New Leaf Venture Partners, L.L.C. — 13F Filings Deep Dive

CIK: 0001631614

Concentrated strategyQuality / disciplined sizing

Total reported value

$43.0M

Reporting period: 2025-09-30 · Number of holdings: 7

New Leaf Venture Partners, L.L.C. disclosed 7 holdings in its latest 13F filing for the period ending 2025-09-30, with total reported value of $43.0M and a quarterly turnover rate of 29.7%.

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Personality snowflake

Concentration: 100
Portfolio Stability: 29.73
Momentum/Contrarian: 50
Sector conviction: 0
Diversification: 14
Sizing Uniformity: 89.53

Sector classification currently covers about 0% of this portfolio's disclosed value; the remainder includes holdings (e.g. unmapped tickers, options, or other security types) not yet covered by our sector mapping.

Recent moves

Trim EWTX
0.0%　-$6.0M
Add ARVN
0.0%　$2.4M
Add COGT
0.0%　$2.1M
Add CRNX
0.0%　$1.1M
Add ALEC
0.0%　$587.5K
Trim 75120L100
0.0%　-$498.5K

Holdings Map

New buyAddUnchangedTrim

Top 10 holdings by weight

Full holdings list this quarter

#	Ticker	Issuer	Asset Subclass	Weight	Weight Change	Shares Change
1	EWTX	Edgewise Therapeutics INC	Stock-Other	38.82%	-11.65%	—
2	ARVN	Arvinas INC	Stock-Other	31.38%	+6.59%	—
3	CRNX	Crinetics Pharmaceuticals In	Stock-Other	13.64%	+3.11%	—
4	COGT	Cogent Biosciences INC	Stock-Other	8.37%	+5.02%	—
5	✓	Rallybio CORP	Stock-Other	3.83%	-0.95%	—
6	ALEC	Alector INC	Stock-Other	2.33%	+1.40%	—
7	✓	Passage Bio INC	Stock-Other	1.63%	-0.33%	-96.50%

Portfolio Performance

Performance for Q3 2026

+20.6%

Performance Last 4 Quarters

+123.8%

Stdev: +60.5%
Beta: +1.26
Alpha: +10.8%
Max Drawdown: -64.5%
Annualized Perf: +22.7%
Batting Avg vs S&P: +46.9%
Sortino: +1.21
Stutzer: +0.18
Treynor: +0.29
Sterling: +0.49
Calmar: +0.35
Information Ratio: +0.27
Tracking Error: +58.7%
Stdev Down: +30.4%
Winning Months %: +56.3%
Losing Months %: +43.8%
Best 12 Months: +124.9%
Worst 12 Months: -55.4%
Efficiency Ratio: +0.2
Sharpe: +0.6
Stdev Sectors: —
Skewness: +1.34
Kurtosis: +4.39
Upside Potential: +2.82

