CIK: 0001224962
Total reported value
$5.1B
| # | Ticker | Issuer | Asset Subclass | Weight | Weight Change | Shares Change | 4Q Trend |
|---|---|---|---|---|---|---|---|
| 1 | NBIX | Neurocrine Biosciences INC | Stock-Healthcare | 11.28% | -0.67% | +33.93% | |
| 2 | AM6 | Amicus Therapeutics INC | Stock-Other | 10.36% | -1.62% | EXIT | |
| 3 | ALNY | Alnylam Pharmaceuticals INC | Stock-Healthcare | 8.16% | — | +25.97% | |
| 4 | GBTUSD | Global Blood Therapeutics In | Stock-Other | 5.09% | — | +8.39% | |
| 5 | ZGNXEUR | Zogenix INC | Stock-Other | 4.94% | — | +6.44% | |
| 6 | PBYI | Puma Biotechnology INC | Stock-Other | 4.25% | — | +25.98% | |
| 7 | LJPC | La Jolla Pharmaceutical Co | Stock-Other | 2.88% | — | — | |
| 8 | RTRXEUR | Retrophin INC | Stock-Other | 2.57% | — | +0.52% | |
| 9 | ✓ | Avexis INC | Stock-Other | 2.49% | — | +147.50% | |
| 10 | ✓ | Corium Intl INC | Stock-Other | 2.49% | — | — | |
| 11 | XLRN | Acceleron Pharma INC | Stock-Other | 2.32% | — | +127.24% | |
| 12 | T8S | Tesaro INC | Stock-Other | 1.93% | — | +8.09% | |
| 13 | RGNX | Regenxbio INC | Stock-Other | 1.82% | — | +5.11% | |
| 14 | DOVA | Dova Pharmaceuticals INC | Stock-Other | 1.64% | — | +2.78% | |
| 15 | IOVA | Iovance Biotherapeutics INC | Stock-Other | 1.41% | — | +8.32% | |
| 16 | ✓ | Nxstage Medical INC | Stock-Other | 1.34% | — | -18.71% | |
| 17 | ANAB | Anaptysbio INC | Stock-Other | 1.32% | — | +3.15% | |
| 18 | AKBA | Akebia Therapeutics INC | Stock-Other | 1.23% | — | +48.18% | |
| 19 | XNCR | Xencor INC | Stock-Other | 1.14% | — | — | |
| 20 | 2655787D | Blueprint Medicines CORP | Stock-Other | 1.14% | — | -4.50% | |
| 21 | ✓ | Stock-Other | 1.05% | — | +90.35% | ||
| 22 | ISRG | Intuitive Surgical INC | Stock-Healthcare | 1.01% | — | +21.74% | |
| 23 | VAC2USD | Vbi Vaccines INC | Stock-Other | 0.97% | — | — | |
| 24 | CTMX | Cytomx Therapeutics INC | Stock-Other | 0.97% | — | — | |
| 25 | HUM | Humana INC | Stock-Healthcare | 0.94% | — | +28.05% | |
| 26 | MYOKEUR | Myokardia INC | Stock-Other | 0.91% | — | -0.44% | |
| 27 | ALDX | Aldeyra Therapeutics INC | Stock-Other | 0.85% | -0.39% | EXIT | |
| 28 | BOLDEUR | Audentes Therapeutics INC | Stock-Other | 0.84% | — | +10.43% | |
| 29 | SELBUSD | Cartesian Therapeutics INC | Stock-Other | 0.81% | — | +45.78% | |
| 30 | VRTX | Vertex Pharmaceuticals INC | Stock-Healthcare | 0.81% | — | -50.02% | |
| 31 | LKFT | Lakefront Biotherapeutic-adr | Stock-Other | 0.81% | — | -8.83% | |
| 32 | IRTC | Irhythm Holdings INC | Stock-Healthcare | 0.74% | — | +31.75% | |
| 33 | CBAYUSD | Cymabay Therapeutics INC | Stock-Other | 0.73% | — | — | |
| 34 | ✓ | Quotient LTD | Stock-Other | 0.71% | — | +0.34% | |
| 35 | BDQM | Albireo Pharma INC | Stock-Other | 0.68% | — | — | |
| 36 | NVTA1EUR | Invitae CORP | Stock-Other | 0.68% | — | +190.15% | |
| 37 | KDMN | Kadmon Holdings INC | Stock-Other | 0.67% | — | — | |
| 38 | ✓ | Avadel Pharmaceuticals PLC | Stock-Other | 0.62% | — | +8.39% | |
| 39 | ONCEEUR | Spark Therapeutics INC | Stock-Other | 0.62% | — | — | |
| 40 | ✓ | Abeona Therapeutics INC | Stock-Other | 0.61% | — | — | |
| 41 | ASMB | Assembly Biosciences, Inc. | Stock-Other | 0.59% | — | — | |
| 42 | EVH | Evolent Health INC - A | Stock-Other | 0.58% | — | -20.88% | |
| 43 | ITCIEUR | Intra-cellular Therapies INC | Stock-Other | 0.56% | — | — | |
| 44 | ATRSEUR | Antares Pharma INC | Stock-Other | 0.54% | — | +2.03% | |
