CIK: 0002018299
Total reported value
$761.7M
Reporting period: 2026-03-31 · Number of holdings: 54
Boxer Capital Management, LLC disclosed 54 holdings in its latest 13F filing for the period ending 2026-03-31, with total reported value of $761.7M and a quarterly turnover rate of 64.7%.
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Boxer Capital Management, LLC's disclosed holdings carry a Herfindahl concentration index of 0.109 — mathematically equivalent to about 9 equally-sized positions, well below its 54 actual disclosed holdings. That gap points to a strategy built around a small core of high-conviction bets rather than broad diversification.
Position sizes vary widely across the portfolio (a coefficient of variation of 2.23), with a handful of outsized bets alongside many smaller positions.
No strong tilt toward either adding to existing winners or initiating outsized new positions was observed in the latest reported quarter.
Sector classification currently covers about 11% of this portfolio's disclosed value; the remainder includes holdings (e.g. unmapped tickers, options, or other security types) not yet covered by our sector mapping.
Add TNGX
0.0% $131.2M
Trim KYMR
0.0% $1.8M
Trim CELC
0.0% $3.2M
Trim PTCT
0.0% -$1.6M
Add VIR
+198.6% $13.0M
Trim URGN
0.0% -$2.7M
| # | Ticker | Issuer | Asset Subclass | Weight | Weight Change | Shares Change | 4Q Trend |
|---|---|---|---|---|---|---|---|
| 1 | TNGX | Tango Therapeutics INC | Stock-Other | 29.87% | +8.78% | — | |
| 2 | KOD | Kodiak Sciences INC | Stock-Other | 6.81% | -0.14% | +19.81% | |
| 3 | RVMD | Revolution Medicines INC | Stock-Healthcare | 6.38% | -0.59% | +25.00% | |
| 4 | KYMR | Kymera Therapeutics INC | Stock-Other | 3.60% | -2.00% | — | |
| 5 | CELC | Celcuity INC | Stock-Other | 3.37% | -1.54% | — | |
| 6 | SRZN | Surrozen INC | Stock-Other | 2.93% | +0.87% | +84.14% | |
| 7 | ABVX | Abivax Sa-adr | Stock-Other | 2.92% | -0.77% | +60.00% | |
| 8 | 430 | Terns Pharmaceuticals INC | Stock-Other | 2.60% | -0.72% | — | |
| 9 | PCVX | Vaxcyte INC | Stock-Other | 2.48% | +2.48% | NEW | |
| 10 | CAPR | Capricor Therapeutics INC | Stock-Other | 2.35% | +0.30% | +81.54% | |
| 11 | PTGX | Protagonist Therapeutics INC | Stock-Other | 2.35% | -0.90% | — | |
| 12 | VIR | Vir Biotechnology INC | Stock-Other | 2.20% | +1.38% | +198.56% | |
| 13 | CRVS | Corvus Pharmaceuticals INC | Stock-Other | 2.11% | +2.11% | NEW | |
| 14 | PRAX | Praxis Precision Medicines I | Stock-Other | 1.97% | -1.03% | — | |
| 15 | PTCT | Ptc Therapeutics INC | Stock-Healthcare | 1.79% | -1.54% | — | |
| 16 | PGEN | Precigen INC | Stock-Other | 1.78% | +0.52% | +154.55% | |
| 17 | DFTX | Definium Therapeutics INC | Stock-Other | 1.49% | +1.49% | NEW | |
| 18 | AMLX | Amylyx Pharmaceuticals INC | Stock-Other | 1.46% | -0.66% | — | |