Reported value over time

Sector allocation

Not enough sector-mapped data yet

Sector allocation over time

Quarterly history

Period	Holdings	Total value	Stability	Top holdings
2025-09-30	7	$43.0M	30	1EWTX 2ARVN 3CRNX Top holdings2025-09-30 1.EWTX 2.ARVN 3.CRNX 4.COGT 5.75120L 6.ALEC 7.702712
2025-06-30	8	$52.9M	0	17027122EWTX 3ARVN Top holdings2025-06-30 1.702712 2.EWTX 3.ARVN 4.CRNX 5.COGT 6.75120L 7.ALEC 8.G6333L
2025-03-31	9	$44.9M	100	1EWTX 2ARVN 3CRNX Top holdings2025-03-31 1.EWTX 2.ARVN 3.CRNX 4.75120L 5.COGT 6.RCKT 7.702712 8.G6333L 9.ALEC
2024-12-31	9	$74.8M	0	1ARVN 2EWTX 3CRNX Top holdings2024-12-31 1.ARVN 2.EWTX 3.CRNX 4.75120L 5.COGT 6.RCKT 7.702712 8.ALEC 9.G6333L
2024-09-30	10	$97.3M	0	1EWTX 2ARVN 3CRNX Top holdings2024-09-30 1.EWTX 2.ARVN 3.CRNX 4.75120L 5.RCKT 6.COGT 7.702712 8.ALEC 9.G6333L 10.ASNSUSD
2024-06-30	10	$82.2M	0	1ARVN 2EWTX 3CRNX Top holdings2024-06-30 1.ARVN 2.EWTX 3.CRNX 4.75120L 5.RCKT 6.COGT 7.702712 8.ALEC 9.ASNSUSD 10.G6333L
2024-03-31	11	$114.3M	0	1ARVN 2EWTX 3DCPHEUR Top holdings2024-03-31 1.ARVN 2.EWTX 3.DCPHEUR 4.CRNX 5.75120L 6.702712 7.RCKT 8.ALEC 9.COGT 10.ASNSUSD
2023-12-31	12	$124.2M	0	1ARVN241358P3EWTX Top holdings2023-12-31 1.ARVN 2.41358P 3.EWTX 4.DCPHEUR 5.75120L 6.CRNX 7.RCKT 8.ALEC 9.702712 10.COGT
2023-09-30	12	$77.9M	0	1ARVN 2DCPHEUR375120L Top holdings2023-09-30 1.ARVN 2.DCPHEUR 3.75120L 4.EWTX 5.COGT 6.CRNX 7.RCKT 8.ALEC 9.702712 10.41358P
2023-06-30	14	$116.4M	0	1ARVN275120L323345J Top holdings2023-06-30 1.ARVN 2.75120L 3.23345J 4.DCPHEUR 5.EWTX 6.COGT 7.CRNX 8.RCKT 9.702712 10.41358P
2023-03-31	17	$121.0M	0	1ARVN275120L3DCPHEUR Top holdings2023-03-31 1.ARVN 2.75120L 3.DCPHEUR 4.23345J 5.EWTX 6.03217L 7.COGT 8.702712 9.41358P 10.CRNX
2022-12-31	17	$138.1M	0	1ARVN275120L3DCPHEUR Top holdings2022-12-31 1.ARVN 2.75120L 3.DCPHEUR 4.EWTX 5.23345J 6.COGT 7.702712 8.03217L 9.ALEC 10.CRNX
2022-09-30	19	$168.5M	0	1ARVN275120L3DCPHEUR Top holdings2022-09-30 1.ARVN 2.75120L 3.DCPHEUR 4.EWTX 5.23345J 6.COGT 7.ALEC 8.702712 9.03217L 10.41358P
2022-06-30	21	$154.4M	0	1ARVN275120L3DCPHEUR Top holdings2022-06-30 1.ARVN 2.75120L 3.DCPHEUR 4.EWTX 5.SRRAEUR 6.23345J 7.41358P 8.702712 9.COGT 10.ALEC
2022-03-31	21	$202.9M	0	1ARVN275120L341358P Top holdings2022-03-31 1.ARVN 2.75120L 3.41358P 4.EWTX 5.DCPHEUR 6.23345J 7.702712 8.03836N 9.CMRXEUR 10.ALEC
2021-12-31	22	$276.0M	0	1ARVN241358P3EWTX Top holdings2021-12-31 1.ARVN 2.41358P 3.EWTX 4.75120L 5.702712 6.23345J 7.DCPHEUR 8.SRRAEUR 9.03836N 10.CMRXEUR
2021-09-30	22	$346.7M	0	1ARVN 2DCPHEUR375120L Top holdings2021-09-30 1.ARVN 2.DCPHEUR 3.75120L 4.EWTX 5.41358P 6.702712 7.23345J 8.SRRAEUR 9.ALEC 10.03836N
2021-06-30	19	$389.6M	0	1ARVN 2CRNX 3EWTX Top holdings2021-06-30 1.ARVN 2.CRNX 3.EWTX 4.DCPHEUR 5.H5861P 6.CMRXEUR 7.03836N 8.PDSB 9.ALEC 10.VSAREUR
2021-03-31	18	$429.7M	100	1ARVN241358P3DCPHEUR Top holdings2021-03-31 1.ARVN 2.41358P 3.DCPHEUR 4.EWTX 5.702712 6.CMRXEUR 7.03836N 8.SRRAEUR 9.ALEC 10.VSAREUR
2020-12-31	17	$432.8M	59	1ARVN 2DCPHEUR3702712 Top holdings2020-12-31 1.ARVN 2.DCPHEUR 3.702712 4.41358P 5.03836N 6.SRRAEUR 7.CMRXEUR 8.COGT 9.VSAREUR 10.ALEC
2020-09-30	18	$248.2M	37	1DCPHEUR 2ARVN341358P Top holdings2020-09-30 1.DCPHEUR 2.ARVN 3.41358P 4.702712 5.03836N 6.CHMA 7.VSAREUR 8.SRRAEUR 9.05455M 10.903214
2020-06-30	20	$348.5M	34	1ARVN 2DCPHEUR3702712 Top holdings2020-06-30 1.ARVN 2.DCPHEUR 3.702712 4.41358P 5.PRNB 6.03836N 7.VSAREUR 8.ALEC 9.05455M 10.H5861P
