| T. Rowe Price Investment Management, Inc. | $1.2B | 0.80% |
| BlackRock, Inc. | $1.1B | 0.02% |
| FMR LLC | $706.8M | 0.04% |
| WELLINGTON MANAGEMENT GROUP LLP | $527.9M | 0.10% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $385.2M | 0.02% |
| STATE STREET CORP | $378.7M | 0.01% |
| VANGUARD CAPITAL MANAGEMENT LLC | $361.8M | 0.01% |
| Avoro Capital Advisors LLC | $219.7M | 2.16% |
| GEODE CAPITAL MANAGEMENT, LLC | $212.0M | 0.01% |
| BANK OF AMERICA CORP /DE/ | $206.0M | 0.02% |
| RTW INVESTMENTS, LP | $179.4M | 1.78% |
| ARMISTICE CAPITAL, LLC | $175.6M | 3.12% |
| Integral Health Asset Management, LLC | $171.4M | 8.20% |
| GOLDMAN SACHS GROUP INC | $161.9M | 0.02% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $146.5M | 0.02% |
| UBS Group AG | $138.6M | 0.02% |
| Caption Management, LLC | $122.4M | 0.71% |
| Polar Capital Holdings Plc | $109.5M | 0.39% |
| PRICE T ROWE ASSOCIATES INC /MD/ | $104.4M | 0.01% |
| CITADEL ADVISORS LLC | $102.4M | 0.02% |
| MORGAN STANLEY | $99.2M | 0.01% |
| Paradigm Biocapital Advisors LP | $97.6M | 1.99% |
| NORTHERN TRUST CORP | $95.0M | 0.01% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $92.1M | 0.01% |
| Deep Track Capital, LP | $90.6M | 1.48% |
| Capital International Investors | $88.2M | 0.02% |
| Ikarian Capital, LLC | $81.9M | 6.65% |
| Frazier Life Sciences Management, L.P. | $76.4M | 1.97% |
| Balyasny Asset Management L.P. | $72.4M | 0.09% |
| PRINCIPAL FINANCIAL GROUP INC | $72.1M | 0.04% |
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | $71.7M | 0.24% |
| Bank of New York Mellon Corp | $66.3M | 0.01% |
| Woodline Partners LP | $65.9M | 0.25% |
| Royalty Pharma Sub-Manager, LLC | $64.6M | 37.40% |
| Logos Global Management LP | $57.7M | 2.88% |
| JPMORGAN CHASE & CO | $56.9M | 0.00% |
| Melqart Asset Management (UK) Ltd | $55.6M | 5.48% |
| VANGUARD FIDUCIARY TRUST CO | $52.7M | 0.01% |
| Qube Research & Technologies Ltd | $51.4M | 0.06% |
| Capital Research Global Investors | $50.8M | 0.01% |
| Fisher Asset Management, LLC | $50.6M | 0.02% |
| Pictet Asset Management Holding SA | $49.3M | 0.05% |
| D. E. Shaw & Co., Inc. | $49.3M | 0.03% |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | $47.1M | 0.05% |
| Affinity Asset Advisors, LLC | $46.2M | 2.38% |
| FEDERATED HERMES, INC. | $46.1M | 0.07% |
| Point72 Asset Management, L.P. | $43.6M | 0.06% |
| Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. | $43.5M | 3.69% |
| MARSHALL WACE, LLP | $43.3M | 0.04% |
| ADAR1 Capital Management, LLC | $41.7M | 2.45% |
| BROWN ADVISORY INC | $40.5M | 0.07% |
| Siren, L.L.C. | $40.5M | 1.12% |
| Foresite Capital Management IV, LLC | $33.2M | 13.99% |
| MPM BIOIMPACT LLC | $33.0M | 2.54% |
| GW&K Investment Management, LLC | $32.6M | 0.29% |
| Invesco Ltd. | $32.0M | 0.00% |
| AMERIPRISE FINANCIAL INC | $31.9M | 0.01% |
| Aberdeen Group plc | $31.9M | 0.05% |
| EVENTIDE ASSET MANAGEMENT, LLC | $31.6M | 0.52% |
| AMERICAN CENTURY COMPANIES INC | $29.3M | 0.02% |
| ALLIANCEBERNSTEIN L.P. | $29.2M | 0.01% |
| TD Asset Management Inc | $27.7M | 0.02% |
| BOOTHBAY FUND MANAGEMENT, LLC | $27.4M | 0.36% |
| FRANKLIN RESOURCES INC | $27.0M | 0.01% |
| RHUMBLINE ADVISERS | $24.4M | 0.02% |
| GROUP ONE TRADING LLC | $24.0M | 0.05% |
| Nuveen, LLC | $23.2M | 0.01% |
| GSK plc | $22.4M | 3.74% |
| Candriam S.C.A. | $22.1M | 0.11% |
| GILDER GAGNON HOWE & CO LLC | $21.8M | 0.26% |
| MILLENNIUM MANAGEMENT LLC | $21.5M | 0.01% |
| JANE STREET GROUP, LLC | $21.2M | 0.00% |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | $20.5M | 0.01% |
| CITIGROUP INC | $20.1M | 0.01% |
| E. Ohman J:or Asset Management AB | $19.8M | 0.52% |
| Vestal Point Capital, LP | $19.8M | 0.55% |
