| ORBIMED ADVISORS LLC | $312.0M | 6.39% |
| FMR LLC | $267.7M | 0.01% |
| Polar Capital Holdings Plc | $198.6M | 0.71% |
| BlackRock, Inc. | $144.4M | 0.00% |
| Commodore Capital LP | $128.4M | 7.43% |
| Vestal Point Capital, LP | $127.4M | 3.56% |
| Bellevue Group AG | $91.0M | 2.17% |
| CITADEL ADVISORS LLC | $73.4M | 0.01% |
| Fairmount Funds Management LLC | $72.7M | 5.25% |
| Venrock Adviser, LLC | $67.7M | 2.53% |
| NOVO HOLDINGS A/S | $50.2M | 4.07% |
| STATE STREET CORP | $42.8M | 0.00% |
| GEODE CAPITAL MANAGEMENT, LLC | $41.8M | 0.00% |
| Logos Global Management LP | $40.8M | 2.04% |
| Caption Management, LLC | $37.5M | 0.22% |
| Pictet Asset Management Holding SA | $36.4M | 0.04% |
| BAKER BROS. ADVISORS LP | $35.5M | 0.20% |
| Rock Springs Capital Management LP | $32.4M | 1.91% |
| Siren, L.L.C. | $29.3M | 0.81% |
| DIMENSIONAL FUND ADVISORS LP | $26.7M | 0.01% |
| First Turn Management, LLC | $24.5M | 2.73% |
| Candriam S.C.A. | $23.3M | 0.12% |
| Jones Hill Capital LP | $23.2M | 4.98% |
| Affinity Asset Advisors, LLC | $23.0M | 1.19% |
| MORGAN STANLEY | $20.3M | 0.00% |
| GOLDMAN SACHS GROUP INC | $18.5M | 0.00% |
| Avidity Partners Management LP | $15.7M | 3.18% |
| NORTHERN TRUST CORP | $14.6M | 0.00% |
| Capricorn Fund Managers Ltd | $14.5M | 2.26% |
| STEMPOINT CAPITAL LP | $14.2M | 2.73% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $14.1M | 0.00% |
| MILLENNIUM MANAGEMENT LLC | $13.5M | 0.01% |
| ADAR1 Capital Management, LLC | $12.9M | 0.76% |
| Spruce Street Capital LP | $12.9M | 3.10% |
| Balyasny Asset Management L.P. | $12.2M | 0.02% |
| JENNISON ASSOCIATES LLC | $12.1M | 0.01% |
| ALLIANCEBERNSTEIN L.P. | $11.9M | 0.00% |
| Woodline Partners LP | $11.8M | 0.04% |
| UBS Group AG | $11.1M | 0.00% |
| JANE STREET GROUP, LLC | $9.7M | 0.00% |
| Soleus Capital Management, L.P. | $9.1M | 0.37% |
| Exome Asset Management LLC | $8.6M | 4.46% |
| Schonfeld Strategic Advisors LLC | $8.6M | 0.06% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $8.1M | 0.00% |
| First Light Asset Management, LLC | $7.9M | 0.71% |
| Patient Square Capital LP | $7.8M | 1.39% |
| D. E. Shaw & Co., Inc. | $7.6M | 0.00% |
| Connor, Clark & Lunn Investment Management Ltd. | $7.5M | 0.02% |
| Nicholas Investment Partners, LP | $7.2M | 0.52% |
| Seven Fleet Capital Management LP | $6.4M | 2.04% |
| AMERIPRISE FINANCIAL INC | $6.3M | 0.00% |
| SPHERA FUNDS MANAGEMENT LTD. | $6.0M | 0.95% |
| WELLINGTON MANAGEMENT GROUP LLP | $5.9M | 0.00% |
| Bank of New York Mellon Corp | $4.7M | 0.00% |
| Cinctive Capital Management LP | $4.4M | 0.29% |
| Longaeva Partners L.P. | $4.4M | 0.16% |
| Nuveen, LLC | $4.2M | 0.00% |
| PRICE T ROWE ASSOCIATES INC /MD/ | $3.8M | 0.00% |
| DV Trading LLC | $3.7M | 0.09% |
| Ikarian Capital, LLC | $3.3M | 0.27% |
| Informed Momentum Co LLC | $3.2M | 0.37% |
| Trexquant Investment LP | $3.1M | 0.02% |
| Lighthouse Investment Partners, LLC | $2.9M | 0.10% |
| HighVista Strategies LLC | $2.9M | 0.79% |
| SummitTX Capital, L.P. | $2.7M | 0.08% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | $2.6M | 0.00% |
| PRUDENTIAL FINANCIAL INC | $2.6M | 0.00% |
| Swiss National Bank | $2.5M | 0.00% |
| AMERICAN CENTURY COMPANIES INC | $2.4M | 0.00% |
| Invesco Ltd. | $2.4M | 0.00% |
| NEUBERGER BERMAN GROUP LLC | $2.4M | 0.00% |
| PRELUDE CAPITAL MANAGEMENT, LLC | $2.1M | 0.16% |
| RHUMBLINE ADVISERS | $2.0M | 0.00% |
| Susquehanna Portfolio Strategies, LLC | $1.9M | 0.03% |
| Tidal Investments LLC | $1.9M | 0.00% |
| BANK OF AMERICA CORP /DE/ | $1.8M | 0.00% |
| TimesSquare Capital Management, LLC | $1.8M | 0.03% |
