management Inc | $2.1M | 0.00% |
| DEUTSCHE BANK AG\ | $1.9M | 0.00% |
| Swiss National Bank | $1.8M | 0.00% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | $1.6M | 0.00% |
| LOS ANGELES CAPITAL MANAGEMENT LLC | $1.3M | 0.01% |
| JPMORGAN CHASE & CO | $1.3M | 0.00% |
| MetLife Investment Management, LLC | $1.3M | 0.01% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | $1.2M | 0.00% |
| Vanguard Global Advisers, LLC | $1.2M | 0.00% |
| Creative Planning | $1.1M | 0.00% |
| VICTORY CAPITAL MANAGEMENT INC | $1.1M | 0.00% |
| Atom Investors LP | $1.1M | 0.08% |
| ADAR1 Capital Management, LLC | $1.0M | 0.06% |
| ALLIANCEBERNSTEIN L.P. | $1.0M | 0.00% |
| PROFUND ADVISORS LLC | $998.6K | 0.04% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | $997.7K | 0.00% |
| SmartHarvest Portfolios, LLC | $970.0K | 0.40% |
| STATE OF WISCONSIN INVESTMENT BOARD | $948.7K | 0.00% |
| WELLS FARGO & COMPANY/MN | $878.1K | 0.00% |
| INTECH INVESTMENT MANAGEMENT LLC | $794.1K | 0.01% |
| Rockefeller Capital Management L.P. | $760.2K | 0.00% |
| Janney Montgomery Scott LLC | $753.0K | 0.00% |
| Legal & General Group Plc | $740.0K | 0.00% |
| NEW YORK STATE COMMON RETIREMENT FUND | $700.3K | 0.00% |
| JANE STREET GROUP, LLC | $686.2K | 0.00% |
| ALLSTATE CORP | $670.4K | 0.01% |
| SEI INVESTMENTS CO | $668.6K | 0.00% |
| Police & Firemen's Retirement System of New Jersey | $634.9K | 0.01% |
| VANGUARD ASSET MANAGEMENT, Ltd | $619.3K | 0.00% |
| Virtus Investment Advisers, LLC | $610.1K | 0.17% |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | $571.1K | 0.00% |
| EverSource Wealth Advisors, LLC | $544.5K | 0.02% |
| Harvest Investment Services, LLC | $530.9K | 0.10% |
| SG Americas Securities, LLC | $507.0K | 0.00% |
| China Universal Asset Management Co., Ltd. | $500.0K | 0.04% |
| Vanguard Personalized Indexing Management, LLC | $492.0K | 0.00% |
| Persistent Asset Partners Ltd | $483.6K | 0.18% |
| ProShare Advisors LLC | $462.8K | 0.00% |
| BARCLAYS PLC | $453.3K | 0.00% |
| Mitsubishi UFJ Asset Management Co., Ltd. | $446.5K | 0.00% |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | $440.4K | 0.00% |
| Entropy Technologies, LP | $432.1K | 0.02% |
| Arrowpoint Investment Partners (Singapore) Pte. Ltd. | $428.1K | 0.38% |
| Jain Global LLC | $426.1K | 0.00% |
| CITIGROUP INC | $410.7K | 0.00% |
| PRUDENTIAL FINANCIAL INC | $400.8K | 0.00% |
| Gotham Asset Management, LLC | $400.3K | 0.00% |
| Quantinno Capital Management LP | $385.8K | 0.00% |
| Alyeska Investment Group, L.P. | $359.8K | 0.00% |
| State of New Jersey Common Pension Fund D | $318.2K | 0.00% |
| PSP Research LLC | $301.2K | 0.21% |
| XTX Topco Ltd | $294.9K | 0.01% |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | $292.9K | 0.01% |
| CANADA PENSION PLAN INVESTMENT BOARD | $290.8K | 0.00% |
| E Fund Management Co., Ltd. | $276.0K | 0.01% |
| Russell Investments Group, Ltd. | $268.6K | 0.00% |
| MANGROVE PARTNERS IM, LLC | $262.7K | 0.02% |
| Tower Research Capital LLC (TRC) | $262.3K | 0.01% |
| SummitTX Capital, L.P. | $262.2K | 0.01% |
| Bleakley Financial Group, LLC | $259.0K | 0.00% |
| Vanguard Investments Australia, Ltd. | $256.0K | 0.00% |
| ARIZONA STATE RETIREMENT SYSTEM | $255.7K | 0.00% |
| Bridgefront Capital, LLC | $227.3K | 0.06% |
| Zurcher Kantonalbank (Zurich Cantonalbank) | $222.7K | 0.00% |
| XPONANCE LLC | $214.2K | 0.00% |
| Hudson Bay Capital Management LP | $212.5K | 0.00% |