| BlackRock, Inc. | $1.1B | 0.02% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $564.0M | 0.03% |
| Capital World Investors | $505.4M | 0.07% |
| VANGUARD CAPITAL MANAGEMENT LLC | $500.7M | 0.01% |
| LSV ASSET MANAGEMENT | $451.2M | 0.97% |
| FMR LLC | $430.2M | 0.02% |
| FRANKLIN RESOURCES INC | $370.3M | 0.09% |
| DIMENSIONAL FUND ADVISORS LP | $358.3M | 0.07% |
| STATE STREET CORP | $357.6M | 0.01% |
| EcoR1 Capital, LLC | $322.6M | 13.69% |
| Bank of New York Mellon Corp | $317.5M | 0.06% |
| FULLER & THALER ASSET MANAGEMENT, INC. | $316.9M | 1.07% |
| AMERIPRISE FINANCIAL INC | $304.1M | 0.07% |
| CITADEL ADVISORS LLC | $254.1M | 0.04% |
| AQR CAPITAL MANAGEMENT LLC | $249.9M | 0.11% |
| MILLENNIUM MANAGEMENT LLC | $243.5M | 0.10% |
| GEODE CAPITAL MANAGEMENT, LLC | $234.0M | 0.01% |
| JPMORGAN CHASE & CO | $220.6M | 0.01% |
| BANK OF AMERICA CORP /DE/ | $191.8M | 0.01% |
| Swedbank AB | $187.6M | 0.20% |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | $167.3M | 0.19% |
| RENAISSANCE TECHNOLOGIES LLC | $154.9M | 0.24% |
| Holocene Advisors, LP | $138.7M | 0.33% |
| MORGAN STANLEY | $132.1M | 0.01% |
| Allianz Asset Management GmbH | $115.4M | 0.12% |
| Sofinnova Investments, Inc. | $113.1M | 4.30% |
| GMT Capital Corp | $109.8M | 5.01% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | $101.2M | 0.09% |
| FRONTIER CAPITAL MANAGEMENT CO LLC | $97.8M | 1.01% |
| Pacer Advisors, Inc. | $95.1M | 0.27% |
| Boston Trust Walden Corp | $92.4M | 0.76% |
| NORTHERN TRUST CORP | $92.4M | 0.01% |
| GOLDENTREE ASSET MANAGEMENT LP | $89.8M | 5.32% |
| WELLINGTON MANAGEMENT GROUP LLP | $86.6M | 0.02% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $83.3M | 0.01% |
| Polaris Capital Management, LLC | $78.5M | 6.42% |
| Alyeska Investment Group, L.P. | $77.7M | 0.22% |
| SYSTEMATIC FINANCIAL MANAGEMENT LP | $77.0M | 1.76% |
| VANGUARD FIDUCIARY TRUST CO | $70.8M | 0.02% |
| GW&K Investment Management, LLC | $70.2M | 0.62% |
| Zurcher Kantonalbank (Zurich Cantonalbank) | $69.1M | 0.15% |
| Point72 Asset Management, L.P. | $68.9M | 0.09% |
| UBS Group AG | $67.5M | 0.01% |
| Nuveen, LLC | $65.4M | 0.02% |
| AMERICAN CENTURY COMPANIES INC | $62.1M | 0.03% |
| Assenagon Asset Management S.A. | $60.5M | 0.09% |
| D. E. Shaw & Co., Inc. | $56.4M | 0.03% |
| JANE STREET GROUP, LLC | $52.7M | 0.01% |
| Qube Research & Technologies Ltd | $49.6M | 0.06% |
| VICTORY CAPITAL MANAGEMENT INC | $48.5M | 0.03% |
| GOLDMAN SACHS GROUP INC | $47.3M | 0.01% |
| Rockefeller Capital Management L.P. | $47.1M | 0.08% |
| Invesco Ltd. | $46.3M | 0.01% |
| BANK OF MONTREAL /CAN/ | $45.2M | 0.02% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $44.8M | 0.01% |
| THOMPSON SIEGEL & WALMSLEY LLC | $44.2M | 0.77% |
| LOOMIS SAYLES & CO L P | $38.9M | 0.05% |
| SG Americas Securities, LLC | $37.8M | 0.04% |
| Quantinno Capital Management LP | $36.2M | 0.06% |
| RAYMOND JAMES FINANCIAL INC | $34.6M | 0.01% |
| ExodusPoint Capital Management, LP | $33.8M | 0.27% |
| PFM Health Sciences, LP | $33.7M | 3.07% |
| Jefferies Financial Group Inc. | $33.2M | 0.23% |
| PERCEPTIVE ADVISORS LLC | $32.1M | 0.63% |
| Retirement Systems of Alabama | $32.0M | 0.11% |
| Pictet Asset Management Holding SA | $31.8M | 0.03% |
| Krensavage Asset Management, LLC | $31.7M | 12.41% |
| RHUMBLINE ADVISERS | $31.1M | 0.03% |
| Saturn V Capital Management LP | $30.8M | 5.58% |
| WEDGE CAPITAL MANAGEMENT L L P/NC | $30.2M | 0.56% |
| Tri Locum Partners LP | $30.0M | 4.21% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | $27.9M | 0.01% |
| SEI INVESTMENTS CO | $27.8M | 0.03% |
| Legal & General Group Plc | $27.5M | 0.01% |
| PANAGORA ASSET MANAGEMENT INC | $27.1M | 0.10% |
| Perpetual Ltd | $26.6M | 0.41% |
