| RA CAPITAL MANAGEMENT, L.P. | $579.8M | 6.14% |
| BlackRock, Inc. | $542.4M | 0.01% |
| BAKER BROS. ADVISORS LP | $487.4M | 2.80% |
| PRIMECAP MANAGEMENT CO/CA/ | $297.2M | 0.23% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $264.5M | 0.01% |
| VANGUARD CAPITAL MANAGEMENT LLC | $258.1M | 0.01% |
| PERCEPTIVE ADVISORS LLC | $206.4M | 4.03% |
| STATE STREET CORP | $197.6M | 0.01% |
| GOLDMAN SACHS GROUP INC | $170.9M | 0.02% |
| WESTFIELD CAPITAL MANAGEMENT CO LP | $167.8M | 0.70% |
| FMR LLC | $147.0M | 0.01% |
| PRICE T ROWE ASSOCIATES INC /MD/ | $143.9M | 0.02% |
| Polar Capital Holdings Plc | $140.5M | 0.50% |
| CITADEL ADVISORS LLC | $126.4M | 0.02% |
| GEODE CAPITAL MANAGEMENT, LLC | $123.2M | 0.01% |
| JPMORGAN CHASE & CO | $120.0M | 0.01% |
| FEDERATED HERMES, INC. | $111.9M | 0.18% |
| Checkpoint Capital L.P. | $106.7M | 38.30% |
| ALLIANCEBERNSTEIN L.P. | $97.5M | 0.03% |
| Capital Research Global Investors | $97.0M | 0.02% |
| JANUS HENDERSON GROUP PLC | $79.9M | 0.04% |
| Point72 Asset Management, L.P. | $73.6M | 0.09% |
| Woodline Partners LP | $66.0M | 0.25% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | $63.1M | 0.10% |
| Siren, L.L.C. | $63.1M | 1.75% |
| MORGAN STANLEY | $61.2M | 0.00% |
| Rock Springs Capital Management LP | $60.0M | 3.54% |
| Pictet Asset Management Holding SA | $57.3M | 0.06% |
| BANK OF AMERICA CORP /DE/ | $54.7M | 0.00% |
| FRANKLIN RESOURCES INC | $54.5M | 0.01% |
| Clearbridge Investments, LLC | $53.0M | 0.05% |
| Integral Health Asset Management, LLC | $52.2M | 2.50% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | $47.1M | 0.01% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $45.8M | 0.01% |
| NORTHERN TRUST CORP | $43.4M | 0.01% |
| LOOMIS SAYLES & CO L P | $40.4M | 0.05% |
| Candriam S.C.A. | $40.4M | 0.21% |
| MILLENNIUM MANAGEMENT LLC | $39.3M | 0.02% |
| Sofinnova Investments, Inc. | $39.1M | 1.49% |
| Logos Global Management LP | $39.1M | 1.95% |
| Driehaus Capital Management LLC | $38.0M | 0.28% |
| VANGUARD FIDUCIARY TRUST CO | $36.7M | 0.01% |
| Opaleye Management Inc. | $35.3M | 4.65% |
| Artisan Partners Limited Partnership | $34.0M | 0.05% |
| AMERIPRISE FINANCIAL INC | $33.4M | 0.01% |
| Invesco Ltd. | $31.7M | 0.00% |
| LORD, ABBETT & CO. LLC | $30.3M | 0.10% |
| ORBIMED ADVISORS LLC | $27.3M | 0.56% |
| BRAIDWELL LP | $27.0M | 0.90% |
| SILVERARC CAPITAL MANAGEMENT, LLC | $26.6M | 2.72% |
| Bank of New York Mellon Corp | $25.5M | 0.00% |
| Qube Research & Technologies Ltd | $24.2M | 0.03% |
| WELLINGTON MANAGEMENT GROUP LLP | $23.8M | 0.00% |
| Squarepoint Ops LLC | $22.9M | 0.03% |
| RENAISSANCE TECHNOLOGIES LLC | $22.4M | 0.04% |
| Hood River Capital Management LLC | $20.9M | 0.21% |
| VOYA INVESTMENT MANAGEMENT LLC | $20.3M | 0.02% |
| UBS Group AG | $20.1M | 0.00% |
| ADAR1 Capital Management, LLC | $18.4M | 1.08% |
| SummitTX Capital, L.P. | $14.4M | 0.45% |
| Connor, Clark & Lunn Investment Management Ltd. | $13.2M | 0.03% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $12.8M | 0.00% |
| DEUTSCHE BANK AG\ | $12.3M | 0.00% |
| M&G PLC | $12.1M | 0.06% |
| PFM Health Sciences, LP | $11.9M | 1.08% |
| NEXTBio Capital Management LP | $11.0M | 5.09% |
| NEW YORK STATE COMMON RETIREMENT FUND | $10.9M | 0.02% |
| Nuveen, LLC | $10.2M | 0.00% |
| SCHRODER INVESTMENT MANAGEMENT GROUP | $10.2M | 0.01% |
| Russell Investments Group, Ltd. | $10.1M | 0.01% |
| Capital World Investors | $10.1M | 0.00% |
| Swiss National Bank | $9.8M | 0.01% |
| AXIOM INVESTORS LLC /DE | $8.0M | 0.09% |
| First Light Asset Management, LLC | $7.6M | 0.68% |
| FIRST TRUST ADVISORS LP | $7.4M | 0.01% |
| Aberdeen Group plc | $6.9M | 0.01% |
