| FMR LLC | $974.5M | 0.05% |
| BAKER BROS. ADVISORS LP | $721.1M | 4.14% |
| Avoro Capital Advisors LLC | $622.6M | 6.12% |
| PRICE T ROWE ASSOCIATES INC /MD/ | $504.8M | 0.06% |
| BVF INC/IL | $458.3M | 14.60% |
| T. Rowe Price Investment Management, Inc. | $455.2M | 0.31% |
| BlackRock, Inc. | $421.5M | 0.01% |
| Atlas Venture Life Science Advisors, LLC | $381.3M | 48.26% |
| WELLINGTON MANAGEMENT GROUP LLP | $324.0M | 0.06% |
| Siren, L.L.C. | $265.4M | 7.36% |
| VANGUARD CAPITAL MANAGEMENT LLC | $239.9M | 0.01% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $239.4M | 0.01% |
| STATE STREET CORP | $199.0M | 0.01% |
| Capital Research Global Investors | $139.4M | 0.02% |
| GEODE CAPITAL MANAGEMENT, LLC | $137.1M | 0.01% |
| Driehaus Capital Management LLC | $86.9M | 0.64% |
| UBS Group AG | $85.3M | 0.01% |
| GOLDMAN SACHS GROUP INC | $74.0M | 0.01% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | $73.0M | 0.02% |
| Holocene Advisors, LP | $69.7M | 0.17% |
| ALLIANCEBERNSTEIN L.P. | $69.1M | 0.02% |
| Merck & Co., Inc. | $64.3M | 18.40% |
| FRONTIER CAPITAL MANAGEMENT CO LLC | $63.3M | 0.65% |
| Commodore Capital LP | $62.5M | 3.61% |
| EVENTIDE ASSET MANAGEMENT, LLC | $52.2M | 0.86% |
| DIMENSIONAL FUND ADVISORS LP | $49.4M | 0.01% |
| DEERFIELD MANAGEMENT COMPANY, L.P. | $46.7M | 0.55% |
| FEDERATED HERMES, INC. | $44.7M | 0.07% |
| JENNISON ASSOCIATES LLC | $42.4M | 0.03% |
| Rock Springs Capital Management LP | $41.4M | 2.44% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $41.3M | 0.01% |
| NORTHERN TRUST CORP | $41.2M | 0.01% |
| Pictet Asset Management Holding SA | $38.8M | 0.04% |
| VANGUARD FIDUCIARY TRUST CO | $35.6M | 0.01% |
| Octagon Capital Advisors LP | $35.4M | 3.92% |
| FRANKLIN RESOURCES INC | $30.1M | 0.01% |
| Alyeska Investment Group, L.P. | $28.5M | 0.08% |
| BRAIDWELL LP | $28.1M | 0.94% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | $27.9M | 0.04% |
| Boxer Capital Management, LLC | $27.4M | 3.60% |
| BANK OF AMERICA CORP /DE/ | $24.1M | 0.00% |
| TD Asset Management Inc | $23.9M | 0.02% |
| Nextech Invest, Ltd. | $23.2M | 1.63% |
| TWO SIGMA INVESTMENTS, LP | $21.4M | 0.02% |
| First Turn Management, LLC | $21.2M | 2.37% |
| RTW INVESTMENTS, LP | $20.0M | 0.20% |
| GILDER GAGNON HOWE & CO LLC | $19.6M | 0.24% |
| Polar Capital Holdings Plc | $17.9M | 0.06% |
| MORGAN STANLEY | $17.7M | 0.00% |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | $17.4M | 0.01% |
| Woodline Partners LP | $17.0M | 0.06% |
| Candriam S.C.A. | $16.8M | 0.09% |
| VOYA INVESTMENT MANAGEMENT LLC | $16.6M | 0.02% |
| Bank of New York Mellon Corp | $16.1M | 0.00% |
| TimesSquare Capital Management, LLC | $14.1M | 0.24% |
| Freestone Grove Partners LP | $13.1M | 0.09% |
| CITADEL ADVISORS LLC | $13.0M | 0.00% |
| Foresite Capital Management VI LLC | $12.2M | 2.65% |
| Eagle Health Investments LP | $12.1M | 2.12% |
| WCM INVESTMENT MANAGEMENT, LLC | $12.1M | 0.03% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $11.2M | 0.00% |
| Nuveen, LLC | $10.7M | 0.00% |
| Deer Management Co. LLC | $10.5M | 1.69% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | $10.0M | 0.01% |
| JPMORGAN CHASE & CO | $10.0M | 0.00% |
| Ensign Peak Advisors, Inc | $9.5M | 0.02% |
| Invesco Ltd. | $9.2M | 0.00% |
| Connor, Clark & Lunn Investment Management Ltd. | $8.7M | 0.02% |
| Universal- Beteiligungs- und Servicegesellschaft mbH | $8.6M | 0.01% |
| Patient Square Capital LP | $8.3M | 1.48% |
| Swiss National Bank | $7.9M | 0.00% |
| FIRST TRUST ADVISORS LP | $7.8M | 0.01% |
| DEUTSCHE BANK AG\ | $7.7M | 0.00% |
| ARMISTICE CAPITAL, LLC | $7.0M | 0.12% |
| Burkehill Global Management, LP | $6.2M | 0.31% |