| Tema ETFs LLC | $1.7M | 0.11% |
| Point72 Asset Management, L.P. | $1.6M | 0.00% |
| NEW YORK STATE COMMON RETIREMENT FUND | $1.5M | 0.00% |
| XTX Topco Ltd | $1.5M | 0.03% |
| Walleye Capital LLC | $1.5M | 0.01% |
| DEUTSCHE BANK AG\ | $1.4M | 0.00% |
| Legal & General Group Plc | $1.3M | 0.00% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | $1.3M | 0.00% |
| ExodusPoint Capital Management, LP | $1.2M | 0.01% |
| J. Goldman & Co LP | $1.1M | 0.03% |
| STATE OF WISCONSIN INVESTMENT BOARD | $1.1M | 0.00% |
| Virtu Financial LLC | $958.0K | 0.04% |
| BOOTHBAY FUND MANAGEMENT, LLC | $956.5K | 0.01% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | $918.9K | 0.00% |
| Brevan Howard Capital Management LP | $871.5K | 0.01% |
| MetLife Investment Management, LLC | $866.1K | 0.00% |
| Artia Global Partners LP | $819.3K | 0.16% |
| FRANKLIN RESOURCES INC | $791.1K | 0.00% |
| JPMORGAN CHASE & CO | $761.8K | 0.00% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | $723.2K | 0.00% |
| Virtus Investment Advisers, LLC | $634.0K | 0.17% |
| Scientech Research LLC | $620.4K | 0.52% |
| CANADA PENSION PLAN INVESTMENT BOARD | $599.8K | 0.00% |
| Optimize Financial Inc | $590.2K | 0.29% |
| FORA Capital, LLC | $577.4K | 0.04% |
| CITIGROUP INC | $576.3K | 0.00% |
| FOX RUN MANAGEMENT, L.L.C. | $569.8K | 0.10% |
| VOYA INVESTMENT MANAGEMENT LLC | $568.0K | 0.00% |
| WELLS FARGO & COMPANY/MN | $560.2K | 0.00% |
| Creative Planning | $535.9K | 0.00% |
| BARCLAYS PLC | $463.7K | 0.00% |
| Jump Financial, LLC | $457.1K | 0.01% |
| Brooklyn Investment Group | $457.1K | 0.01% |
| Police & Firemen's Retirement System of New Jersey | $437.6K | 0.00% |
| State of New Jersey Common Pension Fund D | $437.3K | 0.00% |
| JANUS HENDERSON GROUP PLC | $431.2K | 0.00% |
| Zurcher Kantonalbank (Zurich Cantonalbank) | $428.6K | 0.00% |
| Quantbot Technologies LP | $419.9K | 0.02% |
| AXQ CAPITAL, LP | $416.8K | 0.05% |
| RAYMOND JAMES FINANCIAL INC | $416.0K | 0.00% |
| INTECH INVESTMENT MANAGEMENT LLC | $415.8K | 0.00% |
| China Universal Asset Management Co., Ltd. | $412.9K | 0.03% |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | $410.8K | 0.00% |
| OSAIC HOLDINGS, INC. | $393.3K | 0.00% |
| LETKO, BROSSEAU & ASSOCIATES INC | $376.3K | 0.01% |
| ARIZONA STATE RETIREMENT SYSTEM | $351.4K | 0.00% |
| TD Asset Management Inc | $337.1K | 0.00% |
| ProShare Advisors LLC | $327.7K | 0.00% |
| PROFUND ADVISORS LLC | $323.4K | 0.01% |
| STIFEL FINANCIAL CORP | $310.6K | 0.00% |
| SIMPLEX TRADING, LLC | $309.0K | 0.00% |
| PSP Research LLC | $274.4K | 0.19% |
| Amundi | $271.9K | 0.00% |
| KLP KAPITALFORVALTNING AS | $266.6K | 0.00% |
| Persistent Asset Partners Ltd | $259.0K | 0.10% |
| Quantinno Capital Management LP | $256.3K | 0.00% |
| Entropy Technologies, LP | $239.2K | 0.01% |
| Bridgefront Capital, LLC | $227.6K | 0.06% |
| ROYAL BANK OF CANADA | $212.0K | 0.00% |
| Tower Research Capital LLC (TRC) | $136.1K | 0.00% |
| Ameritas Investment Partners, Inc. | $135.2K | 0.00% |
| Mirae Asset Global Investments Co., Ltd. | $121.4K | 0.00% |
| Russell Investments Group, Ltd. | $117.6K | 0.00% |
| Versant Capital Management, Inc | $61.7K | 0.01% |
| GF FUND MANAGEMENT CO. LTD. | $52.3K | 0.00% |
| NISA INVESTMENT ADVISORS, LLC | $40.9K | 0.00% |
| KBC Group NV | $38.0K | 0.00% |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | $33.1K | 0.00% |
| Farther Finance Advisors, LLC | $30.6K | 0.00% |
| Sterling Capital Management LLC | $10.0K | 0.00% |
| DIADEMA PARTNERS LP | $9.6K | 0.00% |
| SIGNATUREFD, LLC | $9.3K | 0.00% |
| GAMMA Investing LLC | $8.7K | 0.00% |