EcoR1 Capital, LLC SEC 13F Disclosure Analysis

CIK: 0001587114

Sector-focusedMomentum followerQuality / disciplined sizing

Total reported value

$2.4B

Reporting period: 2026-03-31 · Number of holdings: 30

EcoR1 Capital, LLC disclosed 30 holdings in its latest 13F filing for the period ending 2026-03-31, with total reported value of $2.4B and a quarterly turnover rate of 37.4%.

Browse other institutions with $1B to $10B AUM Browse other institutions starting with "E"

Personality snowflake

Concentration: 53.93
Portfolio Stability: 37.44
Momentum/Contrarian: 100
Sector conviction: 100
Diversification: 58
Sizing Uniformity: 82.64

EcoR1 Capital, LLC's disclosed holdings carry a Herfindahl concentration index of 0.135 — mathematically equivalent to about 7 equally-sized positions, well below its 30 actual disclosed holdings. That gap points to a strategy built around a small core of high-conviction bets rather than broad diversification.

Position sizes vary widely across the portfolio (a coefficient of variation of 1.74), with a handful of outsized bets alongside many smaller positions.

No strong tilt toward either adding to existing winners or initiating outsized new positions was observed in the latest reported quarter.

Sector classification currently covers about 16% of this portfolio's disclosed value; the remainder includes holdings (e.g. unmapped tickers, options, or other security types) not yet covered by our sector mapping.

Recent moves

Add 260
+105.8%　$176.7M
Trim ZYME
0.0%　-$29.6M
Trim CRNX
0.0%　-$43.9M
Trim MBX
-63.4%　-$43.8M
Add ANAB
0.0%　$55.0M
Trim XNCR
-34.2%　-$24.5M

Holdings Map

New buyAddUnchangedTrim

Top 10 holdings by weight

Full holdings list this quarter

Showing top 29 holdings (of 30 total)

#	Ticker	Issuer	Asset Subclass	Weight	Weight Change	Shares Change
1	ZYME	Zymeworks INC	Stock-Other	24.41%	-3.03%	—
2	ANAB	Anaptysbio INC	Stock-Other	18.55%	+1.22%	—
3	JAZZ	Jazz Pharmaceuticals plc	Stock-Healthcare	13.69%	+0.53%	—
4	260	Centessa Pharmaceuticals-adr	Stock-Other	10.81%	+7.28%	+105.80%
5	CRNX	Crinetics Pharmaceuticals In	Stock-Other	6.61%	-2.45%	—
6	AKTS	Aktis Oncology INC	Stock-Other	3.66%	+3.66%	NEW
7	ORIC	Oric Pharmaceuticals INC	Stock-Other	3.62%	+1.12%	—
8	CGON	Cg Oncology INC	Stock-Other	3.17%	+1.16%	+3.49%
9	CRSP	CRISPR Therapeutics AG	Stock-Healthcare	2.80%	-0.51%	—
10	ETON	Eton Pharmaceuticals INC	Stock-Other	2.27%	+0.71%	+6.96%
11	LKFT	Lakefront Biotherapeutic-adr	Stock-Other	2.12%	-0.35%	—
12	XNCR	Xencor INC	Stock-Other	1.12%	-1.19%	-34.22%
13	NGNE	Neurogene INC	Stock-Other	1.09%	-0.10%	—
14	BBOT	Bridgebio Oncology Therapeut	Stock-Other	1.07%	-0.53%	—
15	MBX	Mbx Biosciences INC	Stock-Other	0.98%	-2.06%	-63.41%
16	RLAY	Relay Therapeutics INC	Stock-Other	0.80%	+0.80%	NEW
17	ZBIO	Zenas Biopharma INC	Stock-Other	0.66%	-0.64%	—
18	ERAS	Erasca INC	Stock-Other	0.62%	+0.62%	NEW
19	EIKN	Eikon Therapeutics INC	Stock-Other	0.33%	+0.33%	NEW
20	REPL	Replimune Group INC	Stock-Other	0.32%	+0.32%	NEW
21	✓	Zura Bio LTD	Stock-Other	0.30%	+0.30%	NEW
22	PHAT	Phathom Pharmaceuticals INC	Stock-Other	0.29%	+0.29%	NEW
23	MREO	Mereo Biopharma Group Pl-adr	Stock-Other	0.19%	+0.04%	+70.16%
24	STOK	Stoke Therapeutics INC	Stock-Other	0.14%	+0.14%	NEW
25	PRLD	Prelude Therapeutics INC	Stock-Other	0.14%	+0.14%	NEW
26	IBIO	Ibio INC	Stock-Other	0.13%	-0.07%	-28.95%
27	✓	Helix Acquisition CORP Iii	Stock-Other	0.09%	+0.09%	NEW
28	ATRA	Atara Biotherapeutics INC	Stock-Other	0.02%	-0.45%	-82.62%
29	SRZNW	Surrozen Inc-cw25	Stock-Other	0.01%	+0.01%	—

