NL
New Leaf Venture Partners, L.L.C. Historical SEC 13F Holdings & Archive (Q3 2025)
New Leaf Venture Partners, L.L.C.CIK: 0001631614
Concentrated strategyQuality / disciplined sizing
Total reported value
$43.0M
Reporting period: 2025-09-30 · Number of holdings: 7
New Leaf Venture Partners, L.L.C. disclosed 7 holdings in its latest 13F filing for the period ending 2025-09-30, with total reported value of $43.0M and a quarterly turnover rate of 29.7%.
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Personality snowflake
- Concentration
- 100
- Portfolio Stability
- 29.73
- Momentum
- 50
- Sector conviction
- 0
- Diversification
- 14
- Sizing Uniformity
- 89.53
Sector classification currently covers about 0% of this portfolio's disclosed value; the remainder includes holdings (e.g. unmapped tickers, options, or other security types) not yet covered by our sector mapping.
Source and citation information
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Recent moves
View source Form 13F filing on SEC.govTrim EWTX
0.0% -$6.0M
Add ARVN
0.0% $2.4M
Add COGT
0.0% $2.1M
Add CRNX
0.0% $1.1M
Add ALEC
0.0% $587.5K
Trim 75120L100
0.0% -$498.5K
Holdings Map
New buyAddUnchangedTrim
Top 10 holdings by weight
Full holdings list this quarter
| # | Ticker | Issuer | Asset Subclass | Weight | Weight Change | Shares Change | 4Q Trend |
|---|---|---|---|---|---|---|---|
| 1 | EWTX | Edgewise Therapeutics Inc | Stock-Other | 38.82% | -11.65% | — | |
| 2 | ARVN | Arvinas Inc | Stock-Other | 31.38% | +6.59% | — | |
| 3 | CRNX | Crinetics Pharmaceuticals In | Stock-Other | 13.64% | +3.11% | — | |
| 4 | COGT | Cogent Biosciences Inc | Stock-Other | 8.37% | +5.02% | — | |
| 5 | ✓ | Rallybio CORP | Stock-Other | 3.83% | -0.95% | — | |
| 6 | ALEC | Alector Inc | Stock-Other | 2.33% | +1.40% | — | |
| 7 | ✓ | Passage Bio Inc | Stock-Other | 1.63% | -0.33% | -96.50% |
Portfolio Performance
Performance for Q3 2026
+25.2%
Performance Last 4 Quarters
+127.2%
- Stdev
- +59.6%
- Beta
- +1.29
- Alpha
- +10.6%
- Max Drawdown
- -64.5%
- Annualized Perf
- +24.4%
- Batting Avg vs S&P
- +48.5%
- Sortino
- +1.26
- Stutzer
- +0.19
- Treynor
- +0.29
- Sterling
- +0.53
- Calmar
- +0.38
- Information Ratio
- +0.29
- Tracking Error
- +57.7%
- Stdev Down
- +29.9%
- Winning Months %
- +57.6%
- Losing Months %
- +42.4%
- Best 12 Months
- +127.2%
- Worst 12 Months
- -55.4%
- Efficiency Ratio
- +0.23
- Sharpe
- +0.63
- Stdev Sectors
- —
- Skewness
- +1.35
- Kurtosis
- +4.58
- Upside Potential
- +2.85
Reported value over time
Sector allocation
Not enough sector-mapped data yet
Sector allocation over time
Quarterly history
| Period | Holdings | Total value | Stability | Top holdings | |
|---|---|---|---|---|---|
| 2025 Q3 | 7 | $43.0M | 30 | ||
| 2025 Q2 | 8 | $52.9M | 0 | ||
| 2025 Q1 | 9 | $44.9M | 100 | ||
| 2024 Q4 | 9 | $74.8M | 0 | ||
| 2024 Q3 | 10 | $97.3M | 0 | ||
| 2024 Q2 | 10 | $82.2M | 0 | ||
| 2024 Q1 | 11 | $114.3M | 0 | ||
| 2023 Q4 | 12 | $124.2M | 0 | ||
| 2023 Q3 | 12 | $77.9M | 0 | ||
| 2023 Q2 | 14 | $116.4M | 0 | ||
| 2023 Q1 | 17 | $121.0M | 0 | ||
| 2022 Q4 | 17 | $138.1M | 0 | ||
| 2022 Q3 | 19 | $168.5M | 0 | ||
| 2022 Q2 | 21 | $154.4M | 0 | ||
| 2022 Q1 | 21 | $202.9M | 0 | ||
| 2021 Q4 | 22 | $276.0M | 0 | ||
| 2021 Q3 | 22 | $346.7M | 0 | ||
| 2021 Q2 | 19 | $389.6M | 0 | ||
| 2021 Q1 | 18 | $429.7M | 100 | ||
| 2020 Q4 | 17 | $432.8M | 59 | ||
| 2020 Q3 | 18 | $248.2M | 37 | ||
| 2020 Q2 | 20 | $348.5M | 34 | ||
| 2020 Q1 | 20 | $334.3M | 54 | ||
| 2019 Q4 | 19 | $460.3M | 44 | ||
| 2019 Q3 | 19 | $330.6M | 22 | ||
| 2019 Q2 | 21 | $373.1M | 21 | ||
| 2019 Q1 | 20 | $364.9M | 48 | ||
| 2018 Q4 | 20 | $364.3M | 41 | ||
| 2018 Q3 | 20 | $549.6M | 42 | ||
