| Beutel, Goodman & Co Ltd. | $26.4M | 0.18% |
| Affinity Asset Advisors, LLC | $11.5M | 0.59% |
| Balyasny Asset Management L.P. | $9.8M | 0.01% |
| Vivo Capital, LLC | $9.8M | 0.81% |
| Ikarian Capital, LLC | $8.8M | 0.71% |
| GREAT POINT PARTNERS LLC | $8.7M | 2.00% |
| SCOTIA CAPITAL INC. | $7.2M | 0.03% |
| Point72 Asset Management, L.P. | $7.0M | 0.01% |
| UBS Group AG | $5.5M | 0.00% |
| Redmile Group, LLC | $5.1M | 0.34% |
| Rubric Capital Management LP | $5.0M | 0.05% |
| Squadron Capital Management LLC | $4.9M | 1.80% |
| Ally Bridge Group (NY) LLC | $4.8M | 3.86% |
| PFM Health Sciences, LP | $3.9M | 0.36% |
| AMERIPRISE FINANCIAL INC | $3.8M | 0.00% |
| Woodline Partners LP | $3.2M | 0.01% |
| Seven Fleet Capital Management LP | $3.1M | 1.00% |
| Alyeska Investment Group, L.P. | $2.7M | 0.01% |
| Velan Capital Investment Management LP | $2.5M | 1.60% |
| SummitTX Capital, L.P. | $2.4M | 0.07% |
| Aisling Capital Management LP | $2.4M | 0.49% |
| BOOTHBAY FUND MANAGEMENT, LLC | $2.3M | 0.03% |
| DV Trading LLC | $2.0M | 0.05% |
| BANK OF AMERICA CORP /DE/ | $1.9M | 0.00% |
| ROYAL BANK OF CANADA | $1.9M | 0.00% |
| CITADEL ADVISORS LLC | $1.7M | 0.00% |
| MARSHALL WACE, LLP | $1.1M | 0.00% |
| CIBC WORLD MARKET INC. | $1.1M | 0.00% |
| ACADIAN ASSET MANAGEMENT LLC | $671.0K | 0.00% |
| Hudson Bay Capital Management LP | $668.6K | 0.00% |
| TD Waterhouse Canada Inc. | $589.8K | 0.00% |
| INGALLS & SNYDER LLC | $548.0K | 0.02% |
| 1832 Asset Management L.P. | $434.4K | 0.00% |
| GOLDMAN SACHS GROUP INC | $384.3K | 0.00% |
| RAYMOND JAMES FINANCIAL INC | $366.1K | 0.00% |
| DIADEMA PARTNERS LP | $289.6K | 0.05% |
| BANK OF MONTREAL /CAN/ | $276.1K | 0.00% |
| Persistent Asset Partners Ltd | $274.6K | 0.10% |
| JANE STREET GROUP, LLC | $254.0K | 0.00% |
| TORONTO DOMINION BANK | $237.5K | 0.00% |
| GEODE CAPITAL MANAGEMENT, LLC | $185.4K | 0.00% |
| AXQ CAPITAL, LP | $114.1K | 0.01% |
| Integrated Wealth Concepts LLC | $86.9K | 0.00% |
| TCI Wealth Advisors, Inc. | $79.6K | 0.00% |
| TWO SIGMA INVESTMENTS, LP | $78.2K | 0.00% |
| Aptus Capital Advisors, LLC | $76.0K | 0.00% |
| GUARDIAN WEALTH ADVISORS, LLC / NC | $76.0K | 0.00% |
| China Universal Asset Management Co., Ltd. | $72.4K | 0.01% |
| MORGAN STANLEY | $63.9K | 0.00% |
| Federation des caisses Desjardins du Quebec | $49.0K | 0.00% |
| JPMORGAN CHASE & CO | $3.8K | 0.00% |
| NATIONAL BANK OF CANADA /FI/ | $812.0 | 0.00% |
| BNP PARIBAS FINANCIAL MARKETS | $465.5 | 0.00% |
| Caitong International Asset Management Co., Ltd | $7.0 | 0.00% |