| BAKER BROS. ADVISORS LP | $1.1B | 6.44% |
| JANUS HENDERSON GROUP PLC | $1.1B | 0.50% |
| RTW INVESTMENTS, LP | $1.0B | 10.38% |
| Avoro Capital Advisors LLC | $951.8M | 9.36% |
| BlackRock, Inc. | $816.6M | 0.01% |
| PAULSON & CO. INC. | $728.8M | 23.42% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $440.3M | 0.02% |
| VANGUARD CAPITAL MANAGEMENT LLC | $433.0M | 0.01% |
| WELLINGTON MANAGEMENT GROUP LLP | $363.8M | 0.07% |
| STATE STREET CORP | $319.1M | 0.01% |
| CITADEL ADVISORS LLC | $315.4M | 0.05% |
| FMR LLC | $267.9M | 0.01% |
| GEODE CAPITAL MANAGEMENT, LLC | $238.7M | 0.01% |
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | $178.3M | 0.59% |
| Invesco Ltd. | $172.5M | 0.03% |
| PRICE T ROWE ASSOCIATES INC /MD/ | $171.8M | 0.02% |
| Polar Capital Holdings Plc | $151.4M | 0.54% |
| GOLDMAN SACHS GROUP INC | $145.2M | 0.02% |
| ARMISTICE CAPITAL, LLC | $138.5M | 2.46% |
| Hood River Capital Management LLC | $130.6M | 1.31% |
| LORD, ABBETT & CO. LLC | $127.1M | 0.41% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $126.0M | 0.01% |
| JANE STREET GROUP, LLC | $125.2M | 0.02% |
| Point72 Asset Management, L.P. | $123.0M | 0.16% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $113.4M | 0.02% |
| MORGAN STANLEY | $100.1M | 0.01% |
| BANK OF AMERICA CORP /DE/ | $99.2M | 0.01% |
| Pictet Asset Management Holding SA | $97.9M | 0.10% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | $97.0M | 0.15% |
| Artisan Partners Limited Partnership | $96.1M | 0.15% |
| Fiera Capital Corp | $91.1M | 0.31% |
| Rock Springs Capital Management LP | $89.5M | 5.28% |
| AMERICAN CENTURY COMPANIES INC | $85.8M | 0.04% |
| Erste Asset Management GmbH | $81.0M | 0.75% |
| NORTHERN TRUST CORP | $78.1M | 0.01% |
| Caption Management, LLC | $73.3M | 0.43% |
| ALLIANCEBERNSTEIN L.P. | $73.1M | 0.02% |
| Bank of New York Mellon Corp | $71.1M | 0.01% |
| TORONTO DOMINION BANK | $68.3M | 0.10% |
| VANGUARD FIDUCIARY TRUST CO | $67.0M | 0.02% |
| D. E. Shaw & Co., Inc. | $66.7M | 0.04% |
| Woodline Partners LP | $65.9M | 0.25% |
| UBS Group AG | $61.7M | 0.01% |
| Driehaus Capital Management LLC | $58.1M | 0.43% |
| Tri Locum Partners LP | $54.1M | 7.59% |
| AMERIPRISE FINANCIAL INC | $51.4M | 0.01% |
| DEUTSCHE BANK AG\ | $51.3M | 0.02% |
| WESTFIELD CAPITAL MANAGEMENT CO LP | $49.6M | 0.21% |
| 683 Capital Management, LLC | $47.1M | 2.46% |
| Logos Global Management LP | $44.5M | 2.22% |
| Candriam S.C.A. | $44.5M | 0.23% |
| ALKEON CAPITAL MANAGEMENT LLC | $41.9M | 0.07% |
| NEW YORK STATE COMMON RETIREMENT FUND | $39.3M | 0.05% |
| FRANKLIN RESOURCES INC | $38.8M | 0.01% |
| GROUP ONE TRADING LLC | $38.2M | 0.07% |
| RENAISSANCE TECHNOLOGIES LLC | $37.6M | 0.06% |
| Squarepoint Ops LLC | $36.7M | 0.04% |
| RAYMOND JAMES FINANCIAL INC | $34.1M | 0.01% |
| CITIGROUP INC | $33.8M | 0.01% |
| ArrowMark Colorado Holdings LLC | $32.7M | 0.87% |
| Nuveen, LLC | $32.5M | 0.01% |
| VOYA INVESTMENT MANAGEMENT LLC | $31.4M | 0.03% |
| Affinity Asset Advisors, LLC | $28.8M | 1.49% |
| EULAV Asset Management | $25.7M | 0.82% |
| Russell Investments Group, Ltd. | $23.3M | 0.03% |
| Mirae Asset Global Investments Co., Ltd. | $21.4M | 0.01% |
| MILLENNIUM MANAGEMENT LLC | $21.4M | 0.01% |
| SCHRODER INVESTMENT MANAGEMENT GROUP | $20.1M | 0.02% |
| EMERALD ADVISERS, LLC | $19.7M | 0.62% |
| GROUPAMA ASSET MANAGMENT | $18.4M | 0.27% |
| JPMORGAN CHASE & CO | $18.4M | 0.00% |
| PFM Health Sciences, LP | $17.9M | 1.63% |
| Rockefeller Capital Management L.P. | $17.7M | 0.03% |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | $17.2M | 0.02% |
| WELLS FARGO & COMPANY/MN | $16.9M | 0.00% |
| SEGALL BRYANT & HAMILL, LLC | $16.7M | 0.24% |
| Vestal Point Capital, LP | $16.5M | 0.46% |
