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CIK: 0001496201
Total reported value
$766.5M
$766.5M
98 檔
13.0%
According to the latest 13F quarterly dataset, Sphera Funds Management LTD. managed an equity portfolio of $766.5M at the end of Q4 2025, spanning 98 distinct U.S. exchange-listed positions.
Sphera Funds Management LTD. executed strategic sector rebalancing during Q4 2025, establishing 24 new positions while fully exiting 31 holdings and trimming 27 positions.
| # | Ticker | Issuer | Asset Subclass | Weight | Weight Change | Shares Change | 4Q Trend |
|---|---|---|---|---|---|---|---|
| 1 | TEVA | Teva Pharmaceutical-sp Adr | Stock-Healthcare | 6.78% | +1.19% | -25.45% | |
| 2 | BIIB | Biogen Inc | Stock-Healthcare | 3.22% | +2.85% | +14.50% | |
| 3 | MLYS | Mineralys Therapeutics Inc | Stock-Other | 3.15% | -0.59% | +104.18% | |
| 4 | SNDX | Syndax Pharmaceuticals Inc | Stock-Other | 3.10% | +0.20% | +96.68% | |
| 5 | NVMI | Nova Ltd. | Stock-Other | 3.04% | -1.90% | +9.00% | |
| 6 | RARE | Ultragenyx Pharmaceutical In | Stock-Other | 2.89% | -0.13% | +84.54% | |
| 7 | TSEM | Tower Semiconductor Ltd. | Stock-Tech | 2.78% | -0.38% | -60.71% | |
| 8 | COGT | Cogent Biosciences Inc | Stock-Other | 2.60% | -0.22% | +284.16% | |
| 9 | AZNN | Astrazeneca Plc-spons Adr | Stock-Other | 2.40% | — | — | |
| 10 | PRAX | Praxis Precision Medicines I | Stock-Other | 2.28% | +0.55% | NEW | |
| 11 | SNY | Sanofi-adr | Stock-Healthcare | 2.24% | -0.56% | +9.11% | |
| 12 | LLY | Eli Lilly & Co | Stock-Healthcare | 1.88% | -0.06% | -9.96% | |
| 13 | AM6 | Amicus Therapeutics Inc | Stock-Other | 1.81% | -1.39% | EXIT | |
| 14 | ✓ | Immatics NV | Stock-Other | 1.75% | -0.14% | +47.68% | |
| 15 | BMRN | Biomarin Pharmaceutical Inc | Stock-Healthcare | 1.69% | +1.19% | — | |
| 16 | XBI | Ss Spdr S&p Biotech ETF | ETF-Tech | 1.65% | -0.96% | — | |
| 17 | BBIO | Bridgebio Pharma Inc | Stock-Healthcare | 1.59% | -0.51% | -36.90% | |
| 18 | ORIC | Oric Pharmaceuticals Inc | Stock-Other | 1.59% | +0.13% | +132.66% | |
| 19 | DYN | Dyne Therapeutics Inc | Stock-Other | 1.49% | +0.12% | -7.88% | |
| 20 | TRVI | Trevi Therapeutics Inc | Stock-Other | 1.45% | +0.12% | -22.59% | |
| 21 | JNJ | Johnson & Johnson | Stock-Healthcare | 1.43% | -0.16% | -12.25% | |
| 22 | SVRA | Savara Inc | Stock-Other | 1.37% | -0.03% | -12.75% | |
| 23 | SRRK | Scholar Rock Holding CORP | Stock-Other | 1.35% | -0.06% | — | |
| 24 | WVE | Wave Life Sciences Ltd. | Stock-Other | 1.34% | -0.15% | +716.33% | |
| 25 | HELP | Cybin Inc | Stock-Other | 1.31% | +0.65% | +122.90% | |
| 26 | ANNX | Annexon Inc | Stock-Other | 1.28% | — | -26.65% | |
| 27 | BCRX | Biocryst Pharmaceuticals Inc | Stock-Other | 1.26% | -0.76% | — | |
| 28 | CLDX | Celldex Therapeutics Inc | Stock-Other | 1.26% | -0.06% | +15.40% | |
| 29 | SLNOEUR | Soleno Therapeutics Inc | Stock-Other | 1.22% | -1.15% | EXIT | |
| 30 | APLSUSD | Apellis Pharmaceuticals Inc | Stock-Other | 1.22% | -1.37% | EXIT | |
