HS

HighVista Strategies LLC

Diversified strategyQuality / disciplined sizingMomentum follower

Total reported value

$362.2M

Reporting period: 2026-03-31 · Number of holdings: 156

HighVista Strategies LLC disclosed 156 holdings in its latest 13F filing for the period ending 2026-03-31, with total reported value of $362.2M and a quarterly turnover rate of 62.7%.

Personality snowflake

Concentration
6.62
Portfolio Stability
62.72
Momentum/Contrarian
80.76
Sector conviction
61.46
Diversification
100
Sizing Uniformity
87.38

Recent moves

  • Add DBC

    0.0%　$7.0M

  • Trim VRDN

    -64.0%　-$9.0M

  • Trim GPCR

    -35.8%　-$7.5M

  • Add TYRA

    +274.2%　$4.1M

  • Trim OLMA

    -51.3%　-$4.3M

  • Trim MAZE

    -41.4%　-$4.1M

Holdings Map

New buyAddUnchangedTrim

Top 10 holdings by weight

Full holdings list this quarter

#TickerIssuerAsset SubclassWeightWeight ChangeShares Change4Q Trend
1DBCInvesco Db Commodity Index TETF-Commodities8.45%+2.36%—
2ABVXAbivax Sa-adrStock-Other3.48%+0.97%+56.89%
3PRAXPraxis Precision Medicines IStock-Other2.34%—+1.87%
4COGTCogent Biosciences INCStock-Other2.09%-0.99%-41.47%
5SYRESpyre Therapeutics INCStock-Other2.04%—-22.29%
6PCVXVaxcyte INCStock-Other2.00%+0.64%+9.29%
7RVMDRevolution Medicines INCStock-Healthcare1.86%-0.61%-42.36%
8430Terns Pharmaceuticals INCStock-Other1.66%—-34.85%
9GPCRStructure Therapeutics INCStock-Other1.65%-1.81%-35.80%
10NUVLNuvalent Inc-aStock-Other1.60%-0.30%-22.77%
11IMVTImmunovant INCStock-Other1.54%—+1.47%
12SLNOEURSoleno Therapeutics INCStock-Other1.53%—+22.33%
13TYRATyra Biosciences INCStock-Other1.39%+1.15%+274.23%
14AMLXAmylyx Pharmaceuticals INCStock-Other1.35%+0.61%+47.43%
15AMZNAmazon.com INCStock-Consumer Disc1.29%—+28.74%
16LBRXLb Pharmaceuticals INCStock-Other1.18%—+23.90%
17RLAYRelay Therapeutics INCStock-Other1.16%—-22.60%
18INSMInsmed INCStock-Healthcare1.10%-0.67%-38.28%
19NVDANvidia CORPStock-Tech1.08%—+57.67%
20ORKAOruka Therapeutics INCStock-Other1.07%+1.07%NEW
21CYTKCytokinetics INCStock-Healthcare1.07%-0.80%-48.81%
22LQDALiquidia CORPStock-Other1.04%-0.35%-36.06%
23OCULOcular Therapeutix INCStock-Other1.03%—+28.34%
24TARSTarsus Pharmaceuticals INCStock-Other1.02%—-2.05%
25BBIOBridgebio Pharma INCStock-Healthcare1.02%-0.56%-38.21%
26MLTXMoonlake ImmunotherapeuticsStock-Other1.00%+1.00%NEW
27ARGXArgenx Se - AdrStock-Healthcare0.99%—+37.07%
28PTGXProtagonist Therapeutics INCStock-Other0.99%-0.66%-53.97%
29PALIPalisade Bio INCStock-Other0.98%—+55.33%
30DFTXDefinium Therapeutics INCStock-Other0.97%+0.97%NEW
31NRIXNurix Therapeutics INCStock-Other0.97%+0.97%NEW
32AXSMAxsome Therapeutics INCStock-Healthcare0.95%—+83.60%
33IVAInventiva SA - AdrStock-Other0.94%+0.94%NEW
34DYNDyne Therapeutics INCStock-Other0.92%+0.62%+206.71%
35APGEApogee Therapeutics INCStock-Other0.83%-0.90%-59.92%
36GHRSGH Research PLCStock-Other0.83%—-11.36%
37DNTHDianthus Therapeutics INCStock-Other0.82%—-26.60%
38MAZEMaze Therapeutics INCStock-Other0.82%-1.00%-41.39%
39ERASErasca INCStock-Other0.81%+0.81%NEW
40EWTXEdgewise Therapeutics INCStock-Other0.80%—-46.28%
41ELVNEnliven Therapeutics INCStock-Other0.79%+0.46%-11.43%
42XENEXenon Pharmaceuticals INCStock-Other0.79%+0.79%NEW
43CLDXCelldex Therapeutics INCStock-Other0.78%—+72.56%
44VERAVera Therapeutics INCStock-Other0.77%+0.77%NEW
45PHVSPharvaris N.V.Stock-Other0.76%-0.40%-39.73%
46VRDNViridian Therapeutics INCStock-Other0.72%-2.27%-63.96%
47ALKSAlkermes plcStock-Healthcare0.71%+0.52%+177.22%
48ALMSAlumis INCStock-Other0.69%+0.69%NEW
49MSFTMicrosoft CORPStock-Tech0.66%—-1.22%
50EYPTEyepoint INCStock-Other0.65%+0.65%NEW
1–50 of 156

Holding changes this quarter

HighVista Strategies LLC's most significant position changes for 2026-03-31: Sold out: Cidara Therapeutics INC (CDTX); Sold out: Arcellx INC (ACLXGBX); Sold out: Agios Pharmaceuticals INC (AGIO); New buy: Oruka Therapeutics INC (ORKA); Sold out: Apellis Pharmaceuticals INC (APLSUSD).