Portfolio Performance

Performance for Q3 2026

+20.8%

Performance Last 4 Quarters

+47.4%

Based on 58% of reported portfolio value with available pricing

Stdev: +31.8%
Beta: +1.03
Alpha: -20.3%
Max Drawdown: -48.4%
Annualized Perf: -7.3%
Batting Avg vs S&P: +43.5%
Sortino: -0.13
Stutzer: -0.03
Treynor: -0.03
Sterling: -0.5
Calmar: -0.15
Information Ratio: -0.68
Tracking Error: +29%
Stdev Down: +21.5%
Winning Months %: +43.5%
Losing Months %: +56.5%
Best 12 Months: +37.1%
Worst 12 Months: -44.9%
Efficiency Ratio: +0.09
Sharpe: -0.09
Stdev Sectors: 0%
Skewness: +0.29
Kurtosis: +0.77
Upside Potential: +1.85

Reported value over time

Sector allocation

Sector allocation over time

Quarterly history

Period	Holdings	Total value	Stability	Top holdings
2026-03-31	30	$2.4B	37	1ZYME 2ANAB 3JAZZ Top holdings2026-03-31 1.ZYME 2.ANAB 3.JAZZ 4.260 5.CRNX 6.AKTS 7.ORIC 8.CGON 9.CRSP 10.ETON
2025-12-31	30	$2.2B	61	1ZYME 2ANAB 3JAZZ Top holdings2025-12-31 1.ZYME 2.ANAB 3.JAZZ 4.CRNX 5.260 6.CRSP 7.MBX 8.IMNM 9.ORIC 10.LKFT
2025-09-30	30	$2.1B	81	1ZYME 2ANAB 3QURE Top holdings2025-09-30 1.ZYME 2.ANAB 3.QURE 4.JAZZ 5.CRNX 6.CRSP 7.TNGX 8.ORIC 9.APLSUSD 10.XNCR
2025-06-30	37	$1.7B	0	1ZYME 2APLSUSD 3JAZZ Top holdings2025-06-30 1.ZYME 2.APLSUSD 3.JAZZ 4.ANAB 5.CRNX 6.2662247D 7.CRSP 8.QURE 9.TNGX 10.XNCR
2025-03-31	46	$1.7B	100	1APLSUSD 2JAZZ 3ZYME Top holdings2025-03-31 1.APLSUSD 2.JAZZ 3.ZYME 4.ANAB 5.CRNX 6.PRTA 7.SRPT 8.XNCR 9.CRSP 10.QURE
2024-12-31	59	$2.6B	0	1APLSUSD 2ZYME 3CRNX Top holdings2024-12-31 1.APLSUSD 2.ZYME 3.CRNX 4.JAZZ 5.PRTA 6.XNCR 7.PFE 8.ARVN 9.ANAB 10.SRPT
2024-09-30	64	$2.9B	0	1APLSUSD 2ANAB 3CRNX Top holdings2024-09-30 1.APLSUSD 2.ANAB 3.CRNX 4.PRTA 5.JAZZ 6.ZYME 7.ARVN 8.KURA 9.XNCR 10.TNGX
2024-06-30	55	$3.3B	0	1APLSUSD 2PRTA 3SRPT Top holdings2024-06-30 1.APLSUSD 2.PRTA 3.SRPT 4.ANAB 5.CRNX 6.ARVN 7.MORFUSD 8.LKFT 9.KURA 10.TNGX
2024-03-31	59	$4.0B	0	1APLSUSD 2PRTA 3ARVN Top holdings2024-03-31 1.APLSUSD 2.PRTA 3.ARVN 4.SRPT 5.CRNX 6.LKFT 7.ANAB 8.ZYME 9.KURA 10.JAZZ
2023-12-31	51	$3.9B	0	1APLSUSD 2MRTXEUR 3PRTA Top holdings2023-12-31 1.APLSUSD 2.MRTXEUR 3.PRTA 4.ARVN 5.LKFT 6.ACAD 7.ANAB 8.ZYME 9.TNGX 10.JAZZ
2023-09-30	51	$3.0B	0	1PRTA 2APLSUSD 3MRTXEUR Top holdings2023-09-30 1.PRTA 2.APLSUSD 3.MRTXEUR 4.LKFT 5.RVMD 6.ANAB 7.ACAD 8.ARVN 9.XNCR 10.TNGX
2023-06-30	53	$4.1B	0	1PRTA 2APLSUSD 3SRPT Top holdings2023-06-30 1.PRTA 2.APLSUSD 3.SRPT 4.JNJ 5.LKFT 6.MORFUSD 7.RVMD 8.ANAB 9.ACAD 10.XNCR
2023-03-31	58	$3.1B	0	1PRTA 2SRPT 3APLSUSD Top holdings2023-03-31 1.PRTA 2.SRPT 3.APLSUSD 4.LKFT 5.ANAB 6.XNCR 7.MORFUSD 8.RVMD 9.ACAD 10.ARVN