| Yiheng Capital Management, L.P. | $6.1M | 2.65% |
| RHUMBLINE ADVISERS | $6.0M | 0.01% |
| NEUBERGER BERMAN GROUP LLC | $5.9M | 0.00% |
| VICTORY CAPITAL MANAGEMENT INC | $5.7M | 0.00% |
| ALPS ADVISORS INC | $5.5M | 0.03% |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | $5.4M | 0.01% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | $4.7M | 0.00% |
| Rafferty Asset Management, LLC | $4.6M | 0.02% |
| FIFTH THIRD BANCORP | $4.3M | 0.01% |
| Ikarian Capital, LLC | $4.2M | 0.34% |
| Russell Investments Group, Ltd. | $4.1M | 0.00% |
| VANGUARD ASSET MANAGEMENT, Ltd | $3.7M | 0.00% |
| Informed Momentum Co LLC | $3.5M | 0.41% |
| SCHRODER INVESTMENT MANAGEMENT GROUP | $3.4M | 0.00% |
| Moody Aldrich Partners LLC | $3.2M | 0.57% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | $3.2M | 0.00% |
| STATE OF WISCONSIN INVESTMENT BOARD | $3.1M | 0.01% |
| Legal & General Group Plc | $3.1M | 0.00% |
| Monashee Investment Management LLC | $2.9M | 1.59% |
| HARBOR CAPITAL ADVISORS, INC. | $2.8M | 0.23% |
| Rockefeller Capital Management L.P. | $2.7M | 0.00% |
| Sio Capital Management, LLC | $2.7M | 0.39% |
| Zurcher Kantonalbank (Zurich Cantonalbank) | $2.7M | 0.01% |
| MetLife Investment Management, LLC | $2.6M | 0.01% |
| Nan Fung Group Holdings Ltd | $2.6M | 2.12% |
| SEVEN GRAND MANAGERS, LLC | $2.5M | 0.17% |
| ExodusPoint Capital Management, LP | $2.4M | 0.02% |
| Creative Planning | $2.4M | 0.00% |
| Nicholas Investment Partners, LP | $2.3M | 0.16% |
| Vanguard Global Advisers, LLC | $2.3M | 0.00% |
| Neo Ivy Capital Management | $2.3M | 0.59% |
| WELLS FARGO & COMPANY/MN | $2.2M | 0.00% |
| E Fund Management Co., Ltd. | $2.2M | 0.06% |
| Erste Asset Management GmbH | $2.1M | 0.02% |
| PROFUND ADVISORS LLC | $2.1M | 0.08% |
| JANE STREET GROUP, LLC | $2.1M | 0.00% |
| NEW YORK STATE COMMON RETIREMENT FUND | $1.8M | 0.00% |
| DARK FOREST CAPITAL MANAGEMENT LP | $1.8M | 0.16% |
| JANUS HENDERSON GROUP PLC | $1.8M | 0.00% |
| BAMCO INC /NY/ | $1.7M | 0.01% |
| AJU IB Investment Co., Ltd. | $1.6M | 5.36% |
| LBP AM SA | $1.6M | 0.02% |
| Handelsbanken Fonder AB | $1.5M | 0.00% |
| State of New Jersey Common Pension Fund D | $1.4M | 0.01% |
| AQR CAPITAL MANAGEMENT LLC | $1.3M | 0.00% |
| Knights of Columbus Asset Advisors LLC | $1.3M | 0.07% |
| Police & Firemen's Retirement System of New Jersey | $1.3M | 0.01% |
| Odyssean, LLC | $1.2M | 0.45% |
| BOOTHBAY FUND MANAGEMENT, LLC | $1.2M | 0.02% |
| China Universal Asset Management Co., Ltd. | $1.2M | 0.09% |
| BARCLAYS PLC | $1.2M | 0.00% |
| Susquehanna Portfolio Strategies, LLC | $1.1M | 0.02% |
| INTECH INVESTMENT MANAGEMENT LLC | $1.1M | 0.01% |
| KENNEDY CAPITAL MANAGEMENT LLC | $1.1M | 0.02% |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | $1.1M | 0.00% |
| Man Group plc | $1.1M | 0.00% |
| ARIZONA STATE RETIREMENT SYSTEM | $1.1M | 0.01% |
| GUGGENHEIM CAPITAL LLC | $1.1M | 0.01% |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | $1.1M | 0.01% |
| Squarepoint Ops LLC | $1.1M | 0.00% |
| GSA CAPITAL PARTNERS LLP | $1.1M | 0.07% |
| Schonfeld Strategic Advisors LLC | $1.0M | 0.01% |
| Vanguard Investments Australia, Ltd. | $1.0M | 0.00% |
| CITIGROUP INC | $1.0M | 0.00% |
| B. Metzler seel. Sohn & Co. AG | $1.0M | 0.01% |
| ProShare Advisors LLC | $996.3K | 0.00% |
| SEI INVESTMENTS CO | $934.9K | 0.00% |
| Proficio Capital Partners LLC | $903.3K | 0.05% |
| KLP KAPITALFORVALTNING AS | $874.5K | 0.00% |
| PRUDENTIAL FINANCIAL INC | $745.4K | 0.00% |
| Vident Advisory, LLC | $703.1K | 0.01% |
| BRANDYWINE MANAGERS, LLC | $630.5K | 0.37% |
| Keudell/Morrison Wealth Management | $582.2K | 0.12% |
| GLENMEDE TRUST CO NA | $564.6K | 0.00% |
| Blackstone Inc. | $554.7K | 0.00% |