| FMR LLC | $438.9M | 0.02% |
| BlackRock, Inc. | $281.3M | 0.00% |
| JANUS HENDERSON GROUP PLC | $242.0M | 0.12% |
| Capital Research Global Investors | $172.0M | 0.03% |
| BAKER BROS. ADVISORS LP | $131.5M | 0.76% |
| STATE STREET CORP | $126.0M | 0.00% |
| VANGUARD CAPITAL MANAGEMENT LLC | $124.4M | 0.00% |
| Logos Global Management LP | $115.0M | 5.74% |
| FEDERATED HERMES, INC. | $99.5M | 0.16% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | $94.1M | 0.15% |
| Fiera Capital Corp | $84.2M | 0.29% |
| GEODE CAPITAL MANAGEMENT, LLC | $83.3M | 0.01% |
| GOLDMAN SACHS GROUP INC | $63.8M | 0.01% |
| MORGAN STANLEY | $62.0M | 0.00% |
| DEERFIELD MANAGEMENT COMPANY, L.P. | $51.0M | 0.60% |
| GSK plc | $44.4M | 7.41% |
| DIMENSIONAL FUND ADVISORS LP | $44.4M | 0.01% |
| PRICE T ROWE ASSOCIATES INC /MD/ | $43.8M | 0.01% |
| Sofinnova Investments, Inc. | $37.7M | 1.43% |
| Candriam S.C.A. | $36.9M | 0.19% |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | $36.7M | 0.04% |
| Caption Management, LLC | $35.9M | 0.21% |
| BANK OF AMERICA CORP /DE/ | $31.4M | 0.00% |
| Ensign Peak Advisors, Inc | $30.0M | 0.06% |
| Fisher Asset Management, LLC | $29.4M | 0.01% |
| First Turn Management, LLC | $29.1M | 3.25% |
| CITADEL ADVISORS LLC | $25.8M | 0.00% |
| UBS Group AG | $25.4M | 0.00% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $24.8M | 0.00% |
| NORTHERN TRUST CORP | $24.5M | 0.00% |
| Pictet Asset Management Holding SA | $23.9M | 0.03% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $23.8M | 0.00% |
| Qube Research & Technologies Ltd | $19.5M | 0.02% |
| VANGUARD FIDUCIARY TRUST CO | $18.7M | 0.00% |
| Aberdeen Group plc | $18.2M | 0.03% |
| Redmile Group, LLC | $17.4M | 1.15% |
| NEW YORK STATE COMMON RETIREMENT FUND | $17.2M | 0.02% |
| DAFNA Capital Management LLC | $15.9M | 3.61% |
| TANG CAPITAL MANAGEMENT LLC | $15.0M | 0.76% |
| Nuveen, LLC | $14.9M | 0.00% |
| DEUTSCHE BANK AG\ | $12.6M | 0.00% |
| MILLENNIUM MANAGEMENT LLC | $11.9M | 0.00% |
| Point72 Asset Management, L.P. | $10.9M | 0.01% |
| GENERAL AMERICAN INVESTORS CO INC | $9.3M | 0.61% |
| JPMORGAN CHASE & CO | $9.2M | 0.00% |
| JANE STREET GROUP, LLC | $8.9M | 0.00% |
| ENVESTNET ASSET MANAGEMENT INC | $8.5M | 0.00% |
| JENNISON ASSOCIATES LLC | $8.5M | 0.01% |
| Rhenman & Partners Asset Management AB | $8.5M | 1.05% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $8.4M | 0.00% |
| Bank of New York Mellon Corp | $8.3M | 0.00% |
| Nicholas Investment Partners, LP | $8.3M | 0.60% |
| WELLS FARGO & COMPANY/MN | $8.1M | 0.00% |
| AMERICAN CENTURY COMPANIES INC | $8.0M | 0.00% |
| FRANKLIN RESOURCES INC | $7.7M | 0.00% |
| Squadron Capital Management LLC | $7.5M | 2.74% |
| Balyasny Asset Management L.P. | $6.9M | 0.01% |
| Susquehanna Portfolio Strategies, LLC | $6.7M | 0.10% |
| Woodline Partners LP | $6.7M | 0.03% |
| Hudson Bay Capital Management LP | $6.5M | 0.02% |
| Alyeska Investment Group, L.P. | $6.4M | 0.02% |
| Connor, Clark & Lunn Investment Management Ltd. | $5.9M | 0.01% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | $5.8M | 0.00% |
| Man Group plc | $5.7M | 0.01% |
| WCM INVESTMENT MANAGEMENT, LLC | $5.7M | 0.01% |
| SummitTX Capital, L.P. | $5.4M | 0.17% |
| ROYAL BANK OF CANADA | $5.4M | 0.00% |
| VICTORY CAPITAL MANAGEMENT INC | $5.2M | 0.00% |
| Swiss National Bank | $5.2M | 0.00% |
| Creative Planning | $4.8M | 0.00% |
| GREAT LAKES ADVISORS, LLC | $4.7M | 0.04% |
| Russell Investments Group, Ltd. | $4.5M | 0.00% |
| FIDEURAM - INTESA SANPAOLO PRIVATE BANKING S.P.A. | $4.1M | 0.14% |
| NEUBERGER BERMAN GROUP LLC | $4.0M | 0.00% |
| Atle Fund Management AB | $4.0M | 1.30% |