2020-03-31	20	$334.3M	54	1ARVN 2DCPHEUR3702712 Top holdings2020-03-31 1.ARVN 2.DCPHEUR 3.702712 4.41358P 5.PRNB 6.ALEC 7.03836N 8.VSAREUR 9.05455M 10.SRRAEUR
2019-12-31	19	$460.3M	44	1DCPHEUR 2ARVN 3SRRAEUR Top holdings2019-12-31 1.DCPHEUR 2.ARVN 3.SRRAEUR 4.PRNB 5.41358P 6.VSAREUR 7.03836N 8.ALEC 9.G6333L 10.05455M
2019-09-30	19	$330.6M	22	1DCPHEUR 2PRNB 3ARVN Top holdings2019-09-30 1.DCPHEUR 2.PRNB 3.ARVN 4.41358P 5.03836N 6.STIM 7.ALEC 8.G6333L 9.H5861P 10.VSAREUR
2019-06-30	21	$373.1M	21	1DCPHEUR 2PRNB 3ARVN Top holdings2019-06-30 1.DCPHEUR 2.PRNB 3.ARVN 4.41358P 5.STIM 6.ALEC 7.03836N 8.H5861P 9.G6333L 10.CMRXEUR
2019-03-31	20	$364.9M	48	1DCPHEUR 2PRNB 3ARVN Top holdings2019-03-31 1.DCPHEUR 2.PRNB 3.ARVN 4.41358P 5.STIM 6.ALEC 7.03836N 8.G6333L 9.H5861P 10.SRRAEUR
2018-12-31	20	$364.3M	41	1DCPHEUR 2PRNB303836N Top holdings2018-12-31 1.DCPHEUR 2.PRNB 3.03836N 4.STIM 5.ARVN 6.WVE 7.CRSP 8.H5861P 9.903214 10.G6333L
2018-09-30	20	$549.6M	42	1DCPHEUR203836N3PRNB Top holdings2018-09-30 1.DCPHEUR 2.03836N 3.PRNB 4.STIM 5.ARVN 6.WVE 7.CRSP 8.903214 9.H5861P 10.G6333L
2018-06-30	15	$414.3M	90	1DCPHEUR203836N3STIM Top holdings2018-06-30 1.DCPHEUR 2.03836N 3.STIM 4.CRSP 5.903214 6.WVE 7.G6333L 8.SRRAEUR 9.H5861P 10.92529L
2018-03-31	14	$185.2M	46	1DCPHEUR 2CRSP 3WVE Top holdings2018-03-31 1.DCPHEUR 2.CRSP 3.WVE 4.H5861P 5.OXLC 6.SRRAEUR 7.903214 8.AFRM 9.761123 10.TREUR
2017-12-31	16	$213.8M	38	1DCPHEUR 2EWTX 3IRTC Top holdings2017-12-31 1.DCPHEUR 2.EWTX 3.IRTC 4.WVE 5.CRSP 6.OXLC 7.SRRAEUR 8.H5861P 9.SG7 10.761123
2017-09-30	16	$215.5M	76	1DCPHEUR 2IRTC 3EWTX Top holdings2017-09-30 1.DCPHEUR 2.IRTC 3.EWTX 4.OXLC 5.WVE 6.25433V 7.CRSP 8.AVEOEUR 9.SRRAEUR 10.SG7
2017-06-30	15	$142.4M	42	1IRTC292529L3EWTX Top holdings2017-06-30 1.IRTC 2.92529L 3.EWTX 4.OXLC 5.WVE 6.CRSP 7.AVEOEUR 8.SG7 9.SRRAEUR 10.25433V
2017-03-31	16	$195.2M	59	1IRTC292529L3EWTX Top holdings2017-03-31 1.IRTC 2.92529L 3.EWTX 4.WVE 5.OXLC 6.CRSP 7.SG7 8.ALDR1EUR 9.SRRAEUR 10.25433V
2016-12-31	15	$139.6M	37	192529L2EWTX 3OXLC Top holdings2016-12-31 1.92529L 2.EWTX 3.OXLC 4.WVE 5.CRSP 6.25433V 7.SG7 8.DERMEUR 9.ALDR1EUR 10.AVEOEUR
2016-09-30	14	$138.9M	25	1WVE292529L3EWTX Top holdings2016-09-30 1.WVE 2.92529L 3.EWTX 4.OXLC 5.25433V 6.ALDR1EUR 7.DERMEUR 8.SG7 9.DVAX 10.AVEOEUR
2016-06-30	14	$116.2M	35	1EWTX292529L3WVE Top holdings2016-06-30 1.EWTX 2.92529L 3.WVE 4.OXLC 5.25433V 6.DVAX 7.DERMEUR 8.ALDR1EUR 9.SG7 10.AVEOEUR
2016-03-31	13	$110.5M	50	1EWTX292529L325433V Top holdings2016-03-31 1.EWTX 2.92529L 3.25433V 4.OXLC 5.WVE 6.DVAX 7.ALDR1EUR 8.SG7 9.DERMEUR 10.MRNSUSD
2015-12-31	10	$149.4M	75	1EWTX292529L325433V Top holdings2015-12-31 1.EWTX 2.92529L 3.25433V 4.143391 5.OXLC 6.DVAX 7.WVE 8.DERMEUR 9.MRNSUSD 10.CMRXEUR
2015-09-30	13	$115.3M	40	192529L21433913OXLC Top holdings2015-09-30 1.92529L 2.143391 3.OXLC 4.DVAX 5.CMRXEUR 6.DERMEUR 7.MRNSUSD 8.00434H 9.CALAEUR 10.759531
2015-06-30	14	$150.9M	79	1143391292529L3OXLC Top holdings2015-06-30 1.143391 2.92529L 3.OXLC 4.CMRXEUR 5.DVAX 6.MRNSUSD 7.ACAD 8.759531 9.ESPR 10.KPTIEUR
2015-03-31	13	$147.3M	63	192529L27595313OXLC Top holdings2015-03-31 1.92529L 2.759531 3.OXLC 4.ALDR1EUR 5.CMRXEUR 6.DVAX 7.CALAEUR 8.MRNSUSD 9.ACAD 10.KPTIEUR
2014-12-31	13	$205.5M	0	192529L27595313CMRXEUR Top holdings2014-12-31 1.92529L 2.759531 3.CMRXEUR 4.OXLC 5.CALAEUR 6.MEIPUSD 7.ALDR1EUR 8.KPTIEUR 9.MRNSUSD 10.ACAD

