BIOS Capital Management, LP 13F Portfolio & Position Changes

CIK: 0001813845

Concentrated strategyMomentum followerHigh-turnover trader

Total reported value

$52.9M

Reporting period: 2026-03-31 · Number of holdings: 10

BIOS Capital Management, LP disclosed 10 holdings in its latest 13F filing for the period ending 2026-03-31, with total reported value of $52.9M and a quarterly turnover rate of 73.4%.

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Personality snowflake

Concentration: 100
Portfolio Stability: 73.36
Momentum/Contrarian: 100
Sector conviction: 0
Diversification: 12
Sizing Uniformity: 87.54

Sector classification currently covers about 0% of this portfolio's disclosed value; the remainder includes holdings (e.g. unmapped tickers, options, or other security types) not yet covered by our sector mapping.

Recent moves

Add IRD
0.0%　$9.4M
Trim ACTU
0.0%　-$34.0M
Add RNTX
+17.2%　$615.8K
Trim LTRN
-14.4%　-$1.9M
Trim CGTX
0.0%　-$3.5M
Trim INAB
-33.8%　-$344.6K

Holdings Map

New buyAddUnchangedTrim

Top 10 holdings by weight

Full holdings list this quarter

Showing top 6 holdings (of 10 total)

#	Ticker	Issuer	Asset Subclass	Weight	Weight Change	Shares Change
1	ACTU	Actuate Therapeutics INC	Stock-Other	52.09%	-22.35%	—
2	IRD	Opus Genetics INC	Stock-Other	31.70%	+22.74%	—
3	CGTX	Cognition Therapeutics INC	Stock-Other	8.63%	-1.17%	—
4	RNTX	Rein Therapeutics INC	Stock-Other	4.87%	+2.50%	+17.25%
5	LTRN	Lantern Pharma INC	Stock-Other	2.24%	-1.46%	-14.37%
6	INAB	In8bio INC	Stock-Other	0.47%	-0.25%	-33.78%

Portfolio Performance

Performance for Q3 2026

-40.4%

Performance Last 4 Quarters

-70.2%

Based on 68% of reported portfolio value with available pricing

Stdev: +78.2%
Beta: +1.12
Alpha: -72.2%
Max Drawdown: -80.5%
Annualized Perf: -57.5%
Batting Avg vs S&P: +41.2%
Sortino: -0.85
Stutzer: -0.2
Treynor: -0.46
Sterling: -0.66
Calmar: -0.71
Information Ratio: -0.91
Tracking Error: +76.7%
Stdev Down: +61.2%
Winning Months %: +41.2%
Losing Months %: +58.8%
Best 12 Months: -41.1%
Worst 12 Months: -73.9%
Efficiency Ratio: +0.21
Sharpe: -0.66
Stdev Sectors: —
Skewness: +0.15
Kurtosis: -1.07
Upside Potential: +1.55

Reported value over time

Sector allocation

Not enough sector-mapped data yet

Sector allocation over time

Quarterly history

Period	Holdings	Total value	Stability	Top holdings
2026-03-31	10	$52.9M	73	1ACTU 2IRD 3CGTX Top holdings2026-03-31 1.ACTU 2.IRD 3.CGTX 4.RNTX 5.LTRN 6.INAB
2025-12-31	9	$82.6M	11	1ACTU 2CGTX 3IRD Top holdings2025-12-31 1.ACTU 2.CGTX 3.IRD 4.LTRN 5.RNTX 6.INAB
2025-09-30	9	$88.9M	17	1ACTU 2CGTX 3IRD Top holdings2025-09-30 1.ACTU 2.CGTX 3.IRD 4.LTRN 5.RNTX 6.INABEUR
2025-06-30	9	$72.6M	0	1ACTU 2IRD 3LTRN Top holdings2025-06-30 1.ACTU 2.IRD 3.LTRN 4.RNTX 5.CGTX 6.INABEUR
2025-03-31	9	$79.2M	0	1ACTU 2LTRN 3RNTX Top holdings2025-03-31 1.ACTU 2.LTRN 3.RNTX 4.CGTX 5.INABEUR 6.IRD
2024-12-31	9	$94.1M	0	1ACTU 2CGTX 3RNTX Top holdings2024-12-31 1.ACTU 2.CGTX 3.RNTX 4.LTRN 5.INABEUR 6.IRD