| Granahan Investment Management, LLC | $6.8M | 0.33% |
| NEUBERGER BERMAN GROUP LLC | $6.4M | 0.00% |
| WCM INVESTMENT MANAGEMENT, LLC | $6.2M | 0.01% |
| RHUMBLINE ADVISERS | $6.1M | 0.01% |
| KENNEDY CAPITAL MANAGEMENT LLC | $5.7M | 0.12% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | $5.7M | 0.01% |
| Universal- Beteiligungs- und Servicegesellschaft mbH | $5.5M | 0.01% |
| Blue Owl Capital Holdings LP | $5.3M | 1.44% |
| XTX Topco Ltd | $5.2M | 0.09% |
| AQR CAPITAL MANAGEMENT LLC | $5.2M | 0.00% |
| ALGERT GLOBAL LLC | $5.1M | 0.08% |
| Atom Investors LP | $5.0M | 0.35% |
| Balyasny Asset Management L.P. | $4.6M | 0.01% |
| CASTLEARK MANAGEMENT LLC | $4.5M | 0.15% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | $4.4M | 0.00% |
| JANE STREET GROUP, LLC | $4.4M | 0.00% |
| PICTON MAHONEY ASSET MANAGEMENT | $4.4M | 0.03% |
| Rafferty Asset Management, LLC | $4.4M | 0.02% |
| RAYMOND JAMES FINANCIAL INC | $4.3M | 0.00% |
| VANGUARD ASSET MANAGEMENT, Ltd | $4.3M | 0.00% |
| Nan Fung Group Holdings Ltd | $4.3M | 3.52% |
| Harvest Investment Services, LLC | $4.2M | 0.77% |
| Legal & General Group Plc | $4.1M | 0.00% |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | $4.1M | 0.03% |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | $3.8M | 0.00% |
| Utah Retirement Systems | $3.7M | 0.04% |
| SEI INVESTMENTS CO | $3.5M | 0.00% |
| Exome Asset Management LLC | $3.5M | 1.83% |
| Hillsdale Investment Management Inc. | $3.5M | 0.10% |
| TD Asset Management Inc | $3.4M | 0.00% |
| STATE OF WISCONSIN INVESTMENT BOARD | $3.2M | 0.01% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | $3.0M | 0.00% |
| EFG International AG | $3.0M | 0.06% |
| WELLS FARGO & COMPANY/MN | $3.0M | 0.00% |
| ASPIRIANT, LLC | $2.9M | 0.08% |
| LAZARD ASSET MANAGEMENT LLC | $2.9M | 0.00% |
| D. E. Shaw & Co., Inc. | $2.8M | 0.00% |
| Alyeska Investment Group, L.P. | $2.8M | 0.01% |
| HARBOR CAPITAL ADVISORS, INC. | $2.6M | 0.21% |
| PRUDENTIAL FINANCIAL INC | $2.6M | 0.00% |
| Vanguard Global Advisers, LLC | $2.6M | 0.00% |
| Aquatic Capital Management LLC | $2.6M | 0.07% |
| STRS OHIO | $2.5M | 0.01% |
| MetLife Investment Management, LLC | $2.5M | 0.01% |
| PDT Partners, LLC | $2.4M | 0.14% |
| WEDGE CAPITAL MANAGEMENT L L P/NC | $2.1M | 0.04% |
| PROFUND ADVISORS LLC | $2.0M | 0.07% |
| MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC | $2.0M | 0.02% |
| Creative Planning | $1.8M | 0.00% |
| Liberty Mutual Group Asset Management Inc. | $1.8M | 0.14% |
| VICTORY CAPITAL MANAGEMENT INC | $1.8M | 0.00% |
| TUDOR INVESTMENT CORP ET AL | $1.7M | 0.00% |
| State of New Jersey Common Pension Fund D | $1.7M | 0.01% |
| DIMENSIONAL FUND ADVISORS LP | $1.7M | 0.00% |
| SG Americas Securities, LLC | $1.6M | 0.00% |
| Advisors Asset Management, Inc. | $1.6M | 0.03% |
| CAPTRUST FINANCIAL ADVISORS | $1.6M | 0.00% |
| ExodusPoint Capital Management, LP | $1.5M | 0.01% |
| Handelsbanken Fonder AB | $1.5M | 0.01% |
| HighVista Strategies LLC | $1.5M | 0.40% |
| GUGGENHEIM CAPITAL LLC | $1.4M | 0.01% |
| Zurcher Kantonalbank (Zurich Cantonalbank) | $1.4M | 0.00% |
| Knights of Columbus Asset Advisors LLC | $1.4M | 0.08% |
| ARIZONA STATE RETIREMENT SYSTEM | $1.4M | 0.01% |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | $1.3M | 0.00% |
| Police & Firemen's Retirement System of New Jersey | $1.3M | 0.01% |
| HSBC HOLDINGS PLC | $1.2M | 0.00% |
| Vanguard Investments Australia, Ltd. | $1.2M | 0.00% |
| Jasper Ridge Partners, L.P. | $1.2M | 0.03% |
| INTECH INVESTMENT MANAGEMENT LLC | $1.2M | 0.01% |
| KLP KAPITALFORVALTNING AS | $1.1M | 0.00% |
| Bridgefront Capital, LLC | $1.1M | 0.27% |
| STIFEL FINANCIAL CORP | $1.1M | 0.00% |
| CITIGROUP INC | $1.1M | 0.00% |