| 19 | QURE | uniQure N.V. | Stock-Other | 1.42% | -0.10% | +128.28% | |
| 20 | IRD | Opus Genetics INC | Stock-Other | 1.34% | +1.34% | NEW | |
| 21 | CORT | Corcept Therapeutics INC | Stock-Healthcare | 1.32% | +1.32% | NEW | |
| 22 | URGN | UroGen Pharma Ltd. | Stock-Other | 1.18% | -1.38% | — | |
| 23 | REPL | Replimune Group INC | Stock-Other | 1.18% | -0.42% | +56.67% | |
| 24 | COGT | Cogent Biosciences INC | Stock-Other | 1.14% | -0.61% | — | |
| 25 | PALI | Palisade Bio INC | Stock-Other | 1.10% | -1.37% | — | |
| 26 | ✓ | Crescent Biopharma INC. | Stock-Other | 1.09% | +1.09% | NEW | |
| 27 | SLNOEUR | Soleno Therapeutics INC | Stock-Other | 0.88% | +0.88% | NEW | |
| 28 | ALLO | Allogene Therapeutics INC | Stock-Other | 0.87% | +0.87% | NEW | |
| 29 | CYTK | Cytokinetics INC | Stock-Healthcare | 0.87% | -0.52% | — | |
| 30 | CTNM | Contineum Therapeutics Inc-a | Stock-Other | 0.85% | -0.39% | — | |
| 31 | APGE | Apogee Therapeutics INC | Stock-Other | 0.77% | -0.39% | — | |
| 32 | RLMD | Relmada Therapeutics INC | Stock-Other | 0.77% | +0.77% | NEW | |
| 33 | ✓ | Zura Bio LTD | Stock-Other | 0.70% | +0.64% | +1700.00% | |
| 34 | MLTX | Moonlake Immunotherapeutics | Stock-Other | 0.67% | -0.12% | — | |
| 35 | AVTX | Avalo Therapeutics INC | Stock-Other | 0.59% | -0.50% | +9.09% | |
| 36 | INO | Inovio Pharmaceuticals INC | Stock-Other | 0.54% | — | -2.07% | |
| 37 | GPCR | Structure Therapeutics INC | Stock-Other | 0.47% | -0.67% | — | |
| 38 | SRPT | Sarepta Therapeutics INC | Stock-Healthcare | 0.43% | — | — | |
| 39 | HELP | Cybin INC | Stock-Other | 0.40% | -0.88% | -10.49% | |
| 40 | OCUL | Ocular Therapeutix INC | Stock-Other | 0.39% | +0.39% | NEW | |
| 41 | ANTX | An2 Therapeutics INC | Stock-Other | 0.34% | +0.34% | NEW | |
| 42 | CLNN | Clene INC | Stock-Other | 0.31% | +0.05% | +139.07% | |
| 43 | ORIC | Oric Pharmaceuticals INC | Stock-Other | 0.29% | +0.29% | NEW | |
| 44 | SLDB | Solid Biosciences INC | Stock-Other | 0.28% | -0.09% | — | |
| 45 | IVVD | Invivyd INC | Stock-Other | 0.26% | -0.55% | — | |
| 46 | LBRX | Lb Pharmaceuticals INC | Stock-Other | 0.23% | — | — | |
| 47 | KPTI | Karyopharm Therapeutics INC | Stock-Other | 0.22% | — | +19.80% | |
| 48 | NRIX | Nurix Therapeutics INC | Stock-Other | 0.20% | -0.22% | — | |
| 49 | UPB | Upstream Bio INC | Stock-Other | 0.18% | -0.71% | — | |
| 50 | MIST | Milestone Pharmaceuticals In | Stock-Other | 0.10% | -0.19% | — |
Performance for Q3 2026
+15.1%
Performance Last 4 Quarters
+138.7%
Based on 60% of reported portfolio value with available pricing
Boxer Capital Management, LLC's most significant position changes for 2026-03-31: New buy: Vaxcyte INC (PCVX); New buy: Corvus Pharmaceuticals INC (CRVS); Sold out: Cidara Therapeutics INC (CDTX); New buy: Definium Therapeutics INC (DFTX); New buy: Opus Genetics INC (IRD).