| 45 | WVE | Wave Life Sciences Ltd. | Stock-Other | 0.54% | — | -3.02% | |
| 46 | TFX | Teleflex INC | Stock-Healthcare | 0.51% | — | — | |
| 47 | ✓ | Synlogic INC | Stock-Other | 0.50% | — | — | |
| 48 | AVEOEUR | Aveo Pharmaceuticals INC | Stock-Other | 0.48% | — | -43.18% | |
| 49 | BHVN | Biohaven Ltd. | Stock-Other | 0.44% | — | +155.11% | |
| 50 | ARGX | Argenx Se - Adr | Stock-Healthcare | 0.39% | — | — |
| # | Ticker | Issuer | Weight Change | Shares Change | Action |
|---|---|---|---|---|---|
| 1 | NBIX | Neurocrine Biosciences INC | +2.9% | +33.93% | Add |
| 2 | ZGNXEUR | Zogenix INC | +2.4% | +6.44% | Add |
| 3 | AM6 | Amicus Therapeutics INC | +1.6% | +3.42% | Add |
| 4 | ✓ | Avexis INC | +1.4% | +147.50% | Add |
| 5 | XLRN | Acceleron Pharma INC | +1.2% | +127.24% | Add |
| 6 | PBYI | Puma Biotechnology INC | +1% | +25.98% | Add |
| 7 | ALNY | Alnylam Pharmaceuticals INC | +0.8% | +25.97% | Add |
| 8 | ✓ | Alliqua | +0.5% | — | Unchanged |
| 9 | RGNX | Regenxbio INC | +0.5% | +5.11% | Add |
| 10 | AKBA | Akebia Therapeutics INC | +0.4% | +48.18% | Add |
| 11 | ✓ | Abeona Therapeutics INC | +0.4% | — | Unchanged |
| 12 | NVTA1EUR | Invitae CORP | +0.4% | +190.15% | Add |
| 13 | ✓ | Corium Intl INC | +0.3% | — | Unchanged |
| 14 | BHVN | Biohaven Ltd. | +0.3% | +155.11% | Add |
| 15 | OXLC | Oxford Lane Capital Corp. | +0.3% | +955.09% | Add |
| 16 | MYOKEUR | Myokardia INC | +0.2% | -0.44% | Trim |
| 17 | ALDX | Aldeyra Therapeutics INC | +0.2% | +6.93% | Add |
| 18 | ANAB | Anaptysbio INC | +0.2% | +3.15% | Add |
| 19 | BOLDEUR | Audentes Therapeutics INC | +0.2% | +10.43% | Add |
| 20 | IRTC | Irhythm Holdings INC | +0.1% | +31.75% | Add |
| 21 | ASMB | Assembly Biosciences, Inc. | +0.1% | — | Unchanged |
| 22 | ISRG | Intuitive Surgical INC | 0% | +21.74% | Add |
| 23 | 2655787D | Blueprint Medicines CORP | — | -4.50% | Trim |
| 24 | ✓ | 0% | +90.35% | Add | |
| 25 | HUM | Humana INC | 0% | +28.05% | Add |
| 26 | RTRXEUR | Retrophin INC | -0.1% | +0.52% | Add |
| 27 | GBTUSD | Global Blood Therapeutics In | -0.4% | +8.39% | Add |
| 28 | LJPC | La Jolla Pharmaceutical Co | -0.4% | — | Unchanged |
| 29 | ZYNEEUR | Zynerba Pharmaceuticals INC | -0.5% | +30.70% | Add |
| 30 | ✓ | Quotient LTD | -0.6% | +0.34% | Add |
| 31 | EVH | Evolent Health INC - A | -0.8% | -20.88% | Trim |
| 32 | VRTX | Vertex Pharmaceuticals INC | -1% | -50.02% | Trim |
| 33 | SG7 | Sage Therapeutics INC | -1.1% | -21.82% | Trim |
| 34 | ✓ | Versartis INC | -3.7% | -57.16% | Trim |
| 35 | RDUSEUR | Radius Health INC | — | EXIT | Sold out |
| 36 | SRPT | Sarepta Therapeutics INC | — | EXIT | Sold out |
| 37 | ✓ | Axovant Sciences LTD | — | EXIT | Sold out |
| 38 | CBAYUSD | Cymabay Therapeutics INC | — | NEW | New buy |
| 39 | ONCEEUR | Spark Therapeutics INC | — | NEW | New buy |
| 40 | ITCIEUR | Intra-cellular Therapies INC | — | NEW | New buy |
| 41 | TFX | Teleflex INC | — | NEW | New buy |
| 42 | JAZZ | Jazz Pharmaceuticals plc | — | EXIT | Sold out |
| 43 | ✓ | Synlogic INC | — | NEW | New buy |
| 44 | ABMDEUR | Abiomed INC | — | NEW | New buy |
| 45 | ✓ | Athenahealth INC | — | NEW | New buy |
| 46 | MRNSUSD | Marinus Pharmaceuticals INC | — | NEW | New buy |
| 47 | EGRX | Eagle Pharmaceuticals INC | — | EXIT | Sold out |
| 48 | ✓ | — | NEW | New buy | |
| 49 | RARE | Ultragenyx Pharmaceutical In | — | EXIT | Sold out |
| 50 | ANIP | Ani Pharmaceuticals INC | — | EXIT | Sold out |