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ARCH Venture Management, LLC — 13F Portfolio Report & Top Holdings (Q2 2026)
ARCH Venture Management, LLCCIK: 0001274403
ContrarianQuality / disciplined sizing
Total reported value
$1.1B
Reporting period: 2026-06-30 · Number of holdings: 12
ARCH Venture Management, LLC disclosed 12 holdings in its latest 13F filing for the period ending 2026-06-30, with total reported value of $1.1B and a quarterly turnover rate of 52.8%.
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Personality snowflake
- Concentration
- 49.52
- Portfolio Stability
- 52.79
- Momentum
- 0
- Sector conviction
- 0
- Diversification
- 24
- Sizing Uniformity
- 92.72
Sector classification currently covers about 0% of this portfolio's disclosed value; the remainder includes holdings (e.g. unmapped tickers, options, or other security types) not yet covered by our sector mapping.
Source and citation information
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Recent moves
View source Form 13F filing on SEC.govNew buy 698955101
New buy 81221K108
Trim MAZE
0.0% $0.0
Trim LYEL
0.0% -$19.6M
Trim VIR
-1.7% $13.6M
Trim ERAS
0.0% $15.2M
Holdings Map
New buyAddUnchangedTrim
Top 10 holdings by weight
Full holdings list this quarter
| # | Ticker | Issuer | Asset Subclass | Weight | Weight Change | Shares Change | 4Q Trend |
|---|---|---|---|---|---|---|---|
| 1 | ✓ | Stock-Other | 15.95% | +15.95% | NEW | ||
| 2 | BEAM | Beam Therapeutics Inc | Stock-Other | 14.16% | -1.82% | — | |
| 3 | RAPP | Rapport Therapeutics Inc | Stock-Other | 14.12% | -3.11% | — | |
| 4 | ✓ | Stock-Other | 12.42% | +12.42% | NEW | ||
| 5 | ERAS | Erasca Inc | Stock-Other | 11.81% | -5.14% | — | |
| 6 | VIR | Vir Biotechnology Inc | Stock-Other | 11.76% | -5.33% | -1.72% | |
| 7 | MAZE | Maze Therapeutics Inc | Stock-Other | 11.18% | -6.98% | — | |
| 8 | LYEL | Lyell Immunopharma Inc | Stock-Other | 4.14% | -5.48% | — | |
| 9 | GENB | Generate Biomedicines Inc | Stock-Other | 2.98% | -0.61% | — | |
| 10 | TXG | 10x Genomics Inc-class A | Stock-Other | 0.76% | +0.08% | — | |
| 11 | BOLD | Boundless Bio Inc | Stock-Other | 0.61% | +0.61% | NEW | |
| 12 | GOSS | Gossamer Bio Inc | Stock-Other | 0.12% | -0.27% | — |
Portfolio Performance
Performance for Q3 2026
+11.1%
Performance Last 4 Quarters
+142.1%
- Stdev
- +48.1%
- Beta
- +0.84
- Alpha
- +34.5%
- Max Drawdown
- -49%
- Annualized Perf
- +48.2%
- Batting Avg vs S&P
- +56.7%
- Sortino
- +2.36
- Stutzer
- +0.32
- Treynor
- +0.59
- Sterling
- +1.24
- Calmar
- +0.98
- Information Ratio
- +0.67
- Tracking Error
- +47%
- Stdev Down
- +21.2%
- Winning Months %
- +60%
- Losing Months %
- +40%
- Best 12 Months
- +206.5%
- Worst 12 Months
- -32.5%
- Efficiency Ratio
- +0.54
- Sharpe
- +1.04
- Stdev Sectors
- —
- Skewness
- +1.08
- Kurtosis
- +2.01
- Upside Potential
- +4.12
Reported value over time
Sector allocation
Not enough sector-mapped data yet
Sector allocation over time
Quarterly history
| Period | Holdings | Total value | Stability | Top holdings | |
|---|---|---|---|---|---|
| 2026 Q2 | 12 | $1.1B | 53 | ||
| 2026 Q1 | 10 | $677.1M | 38 | ||
| 2025 Q4 | 9 | $651.7M | 28 | ||
| 2025 Q3 | 9 | $492.4M | 77 | ||
| 2025 Q2 | 11 | $299.1M | 0 | ||
| 2025 Q1 | 9 | $206.2M | 100 | ||
| 2024 Q4 | 9 | $230.2M | 0 | ||
| 2024 Q3 | 9 | $260.6M | 0 | ||
| 2024 Q2 | 9 | $266.0M | 0 | ||
| 2024 Q1 | 8 | $80.3M | 0 | ||
| 2023 Q4 | 7 | $163.5M | 0 | ||
| 2023 Q3 | 7 | $154.0M | 0 | ||
| 2023 Q2 | 6 | $162.0M | 0 | ||
| 2023 Q1 | 8 | $207.2M | 0 | ||
| 2022 Q4 | 8 | $390.4M | 0 | ||
| 2022 Q3 | 10 | $771.4M | 0 | ||
| 2022 Q2 | 10 | $820.6M | 0 | ||
| 2022 Q1 | 8 | $699.8M | 0 | ||
| 2021 Q4 | 9 | $945.3M | 0 | ||
| 2020 Q3 | 3 | $20.0M | 39 | ||
| 2020 Q2 | 4 | $29.7M | 94 | ||
| 2020 Q1 | 5 | $59.2M | 36 | ||
| 2019 Q4 | 5 | $76.7M | 69 | ||
| 2019 Q3 | 5 | $91.4M | 91 | ||
| 2019 Q2 | 4 | $96.6M | 13 | ||
| 2019 Q1 | 6 | $103.6M | 100 | ||
| 2018 Q4 | 5 | $99.3M | 0 |
Holding changes this quarter
ARCH Venture Management, LLC's most significant position changes for 2026-06-30: New buy: ; New buy: ; New buy: Boundless Bio Inc (BOLD); Sold out: Q32 Bio Inc (QTTB); Trim: Vir Biotechnology Inc (VIR) — shares -1.72%.