| # | Ticker | Issuer | Weight Change | Shares Change | Action |
|---|---|---|---|---|---|
| 1 | TNGX | Tango Therapeutics INC | +8.8% | — | Unchanged |
| 2 | VIR | Vir Biotechnology INC | +1.4% | +198.56% | Add |
| 3 | SRZN | Surrozen INC | +0.9% | +84.14% | Add |
| 4 | ✓ | Zura Bio LTD | +0.6% | +1700.00% | Add |
| 5 | PGEN | Precigen INC | +0.5% | +154.55% | Add |
| 6 | CAPR | Capricor Therapeutics INC | +0.3% | +81.54% | Add |
| 7 | CLNN | Clene INC | +0.1% | +139.07% | Add |
| 8 | SLDB | Solid Biosciences INC | -0.1% | — | Unchanged |
| 9 | QURE | uniQure N.V. | -0.1% | +128.28% | Add |
| 10 | MLTX | Moonlake Immunotherapeutics | -0.1% | — | Unchanged |
| 11 | KOD | Kodiak Sciences INC | -0.1% | +19.81% | Add |
| 12 | MIST | Milestone Pharmaceuticals In | -0.2% | — | Unchanged |
| 13 | NRIX | Nurix Therapeutics INC | -0.2% | — | Unchanged |
| 14 | CTNM | Contineum Therapeutics Inc-a | -0.4% | — | Unchanged |
| 15 | APGE | Apogee Therapeutics INC | -0.4% | — | Unchanged |
| 16 | REPL | Replimune Group INC | -0.4% | +56.67% | Add |
| 17 | PEPG | Pepgen INC | -0.5% | -27.01% | Trim |
| 18 | AVTX | Avalo Therapeutics INC | -0.5% | +9.09% | Add |
| 19 | CYTK | Cytokinetics INC | -0.5% | — | Unchanged |
| 20 | IVVD | Invivyd INC | -0.6% | — | Unchanged |
| 21 | RVMD | Revolution Medicines INC | -0.6% | +25.00% | Add |
| 22 | COGT | Cogent Biosciences INC | -0.6% | — | Unchanged |
| 23 | AMLX | Amylyx Pharmaceuticals INC | -0.7% | — | Unchanged |
| 24 | GPCR | Structure Therapeutics INC | -0.7% | — | Unchanged |
| 25 | UPB | Upstream Bio INC | -0.7% | — | Unchanged |
| 26 | 430 | Terns Pharmaceuticals INC | -0.7% | — | Unchanged |
| 27 | ABVX | Abivax Sa-adr | -0.8% | +60.00% | Add |
| 28 | HELP | Cybin INC | -0.9% | -10.49% | Trim |
| 29 | PTGX | Protagonist Therapeutics INC | -0.9% | — | Unchanged |
| 30 | PRAX | Praxis Precision Medicines I | -1% | — | Unchanged |
| 31 | PALI | Palisade Bio INC | -1.4% | — | Unchanged |
| 32 | URGN | UroGen Pharma Ltd. | -1.4% | — | Unchanged |
| 33 | CELC | Celcuity INC | -1.5% | — | Unchanged |
| 34 | PTCT | Ptc Therapeutics INC | -1.5% | — | Unchanged |
| 35 | KYMR | Kymera Therapeutics INC | -2% | — | Unchanged |
| 36 | PCVX | Vaxcyte INC | — | NEW | New buy |
| 37 | CRVS | Corvus Pharmaceuticals INC | — | NEW | New buy |
| 38 | CDTX | Cidara Therapeutics INC | — | EXIT | Sold out |
| 39 | DFTX | Definium Therapeutics INC | — | NEW | New buy |
| 40 | IRD | Opus Genetics INC | — | NEW | New buy |
| 41 | CORT | Corcept Therapeutics INC | — | NEW | New buy |
| 42 | ✓ | Crescent Biopharma INC. | — | NEW | New buy |
| 43 | BRD1EUR | Mind Medicine Mindmed INC | — | EXIT | Sold out |
| 44 | SLNOEUR | Soleno Therapeutics INC | — | NEW | New buy |
| 45 | ALLO | Allogene Therapeutics INC | — | NEW | New buy |
| 46 | RLMD | Relmada Therapeutics INC | — | NEW | New buy |
| 47 | ✓ | Crescent Biopharma INC. | — | EXIT | Sold out |
| 48 | OCUL | Ocular Therapeutix INC | — | NEW | New buy |
| 49 | ANTX | An2 Therapeutics INC | — | NEW | New buy |
| 50 | ORIC | Oric Pharmaceuticals INC | — | NEW | New buy |
| Period | Filed | Type | EDGAR |
|---|---|---|---|
| 2026-03-31 | 2026-05-15 | 13F-HR | View on EDGAR |
| 2025-12-31 | 2026-02-17 | 13F-HR | View on EDGAR |
| 2025-09-30 | 2026-02-17 | Amendment | View on EDGAR |
| 2025-09-30 | 2025-11-14 | 13F-HR | View on EDGAR |
| 2025-06-30 | 2026-02-17 | Amendment | View on EDGAR |
| 2025-06-30 | 2025-08-14 | 13F-HR | View on EDGAR |
| 2025-03-31 | 2026-02-17 | Amendment | View on EDGAR |
| 2025-03-31 | 2025-05-15 | 13F-HR | View on EDGAR |
| 2024-12-31 | 2025-02-14 | 13F-HR | View on EDGAR |
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