2022-12-31	66	$3.3B	0	1PRTA 2SRPT 3APLSUSD Top holdings2022-12-31 1.PRTA 2.SRPT 3.APLSUSD 4.ANAB 5.LKFT 6.XNCR 7.ARVN 8.RVMD 9.MORFUSD 10.ACAD
2022-09-30	76	$3.4B	0	1PRTA 2APLSUSD 3SRPT Top holdings2022-09-30 1.PRTA 2.APLSUSD 3.SRPT 4.ANAB 5.ARVN 6.XNCR 7.LKFT 8.MORFUSD 9.SWTXUSD 10.ACAD
2022-06-30	80	$2.9B	0	1PRTA 2APLSUSD 3SRPT Top holdings2022-06-30 1.PRTA 2.APLSUSD 3.SRPT 4.SGENUSD 5.LKFT 6.ANAB 7.XNCR 8.ARVN 9.KURA 10.MORFUSD
2022-03-31	87	$3.2B	0	1PRTA 2APLSUSD 3LKFT Top holdings2022-03-31 1.PRTA 2.APLSUSD 3.LKFT 4.ANAB 5.SRPT 6.MORFUSD 7.ACAD 8.XNCR 9.KURA 10.RCUS
2021-12-31	76	$3.1B	0	1PRTA 2ANAB 3RCUS Top holdings2021-12-31 1.PRTA 2.ANAB 3.RCUS 4.XNCR 5.APLSUSD 6.MORFUSD 7.LKFT 8.NUVB 9.ALEC 10.PTGX
2021-09-30	71	$2.9B	0	1PRTA 2MORFUSD 3ANAB Top holdings2021-09-30 1.PRTA 2.MORFUSD 3.ANAB 4.RCUS 5.XNCR 6.NUVB 7.ALEC 8.MRTXEUR 9.LKFT 10.STTK
2021-06-30	72	$2.7B	91	1PRTA 2MORFUSD 3ANAB Top holdings2021-06-30 1.PRTA 2.MORFUSD 3.ANAB 4.XNCR 5.RLAY 6.NUVB 7.STTK 8.RCUS 9.ALEC 10.SPRY
2021-03-31	71	$2.3B	57	1PRTA 2XNCR 3MORFUSD Top holdings2021-03-31 1.PRTA 2.XNCR 3.MORFUSD 4.ANAB 5.NUVB 6.RLAY 7.SPRY 8.KURA 9.MRTXEUR 10.ORIC
2020-12-31	67	$1.9B	61	1XNCR 2RLAY 3STTK Top holdings2020-12-31 1.XNCR 2.RLAY 3.STTK 4.SPRY 5.PRTA 6.ORIC 7.MRTXEUR 8.MORFUSD 9.ANAB 10.BIIB
2020-09-30	50	$1.4B	62	1XNCR 2KURA 3RLAY Top holdings2020-09-30 1.XNCR 2.KURA 3.RLAY 4.PRTA 5.MORFUSD 6.MRTXEUR 7.ORIC 8.RNAGBP 9.ANAB 10.64049K
2020-06-30	49	$1.4B	98	1XNCR 2PRTA 3ORIC Top holdings2020-06-30 1.XNCR 2.PRTA 3.ORIC 4.MORFUSD 5.KURA 6.ASMB 7.DRNAUSD 8.ANAB 9.RNAGBP 10.64049K
2020-03-31	51	$957.2M	59	1PRTA 2XNCR 3ARVN Top holdings2020-03-31 1.PRTA 2.XNCR 3.ARVN 4.DRNAUSD 5.FATE 6.IRWD 7.ANAB 8.64049K 9.MORFUSD 10.ASMB
2019-12-31	44	$1.1B	76	1PRTA 2FGENEUR 3XNCR Top holdings2019-12-31 1.PRTA 2.FGENEUR 3.XNCR 4.DRNAUSD 5.KURA 6.IRWD 7.ARVN 8.ASMB 9.64049K 10.MORFUSD
2019-09-30	41	$791.9M	59	1XNCR 2PRTA 3FGENEUR Top holdings2019-09-30 1.XNCR 2.PRTA 3.FGENEUR 4.ONCEEUR 5.KURA 6.ARGX 7.DRNAUSD 8.IRWD 9.MORFUSD 10.SLDB
2019-06-30	40	$989.6M	65	1KURA 2XNCR 3ARGX Top holdings2019-06-30 1.KURA 2.XNCR 3.ARGX 4.FGENEUR 5.CRSP 6.ONCEEUR 7.MRTXEUR 8.DRNAUSD 9.IRWD 10.MORFUSD
2019-03-31	41	$1.1B	79	1ARGX 2KURA 3MRTXEUR Top holdings2019-03-31 1.ARGX 2.KURA 3.MRTXEUR 4.CRSP 5.XNCR 6.ONCEEUR 7.IRWD 8.31572Q 9.DRNAUSD 10.ASND
2018-12-31	54	$999.4M	75	1ARGX 2KURA 3FGENEUR Top holdings2018-12-31 1.ARGX 2.KURA 3.FGENEUR 4.IRWD 5.ASMB 6.ONCEEUR 7.ASND 8.IONS 9.31572Q 10.XNCR
