| JANUS HENDERSON GROUP PLC | $237.6M | 0.11% |
| FMR LLC | $193.8M | 0.01% |
| WELLINGTON MANAGEMENT GROUP LLP | $148.2M | 0.03% |
| BlackRock, Inc. | $125.3M | 0.00% |
| STATE STREET CORP | $89.8M | 0.00% |
| Nantahala Capital Management, LLC | $83.5M | 3.07% |
| Avoro Capital Advisors LLC | $77.0M | 0.76% |
| VANGUARD CAPITAL MANAGEMENT LLC | $72.1M | 0.00% |
| Polar Capital Holdings Plc | $56.9M | 0.20% |
| Caption Management, LLC | $53.2M | 0.31% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $52.5M | 0.01% |
| Khrom Capital Management LLC | $50.6M | 4.63% |
| GEODE CAPITAL MANAGEMENT, LLC | $41.4M | 0.00% |
| Woodline Partners LP | $37.2M | 0.14% |
| Deep Track Capital, LP | $36.1M | 0.59% |
| PRICE T ROWE ASSOCIATES INC /MD/ | $34.4M | 0.00% |
| BRAIDWELL LP | $32.1M | 1.07% |
| READYSTATE ASSET MANAGEMENT LP | $31.9M | 1.43% |
| FRANKLIN RESOURCES INC | $28.0M | 0.01% |
| Vestal Point Capital, LP | $24.4M | 0.68% |
| Commodore Capital LP | $21.8M | 1.26% |
| MILLENNIUM MANAGEMENT LLC | $21.0M | 0.01% |
| Hood River Capital Management LLC | $20.9M | 0.21% |
| Pictet Asset Management Holding SA | $20.6M | 0.02% |
| SCHRODER INVESTMENT MANAGEMENT GROUP | $19.8M | 0.02% |
| Catalio Capital Management, LP | $19.3M | 4.04% |
| KINGDON CAPITAL MANAGEMENT, L.L.C. | $19.3M | 2.11% |
| Kynam Capital Management, LP | $18.7M | 1.16% |
| CITADEL ADVISORS LLC | $17.3M | 0.00% |
| Qube Research & Technologies Ltd | $16.2M | 0.02% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $16.0M | 0.00% |
| RENAISSANCE TECHNOLOGIES LLC | $15.0M | 0.02% |
| BANK OF AMERICA CORP /DE/ | $14.7M | 0.00% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $13.6M | 0.00% |
| Ally Bridge Group (NY) LLC | $13.4M | 10.82% |
| NORTHERN TRUST CORP | $13.2M | 0.00% |
| GOLDMAN SACHS GROUP INC | $12.9M | 0.00% |
| JANE STREET GROUP, LLC | $12.1M | 0.00% |
| Ikarian Capital, LLC | $11.5M | 0.94% |
| VANGUARD FIDUCIARY TRUST CO | $11.5M | 0.00% |
| Integral Health Asset Management, LLC | $10.9M | 0.52% |
| Vivo Capital, LLC | $9.9M | 0.82% |
| Aberdeen Group plc | $9.6M | 0.02% |
| Candriam S.C.A. | $9.4M | 0.05% |
| Bank of New York Mellon Corp | $9.3M | 0.00% |
| EMERALD ADVISERS, LLC | $9.2M | 0.29% |
| Penn Capital Management Company, LLC | $9.0M | 0.70% |
| Rock Springs Capital Management LP | $8.6M | 0.51% |
| Logos Global Management LP | $8.4M | 0.42% |
| PFM Health Sciences, LP | $8.3M | 0.76% |
| MORGAN STANLEY | $8.1M | 0.00% |
| UBS Group AG | $7.5M | 0.00% |
| Trexquant Investment LP | $7.4M | 0.05% |
| MARSHALL WACE, LLP | $7.4M | 0.01% |
| Alyeska Investment Group, L.P. | $7.3M | 0.02% |
| SPHERA FUNDS MANAGEMENT LTD. | $7.2M | 1.15% |
| RICE HALL JAMES & ASSOCIATES, LLC | $6.9M | 0.38% |
| Hudson Bay Capital Management LP | $6.8M | 0.02% |
| EMERALD MUTUAL FUND ADVISERS TRUST | $6.7M | 0.33% |
| Boxer Capital Management, LLC | $6.7M | 0.88% |
| National Philanthropic Trust | $6.7M | 0.07% |
| SEB Asset Management AB | $6.3M | 0.03% |
| Squarepoint Ops LLC | $6.2M | 0.01% |
| NEW YORK STATE COMMON RETIREMENT FUND | $6.2M | 0.01% |
| Buckley Capital Advisors, LLC | $6.1M | 4.37% |
| HSBC HOLDINGS PLC | $5.8M | 0.00% |
| HighVista Strategies LLC | $5.5M | 1.53% |
| NICOLET BANKSHARES INC | $5.2M | 0.19% |
| DEUTSCHE BANK AG\ | $5.0M | 0.00% |
| Brevan Howard Capital Management LP | $4.5M | 0.04% |
| NAN FUNG TRINITY (HK) LTD | $4.2M | 0.46% |
| BOOTHBAY FUND MANAGEMENT, LLC | $4.2M | 0.05% |
| Seven Fleet Capital Management LP | $3.9M | 1.23% |
| Granahan Investment Management, LLC | $3.8M | 0.19% |
| Nuveen, LLC | $3.5M | 0.00% |
| Tetragon Partners GP Ltd | $3.4M | 0.66% |
