| BAKER BROS. ADVISORS LP | $759.3M | 4.36% |
| BlackRock, Inc. | $150.0M | 0.00% |
| STATE STREET CORP | $85.8M | 0.00% |
| PRICE T ROWE ASSOCIATES INC /MD/ | $77.7M | 0.01% |
| BRAIDWELL LP | $69.3M | 2.31% |
| GOLDMAN SACHS GROUP INC | $66.3M | 0.01% |
| VANGUARD CAPITAL MANAGEMENT LLC | $65.5M | 0.00% |
| RTW INVESTMENTS, LP | $56.7M | 0.56% |
| TCG Crossover Management, LLC | $55.1M | 1.58% |
| Ikarian Capital, LLC | $52.1M | 4.23% |
| Boxer Capital Management, LLC | $51.9M | 6.81% |
| JANUS HENDERSON GROUP PLC | $50.5M | 0.02% |
| ICONIQ Capital, LLC | $48.3M | 1.08% |
| CITADEL ADVISORS LLC | $39.7M | 0.01% |
| GEODE CAPITAL MANAGEMENT, LLC | $38.1M | 0.00% |
| SILVERARC CAPITAL MANAGEMENT, LLC | $37.8M | 3.86% |
| T. Rowe Price Investment Management, Inc. | $31.9M | 0.02% |
| Balyasny Asset Management L.P. | $27.7M | 0.04% |
| Board of Trustees of The Leland Stanford Junior University | $26.4M | 3.11% |
| Artisan Partners Limited Partnership | $26.3M | 0.04% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | $21.9M | 0.03% |
| MORGAN STANLEY | $19.7M | 0.00% |
| Point72 Asset Management, L.P. | $17.5M | 0.02% |
| DIADEMA PARTNERS LP | $16.8M | 2.85% |
| WELLINGTON MANAGEMENT GROUP LLP | $16.6M | 0.00% |
| NORTHERN TRUST CORP | $14.9M | 0.00% |
| Squadron Capital Management LLC | $14.5M | 5.31% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $13.9M | 0.00% |
| BOOTHBAY FUND MANAGEMENT, LLC | $13.6M | 0.18% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $13.3M | 0.00% |
| DIMENSIONAL FUND ADVISORS LP | $12.0M | 0.00% |
| Invesco Ltd. | $11.6M | 0.00% |
| BANK OF AMERICA CORP /DE/ | $11.4M | 0.00% |
| RENAISSANCE TECHNOLOGIES LLC | $11.2M | 0.02% |
| BOONE CAPITAL MANAGEMENT LLC | $10.7M | 3.29% |
| VANGUARD FIDUCIARY TRUST CO | $9.8M | 0.00% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $9.3M | 0.00% |
| D. E. Shaw & Co., Inc. | $8.8M | 0.01% |
| FEDERATED HERMES, INC. | $8.0M | 0.01% |
| Atom Investors LP | $7.3M | 0.52% |
| FMR LLC | $7.0M | 0.00% |
| TD Asset Management Inc | $6.2M | 0.01% |
| UBS Group AG | $5.8M | 0.00% |
| ALGERT GLOBAL LLC | $5.6M | 0.08% |
| Bruce & Co., Inc. | $5.5M | 1.58% |
| Trexquant Investment LP | $4.7M | 0.03% |
| JANE STREET GROUP, LLC | $4.7M | 0.00% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | $4.6M | 0.00% |
| SPHERA FUNDS MANAGEMENT LTD. | $4.4M | 0.69% |
| PFM Health Sciences, LP | $4.4M | 0.40% |
| Bank of New York Mellon Corp | $4.2M | 0.00% |
| Resolute Capital Asset Partners LLC | $3.8M | 2.01% |
| TWO SIGMA INVESTMENTS, LP | $3.8M | 0.00% |
| Nuveen, LLC | $3.6M | 0.00% |
| Informed Momentum Co LLC | $3.4M | 0.39% |
| AQR CAPITAL MANAGEMENT LLC | $3.3M | 0.00% |
| RIA Advisory Group LLC | $3.2M | 0.77% |
| PRUDENTIAL FINANCIAL INC | $3.1M | 0.00% |
| WELLS FARGO & COMPANY/MN | $2.9M | 0.00% |
| Rafferty Asset Management, LLC | $2.7M | 0.01% |
| Harvest Investment Services, LLC | $2.7M | 0.50% |
| Squarepoint Ops LLC | $2.7M | 0.00% |
| JPMORGAN CHASE & CO | $2.7M | 0.00% |
| NEW YORK STATE COMMON RETIREMENT FUND | $2.7M | 0.00% |
| National Philanthropic Trust | $2.5M | 0.03% |
| Jefferies Financial Group Inc. | $2.5M | 0.02% |
| AMERIPRISE FINANCIAL INC | $2.5M | 0.00% |
| Persistent Asset Partners Ltd | $2.4M | 0.88% |
| Maven Securities LTD | $2.2M | 0.04% |
| Swiss National Bank | $2.2M | 0.00% |
| Jain Global LLC | $2.0M | 0.01% |
| STATE OF WISCONSIN INVESTMENT BOARD | $1.9M | 0.00% |
| FRED ALGER MANAGEMENT, LLC | $1.8M | 0.01% |
| RHUMBLINE ADVISERS | $1.8M | 0.00% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | $1.7M | 0.00% |
| HighVista Strategies LLC | $1.7M | 0.46% |
| POLEN CAPITAL MANAGEMENT LLC | $1.6M | 0.01% |