2018-09-30	51	$1.1B	48	1FGENEUR 2ASMB 3IRWD Top holdings2018-09-30 1.FGENEUR 2.ASMB 3.IRWD 4.ASND 5.KURA 6.SRRK 7.DRNAUSD 8.ONCEEUR 9.MGNX 10.RCUS
2018-06-30	35	$1.1B	69	1FGENEUR 2IRWD 3ASMB Top holdings2018-06-30 1.FGENEUR 2.IRWD 3.ASMB 4.ASND 5.KURA 6.MDGL 7.151020 8.SRRK 9.DRNAUSD 10.MGNX
2018-03-31	32	$997.0M	48	1ASMB 2ASND 3FGENEUR Top holdings2018-03-31 1.ASMB 2.ASND 3.FGENEUR 4.IRWD 5.KURA 6.WVE 7.ARRYEUR 8.DRNAUSD 9.MGNX 10.RCUS
2017-12-31	31	$888.1M	72	1ASMB 2FGENEUR3151020 Top holdings2017-12-31 1.ASMB 2.FGENEUR 3.151020 4.IRWD 5.ASND 6.KURA 7.DRNAUSD 8.ARRYEUR 9.WVE 10.MYOKEUR
2017-09-30	40	$750.3M	88	1ASMB 2FGENEUR 3IRWD Top holdings2017-09-30 1.ASMB 2.FGENEUR 3.IRWD 4.ASND 5.KURA 6.IMMU 7.MYOKEUR 8.LKFT 9.MRNSUSD 10.LIFEUSD
2017-06-30	36	$563.2M	75	10153512IRWD 3ASMB Top holdings2017-06-30 1.015351 2.IRWD 3.ASMB 4.FGENEUR 5.LKFT 6.ASND 7.GILD 8.SGMOQ 9.KURA 10.888846
2017-03-31	33	$395.6M	84	1ASMB 2IRWD 3LKFT Top holdings2017-03-31 1.ASMB 2.IRWD 3.LKFT 4.GILD 5.ASND 6.KURA 7.TBPH 3.25 11-01-23 8.ACRS 9.CTMX 10.14740B
2016-12-31	30	$299.4M	87	1IRWD 2LKFT 3ASMB Top holdings2016-12-31 1.IRWD 2.LKFT 3.ASMB 4.ALXN 5.ASND 6.TBPH 3.25 11-01-23 7.ARDX 8.KURA 9.FPRX 10.ACRS
2016-09-30	31	$325.9M	88	1IRWD 2LKFT 3BMY Top holdings2016-09-30 1.IRWD 2.LKFT 3.BMY 4.ASMB 5.DERMEUR 6.ARDX 7.KURA 8.FPRX 9.FGENEUR 10.GILD
2016-06-30	32	$253.6M	87	1IRWD 2LKFT 3RTRXEUR Top holdings2016-06-30 1.IRWD 2.LKFT 3.RTRXEUR 4.CYTK 5.ASMB 6.FGENEUR 7.XLRN 8.GILD 9.G0177J 10.ITCIEUR
2016-03-31	37	$286.2M	82	1IRWD 2FPRX 3EPZMEUR Top holdings2016-03-31 1.IRWD 2.FPRX 3.EPZMEUR 4.FGENEUR 5.ARRY 3 06-01-20 6.RTRXEUR 7.78464A 8.CYTK 9.GILD 10.ASMB
2015-12-31	31	$318.4M	78	1FGENEUR 2FPRX3G50871 Top holdings2015-12-31 1.FGENEUR 2.FPRX 3.G50871 4.RTRXEUR 5.ARRY 3 06-01-20 6.KURA 7.ASMB 8.CYTK 9.91911K 10.COLL
2015-09-30	25	$219.7M	56	1FGENEUR 2ATRAGBX 3ARRY 3 06-01-20 Top holdings2015-09-30 1.FGENEUR 2.ATRAGBX 3.ARRY 3 06-01-20 4.RTRXEUR 5.EPZMEUR 6.ASMB 7.KRG 8.33938A 9.COLL 10.LIFEUSD
2015-06-30	27	$299.9M	69	1ATRAGBX 2EPZMEUR 3ASMB Top holdings2015-06-30 1.ATRAGBX 2.EPZMEUR 3.ASMB 4.FGENEUR 5.ARRY 3 06-01-20 6.KRG 7.33938A 8.LIFEUSD 9.RTRXEUR 10.KIN1USD
2015-03-31	24	$300.1M	85	1ATRAGBX 2EPZMEUR3756207 Top holdings2015-03-31 1.ATRAGBX 2.EPZMEUR 3.756207 4.IRWD 5.ARRY 3 06-01-20 6.ASMB 7.189464 8.CLVSEUR 9.KRG 10.33938A
2014-12-31	22	$197.6M	0	1KRG 2CLVSEUR3756207 Top holdings2014-12-31 1.KRG 2.CLVSEUR 3.756207 4.ARRY 3 06-01-20 5.MGNX 6.IRWD 7.FGENEUR 8.ATRAGBX 9.KIN1USD 10.SG7