| # | Ticker | Issuer | Weight Change | Shares Change | Action |
|---|---|---|---|---|---|
| 1 | ✓ | +16% | NEW | New buy | |
| 2 | ✓ | +12.4% | NEW | New buy | |
| 3 | BOLD | Boundless Bio Inc | +0.6% | NEW | New buy |
| 4 | TXG | 10x Genomics Inc-class A | +0.1% | — | Unchanged |
| 5 | GOSS | Gossamer Bio Inc | -0.3% | — | Unchanged |
| 6 | QTTB | Q32 Bio Inc | -0.3% | EXIT | Sold out |
| 7 | GENB | Generate Biomedicines Inc | -0.6% | — | Unchanged |
| 8 | BEAM | Beam Therapeutics Inc | -1.8% | — | Unchanged |
| 9 | RAPP | Rapport Therapeutics Inc | -3.1% | — | Unchanged |
| 10 | ERAS | Erasca Inc | -5.1% | — | Unchanged |
| 11 | VIR | Vir Biotechnology Inc | -5.3% | -1.72% | Trim |
| 12 | LYEL | Lyell Immunopharma Inc | -5.5% | — | Unchanged |
| 13 | MAZE | Maze Therapeutics Inc | -7% | — | Unchanged |
Filing History
FAQ
What is ARCH Venture Management, LLC and what type of investor is it?
ARCH Venture Management, LLC is an investment manager that files SEC Form 13F quarterly, disclosing its U.S. public equity holdings to regulators. As of the most recent reporting period (2026-06-30), the firm manages a tracked equity portfolio valued at approximately $1.1B, spread across 12 disclosed positions.
What are ARCH Venture Management, LLC's largest equity positions?
Based on the latest 13F filing, ARCH Venture Management, LLC's top holdings by market value are:
1. — $175.5M (15.9%)
2. Beam Therapeutics Inc (BEAM) — $155.8M (14.2%)
3. Rapport Therapeutics Inc (RAPP) — $155.4M (14.1%)
4. — $136.6M (12.4%)
5. Erasca Inc (ERAS) — $129.9M (11.8%)
What changes did ARCH Venture Management, LLC make in its most recent portfolio filing?
In the latest reported quarter, ARCH Venture Management, LLC made 5 notable position adjustments: 3 new positions were initiated, 0 existing holdings were added to, 1 positions were partially reduced, and 1 were completely exited. The largest of these moves: New buy: ; New buy: ; New buy: Boundless Bio Inc (BOLD); Sold out: Q32 Bio Inc (QTTB); Trim: Vir Biotechnology Inc (VIR) — shares -1.72%
What sectors does ARCH Venture Management, LLC focus on?
Sector breakdown data is not yet available for ARCH Venture Management, LLC. Check back after the next 13F processing cycle.
Investment Profile
ARCH Venture Management, LLC returned an annualized 48.2% over the trailing 30 months — outperforming the S&P 500 by 34.5 points — based on a reconstructed track record of its disclosed 13F positions, with a beta of 0.84 (less volatile than the market) and a 57% quarterly batting average against the index.
Its portfolio is moderately concentrated and moderately active.
Its turnover score has risen from 0 to 53 over the past 4 quarters — a shift toward more active trading.
It has added to its ERAS position over the past two quarters (+$88.8M, now $129.9M), while trimming LYEL over the same stretch (-$39.4M, still holding $45.5M).
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Developer Access
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