CIK: 0001969764
Total reported value
$158.7M
Reporting period: 2026-03-31 · Number of holdings: 38
Propel Bio Management, LLC disclosed 38 holdings in its latest 13F filing for the period ending 2026-03-31, with total reported value of $158.7M and a quarterly turnover rate of 71.4%.
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Propel Bio Management, LLC's disclosed holdings carry a Herfindahl concentration index of 0.063 — mathematically equivalent to about 16 equally-sized positions, well below its 38 actual disclosed holdings. That gap points to a strategy built around a small core of high-conviction bets rather than broad diversification.
Position sizes are fairly uniform across the portfolio (a coefficient of variation of 1.19), suggesting a disciplined, rules-based approach to how much capital goes into each idea.
No strong tilt toward either adding to existing winners or initiating outsized new positions was observed in the latest reported quarter.
Sector classification currently covers about 23% of this portfolio's disclosed value; the remainder includes holdings (e.g. unmapped tickers, options, or other security types) not yet covered by our sector mapping.
Trim ACHV
0.0% -$7.4M
Trim VRDN
-25.6% -$4.7M
Trim PHAT
+13.5% -$2.9M
Trim MIST
0.0% -$3.2M
Trim CMPS
-13.9% -$1.8M
Add DCTH
+123.4% $4.7M
| # | Ticker | Issuer | Asset Subclass | Weight | Weight Change | Shares Change | 4Q Trend |
|---|---|---|---|---|---|---|---|
| 1 | PAGP | Plains Gp Holdings Lp-cl A | Stock-Energy | 19.02% | -1.77% | — | |
| 2 | ACHV | Achieve Life Sciences INC | Stock-Other | 7.17% | -8.90% | — | |
| 3 | PHAT | Phathom Pharmaceuticals INC | Stock-Other | 5.90% | -4.59% | +13.54% | |
| 4 | DCTH | Delcath Systems INC | Stock-Other | 5.77% | +1.99% | +123.42% | |
| 5 | CORT | Corcept Therapeutics INC | Stock-Healthcare | 3.80% | +3.80% | NEW | |
| 6 | ABEO | Abeona Therapeutics INC | Stock-Other | 3.79% | +0.05% | +60.08% | |
| 7 | VOR | Vor Biopharma INC | Stock-Other | 3.52% | +3.52% | NEW | |
| 8 | KYTX | Kyverna Therapeutics INC | Stock-Other | 3.52% | -1.83% | -3.34% | |
| 9 | MIST | Milestone Pharmaceuticals In | Stock-Other | 3.20% | -3.90% | — | |
| 10 | CLDX | Celldex Therapeutics INC | Stock-Other | 2.61% | -0.97% | -14.86% | |
| 11 | CMPS | Compass Pathways PLC | Stock-Other | 2.60% | -2.48% | -13.89% | |
| 12 | VRDN | Viridian Therapeutics INC | Stock-Other | 2.58% | -4.93% | -25.61% | |
| 13 | IVA | Inventiva SA - Adr | Stock-Other | 2.52% | -1.45% | -27.53% | |
| 14 | SABS | Sab Biotherapeutics INC | Stock-Other | 2.45% | +0.37% | +55.13% | |
| 15 | OBIO | Orchestra Biomed Holdings In | Stock-Other | 2.41% | +2.41% | NEW | |
