PB
Pivotal bioVenture Partners Investment Advisor LLC 13F Holdings (Q2 2026) — Stock Portfolio & Buys
Pivotal bioVenture Partners Investment Advisor LLCCIK: 0001844645
Sector-focusedMomentum followerQuality / disciplined sizing
Total reported value
$307.8M
Reporting period: 2026-06-30 · Number of holdings: 13
Pivotal bioVenture Partners Investment Advisor LLC disclosed 13 holdings in its latest 13F filing for the period ending 2026-06-30, with total reported value of $307.8M and a quarterly turnover rate of 38.9%.
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Personality snowflake
- Concentration
- 52.16
- Portfolio Stability
- 38.91
- Momentum
- 100
- Sector conviction
- 100
- Diversification
- 26
- Sizing Uniformity
- 91.32
Pivotal bioVenture Partners Investment Advisor LLC's disclosed holdings carry a Herfindahl concentration index of 0.130 — mathematically equivalent to about 8 equally-sized positions, close to its 13 actual disclosed holdings. Value is spread relatively evenly across the portfolio rather than concentrated in a handful of names.
Position sizes are fairly uniform across the portfolio (a coefficient of variation of 0.87), suggesting a disciplined, rules-based approach to how much capital goes into each idea.
No strong tilt toward either adding to existing winners or initiating outsized new positions was observed in the latest reported quarter.
Sector classification currently covers about 1% of this portfolio's disclosed value; the remainder includes holdings (e.g. unmapped tickers, options, or other security types) not yet covered by our sector mapping.
Source and citation information
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Recent moves
View source Form 13F filing on SEC.govNew buy 05348Y105
Trim OCS
-10.4% -$23.8M
Trim EVMN
0.0% -$18.7M
Add TRVI
+12.2% $14.0M
Add MPLT
-0.0% $9.5M
Trim PCVX
+3.9% $3.1M
Holdings Map
New buyAddUnchangedTrim
Top 10 holdings by weight
Full holdings list this quarter
| # | Ticker | Issuer | Asset Subclass | Weight | Weight Change | Shares Change | 4Q Trend |
|---|---|---|---|---|---|---|---|
| 1 | PCVX | Vaxcyte Inc | Stock-Other | 26.92% | -1.59% | +3.87% | |
| 2 | ARQT | Arcutis Biotherapeutics Inc | Stock-Other | 10.78% | -0.64% | -6.68% | |
| 3 | TRVI | Trevi Therapeutics Inc | Stock-Other | 10.56% | +3.93% | +12.16% | |
| 4 | ✓ | Stock-Other | 10.34% | +10.34% | NEW | ||
| 5 | EVMN | Evommune Inc | Stock-Other | 8.32% | -7.51% | — | |
| 6 | MPLT | Maplight Therapeutics Inc | Stock-Other | 7.12% | +2.68% | -0.00% | |
| 7 | OCS | Oculis Holding AG | Stock-Other | 6.79% | -9.18% | -10.36% | |
| 8 | BIOA | Bioage Labs Inc | Stock-Other | 5.20% | +1.12% | — | |
| 9 | IMNM | Immunome Inc | Stock-Other | 5.04% | -0.69% | — | |
| 10 | ZBIO | Zenas Biopharma Inc | Stock-Other | 4.05% | -0.09% | -17.10% | |
| 11 | AVTX | Avalo Therapeutics Inc | Stock-Other | 2.61% | +1.03% | +46.67% | |
| 12 | RLYB | Rallybio CORP | Stock-Other | 1.56% | +0.60% | — | |
| 13 | RXRX | Recursion Pharmaceuticals-a | Stock-Healthcare | 0.71% | +0.06% | — |
Portfolio Performance
Performance for Q3 2026
-7.3%
Performance Last 4 Quarters
+50.2%
- Stdev
- +35.6%
- Beta
- +1.08
- Alpha
- +0.9%
- Max Drawdown
- -34.7%
- Annualized Perf
- +16.4%
- Batting Avg vs S&P
- +51.9%
- Sortino
- +1.06
- Stutzer
- +0.18
- Treynor
- +0.2
- Sterling
- +0.42
- Calmar
- +0.47
- Information Ratio
- +0.07
- Tracking Error
- +33.1%
- Stdev Down
- +19.9%
- Winning Months %
- +55.6%
- Losing Months %
- +44.4%
- Best 12 Months
- +71.6%
- Worst 12 Months
- -21.8%
- Efficiency Ratio
- +0.19
- Sharpe
- +0.6
- Stdev Sectors
- 0%
- Skewness
- +0.39
- Kurtosis
- -0.02
- Upside Potential
- +2.92
Reported value over time
Sector allocation
Sector allocation over time
Quarterly history
| Period | Holdings | Total value | Stability | Top holdings | |
|---|---|---|---|---|---|
| 2026 Q2 | 13 | $307.8M | 39 | ||
| 2026 Q1 | 13 | $279.8M | 24 | ||
| 2025 Q4 | 12 | $258.7M | 40 | ||
| 2025 Q3 | 10 | $173.0M | 42 | ||
| 2025 Q2 | 12 | $161.3M | 0 | ||
| 2025 Q1 | 11 | $123.6M | 100 | ||
| 2024 Q4 | 11 | $148.1M | 0 | ||
| 2024 Q3 | 11 | $168.5M | 0 | ||
| 2024 Q2 | 10 | $130.1M | 0 | ||
| 2024 Q1 | 11 | $155.6M | 0 | ||
| 2023 Q4 | 13 | $394.2M | 0 | ||
| 2023 Q3 | 13 | $250.7M | 0 | ||
| 2023 Q2 | 11 | $303.3M | 0 | ||
| 2023 Q1 | 11 | $242.9M | 0 | ||
| 2022 Q4 | 10 | $230.0M | 0 | ||
| 2022 Q3 | 11 | $273.7M | 0 | ||
| 2022 Q2 | 11 | $198.5M | 0 | ||
| 2022 Q1 | 11 | $211.4M | 0 | ||
| 2021 Q4 | 10 | $239.2M | 0 | ||
| 2021 Q3 | 9 | $282.9M | 0 | ||
| 2021 Q2 | 8 | $253.7M | 23 | ||
| 2021 Q1 | 9 | $311.7M | 38 | ||
| 2020 Q4 | 9 | $303.3M | — |
Holding changes this quarter
Pivotal bioVenture Partners Investment Advisor LLC's most significant position changes for 2026-06-30: New buy: ; Sold out: Bolt Biotherapeutics Inc (BOLT); Trim: Oculis Holding AG (OCS) — shares -10.36%; Add: Trevi Therapeutics Inc (TRVI) — shares +12.16%; Trim: Maplight Therapeutics Inc (MPLT) — shares -0.00%.