| STIFEL FINANCIAL CORP | $26.4M | 0.02% |
| PRINCIPAL FINANCIAL GROUP INC | $25.6M | 0.01% |
| Man Group plc | $25.6M | 0.05% |
| Universal- Beteiligungs- und Servicegesellschaft mbH | $25.5M | 0.04% |
| Aristotle Capital Management, LLC | $24.7M | 0.05% |
| CITIGROUP INC | $23.7M | 0.01% |
| California Public Employees Retirement System | $23.6M | 0.01% |
| Robeco Institutional Asset Management B.V. | $23.3M | 0.03% |
| Aberdeen Group plc | $21.6M | 0.03% |
| DekaBank Deutsche Girozentrale | $21.4M | 0.04% |
| CANADA PENSION PLAN INVESTMENT BOARD | $21.3M | 0.01% |
| ALLIANCEBERNSTEIN L.P. | $21.0M | 0.01% |
| STOREBRAND ASSET MANAGEMENT AS | $20.6M | 0.06% |
| Swiss National Bank | $20.5M | 0.01% |
| KBC Group NV | $19.3M | 0.05% |
| Engineers Gate Manager LP | $17.6M | 0.22% |
| Gotham Asset Management, LLC | $17.3M | 0.05% |
| FIRST TRUST ADVISORS LP | $17.3M | 0.01% |
| Walleye Capital LLC | $17.2M | 0.07% |
| ENVESTNET ASSET MANAGEMENT INC | $16.9M | 0.00% |
| Rhenman & Partners Asset Management AB | $14.3M | 1.77% |
| SummitTX Capital, L.P. | $13.8M | 0.43% |
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | $13.4M | 0.04% |
| WELLS FARGO & COMPANY/MN | $12.9M | 0.00% |
| VOYA INVESTMENT MANAGEMENT LLC | $12.1M | 0.01% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | $12.0M | 0.01% |
| PUBLIC EMPLOYEES RETIREMENT ASSOCIATION OF COLORADO | $11.8M | 0.05% |
| Schonfeld Strategic Advisors LLC | $11.7M | 0.08% |
| Illinois Municipal Retirement Fund | $11.7M | 0.15% |
| Tweedy, Browne Co LLC | $11.4M | 0.90% |
| NOMURA HOLDINGS INC | $11.4M | 0.03% |
| PRICE T ROWE ASSOCIATES INC /MD/ | $10.6M | 0.00% |
| Amundi | $10.5M | 0.00% |
| Russell Investments Group, Ltd. | $10.4M | 0.01% |
| ACADIAN ASSET MANAGEMENT LLC | $10.4M | 0.01% |
| DIADEMA PARTNERS LP | $10.4M | 1.76% |
| VAN ECK ASSOCIATES CORP | $10.2M | 0.01% |
| Portman Square Capital LLP | $10.0M | 0.39% |
| ALGERT GLOBAL LLC | $9.9M | 0.15% |
| Rokos Capital Management LLP | $9.8M | 0.07% |
| Simplify Asset Management Inc. | $9.8M | 0.15% |
| RENAISSANCE GROUP LLC | $9.7M | 0.40% |
| Hennion & Walsh Asset Management, Inc. | $9.3M | 0.31% |
| VANGUARD ASSET MANAGEMENT, Ltd | $9.3M | 0.01% |
| GREAT LAKES ADVISORS, LLC | $9.3M | 0.08% |
| CASTLEARK MANAGEMENT LLC | $9.2M | 0.30% |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | $9.2M | 0.03% |
| MARTINGALE ASSET MANAGEMENT L P | $8.8M | 0.22% |
| SEB Asset Management AB | $8.8M | 0.04% |
| Cerity Partners LLC | $8.6M | 0.01% |
| ROYAL BANK OF CANADA | $8.6M | 0.00% |
| BTC Capital Management, Inc. | $8.3M | 0.56% |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | $8.2M | 0.01% |
| Susquehanna Portfolio Strategies, LLC | $8.2M | 0.12% |
| LAZARD ASSET MANAGEMENT LLC | $8.1M | 0.01% |
| State of Alaska, Department of Revenue | $7.9M | 0.09% |
| DEAN INVESTMENT ASSOCIATES, LLC | $7.9M | 1.12% |
| Vanguard Global Advisers, LLC | $7.7M | 0.00% |
| Faithward Advisors, LLC | $7.7M | 1.10% |
| Mariner, LLC | $7.6M | 0.01% |
| IFP Advisors, Inc | $7.4M | 0.15% |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | $7.3M | 0.01% |
| LPL Financial LLC | $6.8M | 0.00% |
| HARVEY CAPITAL MANAGEMENT INC | $6.7M | 1.52% |
| Cinctive Capital Management LP | $6.6M | 0.43% |
| O'SHAUGHNESSY ASSET MANAGEMENT, LLC | $6.5M | 0.03% |
| INTECH INVESTMENT MANAGEMENT LLC | $6.5M | 0.06% |
| STATE OF WISCONSIN INVESTMENT BOARD | $6.4M | 0.01% |
| Lighthouse Investment Partners, LLC | $6.4M | 0.22% |
| NEW YORK STATE COMMON RETIREMENT FUND | $6.0M | 0.01% |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | $5.9M | 0.01% |
| NEW YORK STATE TEACHERS RETIREMENT SYSTEM | $5.7M | 0.01% |
| MetLife Investment Management, LLC | $5.6M | 0.03% |
| LOS ANGELES CAPITAL MANAGEMENT LLC | $5.6M | 0.02% |