Position changes disclosed by HighVista Strategies LLC for the quarter ending 2026-03-31, including ticker, issuer, weight change, shares change, and action
#TickerIssuerWeight ChangeShares ChangeAction
1DBCInvesco Db Commodity Index T+2.4%—Unchanged
2TYRATyra Biosciences INC+1.2%+274.23%Add
3ABVXAbivax Sa-adr+1%+56.89%Add
4PCVXVaxcyte INC+0.6%+9.29%Add
5DYNDyne Therapeutics INC+0.6%+206.71%Add
6AMLXAmylyx Pharmaceuticals INC+0.6%+47.43%Add
7ALKSAlkermes plc+0.5%+177.22%Add
8ELVNEnliven Therapeutics INC+0.5%-11.43%Trim
9NUVLNuvalent Inc-a-0.3%-22.77%Trim
10LQDALiquidia CORP-0.4%-36.06%Trim
11GHGuardant Health INC-0.4%-36.46%Trim
12STOKStoke Therapeutics INC-0.4%-45.80%Trim
13PHVSPharvaris N.V.-0.4%-39.73%Trim
14BBOTBridgebio Oncology Therapeut-0.6%-65.90%Trim
15BBIOBridgebio Pharma INC-0.6%-38.21%Trim
16RVMDRevolution Medicines INC-0.6%-42.36%Trim
17PTGXProtagonist Therapeutics INC-0.7%-53.97%Trim
18INSMInsmed INC-0.7%-38.28%Trim
19RYTMRhythm Pharmaceuticals INC-0.8%-60.82%Trim
20CYTKCytokinetics INC-0.8%-48.81%Trim
21MLYSMineralys Therapeutics INC-0.8%-62.44%Trim
22APGEApogee Therapeutics INC-0.9%-59.92%Trim
23COGTCogent Biosciences INC-1%-41.47%Trim
24MAZEMaze Therapeutics INC-1%-41.39%Trim
25OLMAOlema Pharmaceuticals INC-1.1%-51.30%Trim
26GPCRStructure Therapeutics INC-1.8%-35.80%Trim
27VRDNViridian Therapeutics INC-2.3%-63.96%Trim
28CDTXCidara Therapeutics INC—EXITSold out
29ACLXGBXArcellx INC—EXITSold out
30AGIOAgios Pharmaceuticals INC—EXITSold out
31ORKAOruka Therapeutics INC—NEWNew buy
32APLSUSDApellis Pharmaceuticals INC—EXITSold out
33MLTXMoonlake Immunotherapeutics—NEWNew buy
34DFTXDefinium Therapeutics INC—NEWNew buy
35NRIXNurix Therapeutics INC—NEWNew buy
36IVAInventiva SA - Adr—NEWNew buy
37ERASErasca INC—NEWNew buy
38RNAGBPAvidity Biosciences INC—EXITSold out
39XENEXenon Pharmaceuticals INC—NEWNew buy
40VERAVera Therapeutics INC—NEWNew buy
41ALMSAlumis INC—NEWNew buy
42EYPTEyepoint INC—NEWNew buy
43SEPNSepterna INC—EXITSold out
44TNGXTango Therapeutics INC—NEWNew buy
45ASMBAssembly Biosciences INC—NEWNew buy
46JAZZJazz Pharmaceuticals plc—NEWNew buy
47NATLNcr Atleos CORP—NEWNew buy
48ONOn Semiconductor—NEWNew buy
49APPApplovin Corp-class A—EXITSold out
50KODKodiak Sciences INC—NEWNew buy

FAQ

What is HighVista Strategies LLC and what type of investor is it?
HighVista Strategies LLC is a investment manager that files SEC Form 13F quarterly, disclosing its U.S. public equity holdings to regulators. As of the most recent reporting period (2026-03-31), the firm manages a tracked equity portfolio valued at approximately $362.2M, spread across 156 disclosed positions.
What are HighVista Strategies LLC's largest equity positions?
Based on the latest 13F filing, HighVista Strategies LLC's top holdings by market value are: 1. Invesco Db Commodity Index T (DBC) — $30.6M (8.4%) 2. Abivax Sa-adr (ABVX) — $12.6M (3.5%) 3. Praxis Precision Medicines I (PRAX) — $8.5M (2.3%) 4. Cogent Biosciences INC (COGT) — $7.6M (2.1%) 5. Spyre Therapeutics INC (SYRE) — $7.4M (2.0%)
What changes did HighVista Strategies LLC make in its most recent portfolio filing?
In the latest reported quarter, HighVista Strategies LLC made 49 notable position adjustments: 16 new positions were initiated, 6 existing holdings were added to, 20 positions were partially reduced, and 7 were completely exited. The largest of these moves: Sold out: Cidara Therapeutics INC (CDTX); Sold out: Arcellx INC (ACLXGBX); Sold out: Agios Pharmaceuticals INC (AGIO); New buy: Oruka Therapeutics INC (ORKA); Sold out: Apellis Pharmaceuticals INC (APLSUSD)
What sectors does HighVista Strategies LLC focus on?
HighVista Strategies LLC is concentrated in the following sectors based on its current disclosed equity portfolio: • Health Care: 30.6% • Information Technology: 26.9% • Industrials: 15.5% • Consumer Discretionary: 8.3% • Financials: 5.9% • Utilities: 5.2%