PA

Perceptive Advisors LLC

Diversified strategySector-focusedMomentum follower

Total reported value

$5.1B

Reporting period: 2026-03-31 · Number of holdings: 94

PERCEPTIVE ADVISORS LLC disclosed 94 holdings in its latest 13F filing for the period ending 2026-03-31, with total reported value of $5.1B and a quarterly turnover rate of 54.7%.

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Personality snowflake

Concentration
16.41
Portfolio Stability
54.67
Momentum/Contrarian
100
Sector conviction
100
Diversification
100
Sizing Uniformity
83.01

Recent moves

  • Add 260

    +80.2%　$135.9M

  • Add ASND

    +41.6%　$119.7M

  • Add PRAX

    +2.0%　$67.7M

  • Add SYRE

    +23.3%　$90.3M

  • Add RLAY

    +412.3%　$80.9M

  • Add ROIV

    +3.8%　$56.2M

Holdings Map

New buyAddUnchangedTrim

Top 10 holdings by weight

Full holdings list this quarter

#TickerIssuerAsset SubclassWeightWeight ChangeShares Change4Q Trend
1PRAXPraxis Precision Medicines IStock-Other12.82%+2.33%+2.00%
2CELCCelcuity INCStock-Other6.97%+1.35%-1.04%
3ASNDAscendis Pharma A/SStock-Other6.84%+2.73%+41.61%
4ROIVRoivant Sciences Ltd.Stock-Healthcare4.48%+1.39%+3.76%
5260Centessa Pharmaceuticals-adrStock-Other4.08%+2.78%+80.25%
6RYTMRhythm Pharmaceuticals INCStock-Other4.03%-0.83%-6.78%
7SYRESpyre Therapeutics INCStock-Other3.73%+1.94%+23.26%
8NUVLNuvalent Inc-aStock-Other3.16%—-5.08%
9EWTXEdgewise Therapeutics INCStock-Other2.72%+0.75%-0.76%
10PTGXProtagonist Therapeutics INCStock-Other2.54%—-8.85%
11APGEApogee Therapeutics INCStock-Other2.53%-0.61%-33.91%
12TVTXTravere Therapeutics INCStock-Other2.40%-0.51%-3.17%
13AMLXAmylyx Pharmaceuticals INCStock-Other2.25%——
14✓ Immatics NVStock-Other2.00%——
15RLAYRelay Therapeutics INCStock-Other1.90%+1.61%+412.34%
16INBXInhibrx Biosciences INCStock-Other1.90%—-0.69%
17MGTXMeiraGTx Holdings plcStock-Other1.75%——
18ZYMEZymeworks INCStock-Other1.72%—+7.61%
19SLDBSolid Biosciences INCStock-Other1.68%+0.49%+0.62%
20DYNDyne Therapeutics INCStock-Other1.65%—+34.20%
21BCRXBiocryst Pharmaceuticals INCStock-Other1.38%+0.94%+135.07%
22ORKAOruka Therapeutics INCStock-Other1.34%+0.54%-5.49%
23AORTArtivion INCStock-Other1.17%-0.23%-4.94%
24NRIXNurix Therapeutics INCStock-Other1.12%—+4.36%
25MRNAModerna INCStock-Healthcare0.99%+0.99%NEW
26NAUTNautilus Biotechnology INCStock-Other0.95%+0.51%—
27CTMXCytomx Therapeutics INCStock-Other0.93%—+4.32%
28ANROAlto Neuroscience INCStock-Other0.88%—+12.64%
29✓ Engene Holdings INCStock-Other0.78%—-0.71%
30IMVTImmunovant INCStock-Other0.78%—-19.93%
31ISRGIntuitive Surgical INCStock-Healthcare0.77%—-2.84%
32IONSIonis Pharmaceuticals INCStock-Healthcare0.74%+0.74%NEW
33DAWNGBXDay One Biopharmaceuticals IStock-Other0.74%+0.74%NEW
34ABVXAbivax Sa-adrStock-Other0.72%-0.38%-28.25%
35CRVSCorvus Pharmaceuticals INCStock-Other0.66%+0.56%+231.07%
36RGENRepligen CORPStock-Healthcare0.65%-0.27%-11.09%
37JAZZJazz Pharmaceuticals plcStock-Healthcare0.63%——
38DMRADamora Therapeutics INCStock-Other0.62%+0.62%NEW
39XFORX4 Pharmaceuticals INCStock-Other0.54%—+6.70%
40GHGuardant Health INCStock-Healthcare0.54%—+87.50%
41DRUGBright Minds Biosciences INCStock-Other0.54%—-15.97%
42IVVDInvivyd INCStock-Other0.53%-0.43%-4.25%
43SIONSionna Therapeutics INCStock-Other0.52%-0.34%-44.16%
44AXSMAxsome Therapeutics INCStock-Healthcare0.50%—+0.71%
45RVMDRevolution Medicines INCStock-Healthcare0.49%+0.49%NEW
46SABSSab Biotherapeutics INCStock-Other0.48%+0.43%+700.75%
47BLTEBelite Bio INC - AdrStock-Other0.47%-0.71%-63.31%
48TENXTenax Therapeutics INCStock-Other0.45%—+229.68%
49AXGNAxogen INCStock-Other0.45%—-11.07%
50VRDNViridian Therapeutics INCStock-Other0.45%-1.24%-61.52%
1–50 of 94

Holding changes this quarter

Perceptive Advisors LLC's most significant position changes for 2026-03-31: Sold out: Ss Spdr S&p Biotech ETF (XBI); Sold out: Exact Sciences CORP (EXK); Sold out: Arcellx INC (ACLXGBX); Sold out: Boston Scientific CORP (BSX); Sold out: Amicus Therapeutics INC (AM6).