| Trails Edge Capital Partners, LP | $19.8M | 4.53% |
| SPHERA FUNDS MANAGEMENT LTD. | $19.7M | 3.13% |
| NOMURA HOLDINGS INC | $19.3M | 0.05% |
| TWO SIGMA INVESTMENTS, LP | $18.8M | 0.02% |
| First Turn Management, LLC | $18.7M | 2.09% |
| JANUS HENDERSON GROUP PLC | $18.6M | 0.01% |
| Susquehanna Portfolio Strategies, LLC | $18.4M | 0.27% |
| BARCLAYS PLC | $17.6M | 0.00% |
| VOYA INVESTMENT MANAGEMENT LLC | $17.1M | 0.02% |
| DIADEMA PARTNERS LP | $16.5M | 2.80% |
| Handelsbanken Fonder AB | $16.3M | 0.05% |
| Capital World Investors | $16.0M | 0.00% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | $15.9M | 0.00% |
| Swiss National Bank | $15.1M | 0.01% |
| Sarissa Capital Management LP | $15.1M | 9.56% |
| HSBC HOLDINGS PLC | $14.6M | 0.01% |
| DAFNA Capital Management LLC | $14.3M | 3.26% |
| Freestone Grove Partners LP | $14.3M | 0.10% |
| Catalio Capital Management, LP | $14.2M | 2.97% |
| Mirador Capital Partners LP | $13.4M | 1.89% |
| Hudson Bay Capital Management LP | $13.2M | 0.05% |
| EMERALD ADVISERS, LLC | $13.1M | 0.41% |
| California Public Employees Retirement System | $13.1M | 0.01% |
| DEUTSCHE BANK AG\ | $12.3M | 0.00% |
| SEGALL BRYANT & HAMILL, LLC | $11.9M | 0.17% |
| Checkpoint Capital L.P. | $11.9M | 4.26% |
| PINNACLE ASSOCIATES LTD | $11.7M | 0.15% |
| Russell Investments Group, Ltd. | $11.5M | 0.01% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | $11.0M | 0.01% |
| AQR CAPITAL MANAGEMENT LLC | $10.3M | 0.00% |
| Legal & General Group Plc | $10.0M | 0.00% |
| Alyeska Investment Group, L.P. | $9.9M | 0.03% |
| Retirement Systems of Alabama | $9.9M | 0.03% |
| FIRST TRUST ADVISORS LP | $9.6M | 0.01% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | $9.0M | 0.01% |
| EMERALD MUTUAL FUND ADVISERS TRUST | $8.9M | 0.43% |
| STEMPOINT CAPITAL LP | $8.5M | 1.64% |
| Impax Asset Management Group plc | $8.2M | 0.06% |
| ROYCE & ASSOCIATES LP | $8.2M | 0.08% |
| MetLife Investment Management, LLC | $8.1M | 0.04% |
| ALGERT GLOBAL LLC | $7.7M | 0.12% |
| NEW YORK STATE TEACHERS RETIREMENT SYSTEM | $7.3M | 0.01% |
| LMR Partners LLP | $7.1M | 0.02% |
| Creative Planning | $7.1M | 0.00% |
| VANGUARD ASSET MANAGEMENT, Ltd | $7.1M | 0.01% |
| Exome Asset Management LLC | $6.8M | 3.54% |
| PEREGRINE CAPITAL MANAGEMENT LLC | $6.8M | 0.25% |
| Lombard Odier Asset Management (Europe) Ltd | $6.7M | 0.37% |
| Schonfeld Strategic Advisors LLC | $6.7M | 0.05% |
| Boxer Capital Management, LLC | $6.6M | 0.87% |
| Monashee Investment Management LLC | $6.6M | 3.59% |
| DIMENSIONAL FUND ADVISORS LP | $6.2M | 0.00% |
| Sofinnova Investments, Inc. | $6.0M | 0.23% |
| MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC | $6.0M | 0.07% |
| THORNBURG INVESTMENT MANAGEMENT INC | $5.5M | 0.06% |
| Walleye Trading LLC | $5.3M | 0.01% |
| J. Goldman & Co LP | $5.2M | 0.15% |
| NEUBERGER BERMAN GROUP LLC | $5.1M | 0.00% |
| WELLS FARGO & COMPANY/MN | $4.9M | 0.00% |
| Erste Asset Management GmbH | $4.8M | 0.04% |
| Rafferty Asset Management, LLC | $4.8M | 0.02% |
| Aquatic Capital Management LLC | $4.8M | 0.14% |
| Granahan Investment Management, LLC | $4.8M | 0.23% |
| STATE OF WISCONSIN INVESTMENT BOARD | $4.7M | 0.01% |
| SILVERARC CAPITAL MANAGEMENT, LLC | $4.7M | 0.48% |
| Nicholas Investment Partners, LP | $4.6M | 0.33% |
| SEI INVESTMENTS CO | $4.6M | 0.00% |
| Pier Capital, LLC | $4.6M | 0.76% |
| CANADA LIFE ASSURANCE Co | $4.5M | 0.01% |
| RAYMOND JAMES FINANCIAL INC | $4.5M | 0.00% |
| Tyro Capital Management LLC | $4.3M | 0.46% |
| ACT CAPITAL MANAGEMENT, LLC | $4.3M | 3.34% |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | $4.1M | 0.03% |
| Seven Fleet Capital Management LP | $4.0M | 1.28% |