Holding changes this quarter

New Leaf Venture Partners, L.L.C.'s most significant position changes for 2025-09-30: Sold out: Rocket Pharmaceuticals INC (RCKT); Sold out: Iterum Therapeutics PLC; Trim: Passage Bio INC — shares -96.50%.

Position changes disclosed by New Leaf Venture Partners, L.L.C. for the quarter ending 2025-09-30, including ticker, issuer, weight change, shares change, and action
#	Ticker	Issuer	Weight Change	Shares Change	Action
1	ARVN	Arvinas INC	+6.6%	—	Unchanged
2	COGT	Cogent Biosciences INC	+5%	—	Unchanged
3	CRNX	Crinetics Pharmaceuticals In	+3.1%	—	Unchanged
4	ALEC	Alector INC	+1.4%	—	Unchanged
5	✓	Passage Bio INC	-0.3%	-96.50%	Trim
6	✓	Rallybio CORP	-1%	—	Unchanged
7	EWTX	Edgewise Therapeutics INC	-11.7%	—	Unchanged
8	RCKT	Rocket Pharmaceuticals INC	—	EXIT	Sold out
9	✓	Iterum Therapeutics PLC	—	EXIT	Sold out

Filing History

Period	Filed	Type	EDGAR
2025-09-30	2025-11-14	13F-HR	View on EDGAR
2025-06-30	2025-08-13	13F-HR	View on EDGAR
2025-03-31	2025-05-13	13F-HR	View on EDGAR
2024-12-31	2025-02-13	13F-HR	View on EDGAR
2024-09-30	2024-11-13	13F-HR	View on EDGAR
2024-06-30	2024-08-14	13F-HR	View on EDGAR
2024-03-31	2024-05-14	13F-HR	View on EDGAR
2023-12-31	2024-02-14	13F-HR	View on EDGAR
2023-09-30	2023-11-14	13F-HR	View on EDGAR
2023-06-30	2023-08-10	13F-HR	View on EDGAR
2023-03-31	2023-05-11	13F-HR	View on EDGAR
2022-12-31	2023-02-06	13F-HR	View on EDGAR
2022-09-30	2022-11-10	13F-HR	View on EDGAR
2022-06-30	2022-08-09	13F-HR	View on EDGAR
2022-03-31	2022-05-06	13F-HR	View on EDGAR
2021-12-31	2022-02-11	13F-HR	View on EDGAR
2021-09-30	2021-11-12	13F-HR	View on EDGAR
2021-06-30	2021-08-12	13F-HR	View on EDGAR
2021-03-31	2021-08-12	Amendment	View on EDGAR
2021-03-31	2021-05-12	13F-HR	View on EDGAR
2020-12-31	2021-02-10	13F-HR	View on EDGAR
2020-09-30	2020-11-12	13F-HR	View on EDGAR
2020-06-30	2020-08-13	13F-HR	View on EDGAR
2020-03-31	2020-05-14	13F-HR	View on EDGAR
2019-12-31	2020-02-13	13F-HR	View on EDGAR
2019-09-30	2019-11-14	13F-HR	View on EDGAR
2019-06-30	2019-08-13	13F-HR	View on EDGAR
2019-03-31	2019-06-04	Amendment	View on EDGAR
2019-03-31	2019-05-15	13F-HR	View on EDGAR
2018-12-31	2019-02-13	13F-HR	View on EDGAR
2018-09-30	2018-11-13	13F-HR	View on EDGAR
2018-06-30	2018-08-14	13F-HR	View on EDGAR
2018-03-31	2018-05-15	13F-HR	View on EDGAR
2017-12-31	2018-02-14	13F-HR	View on EDGAR
2017-09-30	2017-11-14	13F-HR	View on EDGAR
2017-06-30	2017-08-14	13F-HR	View on EDGAR
2017-03-31	2017-05-15	13F-HR	View on EDGAR
2016-12-31	2017-02-14	13F-HR	View on EDGAR
2016-09-30	2016-11-14	13F-HR	View on EDGAR
2016-06-30	2016-08-15	13F-HR	View on EDGAR
2016-03-31	2016-05-16	13F-HR	View on EDGAR
2015-12-31	2016-02-16	13F-HR	View on EDGAR
2015-09-30	2015-11-16	13F-HR	View on EDGAR
2015-06-30	2015-08-14	13F-HR	View on EDGAR
2015-03-31	2015-05-15	13F-HR	View on EDGAR
2014-12-31	2015-02-17	13F-HR	View on EDGAR

FAQ

What is New Leaf Venture Partners, L.L.C. and what type of investor is it?

New Leaf Venture Partners, L.L.C. is an investment manager that files SEC Form 13F quarterly, disclosing its U.S. public equity holdings to regulators. As of the most recent reporting period (2025-09-30), the firm manages a tracked equity portfolio valued at approximately $43.0M, spread across 7 disclosed positions.

What are New Leaf Venture Partners, L.L.C.'s largest equity positions?