| 31 | NICE | Nice LTD - Spon Adr | Stock-Tech | 1.22% | -0.10% | EXIT | |
| 32 | GSK | Gsk Plc-spon Adr | Stock-Healthcare | 1.16% | -0.37% | — | |
| 33 | ENPH | Enphase Energy Inc | Stock-Tech | 1.16% | -0.86% | EXIT | |
| 34 | NVO | Novo-nordisk A/s-spons Adr | Stock-Healthcare | 1.14% | +0.05% | +9.46% | |
| 35 | CYTK | Cytokinetics Inc | Stock-Healthcare | 1.13% | +0.43% | -43.22% | |
| 36 | ABBV | Abbvie Inc | Stock-Healthcare | 1.12% | -0.05% | — | |
| 37 | SEDG | Solaredge Technologies Inc | Stock-Tech | 1.10% | -0.43% | EXIT | |
| 38 | ACAD | Acadia Pharmaceuticals Inc | Stock-Healthcare | 1.10% | +0.27% | +42.51% | |
| 39 | VOR | Vor Biopharma Inc | Stock-Other | 1.04% | +0.09% | — | |
| 40 | MRK | Merck & Co. Inc. | Stock-Healthcare | 0.99% | +0.05% | — | |
| 41 | NVS | Novartis Ag-sponsored Adr | Stock-Healthcare | 0.99% | +0.12% | — | |
| 42 | FBRX | Forte Biosciences Inc | Stock-Other | 0.98% | -0.07% | -60.81% | |
| 43 | KOD | Kodiak Sciences Inc | Stock-Other | 0.95% | -0.28% | — | |
| 44 | TNGX | Tango Therapeutics Inc | Stock-Other | 0.93% | -0.10% | — | |
| 45 | SEDG 2.25 07-01-29Bond | Solar Edge Technologies | Bond | 0.91% | -0.09% | — | |
| 46 | CATBUSD | Astria Therapeutics Inc | Stock-Other | 0.90% | — | +41.60% | |
| 47 | ✓ | Mediwound LTD | Stock-Other | 0.82% | -0.18% | +24.33% | |
| 48 | CAMT | Camtek Ltd. | Stock-Other | 0.81% | -1.28% | EXIT | |
| 49 | RVMD | Revolution Medicines Inc | Stock-Healthcare | 0.81% | -0.30% | -12.50% | |
| 50 | TLT | Ishares 20+ Year Treasury Bd | ETF-Gov Bonds | 0.79% | -0.12% | — |
| # | Ticker | Issuer | Weight Change | Shares Change | Action |
|---|---|---|---|---|---|
| 1 | COGT | Cogent Biosciences Inc | +2.3% | +284.16% | Add |
| 2 | SNDX | Syndax Pharmaceuticals Inc | +1.8% | +96.68% | Add |
| 3 | MLYS | Mineralys Therapeutics Inc | +1.4% | +104.18% | Add |
| 4 | WVE | Wave Life Sciences Ltd. | +1.3% | +716.33% | Add |
| 5 | PRAX | Praxis Precision Medicines I | +1.1% | -62.93% | Trim |
| 6 | ENPH | Enphase Energy Inc | +1% | +598.50% | Add |
| 7 | APLSUSD | Apellis Pharmaceuticals Inc | +0.9% | +294.22% | Add |
| 8 | HELP | Cybin Inc | +0.9% | +122.90% | Add |
| 9 | BIIB | Biogen Inc | +0.8% | +14.50% | Add |
| 10 | ✓ | Immatics NV | +0.7% | +47.68% | Add |
| 11 | RARE | Ultragenyx Pharmaceutical In | +0.7% | +84.54% | Add |
| 12 | SLNOEUR | Soleno Therapeutics Inc | +0.6% | +227.63% | Add |
| 13 | CLYM | Climb Bio Inc | +0.5% | +114.39% | Add |
| 14 | CATBUSD | Astria Therapeutics Inc | +0.5% | +41.60% | Add |
| 15 | ORIC | Oric Pharmaceuticals Inc | +0.5% | +132.66% | Add |
| 16 | ACAD | Acadia Pharmaceuticals Inc | +0.4% | +42.51% | Add |
| 17 | TEVA | Teva Pharmaceutical-sp Adr | +0.4% | -25.45% | Trim |
| 18 | VSTM | Verastem Inc | +0.4% | +338.89% | Add |
| 19 | DYN | Dyne Therapeutics Inc | +0.4% | -7.88% | Trim |
| 20 | SVRA | Savara Inc | +0.4% | -12.75% | Trim |
| 21 | LLY | Eli Lilly & Co | +0.3% | -9.96% | Trim |
| 22 | ACOG | Alpha Cognition Inc | +0.2% | +67.56% | Add |