| 2018 Q2 | 15 | $414.3M | 90 | ||
| 2018 Q1 | 14 | $185.2M | 46 | ||
| 2017 Q4 | 16 | $213.8M | 38 | ||
| 2017 Q3 | 16 | $215.5M | 76 | ||
| 2017 Q2 | 15 | $142.4M | 42 | ||
| 2017 Q1 | 16 | $195.2M | 59 | ||
| 2016 Q4 | 15 | $139.6M | 37 | ||
| 2016 Q3 | 14 | $138.9M | 25 | ||
| 2016 Q2 | 14 | $116.2M | 35 | ||
| 2016 Q1 | 13 | $110.5M | 50 | ||
| 2015 Q4 | 10 | $149.4M | 75 | ||
| 2015 Q3 | 13 | $115.3M | 40 | ||
| 2015 Q2 | 14 | $150.9M | 79 | ||
| 2015 Q1 | 13 | $147.3M | 63 | ||
| 2014 Q4 | 13 | $205.5M | 0 |
Holding changes this quarter
New Leaf Venture Partners, L.L.C.'s most significant position changes for 2025-09-30: Sold out: Rocket Pharmaceuticals Inc (RCKT); Sold out: Iterum Therapeutics PLC; Trim: Passage Bio Inc — shares -96.50%.
| # | Ticker | Issuer | Weight Change | Shares Change | Action |
|---|---|---|---|---|---|
| 1 | ARVN | Arvinas Inc | +6.6% | — | Unchanged |
| 2 | COGT | Cogent Biosciences Inc | +5% | — | Unchanged |
| 3 | CRNX | Crinetics Pharmaceuticals In | +3.1% | — | Unchanged |
| 4 | ALEC | Alector Inc | +1.4% | — | Unchanged |
| 5 | ✓ | Passage Bio Inc | -0.3% | -96.50% | Trim |
| 6 | ✓ | Rallybio CORP | -1% | — | Unchanged |
| 7 | EWTX | Edgewise Therapeutics Inc | -11.7% | — | Unchanged |
| 8 | RCKT | Rocket Pharmaceuticals Inc | — | EXIT | Sold out |
| 9 | ✓ | Iterum Therapeutics PLC | — | EXIT | Sold out |
Filing History
FAQ
What is New Leaf Venture Partners, L.L.C. and what type of investor is it?
New Leaf Venture Partners, L.L.C. is an investment manager that files SEC Form 13F quarterly, disclosing its U.S. public equity holdings to regulators. As of the most recent reporting period (2025-09-30), the firm manages a tracked equity portfolio valued at approximately $43.0M, spread across 7 disclosed positions.
What are New Leaf Venture Partners, L.L.C.'s largest equity positions?
Based on the latest 13F filing, New Leaf Venture Partners, L.L.C.'s top holdings by market value are:
1. Edgewise Therapeutics Inc (EWTX) — $16.7M (38.8%)
2. Arvinas Inc (ARVN) — $13.5M (31.4%)
3. Crinetics Pharmaceuticals In (CRNX) — $5.9M (13.6%)
4. Cogent Biosciences Inc (COGT) — $3.6M (8.4%)
5. Rallybio CORP — $1.6M (3.8%)
What changes did New Leaf Venture Partners, L.L.C. make in its most recent portfolio filing?
In the latest quarter, New Leaf Venture Partners, L.L.C. took a more defensive posture — trimming 1 positions and completely exiting 2 holdings. The largest of these moves: Sold out: Rocket Pharmaceuticals Inc (RCKT); Sold out: Iterum Therapeutics PLC; Trim: Passage Bio Inc — shares -96.50%
What sectors does New Leaf Venture Partners, L.L.C. focus on?
Sector breakdown data is not yet available for New Leaf Venture Partners, L.L.C.. Check back after the next 13F processing cycle.
💡
Data Source Notice: AlphaSMO is the web's most authoritative 13F / Inside Trader database. Institutional holdings and insider trades presented here are precisely computed to deliver accurate portfolio reporting.
Investment Profile
New Leaf Venture Partners, L.L.C. returned an annualized 24.4% over the trailing 33 months — outperforming the S&P 500 by 10.6 points — based on a reconstructed track record of its disclosed 13F positions, with a beta of 1.29 (more volatile than the market) and a 48% quarterly batting average against the index.
Its portfolio is concentrated and moderately active.
Its turnover score has risen from 0 to 30 over the past 4 quarters — a shift toward more active trading.
It has added to its ARVN position for two straight quarters, increasing it by $2.4M to reach $13.5M.
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Developer Access
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