Based on the latest 13F filing, New Leaf Venture Partners, L.L.C.'s top holdings by market value are: 1. Edgewise Therapeutics INC (EWTX) — $16.7M (38.8%) 2. Arvinas INC (ARVN) — $13.5M (31.4%) 3. Crinetics Pharmaceuticals In (CRNX) — $5.9M (13.6%) 4. Cogent Biosciences INC (COGT) — $3.6M (8.4%) 5. Rallybio CORP — $1.6M (3.8%)

What changes did New Leaf Venture Partners, L.L.C. make in its most recent portfolio filing?

In the latest quarter, New Leaf Venture Partners, L.L.C. took a more defensive posture — trimming 1 positions and completely exiting 2 holdings. The largest of these moves: Sold out: Rocket Pharmaceuticals INC (RCKT); Sold out: Iterum Therapeutics PLC; Trim: Passage Bio INC — shares -96.50%

What sectors does New Leaf Venture Partners, L.L.C. focus on?

Sector breakdown data is not yet available for New Leaf Venture Partners, L.L.C.. Check back after the next 13F processing cycle.

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New Leaf Venture Partners, L.L.C. — 13F Filings Deep Dive

CIK: 0001631614

Concentrated strategyQuality / disciplined sizing

Total reported value

$43.0M

Reporting period: 2025-09-30 · Number of holdings: 7

New Leaf Venture Partners, L.L.C. disclosed 7 holdings in its latest 13F filing for the period ending 2025-09-30, with total reported value of $43.0M and a quarterly turnover rate of 29.7%.

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Personality snowflake

Concentration: 100
Portfolio Stability: 29.73
Momentum/Contrarian: 50
Sector conviction: 0
Diversification: 14
Sizing Uniformity: 89.53

Recent moves

Trim EWTX
0.0%　-$6.0M
Add ARVN
0.0%　$2.4M
Add COGT
0.0%　$2.1M
Add CRNX
0.0%　$1.1M
Add ALEC
0.0%　$587.5K
Trim 75120L100
0.0%　-$498.5K

Holdings Map

New buyAddUnchangedTrim

Top 10 holdings by weight

Full holdings list this quarter

#	Ticker	Issuer	Asset Subclass	Weight	Weight Change	Shares Change
1	EWTX	Edgewise Therapeutics INC	Stock-Other	38.82%	-11.65%	—
2	ARVN	Arvinas INC	Stock-Other	31.38%	+6.59%	—
3	CRNX	Crinetics Pharmaceuticals In	Stock-Other	13.64%	+3.11%	—
4	COGT	Cogent Biosciences INC	Stock-Other	8.37%	+5.02%	—
5	✓	Rallybio CORP	Stock-Other	3.83%	-0.95%	—
6	ALEC	Alector INC	Stock-Other	2.33%	+1.40%	—
7	✓	Passage Bio INC	Stock-Other	1.63%	-0.33%	-96.50%

Portfolio Performance

Performance for Q3 2026

+20.6%

Performance Last 4 Quarters

+123.8%

Stdev: +60.5%
Beta: +1.26
Alpha: +10.8%
Max Drawdown: -64.5%
Annualized Perf: +22.7%
Batting Avg vs S&P: +46.9%
Sortino: +1.21
Stutzer: +0.18
Treynor: +0.29
Sterling: +0.49
Calmar: +0.35
Information Ratio: +0.27
Tracking Error: +58.7%
Stdev Down: +30.4%
Winning Months %: +56.3%
Losing Months %: +43.8%
Best 12 Months: +124.9%
Worst 12 Months: -55.4%
Efficiency Ratio: +0.2
Sharpe: +0.6
Stdev Sectors: —
Skewness: +1.34
Kurtosis: +4.39
Upside Potential: +2.82