| 16 | FDMT | 4d Molecular Therapeutics In | Stock-Other | 2.26% | +2.26% | NEW | |
| 17 | OCS | Oculis Holding AG | Stock-Other | 2.07% | -0.88% | -29.29% | |
| 18 | OCUL | Ocular Therapeutix INC | Stock-Other | 2.03% | +2.03% | NEW | |
| 19 | UPB | Upstream Bio INC | Stock-Other | 1.95% | +1.95% | NEW | |
| 20 | AQST | Aquestive Therapeutics INC | Stock-Other | 1.86% | +1.86% | NEW | |
| 21 | EYPT | Eyepoint INC | Stock-Other | 1.76% | +1.76% | NEW | |
| 22 | TRVI | Trevi Therapeutics INC | Stock-Other | 1.67% | +1.67% | NEW | |
| 23 | ZVRA | Zevra Therapeutics INC | Stock-Other | 1.66% | +1.17% | +343.47% | |
| 24 | VTLUSD | Immunic INC | Stock-Other | 1.65% | +1.65% | NEW | |
| 25 | CHRS | Coherus Oncology INC | Stock-Other | 1.52% | +1.52% | NEW | |
| 26 | OVID | Ovid Therapeutics INC | Stock-Other | 1.28% | +1.28% | NEW | |
| 27 | PALI | Palisade Bio INC | Stock-Other | 1.26% | +1.26% | NEW | |
| 28 | KLRS | Kalaris Therapeutics INC | Stock-Other | 1.08% | +0.78% | +603.33% | |
| 29 | QURE | uniQure N.V. | Stock-Other | 1.08% | +1.08% | NEW | |
| 30 | LONA | Leonabio INC | Stock-Other | 0.94% | -0.02% | — | |
| 31 | NUVB | Nuvation Bio INC | Stock-Other | 0.89% | +0.89% | NEW | |
| 32 | MAZE | Maze Therapeutics INC | Stock-Other | 0.82% | +0.82% | NEW | |
| 33 | EVMN | Evommune INC | Stock-Other | 0.81% | +0.81% | NEW | |
| 34 | CRVS | Corvus Pharmaceuticals INC | Stock-Other | 0.79% | +0.79% | NEW | |
| 35 | ALDX | Aldeyra Therapeutics INC | Stock-Other | 0.78% | +0.78% | NEW | |
| 36 | ARTV | Artiva Biotherapeutics INC | Stock-Other | 0.60% | +0.60% | NEW | |
| 37 | ✓ | Connect Biopharma Hldgs LTD | Stock-Other | 0.35% | +0.35% | NEW | |
| 38 | MSLE | Satellos Bioscience INC | Stock-Other | 0.04% | +0.04% | NEW |
Performance for Q3 2026
+10.6%
Performance Last 4 Quarters
+49.3%
Based on 85% of reported portfolio value with available pricing
| Period | Holdings | Total value | Stability | Top holdings |
|---|---|---|---|---|
| 2026-03-31 | 38 | $158.7M | 71 | |
| 2025-12-31 | 20 | $117.1M | 68 | |
| 2025-09-30 | 16 | $99.9M | 69 | |
| 2025-06-30 | 16 | $82.4M | 0 | |
| 2025-03-31 | 18 | $86.1M | 0 | |
| 2024-12-31 | 21 | $100.7M | 0 | |
| 2024-09-30 | 21 | $172.4M | 0 | |
| 2024-06-30 | 25 | $154.2M | 0 | |
| 2024-03-31 | 29 | $171.8M | 0 | |
| 2023-12-31 | 34 | $120.6M | 0 |
Propel Bio Management, LLC's most significant position changes for 2026-03-31: New buy: Corcept Therapeutics INC (CORT); New buy: Vor Biopharma INC (VOR); New buy: Orchestra Biomed Holdings In (OBIO); New buy: 4d Molecular Therapeutics In (FDMT); Sold out: Nektar Therapeutics (NKTR).