| # | Ticker | Issuer | Weight Change | Shares Change | Action |
|---|---|---|---|---|---|
| 1 | ✓ | +10.3% | NEW | New buy | |
| 2 | TRVI | Trevi Therapeutics Inc | +3.9% | +12.16% | Add |
| 3 | MPLT | Maplight Therapeutics Inc | +2.7% | -0.00% | Trim |
| 4 | BIOA | Bioage Labs Inc | +1.1% | — | Unchanged |
| 5 | AVTX | Avalo Therapeutics Inc | +1% | +46.67% | Add |
| 6 | RLYB | Rallybio CORP | +0.6% | — | Unchanged |
| 7 | RXRX | Recursion Pharmaceuticals-a | +0.1% | — | Unchanged |
| 8 | BOLT | Bolt Biotherapeutics Inc | -0.1% | EXIT | Sold out |
| 9 | ZBIO | Zenas Biopharma Inc | -0.1% | -17.10% | Trim |
| 10 | ARQT | Arcutis Biotherapeutics Inc | -0.6% | -6.68% | Trim |
| 11 | IMNM | Immunome Inc | -0.7% | — | Unchanged |
| 12 | PCVX | Vaxcyte Inc | -1.6% | +3.87% | Add |
| 13 | EVMN | Evommune Inc | -7.5% | — | Unchanged |
| 14 | OCS | Oculis Holding AG | -9.2% | -10.36% | Trim |
* This report is exclusively curated by the AlphaSMO team. AlphaSMO is the web's most authoritative 13F / Inside Trader database, delivering precise insider trading and institutional holdings insights.
Filing History
FAQ
What is Pivotal bioVenture Partners Investment Advisor LLC and what type of investor is it?
Pivotal bioVenture Partners Investment Advisor LLC is an investment manager that files SEC Form 13F quarterly, disclosing its U.S. public equity holdings to regulators. As of the most recent reporting period (2026-06-30), the firm manages a tracked equity portfolio valued at approximately $307.8M, spread across 13 disclosed positions.
What are Pivotal bioVenture Partners Investment Advisor LLC's largest equity positions?
Based on the latest 13F filing, Pivotal bioVenture Partners Investment Advisor LLC's top holdings by market value are:
1. Vaxcyte Inc (PCVX) — $82.9M (26.9%)
2. Arcutis Biotherapeutics Inc (ARQT) — $33.2M (10.8%)
3. Trevi Therapeutics Inc (TRVI) — $32.5M (10.6%)
4. — $31.8M (10.3%)
5. Evommune Inc (EVMN) — $25.6M (8.3%)
What changes did Pivotal bioVenture Partners Investment Advisor LLC make in its most recent portfolio filing?
In the latest reported quarter, Pivotal bioVenture Partners Investment Advisor LLC made 9 notable position adjustments: 1 new positions were initiated, 3 existing holdings were added to, 4 positions were partially reduced, and 1 were completely exited. The largest of these moves: New buy: ; Sold out: Bolt Biotherapeutics Inc (BOLT); Trim: Oculis Holding AG (OCS) — shares -10.36%; Add: Trevi Therapeutics Inc (TRVI) — shares +12.16%; Trim: Maplight Therapeutics Inc (MPLT) — shares -0.00%
What sectors does Pivotal bioVenture Partners Investment Advisor LLC focus on?
Pivotal bioVenture Partners Investment Advisor LLC is concentrated in the following sectors based on its current disclosed equity portfolio:
• Health Care: 100.0%
Investment Profile
Pivotal bioVenture Partners Investment Advisor LLC returned an annualized 16.4% over the trailing 27 months — outperforming the S&P 500 by 0.9 points — based on a reconstructed track record of its disclosed 13F positions, with a beta of 1.08 (roughly in line with the market) and a 52% quarterly batting average against the index.
Its portfolio is moderately concentrated and moderately active, with 100.0% of the portfolio concentrated in Health Care.
Its turnover score has risen from 0 to 39 over the past 4 quarters — a shift toward more active trading.
It has added to its PCVX position over the past two quarters (+$19.5M, now $82.9M), while trimming OCS over the same stretch (-$24.8M, still holding $20.9M).
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