Reported value over time

Sector allocation

Not enough sector-mapped data yet

Sector allocation over time

Quarterly history

Period	Holdings	Total value	Stability	Top holdings
2025-09-30	7	$43.0M	30	1EWTX 2ARVN 3CRNX Top holdings2025-09-30 1.EWTX 2.ARVN 3.CRNX 4.COGT 5.75120L 6.ALEC 7.702712
2025-06-30	8	$52.9M	0	17027122EWTX 3ARVN Top holdings2025-06-30 1.702712 2.EWTX 3.ARVN 4.CRNX 5.COGT 6.75120L 7.ALEC 8.G6333L
2025-03-31	9	$44.9M	100	1EWTX 2ARVN 3CRNX Top holdings2025-03-31 1.EWTX 2.ARVN 3.CRNX 4.75120L 5.COGT 6.RCKT 7.702712 8.G6333L 9.ALEC
2024-12-31	9	$74.8M	0	1ARVN 2EWTX 3CRNX Top holdings2024-12-31 1.ARVN 2.EWTX 3.CRNX 4.75120L 5.COGT 6.RCKT 7.702712 8.ALEC 9.G6333L
2024-09-30	10	$97.3M	0	1EWTX 2ARVN 3CRNX Top holdings2024-09-30 1.EWTX 2.ARVN 3.CRNX 4.75120L 5.RCKT 6.COGT 7.702712 8.ALEC 9.G6333L 10.ASNSUSD
2024-06-30	10	$82.2M	0	1ARVN 2EWTX 3CRNX Top holdings2024-06-30 1.ARVN 2.EWTX 3.CRNX 4.75120L 5.RCKT 6.COGT 7.702712 8.ALEC 9.ASNSUSD 10.G6333L
2024-03-31	11	$114.3M	0	1ARVN 2EWTX 3DCPHEUR Top holdings2024-03-31 1.ARVN 2.EWTX 3.DCPHEUR 4.CRNX 5.75120L 6.702712 7.RCKT 8.ALEC 9.COGT 10.ASNSUSD
2023-12-31	12	$124.2M	0	1ARVN241358P3EWTX Top holdings2023-12-31 1.ARVN 2.41358P 3.EWTX 4.DCPHEUR 5.75120L 6.CRNX 7.RCKT 8.ALEC 9.702712 10.COGT
2023-09-30	12	$77.9M	0	1ARVN 2DCPHEUR375120L Top holdings2023-09-30 1.ARVN 2.DCPHEUR 3.75120L 4.EWTX 5.COGT 6.CRNX 7.RCKT 8.ALEC 9.702712 10.41358P
2023-06-30	14	$116.4M	0	1ARVN275120L323345J Top holdings2023-06-30 1.ARVN 2.75120L 3.23345J 4.DCPHEUR 5.EWTX 6.COGT 7.CRNX 8.RCKT 9.702712 10.41358P
2023-03-31	17	$121.0M	0	1ARVN275120L3DCPHEUR Top holdings2023-03-31 1.ARVN 2.75120L 3.DCPHEUR 4.23345J 5.EWTX 6.03217L 7.COGT 8.702712 9.41358P 10.CRNX
2022-12-31	17	$138.1M	0	1ARVN275120L3DCPHEUR Top holdings2022-12-31 1.ARVN 2.75120L 3.DCPHEUR 4.EWTX 5.23345J 6.COGT 7.702712 8.03217L 9.ALEC 10.CRNX
2022-09-30	19	$168.5M	0	1ARVN275120L3DCPHEUR Top holdings2022-09-30 1.ARVN 2.75120L 3.DCPHEUR 4.EWTX 5.23345J 6.COGT 7.ALEC 8.702712 9.03217L 10.41358P
2022-06-30	21	$154.4M	0	1ARVN275120L3DCPHEUR Top holdings2022-06-30 1.ARVN 2.75120L 3.DCPHEUR 4.EWTX 5.SRRAEUR 6.23345J 7.41358P 8.702712 9.COGT 10.ALEC
2022-03-31	21	$202.9M	0	1ARVN275120L341358P Top holdings2022-03-31 1.ARVN 2.75120L 3.41358P 4.EWTX 5.DCPHEUR 6.23345J 7.702712 8.03836N 9.CMRXEUR 10.ALEC
2021-12-31	22	$276.0M	0	1ARVN241358P3EWTX Top holdings2021-12-31 1.ARVN 2.41358P 3.EWTX 4.75120L 5.702712 6.23345J 7.DCPHEUR 8.SRRAEUR 9.03836N 10.CMRXEUR
2021-09-30	22	$346.7M	0	1ARVN 2DCPHEUR375120L Top holdings2021-09-30 1.ARVN 2.DCPHEUR 3.75120L 4.EWTX 5.41358P 6.702712 7.23345J 8.SRRAEUR 9.ALEC 10.03836N
2021-06-30	19	$389.6M	0	1ARVN 2CRNX 3EWTX Top holdings2021-06-30 1.ARVN 2.CRNX 3.EWTX 4.DCPHEUR 5.H5861P 6.CMRXEUR 7.03836N 8.PDSB 9.ALEC 10.VSAREUR
2021-03-31	18	$429.7M	100	1ARVN241358P3DCPHEUR Top holdings2021-03-31 1.ARVN 2.41358P 3.DCPHEUR 4.EWTX 5.702712 6.CMRXEUR 7.03836N 8.SRRAEUR 9.ALEC 10.VSAREUR
2020-12-31	17	$432.8M	59	1ARVN 2DCPHEUR3702712 Top holdings2020-12-31 1.ARVN 2.DCPHEUR 3.702712 4.41358P 5.03836N 6.SRRAEUR 7.CMRXEUR 8.COGT 9.VSAREUR 10.ALEC
2020-09-30	18	$248.2M	37	1DCPHEUR 2ARVN341358P Top holdings2020-09-30 1.DCPHEUR 2.ARVN 3.41358P 4.702712 5.03836N 6.CHMA 7.VSAREUR 8.SRRAEUR 9.05455M 10.903214
2020-06-30	20	$348.5M	34	1ARVN 2DCPHEUR3702712 Top holdings2020-06-30 1.ARVN 2.DCPHEUR 3.702712 4.41358P 5.PRNB 6.03836N 7.VSAREUR 8.ALEC 9.05455M 10.H5861P
