BC
BIOS Capital Management, LP — 13F Portfolio Changes & Top Buys (Q2 2026)
BIOS Capital Management, LPCIK: 0001813845
Concentrated strategyMomentum followerQuality / disciplined sizing
Total reported value
$41.7M
Reporting period: 2026-06-30 · Number of holdings: 9
BIOS Capital Management, LP disclosed 9 holdings in its latest 13F filing for the period ending 2026-06-30, with total reported value of $41.7M and a quarterly turnover rate of 35.8%.
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Personality snowflake
- Concentration
- 100
- Portfolio Stability
- 35.8
- Momentum
- 100
- Sector conviction
- 0
- Diversification
- 12
- Sizing Uniformity
- 90.14
Sector classification currently covers about 0% of this portfolio's disclosed value; the remainder includes holdings (e.g. unmapped tickers, options, or other security types) not yet covered by our sector mapping.
Source and citation information
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Recent moves
View source Form 13F filing on SEC.govTrim ACTU
0.0% -$12.2M
Add CGTX
0.0% $2.3M
Add IRD
0.0% -$1.6M
Add RNTX
+50.4% $524.6K
Add LTRN
-71.1% -$144.3K
Trim INAB
-51.8% -$134.2K
Holdings Map
New buyAddUnchangedTrim
Top 10 holdings by weight
Full holdings list this quarter
Showing top 6 holdings (of 9 total)
| # | Ticker | Issuer | Asset Subclass | Weight | Weight Change | Shares Change | 4Q Trend |
|---|---|---|---|---|---|---|---|
| 1 | ACTU | Actuate Therapeutics Inc | Stock-Other | 36.90% | -15.19% | — | |
| 2 | IRD | Opus Genetics Inc | Stock-Other | 36.33% | +4.63% | — | |
| 3 | CGTX | Cognition Therapeutics Inc | Stock-Other | 16.56% | +7.93% | — | |
| 4 | RNTX | Rein Therapeutics Inc | Stock-Other | 7.44% | +2.57% | +50.44% | |
| 5 | LTRN | Lantern Pharma Inc | Stock-Other | 2.50% | +0.26% | -71.15% | |
| 6 | INAB | In8bio Inc | Stock-Other | 0.27% | -0.20% | -51.76% |
Portfolio Performance
Performance for Q3 2026
-18.8%
Performance Last 4 Quarters
-63.9%
- Stdev
- +74.2%
- Beta
- +0.89
- Alpha
- -39.9%
- Max Drawdown
- -74.1%
- Annualized Perf
- -40.4%
- Batting Avg vs S&P
- +44.4%
- Sortino
- -0.42
- Stutzer
- -0.09
- Treynor
- -0.25
- Sterling
- -0.53
- Calmar
- -0.55
- Information Ratio
- -0.57
- Tracking Error
- +73.2%
- Stdev Down
- +54.7%
- Winning Months %
- +44.4%
- Losing Months %
- +55.6%
- Best 12 Months
- -25.9%
- Worst 12 Months
- -63.9%
- Efficiency Ratio
- +0.16
- Sharpe
- -0.31
- Stdev Sectors
- —
- Skewness
- -0.07
- Kurtosis
- -0.92
- Upside Potential
- +1.83
Reported value over time
Sector allocation
Not enough sector-mapped data yet
Sector allocation over time
Quarterly history
Holding changes this quarter
BIOS Capital Management, LP's most significant position changes for 2026-06-30: Add: Rein Therapeutics Inc (RNTX) — shares +50.44%; Trim: Lantern Pharma Inc (LTRN) — shares -71.15%; Trim: In8bio Inc (INAB) — shares -51.76%.
| # | Ticker | Issuer | Weight Change | Shares Change | Action |
|---|---|---|---|---|---|
| 1 | CGTX | Cognition Therapeutics Inc | +7.9% | — | Unchanged |
| 2 | IRD | Opus Genetics Inc | +4.6% | — | Unchanged |
| 3 | RNTX | Rein Therapeutics Inc | +2.6% | +50.44% | Add |
| 4 | LTRN | Lantern Pharma Inc | +0.3% | -71.15% | Trim |
| 5 | INAB | In8bio Inc | -0.2% | -51.76% | Trim |
| 6 | ACTU | Actuate Therapeutics Inc | -15.2% | — | Unchanged |
Filing History
FAQ
What is BIOS Capital Management, LP and what type of investor is it?
BIOS Capital Management, LP is an investment manager that files SEC Form 13F quarterly, disclosing its U.S. public equity holdings to regulators. As of the most recent reporting period (2026-06-30), the firm manages a tracked equity portfolio valued at approximately $41.7M, spread across 9 disclosed positions.
What are BIOS Capital Management, LP's largest equity positions?
Based on the latest 13F filing, BIOS Capital Management, LP's top holdings by market value are:
1. Actuate Therapeutics Inc (ACTU) — $15.4M (36.9%)
2. Opus Genetics Inc (IRD) — $15.1M (36.3%)
3. Cognition Therapeutics Inc (CGTX) — $6.9M (16.6%)
4. Rein Therapeutics Inc (RNTX) — $3.1M (7.4%)
5. Lantern Pharma Inc (LTRN) — $1.0M (2.5%)
What changes did BIOS Capital Management, LP make in its most recent portfolio filing?
In the latest reported quarter, BIOS Capital Management, LP made 3 notable position adjustments: 0 new positions were initiated, 1 existing holdings were added to, 2 positions were partially reduced, and 0 were completely exited. The largest of these moves: Add: Rein Therapeutics Inc (RNTX) — shares +50.44%; Trim: Lantern Pharma Inc (LTRN) — shares -71.15%; Trim: In8bio Inc (INAB) — shares -51.76%
What sectors does BIOS Capital Management, LP focus on?
Sector breakdown data is not yet available for BIOS Capital Management, LP. Check back after the next 13F processing cycle.
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Data Source Notice: AlphaSMO is the web's most authoritative 13F / Inside Trader database. Institutional holdings and insider trades presented here are precisely computed to deliver accurate portfolio reporting.
Investment Profile
BIOS Capital Management, LP returned an annualized -40.4% over the trailing 18 months — underperforming the S&P 500 by 39.9 points — based on a reconstructed track record of its disclosed 13F positions, with a beta of 0.89 (less volatile than the market) and a 44% quarterly batting average against the index.
Its portfolio is concentrated and moderately active.
Its turnover score has risen from 0 to 36 over the past 4 quarters — a shift toward more active trading.
It has added to its RNTX position over the past two quarters (+$1.1M, now $3.1M), while trimming ACTU over the same stretch (-$46.1M, still holding $15.4M).
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BP
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Developer Access
Access BIOS Capital Management, LP's institutional profile programmatically:
REST API
curl https://alphasmo.com/api/v1/institutions/bios-capital-management-lpCLI
npx alphasmo institutions get bios-capital-management-lp