| GILDER GAGNON HOWE & CO LLC | $15.4M | 0.18% |
| Swiss National Bank | $15.3M | 0.01% |
| SIMPLEX TRADING, LLC | $15.3M | 0.01% |
| Connor, Clark & Lunn Investment Management Ltd. | $14.6M | 0.03% |
| Integral Health Asset Management, LLC | $13.1M | 0.63% |
| IMC-Chicago, LLC | $13.1M | 0.00% |
| Clearbridge Investments, LLC | $12.8M | 0.01% |
| SEI INVESTMENTS CO | $12.7M | 0.01% |
| Rhenman & Partners Asset Management AB | $12.6M | 1.55% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | $12.5M | 0.00% |
| California Public Employees Retirement System | $12.1M | 0.01% |
| WCM INVESTMENT MANAGEMENT, LLC | $11.9M | 0.03% |
| FIRST TRUST ADVISORS LP | $11.6M | 0.01% |
| MARSHALL WACE, LLP | $11.5M | 0.01% |
| RHUMBLINE ADVISERS | $11.4M | 0.01% |
| Tao Capital Management LP | $11.0M | 9.25% |
| Universal- Beteiligungs- und Servicegesellschaft mbH | $9.7M | 0.02% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | $8.9M | 0.01% |
| FEDERATED HERMES, INC. | $8.8M | 0.01% |
| EMERALD MUTUAL FUND ADVISERS TRUST | $8.6M | 0.42% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | $8.5M | 0.01% |
| Assenagon Asset Management S.A. | $8.4M | 0.01% |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | $8.4M | 0.06% |
| AQR CAPITAL MANAGEMENT LLC | $8.4M | 0.00% |
| ENVESTNET ASSET MANAGEMENT INC | $8.1M | 0.00% |
| Cinctive Capital Management LP | $8.0M | 0.52% |
| Walleye Capital LLC | $7.6M | 0.03% |
| VANGUARD ASSET MANAGEMENT, Ltd | $7.4M | 0.01% |
| HighTower Advisors, LLC | $7.3M | 0.01% |
| STATE OF WISCONSIN INVESTMENT BOARD | $7.0M | 0.02% |
| Rheos Capital Works Inc. | $6.9M | 0.46% |
| NEUBERGER BERMAN GROUP LLC | $6.7M | 0.01% |
| JOURNEY STRATEGIC WEALTH LLC | $6.7M | 0.17% |
| ROYAL BANK OF CANADA | $6.6M | 0.00% |
| CANADA PENSION PLAN INVESTMENT BOARD | $6.4M | 0.00% |
| TD Asset Management Inc | $6.3M | 0.01% |
| MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC | $6.3M | 0.07% |
| Creative Planning | $6.3M | 0.00% |
| Legal & General Group Plc | $6.2M | 0.00% |
| TUDOR INVESTMENT CORP ET AL | $6.1M | 0.01% |
| Rafferty Asset Management, LLC | $5.5M | 0.02% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | $5.3M | 0.01% |
| Eversept Partners, LP | $5.2M | 0.28% |
| PEAK6 LLC | $5.2M | 0.01% |
| EFG International AG | $5.1M | 0.11% |
| LPL Financial LLC | $4.9M | 0.00% |
| MetLife Investment Management, LLC | $4.9M | 0.02% |
| SPHERA FUNDS MANAGEMENT LTD. | $4.7M | 0.75% |
| Hennion & Walsh Asset Management, Inc. | $4.5M | 0.15% |
| DIMENSIONAL FUND ADVISORS LP | $4.5M | 0.00% |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | $4.4M | 0.28% |
| ALGERT GLOBAL LLC | $4.3M | 0.06% |
| Vanguard Global Advisers, LLC | $4.2M | 0.00% |
| DekaBank Deutsche Girozentrale | $4.1M | 0.01% |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | $3.7M | 0.01% |
| PRUDENTIAL FINANCIAL INC | $3.6M | 0.00% |
| Susquehanna Portfolio Strategies, LLC | $3.3M | 0.05% |
| VICTORY CAPITAL MANAGEMENT INC | $3.1M | 0.00% |
| Nan Fung Group Holdings Ltd | $3.0M | 2.45% |
| Entropy Technologies, LP | $2.9M | 0.14% |
| ExodusPoint Capital Management, LP | $2.9M | 0.02% |
| Pathstone Holdings, LLC | $2.9M | 0.01% |
| Handelsbanken Fonder AB | $2.8M | 0.01% |
| BAMCO INC /NY/ | $2.8M | 0.01% |
| CASTLEARK MANAGEMENT LLC | $2.8M | 0.09% |
| State of New Jersey Common Pension Fund D | $2.6M | 0.01% |
| PROFUND ADVISORS LLC | $2.5M | 0.09% |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | $2.4M | 0.00% |
| Police & Firemen's Retirement System of New Jersey | $2.4M | 0.02% |
| MARTINGALE ASSET MANAGEMENT L P | $2.3M | 0.06% |
| ASSETMARK, INC | $2.3M | 0.00% |
| China Universal Asset Management Co., Ltd. | $2.2M | 0.17% |
| INTECH INVESTMENT MANAGEMENT LLC | $2.2M | 0.02% |