Holding changes this quarter

EcoR1 Capital, LLC's most significant position changes for 2026-03-31: New buy: Aktis Oncology INC (AKTS); Sold out: Immunome INC (IMNM); Sold out: Structure Therapeutics INC (GPCR); Sold out: Vaxcyte INC (PCVX); New buy: Relay Therapeutics INC (RLAY).

Position changes disclosed by EcoR1 Capital, LLC for the quarter ending 2026-03-31, including ticker, issuer, weight change, shares change, and action
#	Ticker	Issuer	Weight Change	Shares Change	Action
1	260	Centessa Pharmaceuticals-adr	+7.3%	+105.80%	Add
2	ANAB	Anaptysbio INC	+1.2%	—	Unchanged
3	CGON	Cg Oncology INC	+1.2%	+3.49%	Add
4	ORIC	Oric Pharmaceuticals INC	+1.1%	—	Unchanged
5	ETON	Eton Pharmaceuticals INC	+0.7%	+6.96%	Add
6	JAZZ	Jazz Pharmaceuticals plc	+0.5%	—	Unchanged
7	MREO	Mereo Biopharma Group Pl-adr	0%	+70.16%	Add
8	SRZNW	Surrozen Inc-cw25	0%	—	Unchanged
9	IBIO	Ibio INC	-0.1%	-28.95%	Trim
10	NGNE	Neurogene INC	-0.1%	—	Unchanged
11	LKFT	Lakefront Biotherapeutic-adr	-0.4%	—	Unchanged
12	ATRA	Atara Biotherapeutics INC	-0.5%	-82.62%	Trim
13	CRSP	CRISPR Therapeutics AG	-0.5%	—	Unchanged
14	BBOT	Bridgebio Oncology Therapeut	-0.5%	—	Unchanged
15	ZBIO	Zenas Biopharma INC	-0.6%	—	Unchanged
16	XNCR	Xencor INC	-1.2%	-34.22%	Trim
17	MBX	Mbx Biosciences INC	-2.1%	-63.41%	Trim
18	CRNX	Crinetics Pharmaceuticals In	-2.5%	—	Unchanged
19	ZYME	Zymeworks INC	-3%	—	Unchanged
20	AKTS	Aktis Oncology INC	—	NEW	New buy
21	IMNM	Immunome INC	—	EXIT	Sold out
22	GPCR	Structure Therapeutics INC	—	EXIT	Sold out
23	PCVX	Vaxcyte INC	—	EXIT	Sold out
24	RLAY	Relay Therapeutics INC	—	NEW	New buy
25	AQST	Aquestive Therapeutics INC	—	EXIT	Sold out
26	VYGR	Voyager Therapeutics INC	—	EXIT	Sold out
27	ERAS	Erasca INC	—	NEW	New buy
28	MNKD	Mannkind CORP	—	EXIT	Sold out
29	NUVB-WS	Nuvation Bio INC -cw27	—	EXIT	Sold out
30	EIKN	Eikon Therapeutics INC	—	NEW	New buy
31	REPL	Replimune Group INC	—	NEW	New buy
32	✓	Zura Bio LTD	—	NEW	New buy
33	PHAT	Phathom Pharmaceuticals INC	—	NEW	New buy
34	EOLS	Evolus INC	—	EXIT	Sold out
35	STOK	Stoke Therapeutics INC	—	NEW	New buy
36	PRLD	Prelude Therapeutics INC	—	NEW	New buy
37	✓	Helix Acquisition CORP Iii	—	NEW	New buy
38	CAMP	Camp4 Therapeutics CORP	—	EXIT	Sold out

Filing History

Period	Filed	Type	EDGAR
2026-03-31	2026-05-15	13F-HR	View on EDGAR
2025-12-31	2026-02-17	13F-HR	View on EDGAR
2025-09-30	2025-11-14	13F-HR	View on EDGAR
2025-06-30	2025-08-14	13F-HR	View on EDGAR
2025-03-31	2025-05-15	13F-HR	View on EDGAR
2024-12-31	2025-02-14	13F-HR	View on EDGAR
2024-09-30	2024-11-14	13F-HR	View on EDGAR
2024-06-30	2024-08-14	13F-HR	View on EDGAR
2024-03-31	2024-05-15	13F-HR	View on EDGAR
2023-12-31	2024-02-14	13F-HR	View on EDGAR
2023-09-30	2023-11-14	13F-HR	View on EDGAR
2023-06-30	2023-08-14	13F-HR	View on EDGAR
2023-03-31	2023-05-15	13F-HR	View on EDGAR
2022-12-31	2023-02-14	13F-HR	View on EDGAR
2022-09-30	2022-11-14	13F-HR	View on EDGAR
2022-06-30	2022-08-15	13F-HR	View on EDGAR
2022-03-31	2022-05-16	13F-HR	View on EDGAR
2021-12-31	2022-02-14	13F-HR	View on EDGAR
2021-09-30	2021-11-22	Amendment	View on EDGAR
2021-09-30	2021-11-15	13F-HR	View on EDGAR
2021-06-30	2021-08-16	13F-HR	View on EDGAR
2021-03-31	2021-05-17	13F-HR	View on EDGAR
2020-12-31	2021-02-16	13F-HR	View on EDGAR
2020-09-30	2020-11-16	13F-HR	View on EDGAR
2020-06-30	2020-08-14	13F-HR	View on EDGAR
2020-03-31	2020-05-15	13F-HR	View on EDGAR
2019-12-31	2020-02-18	Amendment	View on EDGAR
2019-12-31	2020-02-14	13F-HR	View on EDGAR
2019-09-30	2019-11-14	13F-HR	View on EDGAR
2019-06-30	2019-08-14	13F-HR	View on EDGAR
2019-03-31	2019-05-15	13F-HR	View on EDGAR
2018-12-31	2019-02-14	13F-HR	View on EDGAR
2018-09-30	2018-11-14	13F-HR	View on EDGAR
2018-06-30	2018-08-14	13F-HR	View on EDGAR
2018-03-31	2018-05-15	13F-HR	View on EDGAR
2017-12-31	2018-02-14	13F-HR	View on EDGAR
2017-09-30	2017-11-14	13F-HR	View on EDGAR
2017-06-30	2017-08-14	13F-HR	View on EDGAR
2017-03-31	2017-05-19	Amendment	View on EDGAR
2017-03-31	2017-05-15	13F-HR	View on EDGAR
2016-12-31	2017-02-15	Amendment	View on EDGAR
2016-12-31	2017-02-15	Amendment	View on EDGAR
2016-12-31	2017-02-14	13F-HR	View on EDGAR
2016-09-30	2016-11-14	13F-HR	View on EDGAR
2016-06-30	2016-08-15	13F-HR	View on EDGAR
2016-03-31	2016-05-16	13F-HR	View on EDGAR
2015-12-31	2016-02-16	13F-HR	View on EDGAR
2015-09-30	2015-11-16	13F-HR	View on EDGAR
2015-06-30	2015-08-14	13F-HR	View on EDGAR
2015-03-31	2015-05-18	Amendment	View on EDGAR
2015-03-31	2015-05-15	13F-HR	View on EDGAR
2014-12-31	2015-02-17	13F-HR	View on EDGAR

