SYRE

Spyre Therapeutics INC

+$1.5B

Net Activity

Institutions Holding

199

Popularity Rank

#2898

Avg Weight

0.49%

Total Value

$4.2B

Ownership Trend

199 institutions currently hold SYRE, with 119 net buyers and 62 net sellers this quarter.

Institutional Moves

Institutional Moves (Q1 2026)

Majority Increased

Based on recent trading activity

Net Selling Institutions

62

Net Buying Institutions

119

Key Holders

Key Holders

Top 5 by Value

FL
FMR LLC
$594.2M
BI
BlackRock, Inc.
$278.5M
RI
Rtw Investments, LP
$210.4M
FF
Fairmount Funds Management LLC
$202.7M
PA
Perceptive Advisors LLC
$190.8M

Top 5 by Conviction

RC
Remedium Capital Partners, LLC
26.13%
FF
Fairmount Funds Management LLC
14.64%
VA
Venrock Adviser, LLC
6.94%
CC
Commodore Capital LP
5.58%
TC
Tang Capital Management LLC
4.85%
View all 199 holding institutions

Quarterly Activity

Recent Activity

+$1.7B

Total Buy Value

$982.4M

Total Sell Value

New buy53
Trim50
Add66
Sold out12

119

Net Buyers

62

Net Sellers

Insider Trading (Form 4)

Form 144 Pre-Sale Notices

5

Filings (90d)

$407.88M

Total Est. Value

4.78M shares

Planned Shares

Last Filed 2026-07-01
FilerFiling DateEst. Value
CAMERON TURTLE2026-07-01$4.00M
Burrows Scott L2026-06-25$1.31M
Fairmount Funds Management LLC2026-06-23$399.66M
HENDERSON MICHAEL THOMAS2026-06-22$1.77M
Sloan Sheldon2026-06-03$1.15M

Form 144 is a planned sale notice, not an executed transaction. Form 144 Tracker。

Beneficial Ownership (13D/13G)

No Schedule 13D/13G filings for this ticker

Material Events (8-K)

No Form 8-K filings for this ticker

FAQ

Who are the top institutional investors holding SPYRE THERAPEUTICS INC (SYRE)?
Major stakeholders currently include FMR LLC ($594.2M), BlackRock, Inc. ($278.5M), Rtw Investments, LP ($210.4M). Based on the latest 13F filings, there are a total of 199 tracked investment funds and institutions maintaining positions in SYRE.
What is the overall institutional sentiment toward SYRE recently?
Institutional sentiment appears Bullish (Net Buying). During the most recent reporting quarter, the stock experienced a net inflow of $1.5B, driven by 119 managers accumulating shares while 62 reduced their exposure.
Which institutions have been selling or reducing their SYRE positions?
In the latest period, 50 funds trimmed their holdings, and 12 managers completely exited their positions. The aggregate reported sell value was $982.4M.
Are there any notable investors adding SYRE to their portfolios?
Yes, buying activity remains notable. 53 institutions opened new positions in {ticker}, and 66 existing holders added to their shares. The total reported buy value for the quarter amounted to $1.7B.

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