2020-03-31	20	$334.3M	54	1ARVN 2DCPHEUR3702712 Top holdings2020-03-31 1.ARVN 2.DCPHEUR 3.702712 4.41358P 5.PRNB 6.ALEC 7.03836N 8.VSAREUR 9.05455M 10.SRRAEUR
2019-12-31	19	$460.3M	44	1DCPHEUR 2ARVN 3SRRAEUR Top holdings2019-12-31 1.DCPHEUR 2.ARVN 3.SRRAEUR 4.PRNB 5.41358P 6.VSAREUR 7.03836N 8.ALEC 9.G6333L 10.05455M
2019-09-30	19	$330.6M	22	1DCPHEUR 2PRNB 3ARVN Top holdings2019-09-30 1.DCPHEUR 2.PRNB 3.ARVN 4.41358P 5.03836N 6.STIM 7.ALEC 8.G6333L 9.H5861P 10.VSAREUR
2019-06-30	21	$373.1M	21	1DCPHEUR 2PRNB 3ARVN Top holdings2019-06-30 1.DCPHEUR 2.PRNB 3.ARVN 4.41358P 5.STIM 6.ALEC 7.03836N 8.H5861P 9.G6333L 10.CMRXEUR
2019-03-31	20	$364.9M	48	1DCPHEUR 2PRNB 3ARVN Top holdings2019-03-31 1.DCPHEUR 2.PRNB 3.ARVN 4.41358P 5.STIM 6.ALEC 7.03836N 8.G6333L 9.H5861P 10.SRRAEUR
2018-12-31	20	$364.3M	41	1DCPHEUR 2PRNB303836N Top holdings2018-12-31 1.DCPHEUR 2.PRNB 3.03836N 4.STIM 5.ARVN 6.WVE 7.CRSP 8.H5861P 9.903214 10.G6333L
2018-09-30	20	$549.6M	42	1DCPHEUR203836N3PRNB Top holdings2018-09-30 1.DCPHEUR 2.03836N 3.PRNB 4.STIM 5.ARVN 6.WVE 7.CRSP 8.903214 9.H5861P 10.G6333L
2018-06-30	15	$414.3M	90	1DCPHEUR203836N3STIM Top holdings2018-06-30 1.DCPHEUR 2.03836N 3.STIM 4.CRSP 5.903214 6.WVE 7.G6333L 8.SRRAEUR 9.H5861P 10.92529L
2018-03-31	14	$185.2M	46	1DCPHEUR 2CRSP 3WVE Top holdings2018-03-31 1.DCPHEUR 2.CRSP 3.WVE 4.H5861P 5.OXLC 6.SRRAEUR 7.903214 8.AFRM 9.761123 10.TREUR
2017-12-31	16	$213.8M	38	1DCPHEUR 2EWTX 3IRTC Top holdings2017-12-31 1.DCPHEUR 2.EWTX 3.IRTC 4.WVE 5.CRSP 6.OXLC 7.SRRAEUR 8.H5861P 9.SG7 10.761123
2017-09-30	16	$215.5M	76	1DCPHEUR 2IRTC 3EWTX Top holdings2017-09-30 1.DCPHEUR 2.IRTC 3.EWTX 4.OXLC 5.WVE 6.25433V 7.CRSP 8.AVEOEUR 9.SRRAEUR 10.SG7
2017-06-30	15	$142.4M	42	1IRTC292529L3EWTX Top holdings2017-06-30 1.IRTC 2.92529L 3.EWTX 4.OXLC 5.WVE 6.CRSP 7.AVEOEUR 8.SG7 9.SRRAEUR 10.25433V
2017-03-31	16	$195.2M	59	1IRTC292529L3EWTX Top holdings2017-03-31 1.IRTC 2.92529L 3.EWTX 4.WVE 5.OXLC 6.CRSP 7.SG7 8.ALDR1EUR 9.SRRAEUR 10.25433V
2016-12-31	15	$139.6M	37	192529L2EWTX 3OXLC Top holdings2016-12-31 1.92529L 2.EWTX 3.OXLC 4.WVE 5.CRSP 6.25433V 7.SG7 8.DERMEUR 9.ALDR1EUR 10.AVEOEUR
2016-09-30	14	$138.9M	25	1WVE292529L3EWTX Top holdings2016-09-30 1.WVE 2.92529L 3.EWTX 4.OXLC 5.25433V 6.ALDR1EUR 7.DERMEUR 8.SG7 9.DVAX 10.AVEOEUR
2016-06-30	14	$116.2M	35	1EWTX292529L3WVE Top holdings2016-06-30 1.EWTX 2.92529L 3.WVE 4.OXLC 5.25433V 6.DVAX 7.DERMEUR 8.ALDR1EUR 9.SG7 10.AVEOEUR
2016-03-31	13	$110.5M	50	1EWTX292529L325433V Top holdings2016-03-31 1.EWTX 2.92529L 3.25433V 4.OXLC 5.WVE 6.DVAX 7.ALDR1EUR 8.SG7 9.DERMEUR 10.MRNSUSD
2015-12-31	10	$149.4M	75	1EWTX292529L325433V Top holdings2015-12-31 1.EWTX 2.92529L 3.25433V 4.143391 5.OXLC 6.DVAX 7.WVE 8.DERMEUR 9.MRNSUSD 10.CMRXEUR
2015-09-30	13	$115.3M	40	192529L21433913OXLC Top holdings2015-09-30 1.92529L 2.143391 3.OXLC 4.DVAX 5.CMRXEUR 6.DERMEUR 7.MRNSUSD 8.00434H 9.CALAEUR 10.759531
2015-06-30	14	$150.9M	79	1143391292529L3OXLC Top holdings2015-06-30 1.143391 2.92529L 3.OXLC 4.CMRXEUR 5.DVAX 6.MRNSUSD 7.ACAD 8.759531 9.ESPR 10.KPTIEUR
2015-03-31	13	$147.3M	63	192529L27595313OXLC Top holdings2015-03-31 1.92529L 2.759531 3.OXLC 4.ALDR1EUR 5.CMRXEUR 6.DVAX 7.CALAEUR 8.MRNSUSD 9.ACAD 10.KPTIEUR
2014-12-31	13	$205.5M	0	192529L27595313CMRXEUR Top holdings2014-12-31 1.92529L 2.759531 3.CMRXEUR 4.OXLC 5.CALAEUR 6.MEIPUSD 7.ALDR1EUR 8.KPTIEUR 9.MRNSUSD 10.ACAD