| 23 | RVMD | Revolution Medicines Inc | +0.2% | -12.50% | Trim |
| 24 | AMD | Advanced Micro Devices | +0.2% | +16.61% | Add |
| 25 | AZNN | Astrazeneca Plc-spons Adr | +0.2% | — | Unchanged |
| 26 | AVGO | Broadcom Inc | +0.2% | +48.82% | Add |
| 27 | CAMT | Camtek Ltd. | +0.2% | +35.97% | Add |
| 28 | AM6 | Amicus Therapeutics Inc | +0.2% | -33.57% | Trim |
| 29 | CLDX | Celldex Therapeutics Inc | +0.1% | +15.40% | Add |
| 30 | ANNX | Annexon Inc | +0.1% | -26.65% | Trim |
| 31 | MRK | Merck & Co. Inc. | +0.1% | — | Unchanged |
| 32 | KURA | Kura Oncology Inc | +0.1% | +20.36% | Add |
| 33 | ✓ | Mediwound LTD | +0.1% | +24.33% | Add |
| 34 | TSHA | Taysha Gene Therapies Inc | +0.1% | -9.80% | Trim |
| 35 | NVMI | Nova Ltd. | +0.1% | +9.00% | Add |
| 36 | VYGR | Voyager Therapeutics Inc | +0.1% | +70.08% | Add |
| 37 | SNY | Sanofi-adr | +0.1% | +9.11% | Add |
| 38 | GSK | Gsk Plc-spon Adr | +0.1% | — | Unchanged |
| 39 | VTYXUSD | Ventyx Biosciences Inc | 0% | -59.08% | Trim |
| 40 | BMY | Bristol-myers Squibb Co | 0% | — | Unchanged |
| 41 | SEDG | Solaredge Technologies Inc | — | +39.42% | Add |
| 42 | DAWNGBX | Day One Biopharmaceuticals I | — | -17.11% | Trim |
| 43 | IBIT | Ishares Bitcoin Trust ETF | — | +40.08% | Add |
| 44 | NVS | Novartis Ag-sponsored Adr | 0% | — | Unchanged |
| 45 | APLT | Applied Therapeutics Inc | 0% | — | Unchanged |
| 46 | OKUR | Onkure Therapeutics Inc-a | 0% | — | Unchanged |
| 47 | CRVS | Corvus Pharmaceuticals Inc | 0% | — | Unchanged |
| 48 | JANX | Janux Therapeutics Inc | 0% | +83.88% | Add |
| 49 | PEPG | Pepgen Inc | 0% | -29.16% | Trim |
| 50 | TRVI | Trevi Therapeutics Inc | 0% | -22.59% | Trim |
According to official SEC Form 13F filings, Sphera Funds Management LTD. reported a total U.S. public equity portfolio value of $766.5M across 98 disclosed positions in Q4 2025.
Expert Analysis & Guides for Tracking Wall Street Smart Money Movements
Learn how SEC Form 13F filings work, the $100M threshold, 45-day reporting lag, and how to track top hedge fund holdings.
In terms of portfolio concentration, the top 5 core holdings (including TEVA, BIIB, MLYS) accounted for 13.0% of total reported equity market value during Q4 2025.
Top New Position Initiated
BMRN
市值: $8.7M
Top Position Liquidated / Trimmed
CDTX
前期市值: $16.8M
During Q4 2025, Sphera Funds Management LTD.'s top holdings by market value included TEVA (6.8%)、BIIB (3.2%)、MLYS (3.1%). The largest single position, TEVA, represented 6.8% of total portfolio value.
In Q4 2025, Sphera Funds Management LTD. made 114 total portfolio adjustments, initiating 24 new buys, adding to 32 positions, trimming 27 holdings, and fully liquidating 31 stocks.
All holding records on this page are fetched directly from the U.S. Securities and Exchange Commission (SEC) EDGAR system (Form 13F-HR). AlphaSMO parses CUSIP identifiers and formats data into Schema.org-compliant datasets.
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