目前共有 23 家機構持有 XLO，以下依持股市值由高至低排序。
| 主要持有機構 | 總市值 | 平均佔比 |
|---|---|---|
| Bain Capital Life Sciences Investors, LLC | US$558.4萬 | 0.50% |
| Frazier Life Sciences Management, L.P. | US$355.3萬 | 0.09% |
| Sio Capital Management, LLC | US$128.2萬 | 0.18% |
| VANGUARD CAPITAL MANAGEMENT LLC | US$104.0萬 | 0.00% |
| Caligan Partners LP | US$94.3萬 | 0.06% |
| Merck & Co., Inc. | US$89.1萬 | 0.26% |
| Stonepine Capital Management, LLC | US$54.0萬 | 0.22% |
| MORGAN STANLEY | US$48.4萬 | 0.00% |
| RENAISSANCE TECHNOLOGIES LLC | US$41.7萬 | 0.00% |
| AJU IB Investment Co., Ltd. | US$40.1萬 | 1.31% |
| GEODE CAPITAL MANAGEMENT, LLC | US$31.3萬 | 0.00% |
| FMR LLC | US$30.7萬 | 0.00% |
| VANGUARD FIDUCIARY TRUST CO | US$23.9萬 | 0.00% |
| GSA CAPITAL PARTNERS LLP | US$14.3萬 | 0.01% |
| Velan Capital Investment Management LP | US$12.0萬 | 0.08% |
| Ghisallo Capital Management LLC | US$11.6萬 | 0.00% |
| STATE STREET CORP | US$11.2萬 | 0.00% |
| CWM, LLC | US$3.5萬 | 0.00% |
| UBS Group AG | US$3.4萬 | 0.00% |
| JPMORGAN CHASE & CO | US$1976.0 | 0.00% |
| Vanguard Global Advisers, LLC | US$1766.0 | 0.00% |
| ROYAL BANK OF CANADA | US$1000.0 | 0.00% |
| Key Financial Inc | US$496.0 | 0.00% |