Holding changes this quarter

Position changes disclosed by New Leaf Venture Partners, L.L.C. for the quarter ending 2025-09-30, including ticker, issuer, weight change, shares change, and action
#	Ticker	Issuer	Weight Change	Shares Change	Action
1	ARVN	Arvinas INC	+6.6%	—	Unchanged
2	COGT	Cogent Biosciences INC	+5%	—	Unchanged
3	CRNX	Crinetics Pharmaceuticals In	+3.1%	—	Unchanged
4	ALEC	Alector INC	+1.4%	—	Unchanged
5	✓	Passage Bio INC	-0.3%	-96.50%	Trim
6	✓	Rallybio CORP	-1%	—	Unchanged
7	EWTX	Edgewise Therapeutics INC	-11.7%	—	Unchanged
8	RCKT	Rocket Pharmaceuticals INC	—	EXIT	Sold out
9	✓	Iterum Therapeutics PLC	—	EXIT	Sold out

Filing History

Period	Filed	Type	EDGAR
2025-09-30	2025-11-14	13F-HR	View on EDGAR
2025-06-30	2025-08-13	13F-HR	View on EDGAR
2025-03-31	2025-05-13	13F-HR	View on EDGAR
2024-12-31	2025-02-13	13F-HR	View on EDGAR
2024-09-30	2024-11-13	13F-HR	View on EDGAR
2024-06-30	2024-08-14	13F-HR	View on EDGAR
2024-03-31	2024-05-14	13F-HR	View on EDGAR
2023-12-31	2024-02-14	13F-HR	View on EDGAR
2023-09-30	2023-11-14	13F-HR	View on EDGAR
2023-06-30	2023-08-10	13F-HR	View on EDGAR
2023-03-31	2023-05-11	13F-HR	View on EDGAR
2022-12-31	2023-02-06	13F-HR	View on EDGAR
2022-09-30	2022-11-10	13F-HR	View on EDGAR
2022-06-30	2022-08-09	13F-HR	View on EDGAR
2022-03-31	2022-05-06	13F-HR	View on EDGAR
2021-12-31	2022-02-11	13F-HR	View on EDGAR
2021-09-30	2021-11-12	13F-HR	View on EDGAR
2021-06-30	2021-08-12	13F-HR	View on EDGAR
2021-03-31	2021-08-12	Amendment	View on EDGAR
2021-03-31	2021-05-12	13F-HR	View on EDGAR
2020-12-31	2021-02-10	13F-HR	View on EDGAR
2020-09-30	2020-11-12	13F-HR	View on EDGAR
2020-06-30	2020-08-13	13F-HR	View on EDGAR
2020-03-31	2020-05-14	13F-HR	View on EDGAR
2019-12-31	2020-02-13	13F-HR	View on EDGAR
2019-09-30	2019-11-14	13F-HR	View on EDGAR
2019-06-30	2019-08-13	13F-HR	View on EDGAR
2019-03-31	2019-06-04	Amendment	View on EDGAR
2019-03-31	2019-05-15	13F-HR	View on EDGAR
2018-12-31	2019-02-13	13F-HR	View on EDGAR
2018-09-30	2018-11-13	13F-HR	View on EDGAR
2018-06-30	2018-08-14	13F-HR	View on EDGAR
2018-03-31	2018-05-15	13F-HR	View on EDGAR
2017-12-31	2018-02-14	13F-HR	View on EDGAR
2017-09-30	2017-11-14	13F-HR	View on EDGAR
2017-06-30	2017-08-14	13F-HR	View on EDGAR
2017-03-31	2017-05-15	13F-HR	View on EDGAR
2016-12-31	2017-02-14	13F-HR	View on EDGAR
2016-09-30	2016-11-14	13F-HR	View on EDGAR
2016-06-30	2016-08-15	13F-HR	View on EDGAR
2016-03-31	2016-05-16	13F-HR	View on EDGAR
2015-12-31	2016-02-16	13F-HR	View on EDGAR
2015-09-30	2015-11-16	13F-HR	View on EDGAR
2015-06-30	2015-08-14	13F-HR	View on EDGAR
2015-03-31	2015-05-15	13F-HR	View on EDGAR
2014-12-31	2015-02-17	13F-HR	View on EDGAR