| Centiva Capital, LP | $3.4M | 0.02% |
| ORBIMED ADVISORS LLC | $3.3M | 0.07% |
| TUDOR INVESTMENT CORP ET AL | $3.3M | 0.01% |
| STATE OF WISCONSIN INVESTMENT BOARD | $3.0M | 0.01% |
| Swiss National Bank | $3.0M | 0.00% |
| XTX Topco Ltd | $2.9M | 0.05% |
| MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC | $2.8M | 0.03% |
| Rafferty Asset Management, LLC | $2.7M | 0.01% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | $2.4M | 0.00% |
| Artia Global Partners LP | $2.3M | 0.46% |
| Atle Fund Management AB | $2.2M | 0.71% |
| SEI INVESTMENTS CO | $2.1M | 0.00% |
| Exome Asset Management LLC | $2.1M | 1.07% |
| KVP Capital Advisors, LP | $2.0M | 1.49% |
| ALLIANCEBERNSTEIN L.P. | $2.0M | 0.00% |
| RHUMBLINE ADVISERS | $2.0M | 0.00% |
| Russell Investments Group, Ltd. | $2.0M | 0.00% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | $2.0M | 0.00% |
| Diametric Capital, LP | $1.9M | 0.50% |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | $1.9M | 0.00% |
| CITIGROUP INC | $1.9M | 0.00% |
| SummitTX Capital, L.P. | $1.9M | 0.06% |
| BARCLAYS PLC | $1.8M | 0.00% |
| DV Trading LLC | $1.8M | 0.04% |
| Engineers Gate Manager LP | $1.6M | 0.02% |
| Moody Aldrich Partners LLC | $1.6M | 0.29% |
| TWO SIGMA INVESTMENTS, LP | $1.6M | 0.00% |
| Y-Intercept (Hong Kong) Ltd | $1.6M | 0.03% |
| ADAR1 Capital Management, LLC | $1.6M | 0.09% |
| Ruffer LLP | $1.6M | 0.06% |
| JPMORGAN CHASE & CO | $1.6M | 0.00% |
| Invesco Ltd. | $1.5M | 0.00% |
| Anson Funds Management LP | $1.5M | 0.13% |
| BANQUE PICTET & CIE SA | $1.3M | 0.01% |
| PROFUND ADVISORS LLC | $1.2M | 0.04% |
| Legal & General Group Plc | $1.2M | 0.00% |
| LOS ANGELES CAPITAL MANAGEMENT LLC | $1.1M | 0.00% |
| LAZARD ASSET MANAGEMENT LLC | $1.1M | 0.00% |
| D. E. Shaw & Co., Inc. | $1.0M | 0.00% |
| CANTOR FITZGERALD, L. P. | $1.0M | 0.01% |
| VANGUARD ASSET MANAGEMENT, Ltd | $1.0M | 0.00% |
| F/m Investments LLC | $982.7K | 0.07% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | $963.4K | 0.00% |
| FRED ALGER MANAGEMENT, LLC | $944.6K | 0.00% |
| MetLife Investment Management, LLC | $920.7K | 0.00% |
| CAPITAL FUND MANAGEMENT S.A. | $887.6K | 0.00% |
| TWINBEECH CAPITAL LP | $877.2K | 0.09% |
| Alberta Investment Management Corp | $837.0K | 0.01% |
| GUGGENHEIM CAPITAL LLC | $814.4K | 0.01% |
| Erste Asset Management GmbH | $779.3K | 0.01% |
| ExodusPoint Capital Management, LP | $778.1K | 0.01% |
| Weiss Asset Management LP | $770.0K | 0.01% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | $766.0K | 0.00% |
| PRUDENTIAL FINANCIAL INC | $764.9K | 0.00% |
| AQR CAPITAL MANAGEMENT LLC | $708.2K | 0.00% |
| PRELUDE CAPITAL MANAGEMENT, LLC | $707.8K | 0.05% |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | $701.0K | 0.01% |
| WELLS FARGO & COMPANY/MN | $694.7K | 0.00% |
| Man Group plc | $692.3K | 0.00% |
| GC Wealth Management RIA, LLC | $670.5K | 0.03% |
| GROUP ONE TRADING LLC | $668.0K | 0.00% |
| Vanguard Global Advisers, LLC | $645.0K | 0.00% |
| SG Americas Securities, LLC | $641.0K | 0.00% |
| SIMPLEX TRADING, LLC | $608.2K | 0.00% |
| FOX RUN MANAGEMENT, L.L.C. | $606.8K | 0.11% |
| FORA Capital, LLC | $601.4K | 0.04% |
| CREDIT AGRICOLE S A | $585.9K | 0.00% |
| Universal- Beteiligungs- und Servicegesellschaft mbH | $570.8K | 0.00% |
| OXFORD ASSET MANAGEMENT LLP | $524.4K | 0.23% |
| State of New Jersey Common Pension Fund D | $522.4K | 0.00% |
| Handelsbanken Fonder AB | $516.0K | 0.00% |
| Sofinnova Investments, Inc. | $491.8K | 0.02% |
| INTECH INVESTMENT MANAGEMENT LLC | $472.4K | 0.00% |
| Police & Firemen's Retirement System of New Jersey | $459.1K | 0.00% |