| # | Ticker | Issuer | Weight Change | Shares Change | Action |
|---|---|---|---|---|---|
| 1 | DCTH | Delcath Systems INC | +2% | +123.42% | Add |
| 2 | ZVRA | Zevra Therapeutics INC | +1.2% | +343.47% | Add |
| 3 | KLRS | Kalaris Therapeutics INC | +0.8% | +603.33% | Add |
| 4 | SABS | Sab Biotherapeutics INC | +0.4% | +55.13% | Add |
| 5 | ABEO | Abeona Therapeutics INC | +0.1% | +60.08% | Add |
| 6 | LONA | Leonabio INC | 0% | — | Unchanged |
| 7 | OCS | Oculis Holding AG | -0.9% | -29.29% | Trim |
| 8 | CLDX | Celldex Therapeutics INC | -1% | -14.86% | Trim |
| 9 | IVA | Inventiva SA - Adr | -1.5% | -27.53% | Trim |
| 10 | PAGP | Plains Gp Holdings Lp-cl A | -1.8% | — | Unchanged |
| 11 | KYTX | Kyverna Therapeutics INC | -1.8% | -3.34% | Trim |
| 12 | CMPS | Compass Pathways PLC | -2.5% | -13.89% | Trim |
| 13 | MIST | Milestone Pharmaceuticals In | -3.9% | — | Unchanged |
| 14 | PHAT | Phathom Pharmaceuticals INC | -4.6% | +13.54% | Add |
| 15 | VRDN | Viridian Therapeutics INC | -4.9% | -25.61% | Trim |
| 16 | ACHV | Achieve Life Sciences INC | -8.9% | — | Unchanged |
| 17 | CORT | Corcept Therapeutics INC | — | NEW | New buy |
| 18 | VOR | Vor Biopharma INC | — | NEW | New buy |
| 19 | OBIO | Orchestra Biomed Holdings In | — | NEW | New buy |
| 20 | FDMT | 4d Molecular Therapeutics In | — | NEW | New buy |
| 21 | NKTR | Nektar Therapeutics | — | EXIT | Sold out |
| 22 | OCUL | Ocular Therapeutix INC | — | NEW | New buy |
| 23 | UPB | Upstream Bio INC | — | NEW | New buy |
| 24 | AQST | Aquestive Therapeutics INC | — | NEW | New buy |
| 25 | EYPT | Eyepoint INC | — | NEW | New buy |
| 26 | TRVI | Trevi Therapeutics INC | — | NEW | New buy |
| 27 | VTLUSD | Immunic INC | — | NEW | New buy |
| 28 | CHRS | Coherus Oncology INC | — | NEW | New buy |
| 29 | OVID | Ovid Therapeutics INC | — | NEW | New buy |
| 30 | PALI | Palisade Bio INC | — | NEW | New buy |
| 31 | QURE | uniQure N.V. | — | NEW | New buy |
| 32 | RGNX | Regenxbio INC | — | EXIT | Sold out |
| 33 | NUVB | Nuvation Bio INC | — | NEW | New buy |
| 34 | MAZE | Maze Therapeutics INC | — | NEW | New buy |
| 35 | EVMN | Evommune INC | — | NEW | New buy |
| 36 | CRVS | Corvus Pharmaceuticals INC | — | NEW | New buy |
| 37 | ALDX | Aldeyra Therapeutics INC | — | NEW | New buy |
| 38 | ARTV | Artiva Biotherapeutics INC | — | NEW | New buy |
| 39 | LENZ | Lenz Therapeutics INC | — | EXIT | Sold out |
| 40 | AARD | Aardvark Therapeutics INC | — | EXIT | Sold out |
| 41 | ✓ | Connect Biopharma Hldgs LTD | — | NEW | New buy |
| 42 | MSLE | Satellos Bioscience INC | — | NEW | New buy |
| Period | Filed | Type | EDGAR |
|---|---|---|---|
| 2026-03-31 | 2026-05-14 | 13F-HR | View on EDGAR |
| 2025-12-31 | 2026-02-11 | 13F-HR | View on EDGAR |
| 2025-09-30 | 2025-11-12 | 13F-HR | View on EDGAR |
| 2025-06-30 | 2025-08-13 | 13F-HR | View on EDGAR |
| 2025-03-31 | 2025-05-15 | 13F-HR | View on EDGAR |
| 2024-12-31 | 2025-02-14 | 13F-HR | View on EDGAR |
| 2024-09-30 | 2024-11-13 | 13F-HR | View on EDGAR |
| 2024-06-30 | 2024-08-12 | 13F-HR | View on EDGAR |
| 2024-03-31 | 2024-05-13 | 13F-HR | View on EDGAR |
| 2023-12-31 | 2024-02-14 | 13F-HR | View on EDGAR |
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