FAQ

What is EcoR1 Capital, LLC and what type of investor is it?

EcoR1 Capital, LLC is a investment manager that files SEC Form 13F quarterly, disclosing its U.S. public equity holdings to regulators. As of the most recent reporting period (2026-03-31), the firm manages a tracked equity portfolio valued at approximately $2.4B, spread across 30 disclosed positions.

What are EcoR1 Capital, LLC's largest equity positions?

Based on the latest 13F filing, EcoR1 Capital, LLC's top holdings by market value are: 1. Zymeworks INC (ZYME) — $575.2M (24.4%) 2. Anaptysbio INC (ANAB) — $437.0M (18.6%) 3. Jazz Pharmaceuticals plc (JAZZ) — $322.6M (13.7%) 4. Centessa Pharmaceuticals-adr (260) — $254.6M (10.8%) 5. Crinetics Pharmaceuticals In (CRNX) — $155.7M (6.6%)

What changes did EcoR1 Capital, LLC make in its most recent portfolio filing?

In the latest reported quarter, EcoR1 Capital, LLC made 27 notable position adjustments: 10 new positions were initiated, 4 existing holdings were added to, 4 positions were partially reduced, and 9 were completely exited. The largest of these moves: New buy: Aktis Oncology INC (AKTS); Sold out: Immunome INC (IMNM); Sold out: Structure Therapeutics INC (GPCR); Sold out: Vaxcyte INC (PCVX); New buy: Relay Therapeutics INC (RLAY)

What sectors does EcoR1 Capital, LLC focus on?

EcoR1 Capital, LLC is concentrated in the following sectors based on its current disclosed equity portfolio: • Health Care: 100.0%

Peer Institutions

Institutions with a similar AUM

American Portfolios Advisors

CIK 0001961150

Total reported value

$2.4B

3,531 stks

2022-09-30

Stale — no recent filing

Concentration2.8

Portfolio Stability0.0

Sector conviction48.0

AUM within 0.1% of this institution

View detail

Keeley Asset Management CORP

CIK 0001056504

Total reported value

$2.4B

270 stks

2016-12-31

Stale — no recent filing

Concentration4.8

Portfolio Stability25.7

Sector conviction100.0

AUM within 0.2% of this institution

View detail

Security Capital Research & Management INC

CIK 0001068829

Total reported value

$2.4B

42 stks

2020-06-30

Stale — no recent filing

Concentration21.3

Portfolio Stability53.7

Sector conviction0.0

AUM within 0.2% of this institution

View detail

Similar Holdings Style

Institutions with overlapping top holdings

Driehaus Capital Management LLC

CIK 0000938206

Total reported value

$13.6B

356 stks

2026-03-31

Concentration2.8

Portfolio Stability64.6

Sector conviction59.8

1 of the top 5 holdings overlap, including Crinetics Pharmaceuticals In

View detail

Systematic Financial Management LP

CIK 0001085936

Total reported value

$4.4B

408 stks

2026-03-31

Concentration3.4

Portfolio Stability19.4

Sector conviction41.3

1 of the top 5 holdings overlap, including Jazz Pharmaceuticals plc

View detail

GMT Capital Corp

CIK 0001106191

Total reported value

$2.2B

77 stks

2026-03-31

Concentration32.1

Portfolio Stability38.8

Sector conviction51.7

1 of the top 5 holdings overlap, including Jazz Pharmaceuticals plc

View detail

EcoR1 Capital, LLC SEC 13F Disclosure Analysis

CIK: 0001587114

Sector-focusedMomentum followerQuality / disciplined sizing

Total reported value

$2.4B

Reporting period: 2026-03-31 · Number of holdings: 30

EcoR1 Capital, LLC disclosed 30 holdings in its latest 13F filing for the period ending 2026-03-31, with total reported value of $2.4B and a quarterly turnover rate of 37.4%.