Position changes disclosed by Perceptive Advisors LLC for the quarter ending 2026-03-31, including ticker, issuer, weight change, shares change, and action
#TickerIssuerWeight ChangeShares ChangeAction
1260Centessa Pharmaceuticals-adr+2.8%+80.25%Add
2ASNDAscendis Pharma A/S+2.7%+41.61%Add
3PRAXPraxis Precision Medicines I+2.3%+2.00%Add
4SYRESpyre Therapeutics INC+1.9%+23.26%Add
5RLAYRelay Therapeutics INC+1.6%+412.34%Add
6ROIVRoivant Sciences Ltd.+1.4%+3.76%Add
7CELCCelcuity INC+1.4%-1.04%Trim
8BCRXBiocryst Pharmaceuticals INC+0.9%+135.07%Add
9EWTXEdgewise Therapeutics INC+0.8%-0.76%Trim
10CRVSCorvus Pharmaceuticals INC+0.6%+231.07%Add
11ORKAOruka Therapeutics INC+0.5%-5.49%Trim
12NAUTNautilus Biotechnology INC+0.5%—Unchanged
13SLDBSolid Biosciences INC+0.5%+0.62%Add
14SABSSab Biotherapeutics INC+0.4%+700.75%Add
15AORTArtivion INC-0.2%-4.94%Trim
16RGENRepligen CORP-0.3%-11.09%Trim
17SIONSionna Therapeutics INC-0.3%-44.16%Trim
18ABVXAbivax Sa-adr-0.4%-28.25%Trim
19IVVDInvivyd INC-0.4%-4.25%Trim
20OMDAOmada Health INC-0.5%-67.19%Trim
21TVTXTravere Therapeutics INC-0.5%-3.17%Trim
22APGEApogee Therapeutics INC-0.6%-33.91%Trim
23NBIXNeurocrine Biosciences INC-0.7%-80.35%Trim
24BLTEBelite Bio INC - Adr-0.7%-63.31%Trim
25RYTMRhythm Pharmaceuticals INC-0.8%-6.78%Trim
26VRDNViridian Therapeutics INC-1.2%-61.52%Trim
27XBISs Spdr S&p Biotech ETF—EXITSold out
28EXKExact Sciences CORP—EXITSold out
29ACLXGBXArcellx INC—EXITSold out
30BSXBoston Scientific CORP—EXITSold out
31AM6Amicus Therapeutics INC—EXITSold out
32CATBUSDAstria Therapeutics INC—EXITSold out
33MRNAModerna INC—NEWNew buy
34DHRDanaher CORP—EXITSold out
35IONSIonis Pharmaceuticals INC—NEWNew buy
36DAWNGBXDay One Biopharmaceuticals I—NEWNew buy
37CDTXCidara Therapeutics INC—EXITSold out
38IRONDisc Medicine INC—EXITSold out
39PENPenumbra INC—EXITSold out
40DMRADamora Therapeutics INC—NEWNew buy
41CAICaris Life Sciences INC—EXITSold out
42RAPTRapt Therapeutics INC—EXITSold out
43PVLAPalvella Therapeutics INC—EXITSold out
44RVMDRevolution Medicines INC—NEWNew buy
45KODKodiak Sciences INC—EXITSold out
46BIIBBiogen INC—EXITSold out
47ALDXAldeyra Therapeutics INC—EXITSold out
48MIRMMirum Pharmaceuticals INC—EXITSold out
49GRALGrail INC—EXITSold out
50DBVTDbv Technologies Sa-spon Adr—NEWNew buy

FAQ

What is Perceptive Advisors LLC and what type of investor is it?
Perceptive Advisors LLC is a investment manager that files SEC Form 13F quarterly, disclosing its U.S. public equity holdings to regulators. As of the most recent reporting period (2026-03-31), the firm manages a tracked equity portfolio valued at approximately $5.1B, spread across 94 disclosed positions.
What are Perceptive Advisors LLC's largest equity positions?
Based on the latest 13F filing, Perceptive Advisors LLC's top holdings by market value are: 1. Praxis Precision Medicines I (PRAX) — $656.0M (12.8%) 2. Celcuity INC (CELC) — $356.9M (7.0%) 3. Ascendis Pharma A/S (ASND) — $350.3M (6.8%) 4. Roivant Sciences Ltd. (ROIV) — $229.5M (4.5%) 5. Centessa Pharmaceuticals-adr (260) — $208.9M (4.1%)
What changes did Perceptive Advisors LLC make in its most recent portfolio filing?
In the latest reported quarter, Perceptive Advisors LLC made 49 notable position adjustments: 6 new positions were initiated, 10 existing holdings were added to, 15 positions were partially reduced, and 18 were completely exited. The largest of these moves: Sold out: Ss Spdr S&p Biotech ETF (XBI); Sold out: Exact Sciences CORP (EXK); Sold out: Arcellx INC (ACLXGBX); Sold out: Boston Scientific CORP (BSX); Sold out: Amicus Therapeutics INC (AM6)
What sectors does Perceptive Advisors LLC focus on?
Perceptive Advisors LLC is concentrated in the following sectors based on its current disclosed equity portfolio: • Health Care: 100.0%

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