5V
5AM Venture Management, LLC 13F Holdings & Recent Stock Buys (Q2 2026)
5AM Venture Management, LLCCIK: 0001799883
Quality / disciplined sizing
Total reported value
$287.9M
Reporting period: 2026-06-30 · Number of holdings: 16
5AM Venture Management, LLC disclosed 16 holdings in its latest 13F filing for the period ending 2026-06-30, with total reported value of $287.9M and a quarterly turnover rate of 54.5%.
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Personality snowflake
- Concentration
- 32.58
- Portfolio Stability
- 54.47
- Momentum
- 50
- Sector conviction
- 0
- Diversification
- 32
- Sizing Uniformity
- 94.31
Sector classification currently covers about 0% of this portfolio's disclosed value; the remainder includes holdings (e.g. unmapped tickers, options, or other security types) not yet covered by our sector mapping.
Source and citation information
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Recent moves
View source Form 13F filing on SEC.govSold out ERAS
Add MPLT
0.0% $14.7M
Sold out 260
Add ZNTL
0.0% $9.9M
Trim TRDA
0.0% -$21.3M
Add ARTV
0.0% $7.7M
Holdings Map
New buyAddUnchangedTrim
Top 10 holdings by weight
Full holdings list this quarter
| # | Ticker | Issuer | Asset Subclass | Weight | Weight Change | Shares Change | 4Q Trend |
|---|---|---|---|---|---|---|---|
| 1 | MPLT | Maplight Therapeutics Inc | Stock-Other | 11.83% | +6.47% | — | |
| 2 | TYRA | Tyra Biosciences Inc | Stock-Other | 11.42% | +0.48% | — | |
| 3 | TRDA | Entrada Therapeutics Inc | Stock-Other | 10.37% | -3.84% | — | |
| 4 | PHVS | Pharvaris N.V. | Stock-Other | 9.58% | +3.32% | — | |
| 5 | CAMP | Camp4 Therapeutics CORP | Stock-Other | 8.91% | +1.72% | — | |
| 6 | ARTV | Artiva Biotherapeutics Inc | Stock-Other | 7.93% | +3.72% | — | |
| 7 | TECX | Tectonic Therapeutic Inc | Stock-Other | 7.24% | +2.03% | — | |
| 8 | ZNTL | Zentalis Pharmaceuticals Inc | Stock-Other | 6.65% | +4.09% | — | |
| 9 | CLDX | Celldex Therapeutics Inc | Stock-Other | 6.43% | +2.05% | — | |
| 10 | EYPT | Eyepoint Inc | Stock-Other | 5.22% | +1.46% | — | |
| 11 | BHVN | Biohaven Ltd. | Stock-Other | 3.82% | +2.08% | — | |
| 12 | SRZN | Surrozen Inc | Stock-Other | 2.44% | -0.69% | -30.00% | |
| 13 | SKYE | Skye Bioscience Inc | Stock-Other | 2.33% | +0.68% | — | |
| 14 | ALXO | Alx Oncology Holdings Inc | Stock-Other | 2.20% | +0.50% | — | |
| 15 | TARA | Protara Therapeutic Inc | Stock-Other | 1.82% | -0.16% | — | |
| 16 | SLN | Silence Therapeutics Plc-adr | Stock-Other | 1.82% | +1.12% | — |
Portfolio Performance
Performance for Q3 2026
-9.5%
Performance Last 4 Quarters
-29.1%
- Stdev
- +71.7%
- Beta
- +1.46
- Alpha
- -34%
- Max Drawdown
- -70.6%
- Annualized Perf
- -22.8%
- Batting Avg vs S&P
- +41.7%
- Sortino
- -0.12
- Stutzer
- -0.02
- Treynor
- -0.03
- Sterling
- -0.42
- Calmar
- -0.32
- Information Ratio
- -0.36
- Tracking Error
- +69.4%
- Stdev Down
- +39.4%
- Winning Months %
- +44.4%
- Losing Months %
- +55.6%
- Best 12 Months
- +54.1%
- Worst 12 Months
- -66.9%
- Efficiency Ratio
- +0.11
- Sharpe
- -0.07
- Stdev Sectors
- —
- Skewness
- +2.37
- Kurtosis
- +9.43
- Upside Potential
- +1.96
Reported value over time
Sector allocation
Not enough sector-mapped data yet
Sector allocation over time
Quarterly history
| Period | Holdings | Total value | Stability | Top holdings | |
|---|---|---|---|---|---|
| 2026 Q2 | 16 | $287.9M | 54 | ||
| 2026 Q1 | 20 | $360.2M | 46 | ||
| 2025 Q4 | 21 | $318.1M | 60 | ||
| 2025 Q3 | 25 | $273.0M | 54 | ||
| 2025 Q2 | 29 | $260.1M | 0 | ||
| 2025 Q1 | 31 | $264.4M | 100 | ||
| 2024 Q4 | 31 | $419.1M | 0 | ||
| 2024 Q3 | 28 | $484.0M | 0 | ||
| 2024 Q2 | 28 | $447.1M | 0 | ||
| 2024 Q1 | 26 | $446.6M | 0 | ||
| 2023 Q4 | 25 | $377.0M | 0 | ||
| 2023 Q3 | 26 | $347.5M | 0 | ||
| 2023 Q2 | 24 | $401.4M | 0 | ||
| 2023 Q1 | 24 | $391.0M | 0 | ||
| 2022 Q4 | 21 | $372.1M | 0 | ||
| 2022 Q3 | 21 | $522.0M | 0 | ||
| 2022 Q2 | 21 | $404.2M | 0 | ||
| 2022 Q1 | 19 | $457.8M | 0 | ||
| 2021 Q4 | 17 | $532.8M | 0 | ||
| 2021 Q3 | 16 | $492.5M | 0 | ||
| 2021 Q2 | 12 | $397.3M | 51 | ||
| 2021 Q1 | 11 | $555.4M | 87 | ||
| 2020 Q4 | 10 | $296.9M | 39 | ||
| 2020 Q3 | 9 | $380.3M | 19 | ||
| 2020 Q2 | 9 | $456.6M | 47 | ||
| 2020 Q1 | 8 | $323.0M | 39 | ||
| 2019 Q4 | 9 | $464.8M | 0 |
💡
Data Source Notice: AlphaSMO is the web's most authoritative 13F / Inside Trader database. Institutional holdings and insider trades presented here are precisely computed to deliver accurate portfolio reporting.