| DEUTSCHE BANK AG\ | $1.6M | 0.00% |
| JACOBS LEVY EQUITY MANAGEMENT, INC | $1.6M | 0.01% |
| VICTORY CAPITAL MANAGEMENT INC | $1.4M | 0.00% |
| PROFUND ADVISORS LLC | $1.2M | 0.04% |
| Vanguard Global Advisers, LLC | $1.2M | 0.00% |
| PANAGORA ASSET MANAGEMENT INC | $1.1M | 0.00% |
| Walleye Capital LLC | $1.1M | 0.00% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | $1.1M | 0.00% |
| FRANKLIN RESOURCES INC | $1.1M | 0.00% |
| ALLIANCEBERNSTEIN L.P. | $1.1M | 0.00% |
| Aries Wealth Management | $953.0K | 0.21% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | $847.8K | 0.00% |
| Schonfeld Strategic Advisors LLC | $844.4K | 0.01% |
| Headlands Technologies LLC | $785.0K | 0.09% |
| MetLife Investment Management, LLC | $776.2K | 0.00% |
| Legal & General Group Plc | $769.0K | 0.00% |
| SIMPLEX TRADING, LLC | $753.1K | 0.00% |
| VANGUARD ASSET MANAGEMENT, Ltd | $730.9K | 0.00% |
| Russell Investments Group, Ltd. | $710.2K | 0.00% |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | $693.8K | 0.01% |
| XTX Topco Ltd | $685.3K | 0.01% |
| Optimize Financial Inc | $679.6K | 0.33% |
| SG Americas Securities, LLC | $653.0K | 0.00% |
| Artia Global Partners LP | $648.8K | 0.13% |
| Palumbo Wealth Management LLC | $583.4K | 0.14% |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | $575.7K | 0.00% |
| Vanguard Personalized Indexing Management, LLC | $571.3K | 0.01% |
| Cerity Partners LLC | $566.8K | 0.00% |
| Continuum Advisory, LLC | $566.2K | 0.05% |
| MILLENNIUM MANAGEMENT LLC | $543.9K | 0.00% |
| SIG BROKERAGE, LP | $510.8K | 0.01% |
| Campbell & CO Investment Adviser LLC | $503.9K | 0.03% |
| Engineers Gate Manager LP | $458.1K | 0.01% |
| LPL Financial LLC | $456.1K | 0.00% |
| Caption Management, LLC | $438.4K | 0.00% |
| Virtus Investment Advisers, LLC | $436.5K | 0.12% |
| Quantinno Capital Management LP | $434.4K | 0.00% |
| BARCLAYS PLC | $430.9K | 0.00% |
| INTECH INVESTMENT MANAGEMENT LLC | $418.3K | 0.00% |
| Police & Firemen's Retirement System of New Jersey | $413.6K | 0.00% |
| China Universal Asset Management Co., Ltd. | $413.0K | 0.03% |
| CITIGROUP INC | $407.4K | 0.00% |
| VOYA INVESTMENT MANAGEMENT LLC | $406.4K | 0.00% |
| AMERICAN CENTURY COMPANIES INC | $394.8K | 0.00% |
| SEI INVESTMENTS CO | $392.1K | 0.00% |
| Y-Intercept (Hong Kong) Ltd | $381.4K | 0.01% |
| PSP Research LLC | $381.2K | 0.27% |
| State of New Jersey Common Pension Fund D | $378.5K | 0.00% |
| TUDOR INVESTMENT CORP ET AL | $367.9K | 0.00% |
| Virtu Financial LLC | $355.0K | 0.01% |
| Verdad Advisers, LP | $347.5K | 0.39% |
| Brooklyn Investment Group | $346.5K | 0.01% |
| E Fund Management Co., Ltd. | $342.7K | 0.01% |
| Creative Planning | $320.8K | 0.00% |
| ALLSTATE CORP | $320.6K | 0.00% |
| ProShare Advisors LLC | $313.2K | 0.00% |
| Vanguard Investments Australia, Ltd. | $312.6K | 0.00% |
| ARIZONA STATE RETIREMENT SYSTEM | $304.2K | 0.00% |
| Quadrature Capital Ltd | $299.9K | 0.00% |
| J. Goldman & Co LP | $290.1K | 0.01% |
| Brevan Howard Capital Management LP | $263.4K | 0.00% |
| KLP KAPITALFORVALTNING AS | $244.0K | 0.00% |
| Cetera Investment Advisers | $227.8K | 0.00% |
| Cambridge Investment Research Advisors, Inc. | $214.0K | 0.00% |
| MANGROVE PARTNERS IM, LLC | $211.5K | 0.02% |
| Tower Research Capital LLC (TRC) | $209.6K | 0.01% |
| CANADA LIFE ASSURANCE Co | $189.0K | 0.00% |
| CWM, LLC | $131.5K | 0.00% |
| Mirae Asset Global Investments Co., Ltd. | $121.4K | 0.00% |
| STRS OHIO | $118.2K | 0.00% |
| Ameritas Investment Partners, Inc. | $118.1K | 0.00% |
| NISA INVESTMENT ADVISORS, LLC | $117.1K | 0.00% |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | $109.1K | 0.00% |