Holding changes this quarter

BIOS Capital Management, LP's most significant position changes for 2026-03-31: Add: Rein Therapeutics INC (RNTX) — shares +17.25%; Trim: Lantern Pharma INC (LTRN) — shares -14.37%; Trim: In8bio INC (INAB) — shares -33.78%.

Position changes disclosed by BIOS Capital Management, LP for the quarter ending 2026-03-31, including ticker, issuer, weight change, shares change, and action
#	Ticker	Issuer	Weight Change	Shares Change	Action
1	IRD	Opus Genetics INC	+22.7%	—	Unchanged
2	RNTX	Rein Therapeutics INC	+2.5%	+17.25%	Add
3	INAB	In8bio INC	-0.3%	-33.78%	Trim
4	CGTX	Cognition Therapeutics INC	-1.2%	—	Unchanged
5	LTRN	Lantern Pharma INC	-1.5%	-14.37%	Trim
6	ACTU	Actuate Therapeutics INC	-22.4%	—	Unchanged

Filing History

Period	Filed	Type	EDGAR
2026-03-31	2026-05-13	13F-HR	View on EDGAR
2025-12-31	2026-02-13	13F-HR	View on EDGAR
2025-09-30	2025-11-12	13F-HR	View on EDGAR
2025-06-30	2025-08-12	13F-HR	View on EDGAR
2025-03-31	2025-05-14	13F-HR	View on EDGAR
2024-12-31	2025-02-18	Amendment	View on EDGAR
2024-12-31	2025-02-10	13F-HR	View on EDGAR

FAQ

What is BIOS Capital Management, LP and what type of investor is it?

BIOS Capital Management, LP is an investment manager that files SEC Form 13F quarterly, disclosing its U.S. public equity holdings to regulators. As of the most recent reporting period (2026-03-31), the firm manages a tracked equity portfolio valued at approximately $52.9M, spread across 10 disclosed positions.

What are BIOS Capital Management, LP's largest equity positions?

Based on the latest 13F filing, BIOS Capital Management, LP's top holdings by market value are: 1. Actuate Therapeutics INC (ACTU) — $27.5M (52.1%) 2. Opus Genetics INC (IRD) — $16.8M (31.7%) 3. Cognition Therapeutics INC (CGTX) — $4.6M (8.6%) 4. Rein Therapeutics INC (RNTX) — $2.6M (4.9%) 5. Lantern Pharma INC (LTRN) — $1.2M (2.2%)

What changes did BIOS Capital Management, LP make in its most recent portfolio filing?

In the latest reported quarter, BIOS Capital Management, LP made 3 notable position adjustments: 0 new positions were initiated, 1 existing holdings were added to, 2 positions were partially reduced, and 0 were completely exited. The largest of these moves: Add: Rein Therapeutics INC (RNTX) — shares +17.25%; Trim: Lantern Pharma INC (LTRN) — shares -14.37%; Trim: In8bio INC (INAB) — shares -33.78%

What sectors does BIOS Capital Management, LP focus on?

Sector breakdown data is not yet available for BIOS Capital Management, LP. Check back after the next 13F processing cycle.

