| FMR LLC | $594.2M | 0.03% |
| BlackRock, Inc. | $278.5M | 0.00% |
| RTW INVESTMENTS, LP | $210.4M | 2.09% |
| Fairmount Funds Management LLC | $202.7M | 14.64% |
| PERCEPTIVE ADVISORS LLC | $190.8M | 3.73% |
| Venrock Adviser, LLC | $185.9M | 6.94% |
| VANGUARD CAPITAL MANAGEMENT LLC | $154.2M | 0.00% |
| Driehaus Capital Management LLC | $140.8M | 1.03% |
| STATE STREET CORP | $131.5M | 0.00% |
| Paradigm Biocapital Advisors LP | $98.7M | 2.02% |
| Commodore Capital LP | $96.5M | 5.58% |
| TCG Crossover Management, LLC | $95.9M | 2.74% |
| TANG CAPITAL MANAGEMENT LLC | $95.4M | 4.85% |
| WELLINGTON MANAGEMENT GROUP LLP | $92.0M | 0.02% |
| Capital International Investors | $88.1M | 0.02% |
| GEODE CAPITAL MANAGEMENT, LLC | $86.8M | 0.01% |
| JANUS HENDERSON GROUP PLC | $83.6M | 0.04% |
| RA CAPITAL MANAGEMENT, L.P. | $81.8M | 0.87% |
| PRICE T ROWE ASSOCIATES INC /MD/ | $80.6M | 0.01% |
| Remedium Capital Partners, LLC | $73.5M | 26.13% |
| Affinity Asset Advisors, LLC | $64.5M | 3.33% |
| BANK OF AMERICA CORP /DE/ | $61.9M | 0.00% |
| BAKER BROS. ADVISORS LP | $50.4M | 0.29% |
| BRAIDWELL LP | $47.1M | 1.57% |
| FRANKLIN RESOURCES INC | $44.5M | 0.01% |
| JPMORGAN CHASE & CO | $44.5M | 0.00% |
| Caligan Partners LP | $44.3M | 2.95% |
| Siren, L.L.C. | $41.3M | 1.14% |
| Polar Capital Holdings Plc | $40.0M | 0.14% |
| UBS Group AG | $33.9M | 0.01% |
| Capital World Investors | $33.6M | 0.00% |
| EMERALD ADVISERS, LLC | $30.9M | 0.98% |
| Candriam S.C.A. | $30.8M | 0.16% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $29.5M | 0.00% |
| NORTHERN TRUST CORP | $29.2M | 0.00% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $28.4M | 0.00% |
| Pictet Asset Management Holding SA | $24.8M | 0.03% |
| VANGUARD FIDUCIARY TRUST CO | $23.4M | 0.01% |
| EMERALD MUTUAL FUND ADVISERS TRUST | $20.6M | 1.00% |
| SAMLYN CAPITAL, LLC | $20.0M | 0.34% |
| ADAR1 Capital Management, LLC | $17.1M | 1.00% |
| Blackstone Inc. | $14.8M | 0.06% |
| VICTORY CAPITAL MANAGEMENT INC | $14.7M | 0.01% |
| GOLDMAN SACHS GROUP INC | $13.6M | 0.00% |
| Woodline Partners LP | $13.4M | 0.05% |
| MORGAN STANLEY | $12.4M | 0.00% |
| Caption Management, LLC | $12.0M | 0.07% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | $10.5M | 0.00% |
| BOOTHBAY FUND MANAGEMENT, LLC | $9.7M | 0.13% |
| Bank of New York Mellon Corp | $9.7M | 0.00% |
| SILVERARC CAPITAL MANAGEMENT, LLC | $9.4M | 0.96% |
| FIRST TRUST ADVISORS LP | $9.0M | 0.01% |
| Universal- Beteiligungs- und Servicegesellschaft mbH | $8.6M | 0.01% |
| STEMPOINT CAPITAL LP | $8.5M | 1.62% |
| AMERIPRISE FINANCIAL INC | $8.0M | 0.00% |
| Nuveen, LLC | $7.8M | 0.00% |
| Ensign Peak Advisors, Inc | $7.5M | 0.01% |
| MILLENNIUM MANAGEMENT LLC | $7.4M | 0.00% |
| HighVista Strategies LLC | $7.4M | 2.04% |
| MARSHALL WACE, LLP | $7.0M | 0.01% |
| TD Asset Management Inc | $6.9M | 0.01% |
| Invesco Ltd. | $6.7M | 0.00% |
| DEUTSCHE BANK AG\ | $6.5M | 0.00% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $6.5M | 0.00% |
| CITADEL ADVISORS LLC | $6.2M | 0.00% |
| ARMISTICE CAPITAL, LLC | $6.1M | 0.11% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | $5.7M | 0.00% |
| SEVEN GRAND MANAGERS, LLC | $5.0M | 0.34% |
| B Group, Inc. | $5.0M | 3.74% |
| F/m Investments LLC | $5.0M | 0.33% |
| Swiss National Bank | $4.9M | 0.00% |
| ExodusPoint Capital Management, LP | $4.4M | 0.04% |
| RHUMBLINE ADVISERS | $4.3M | 0.00% |
| MERCER GLOBAL ADVISORS INC /ADV | $3.6M | 0.01% |
| Atle Fund Management AB | $3.5M | 1.13% |
| Rockefeller Capital Management L.P. | $3.2M | 0.01% |
| ALPS ADVISORS INC | $3.2M | 0.02% |
| PRUDENTIAL FINANCIAL INC | $3.0M | 0.00% |