Browse other institutions with $1B to $10B AUM Browse other institutions starting with "E"

Personality snowflake

Concentration: 53.93
Portfolio Stability: 37.44
Momentum/Contrarian: 100
Sector conviction: 100
Diversification: 58
Sizing Uniformity: 82.64

Position sizes vary widely across the portfolio (a coefficient of variation of 1.74), with a handful of outsized bets alongside many smaller positions.

No strong tilt toward either adding to existing winners or initiating outsized new positions was observed in the latest reported quarter.

Recent moves

Add 260
+105.8%　$176.7M
Trim ZYME
0.0%　-$29.6M
Trim CRNX
0.0%　-$43.9M
Trim MBX
-63.4%　-$43.8M
Add ANAB
0.0%　$55.0M
Trim XNCR
-34.2%　-$24.5M

Holdings Map

New buyAddUnchangedTrim

Top 10 holdings by weight

Full holdings list this quarter

Showing top 29 holdings (of 30 total)

#	Ticker	Issuer	Asset Subclass	Weight	Weight Change	Shares Change
1	ZYME	Zymeworks INC	Stock-Other	24.41%	-3.03%	—
2	ANAB	Anaptysbio INC	Stock-Other	18.55%	+1.22%	—
3	JAZZ	Jazz Pharmaceuticals plc	Stock-Healthcare	13.69%	+0.53%	—
4	260	Centessa Pharmaceuticals-adr	Stock-Other	10.81%	+7.28%	+105.80%
5	CRNX	Crinetics Pharmaceuticals In	Stock-Other	6.61%	-2.45%	—
6	AKTS	Aktis Oncology INC	Stock-Other	3.66%	+3.66%	NEW
7	ORIC	Oric Pharmaceuticals INC	Stock-Other	3.62%	+1.12%	—
8	CGON	Cg Oncology INC	Stock-Other	3.17%	+1.16%	+3.49%
9	CRSP	CRISPR Therapeutics AG	Stock-Healthcare	2.80%	-0.51%	—
10	ETON	Eton Pharmaceuticals INC	Stock-Other	2.27%	+0.71%	+6.96%
11	LKFT	Lakefront Biotherapeutic-adr	Stock-Other	2.12%	-0.35%	—
12	XNCR	Xencor INC	Stock-Other	1.12%	-1.19%	-34.22%
13	NGNE	Neurogene INC	Stock-Other	1.09%	-0.10%	—
14	BBOT	Bridgebio Oncology Therapeut	Stock-Other	1.07%	-0.53%	—
15	MBX	Mbx Biosciences INC	Stock-Other	0.98%	-2.06%	-63.41%
16	RLAY	Relay Therapeutics INC	Stock-Other	0.80%	+0.80%	NEW
17	ZBIO	Zenas Biopharma INC	Stock-Other	0.66%	-0.64%	—
18	ERAS	Erasca INC	Stock-Other	0.62%	+0.62%	NEW
19	EIKN	Eikon Therapeutics INC	Stock-Other	0.33%	+0.33%	NEW
20	REPL	Replimune Group INC	Stock-Other	0.32%	+0.32%	NEW
21	✓	Zura Bio LTD	Stock-Other	0.30%	+0.30%	NEW
22	PHAT	Phathom Pharmaceuticals INC	Stock-Other	0.29%	+0.29%	NEW
23	MREO	Mereo Biopharma Group Pl-adr	Stock-Other	0.19%	+0.04%	+70.16%
24	STOK	Stoke Therapeutics INC	Stock-Other	0.14%	+0.14%	NEW
25	PRLD	Prelude Therapeutics INC	Stock-Other	0.14%	+0.14%	NEW
26	IBIO	Ibio INC	Stock-Other	0.13%	-0.07%	-28.95%
27	✓	Helix Acquisition CORP Iii	Stock-Other	0.09%	+0.09%	NEW
28	ATRA	Atara Biotherapeutics INC	Stock-Other	0.02%	-0.45%	-82.62%
29	SRZNW	Surrozen Inc-cw25	Stock-Other	0.01%	+0.01%	—

Portfolio Performance

Performance for Q3 2026

+20.8%

Performance Last 4 Quarters

+47.4%

Based on 58% of reported portfolio value with available pricing

Stdev: +31.8%
Beta: +1.03
Alpha: -20.3%
Max Drawdown: -48.4%
Annualized Perf: -7.3%
Batting Avg vs S&P: +43.5%
Sortino: -0.13
Stutzer: -0.03
Treynor: -0.03
Sterling: -0.5
Calmar: -0.15
Information Ratio: -0.68
Tracking Error: +29%
Stdev Down: +21.5%
Winning Months %: +43.5%
Losing Months %: +56.5%
Best 12 Months: +37.1%
Worst 12 Months: -44.9%
Efficiency Ratio: +0.09
Sharpe: -0.09
Stdev Sectors: 0%
Skewness: +0.29
Kurtosis: +0.77
Upside Potential: +1.85