Peer Institutions

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First Reserve GP XIII Ltd

CIK 0001706604

Total reported value

$52.9M

1 stks

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Concentration100.0

Portfolio Stability100.0

Sector conviction0.0

AUM within 0.0% of this institution

View detail

Irth Capital Management LP

CIK 0002046144

Total reported value

$52.8M

1 stks

2026-03-31

Concentration100.0

Portfolio Stability17.1

Sector conviction0.0

AUM within 0.2% of this institution

View detail

ProQuest Associates IV LLC

CIK 0001431819

Total reported value

$53.0M

5 stks

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Stale — no recent filing

Concentration100.0

Portfolio Stability20.4

Sector conviction0.0

AUM within 0.2% of this institution

View detail

Similar Holdings Style

Institutions with overlapping top holdings

Kck LTD.

CIK 0001657662

Total reported value

$15.1M

2 stks

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Stale — no recent filing

Concentration100.0

Portfolio Stability0.0

Sector conviction0.0

1 of the top 5 holdings overlap, including Rein Therapeutics INC

View detail

Personality snowflake

Concentration

100

Portfolio Stability

73.36

Momentum/Contrarian

100

Sector conviction

Diversification

Sizing Uniformity

87.54

Ticker

Issuer

Asset Subclass

Weight

Weight Change

Shares Change

4Q Trend

ACTU

Actuate Therapeutics INC

Stock-Other

52.09%

-22.35%

—

IRD

Opus Genetics INC

Stock-Other

31.70%

+22.74%

—

CGTX

Cognition Therapeutics INC

Stock-Other

8.63%

-1.17%

—

RNTX

Rein Therapeutics INC

Stock-Other

4.87%

+2.50%

+17.25%

LTRN

Lantern Pharma INC

Stock-Other

2.24%

-1.46%

-14.37%

INAB

In8bio INC

Stock-Other

0.47%

-0.25%

-33.78%

Portfolio Performance

Performance for Q3 2026

-40.4%

Performance Last 4 Quarters

-70.2%

Based on 68% of reported portfolio value with available pricing

Stdev: +78.2%
Beta: +1.12
Alpha: -72.2%
Max Drawdown: -80.5%
Annualized Perf: -57.5%
Batting Avg vs S&P: +41.2%
Sortino: -0.85
Stutzer: -0.2
Treynor: -0.46
Sterling: -0.66
Calmar: -0.71
Information Ratio: -0.91
Tracking Error: +76.7%
Stdev Down: +61.2%
Winning Months %: +41.2%
Losing Months %: +58.8%
Best 12 Months: -41.1%
Worst 12 Months: -73.9%
Efficiency Ratio: +0.21
Sharpe: -0.66
Stdev Sectors: —
Skewness: +0.15
Kurtosis: -1.07
Upside Potential: +1.55

Quarterly history

Period	Holdings	Total value	Stability	Top holdings
2026-03-31	10	$52.9M	73	1ACTU 2IRD 3CGTX Top holdings2026-03-31 1.ACTU 2.IRD 3.CGTX 4.RNTX 5.LTRN 6.INAB
2025-12-31	9	$82.6M	11	1ACTU 2CGTX 3IRD Top holdings2025-12-31 1.ACTU 2.CGTX 3.IRD 4.LTRN 5.RNTX 6.INAB
2025-09-30	9	$88.9M	17	1ACTU 2CGTX 3IRD Top holdings2025-09-30 1.ACTU 2.CGTX 3.IRD 4.LTRN 5.RNTX 6.INABEUR
2025-06-30	9	$72.6M	0	1ACTU 2IRD 3LTRN Top holdings2025-06-30 1.ACTU 2.IRD 3.LTRN 4.RNTX 5.CGTX 6.INABEUR
2025-03-31	9	$79.2M	0	1ACTU 2LTRN 3RNTX Top holdings2025-03-31 1.ACTU 2.LTRN 3.RNTX 4.CGTX 5.INABEUR 6.IRD
2024-12-31	9	$94.1M	0	1ACTU 2CGTX 3RNTX Top holdings2024-12-31 1.ACTU 2.CGTX 3.RNTX 4.LTRN 5.INABEUR 6.IRD