| TWO SIGMA INVESTMENTS, LP | $4.0M | 0.00% |
| Tema ETFs LLC | $3.7M | 0.25% |
| Tidal Investments LLC | $3.7M | 0.01% |
| Invesco Ltd. | $3.7M | 0.00% |
| RHUMBLINE ADVISERS | $3.6M | 0.00% |
| ALLIANCEBERNSTEIN L.P. | $3.5M | 0.00% |
| Squarepoint Ops LLC | $3.3M | 0.00% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | $3.2M | 0.00% |
| PLATINUM INVESTMENT MANAGEMENT LTD | $3.1M | 0.77% |
| CITIGROUP INC | $3.0M | 0.00% |
| Rafferty Asset Management, LLC | $2.9M | 0.01% |
| Seven Fleet Capital Management LP | $2.9M | 0.91% |
| SEI INVESTMENTS CO | $2.8M | 0.00% |
| KVP Capital Advisors, LP | $2.7M | 1.98% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | $2.4M | 0.00% |
| ALPS ADVISORS INC | $2.4M | 0.01% |
| Legal & General Group Plc | $2.3M | 0.00% |
| Mitsubishi UFJ Asset Management Co., Ltd. | $2.2M | 0.00% |
| ASSETMARK, INC | $2.2M | 0.00% |
| SCHRODER INVESTMENT MANAGEMENT GROUP | $2.1M | 0.00% |
| MML INVESTORS SERVICES, LLC | $2.0M | 0.01% |
| AlphaCore Capital LLC | $1.9M | 0.05% |
| XTX Topco Ltd | $1.9M | 0.03% |
| Lido Advisors, LLC | $1.8M | 0.01% |
| Y-Intercept (Hong Kong) Ltd | $1.8M | 0.03% |
| VANGUARD ASSET MANAGEMENT, Ltd | $1.7M | 0.00% |
| DekaBank Deutsche Girozentrale | $1.7M | 0.00% |
| Orion Porfolio Solutions, LLC | $1.6M | 0.01% |
| ACUTA CAPITAL PARTNERS, LLC | $1.6M | 1.15% |
| FIRST TRUST ADVISORS LP | $1.6M | 0.00% |
| MetLife Investment Management, LLC | $1.5M | 0.01% |
| MARTINGALE ASSET MANAGEMENT L P | $1.5M | 0.04% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | $1.5M | 0.00% |
| AMERIPRISE FINANCIAL INC | $1.5M | 0.00% |
| TD Asset Management Inc | $1.5M | 0.00% |
| STATE OF WISCONSIN INVESTMENT BOARD | $1.4M | 0.00% |
| TUDOR INVESTMENT CORP ET AL | $1.4M | 0.00% |
| AQR CAPITAL MANAGEMENT LLC | $1.4M | 0.00% |
| WESBANCO BANK INC | $1.3M | 0.04% |
| Knights of Columbus Asset Advisors LLC | $1.3M | 0.07% |
| PROFUND ADVISORS LLC | $1.3M | 0.05% |
| FLAX POND CAPITAL, LLC | $1.3M | 1.05% |
| Atom Investors LP | $1.3M | 0.09% |
| Vanguard Global Advisers, LLC | $1.2M | 0.00% |
| SG Americas Securities, LLC | $1.1M | 0.00% |
| WELLINGTON MANAGEMENT GROUP LLP | $1.1M | 0.00% |
| Handelsbanken Fonder AB | $1.0M | 0.00% |
| STRS OHIO | $992.9K | 0.00% |
| BOOTHBAY FUND MANAGEMENT, LLC | $924.7K | 0.01% |
| State of New Jersey Common Pension Fund D | $898.2K | 0.00% |
| Zurcher Kantonalbank (Zurich Cantonalbank) | $878.7K | 0.00% |
| STIFEL FINANCIAL CORP | $856.8K | 0.00% |
| INTECH INVESTMENT MANAGEMENT LLC | $843.0K | 0.01% |
| Ishara Investments LP | $819.7K | 0.78% |
| Quantinno Capital Management LP | $771.8K | 0.00% |
| Quantedge Capital Pte Ltd | $769.7K | 0.42% |
| Police & Firemen's Retirement System of New Jersey | $768.1K | 0.01% |
| Palumbo Wealth Management LLC | $762.6K | 0.19% |
| ARIZONA STATE RETIREMENT SYSTEM | $721.9K | 0.00% |
| Vanguard Investments Australia, Ltd. | $697.6K | 0.00% |
| ADAR1 Capital Management, LLC | $666.4K | 0.04% |
| NANO CAP NEW MILLENNIUM GROWTH FUND L P | $666.4K | 0.62% |
| HSBC HOLDINGS PLC | $644.9K | 0.00% |
| Snowden Capital Advisors LLC | $640.8K | 0.02% |
| Cetera Investment Advisers | $628.5K | 0.00% |
| PRUDENTIAL FINANCIAL INC | $581.9K | 0.00% |
| KLP KAPITALFORVALTNING AS | $576.4K | 0.00% |
| GUGGENHEIM CAPITAL LLC | $569.5K | 0.00% |
| Birchview Capital, LP | $561.8K | 0.32% |
| ProShare Advisors LLC | $540.0K | 0.00% |
| BARCLAYS PLC | $532.5K | 0.00% |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | $520.9K | 0.00% |
| Vanguard Personalized Indexing Management, LLC | $520.3K | 0.01% |
| China Universal Asset Management Co., Ltd. | $519.2K | 0.04% |
| OPPENHEIMER ASSET MANAGEMENT INC. | $514.6K | 0.01% |