| FRED ALGER MANAGEMENT, LLC | $3.0M | 0.01% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | $3.0M | 0.00% |
| SCHRODER INVESTMENT MANAGEMENT GROUP | $2.9M | 0.00% |
| Rafferty Asset Management, LLC | $2.9M | 0.01% |
| Balyasny Asset Management L.P. | $2.8M | 0.00% |
| VOYA INVESTMENT MANAGEMENT LLC | $2.7M | 0.00% |
| Susquehanna Portfolio Strategies, LLC | $2.7M | 0.04% |
| DIMENSIONAL FUND ADVISORS LP | $2.4M | 0.00% |
| ALLIANCEBERNSTEIN L.P. | $2.3M | 0.00% |
| BARCLAYS PLC | $2.3M | 0.00% |
| Legal & General Group Plc | $2.3M | 0.00% |
| MetLife Investment Management, LLC | $1.9M | 0.01% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | $1.8M | 0.00% |
| VANGUARD ASSET MANAGEMENT, Ltd | $1.7M | 0.00% |
| WELLS FARGO & COMPANY/MN | $1.7M | 0.00% |
| Vanguard Global Advisers, LLC | $1.6M | 0.00% |
| Cinctive Capital Management LP | $1.4M | 0.09% |
| STATE OF WISCONSIN INVESTMENT BOARD | $1.3M | 0.00% |
| PROFUND ADVISORS LLC | $1.3M | 0.05% |
| Waverly Advisors, LLC | $1.3M | 0.01% |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | $1.3M | 0.01% |
| XTX Topco Ltd | $1.2M | 0.02% |
| NEW YORK STATE COMMON RETIREMENT FUND | $1.1M | 0.00% |
| Ellsworth Advisors, LLC | $1.1M | 0.21% |
| AQR CAPITAL MANAGEMENT LLC | $1.1M | 0.00% |
| RAYMOND JAMES FINANCIAL INC | $996.4K | 0.00% |
| Seven Fleet Capital Management LP | $993.2K | 0.32% |
| Assenagon Asset Management S.A. | $940.6K | 0.00% |
| Police & Firemen's Retirement System of New Jersey | $926.1K | 0.01% |
| Global Endowment Management, LP | $917.0K | 0.10% |
| KENNEDY CAPITAL MANAGEMENT LLC | $851.1K | 0.02% |
| State of New Jersey Common Pension Fund D | $843.4K | 0.00% |
| INTECH INVESTMENT MANAGEMENT LLC | $829.4K | 0.01% |
| Creative Planning | $781.1K | 0.00% |
| Zurcher Kantonalbank (Zurich Cantonalbank) | $703.9K | 0.00% |
| China Universal Asset Management Co., Ltd. | $703.0K | 0.05% |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | $701.4K | 0.00% |
| ProShare Advisors LLC | $680.8K | 0.00% |
| ARIZONA STATE RETIREMENT SYSTEM | $677.8K | 0.00% |
| SG Americas Securities, LLC | $676.0K | 0.00% |
| Vanguard Investments Australia, Ltd. | $646.3K | 0.00% |
| BROWN ADVISORY INC | $625.5K | 0.00% |
| CITIGROUP INC | $605.6K | 0.00% |
| KLP KAPITALFORVALTNING AS | $549.8K | 0.00% |
| Russell Investments Group, Ltd. | $500.9K | 0.00% |
| Carlyle Group Inc. | $485.2K | 0.00% |
| Man Group plc | $481.5K | 0.00% |
| MARTINGALE ASSET MANAGEMENT L P | $458.0K | 0.01% |
| SEI INVESTMENTS CO | $452.7K | 0.00% |
| Tower Research Capital LLC (TRC) | $443.4K | 0.01% |
| Bridgefront Capital, LLC | $436.4K | 0.11% |
| TUDOR INVESTMENT CORP ET AL | $421.9K | 0.00% |
| RWC Asset Management LLP | $411.9K | 0.02% |
| Virtus Investment Advisers, LLC | $409.1K | 0.11% |
| Virtu Financial LLC | $408.0K | 0.02% |
| CAPSTONE INVESTMENT ADVISORS, LLC | $380.2K | 0.00% |
| E Fund Management Co., Ltd. | $360.9K | 0.01% |
| Scientech Research LLC | $357.5K | 0.30% |
| TWO SIGMA SECURITIES, LLC | $345.6K | 0.04% |
| AlphaCentric Advisors LLC | $334.6K | 0.33% |
| XPONANCE LLC | $325.1K | 0.00% |
| TEACHER RETIREMENT SYSTEM OF TEXAS | $316.8K | 0.00% |
| Arrowpoint Investment Partners (Singapore) Pte. Ltd. | $309.7K | 0.28% |
| High Net Worth Advisory Group LLC | $302.6K | 0.07% |
| LOS ANGELES CAPITAL MANAGEMENT LLC | $295.5K | 0.00% |
| Ameritas Investment Partners, Inc. | $282.1K | 0.01% |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | $262.3K | 0.02% |
| PSP Research LLC | $260.2K | 0.18% |
| Persistent Asset Partners Ltd | $242.3K | 0.09% |
| Quantinno Capital Management LP | $230.1K | 0.00% |
| STRS OHIO | $227.0K | 0.00% |
| Vanguard Personalized Indexing Management, LLC | $221.8K | 0.00% |