Holding changes this quarter
5AM Venture Management, LLC's most significant position changes for 2026-06-30: Sold out: Erasca Inc (ERAS); Sold out: Centessa Pharmaceuticals-adr (260); Sold out: GH Research PLC (GHRS); Sold out: Rallybio CORP (RLYB); Trim: Surrozen Inc (SRZN) — shares -30.00%.
| # | Ticker | Issuer | Weight Change | Shares Change | Action |
|---|---|---|---|---|---|
| 1 | MPLT | Maplight Therapeutics Inc | +6.5% | — | Unchanged |
| 2 | ZNTL | Zentalis Pharmaceuticals Inc | +4.1% | — | Unchanged |
| 3 | ARTV | Artiva Biotherapeutics Inc | +3.7% | — | Unchanged |
| 4 | PHVS | Pharvaris N.V. | +3.3% | — | Unchanged |
| 5 | BHVN | Biohaven Ltd. | +2.1% | — | Unchanged |
| 6 | CLDX | Celldex Therapeutics Inc | +2.1% | — | Unchanged |
| 7 | TECX | Tectonic Therapeutic Inc | +2% | — | Unchanged |
| 8 | CAMP | Camp4 Therapeutics CORP | +1.7% | — | Unchanged |
| 9 | EYPT | Eyepoint Inc | +1.5% | — | Unchanged |
| 10 | SLN | Silence Therapeutics Plc-adr | +1.1% | — | Unchanged |
| 11 | SKYE | Skye Bioscience Inc | +0.7% | — | Unchanged |
| 12 | ALXO | Alx Oncology Holdings Inc | +0.5% | — | Unchanged |
| 13 | TYRA | Tyra Biosciences Inc | +0.5% | — | Unchanged |
| 14 | TARA | Protara Therapeutic Inc | -0.2% | — | Unchanged |
| 15 | SRZN | Surrozen Inc | -0.7% | -30.00% | Trim |
| 16 | RLYB | Rallybio CORP | -0.7% | EXIT | Sold out |
| 17 | GHRS | GH Research PLC | -2.2% | EXIT | Sold out |
| 18 | TRDA | Entrada Therapeutics Inc | -3.8% | — | Unchanged |
| 19 | 260 | Centessa Pharmaceuticals-adr | -6.4% | EXIT | Sold out |
| 20 | ERAS | Erasca Inc | -15.7% | EXIT | Sold out |
Filing History
FAQ
What is 5AM Venture Management, LLC and what type of investor is it?
5AM Venture Management, LLC is an investment manager that files SEC Form 13F quarterly, disclosing its U.S. public equity holdings to regulators. As of the most recent reporting period (2026-06-30), the firm manages a tracked equity portfolio valued at approximately $287.9M, spread across 16 disclosed positions.
What are 5AM Venture Management, LLC's largest equity positions?
Based on the latest 13F filing, 5AM Venture Management, LLC's top holdings by market value are:
1. Maplight Therapeutics Inc (MPLT) — $34.0M (11.8%)
2. Tyra Biosciences Inc (TYRA) — $32.9M (11.4%)
3. Entrada Therapeutics Inc (TRDA) — $29.9M (10.4%)
4. Pharvaris N.V. (PHVS) — $27.6M (9.6%)
5. Camp4 Therapeutics CORP (CAMP) — $25.6M (8.9%)
What changes did 5AM Venture Management, LLC make in its most recent portfolio filing?
In the latest quarter, 5AM Venture Management, LLC took a more defensive posture — trimming 1 positions and completely exiting 4 holdings. The largest of these moves: Sold out: Erasca Inc (ERAS); Sold out: Centessa Pharmaceuticals-adr (260); Sold out: GH Research PLC (GHRS); Sold out: Rallybio CORP (RLYB); Trim: Surrozen Inc (SRZN) — shares -30.00%
What sectors does 5AM Venture Management, LLC focus on?
Sector breakdown data is not yet available for 5AM Venture Management, LLC. Check back after the next 13F processing cycle.
Investment Profile
5AM Venture Management, LLC returned an annualized -22.8% over the trailing 36 months — underperforming the S&P 500 by 34.0 points — based on a reconstructed track record of its disclosed 13F positions, with a beta of 1.46 (more volatile than the market) and a 42% quarterly batting average against the index.
Its portfolio is broadly diversified and moderately active.
Its turnover score has risen from 0 to 54 over the past 4 quarters — a shift toward more active trading.
It has added to its MPLT position over the past two quarters (+$17.4M, now $34.0M), while trimming CAMP over the same stretch (-$10.3M, still holding $25.6M).
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Developer Access
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REST API
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