| RA CAPITAL MANAGEMENT, L.P. | $1655.3万 | 0.18% |
| ACORN CAPITAL ADVISORS, LLC | $1175.6万 | 3.34% |
| StepStone Group LP | $1101.5万 | 5.31% |
| ADAR1 Capital Management, LLC | $1008.1万 | 0.59% |
| Prosight Management, LP | $891.9万 | 1.46% |
| BVF INC/IL | $819.3万 | 0.26% |
| Vivo Capital, LLC | $798.1万 | 0.66% |
| Vestal Point Capital, LP | $761.7万 | 0.21% |
| Foresite Capital Management VI LLC | $598.6万 | 1.30% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | $498.8万 | 0.01% |
| Sio Capital Management, LLC | $446.7万 | 0.64% |
| VANGUARD CAPITAL MANAGEMENT LLC | $241.1万 | 0.00% |
| NEA Management Company, LLC | $198.1万 | 0.11% |
| Rosalind Advisors, Inc. | $183.7万 | 0.74% |
| RENAISSANCE TECHNOLOGIES LLC | $156.2万 | 0.00% |
| Carlyle Group Inc. | $111.7万 | 0.01% |
| Affinity Asset Advisors, LLC | $99.8万 | 0.05% |
| Sofinnova Investments, Inc. | $58.7万 | 0.02% |
| Stonepine Capital Management, LLC | $54.9万 | 0.22% |
| Shay Capital LLC | $54.7万 | 0.05% |
| CANTOR FITZGERALD, L. P. | $41.4万 | 0.01% |
| GEODE CAPITAL MANAGEMENT, LLC | $40.9万 | 0.00% |
| Rangeley Capital, LLC | $39.3万 | 0.38% |
| Aisling Capital Management LP | $36.7万 | 0.08% |
| BlackRock, Inc. | $20.5万 | 0.00% |
| VANGUARD FIDUCIARY TRUST CO | $18.0万 | 0.00% |
| Aldebaran Capital, LLC | $16.7万 | 0.13% |
| CITADEL ADVISORS LLC | $15.6万 | 0.00% |
| HRT FINANCIAL LP | $15.3万 | 0.00% |
| MARSHALL WACE, LLP | $15.1万 | 0.00% |
| XTX Topco Ltd | $14.1万 | 0.00% |
| MILLENNIUM MANAGEMENT LLC | $12.6万 | 0.00% |
| JANE STREET GROUP, LLC | $11.1万 | 0.00% |
| BARCLAYS PLC | $10.4万 | 0.00% |
| TWO SIGMA INVESTMENTS, LP | $10.0万 | 0.00% |
| GSA CAPITAL PARTNERS LLP | $9.2万 | 0.01% |
| NORTHERN TRUST CORP | $8.2万 | 0.00% |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | $6.7万 | 0.00% |
| MORGAN STANLEY | $5.9万 | 0.00% |
| WELLS FARGO & COMPANY/MN | $5.6万 | 0.00% |
| STATE STREET CORP | $5.6万 | 0.00% |
| NewEdge Advisors, LLC | $4.5万 | 0.00% |
| UBS Group AG | $1.4万 | 0.00% |
| Vanguard Global Advisers, LLC | $3084.0 | 0.00% |
| ROYAL BANK OF CANADA | $1000.0 | 0.00% |
| TRUST CO OF TOLEDO NA /OH/ | $563.0 | 0.00% |
| OSAIC HOLDINGS, INC. | $372.0 | 0.00% |
| JPMORGAN CHASE & CO | $171.0 | 0.00% |
| BNP PARIBAS FINANCIAL MARKETS | $11.6 | 0.00% |
| CITIGROUP INC | $4.0 | 0.00% |