Reported value over time

Sector allocation

Sector allocation over time

Quarterly history

Period	Holdings	Total value	Stability	Top holdings
2026-03-31	30	$2.4B	37	1ZYME 2ANAB 3JAZZ Top holdings2026-03-31 1.ZYME 2.ANAB 3.JAZZ 4.260 5.CRNX 6.AKTS 7.ORIC 8.CGON 9.CRSP 10.ETON
2025-12-31	30	$2.2B	61	1ZYME 2ANAB 3JAZZ Top holdings2025-12-31 1.ZYME 2.ANAB 3.JAZZ 4.CRNX 5.260 6.CRSP 7.MBX 8.IMNM 9.ORIC 10.LKFT
2025-09-30	30	$2.1B	81	1ZYME 2ANAB 3QURE Top holdings2025-09-30 1.ZYME 2.ANAB 3.QURE 4.JAZZ 5.CRNX 6.CRSP 7.TNGX 8.ORIC 9.APLSUSD 10.XNCR
2025-06-30	37	$1.7B	0	1ZYME 2APLSUSD 3JAZZ Top holdings2025-06-30 1.ZYME 2.APLSUSD 3.JAZZ 4.ANAB 5.CRNX 6.2662247D 7.CRSP 8.QURE 9.TNGX 10.XNCR
2025-03-31	46	$1.7B	100	1APLSUSD 2JAZZ 3ZYME Top holdings2025-03-31 1.APLSUSD 2.JAZZ 3.ZYME 4.ANAB 5.CRNX 6.PRTA 7.SRPT 8.XNCR 9.CRSP 10.QURE
2024-12-31	59	$2.6B	0	1APLSUSD 2ZYME 3CRNX Top holdings2024-12-31 1.APLSUSD 2.ZYME 3.CRNX 4.JAZZ 5.PRTA 6.XNCR 7.PFE 8.ARVN 9.ANAB 10.SRPT
2024-09-30	64	$2.9B	0	1APLSUSD 2ANAB 3CRNX Top holdings2024-09-30 1.APLSUSD 2.ANAB 3.CRNX 4.PRTA 5.JAZZ 6.ZYME 7.ARVN 8.KURA 9.XNCR 10.TNGX
2024-06-30	55	$3.3B	0	1APLSUSD 2PRTA 3SRPT Top holdings2024-06-30 1.APLSUSD 2.PRTA 3.SRPT 4.ANAB 5.CRNX 6.ARVN 7.MORFUSD 8.LKFT 9.KURA 10.TNGX
2024-03-31	59	$4.0B	0	1APLSUSD 2PRTA 3ARVN Top holdings2024-03-31 1.APLSUSD 2.PRTA 3.ARVN 4.SRPT 5.CRNX 6.LKFT 7.ANAB 8.ZYME 9.KURA 10.JAZZ
2023-12-31	51	$3.9B	0	1APLSUSD 2MRTXEUR 3PRTA Top holdings2023-12-31 1.APLSUSD 2.MRTXEUR 3.PRTA 4.ARVN 5.LKFT 6.ACAD 7.ANAB 8.ZYME 9.TNGX 10.JAZZ
2023-09-30	51	$3.0B	0	1PRTA 2APLSUSD 3MRTXEUR Top holdings2023-09-30 1.PRTA 2.APLSUSD 3.MRTXEUR 4.LKFT 5.RVMD 6.ANAB 7.ACAD 8.ARVN 9.XNCR 10.TNGX
2023-06-30	53	$4.1B	0	1PRTA 2APLSUSD 3SRPT Top holdings2023-06-30 1.PRTA 2.APLSUSD 3.SRPT 4.JNJ 5.LKFT 6.MORFUSD 7.RVMD 8.ANAB 9.ACAD 10.XNCR
2023-03-31	58	$3.1B	0	1PRTA 2SRPT 3APLSUSD Top holdings2023-03-31 1.PRTA 2.SRPT 3.APLSUSD 4.LKFT 5.ANAB 6.XNCR 7.MORFUSD 8.RVMD 9.ACAD 10.ARVN
2022-12-31	66	$3.3B	0	1PRTA 2SRPT 3APLSUSD Top holdings2022-12-31 1.PRTA 2.SRPT 3.APLSUSD 4.ANAB 5.LKFT 6.XNCR 7.ARVN 8.RVMD 9.MORFUSD 10.ACAD
2022-09-30	76	$3.4B	0	1PRTA 2APLSUSD 3SRPT Top holdings2022-09-30 1.PRTA 2.APLSUSD 3.SRPT 4.ANAB 5.ARVN 6.XNCR 7.LKFT 8.MORFUSD 9.SWTXUSD 10.ACAD
2022-06-30	80	$2.9B	0	1PRTA 2APLSUSD 3SRPT Top holdings2022-06-30 1.PRTA 2.APLSUSD 3.SRPT 4.SGENUSD 5.LKFT 6.ANAB 7.XNCR 8.ARVN 9.KURA 10.MORFUSD
2022-03-31	87	$3.2B	0	1PRTA 2APLSUSD 3LKFT Top holdings2022-03-31 1.PRTA 2.APLSUSD 3.LKFT 4.ANAB 5.SRPT 6.MORFUSD 7.ACAD 8.XNCR 9.KURA 10.RCUS
2021-12-31	76	$3.1B	0	1PRTA 2ANAB 3RCUS Top holdings2021-12-31 1.PRTA 2.ANAB 3.RCUS 4.XNCR 5.APLSUSD 6.MORFUSD 7.LKFT 8.NUVB 9.ALEC 10.PTGX
2021-09-30	71	$2.9B	0	1PRTA 2MORFUSD 3ANAB Top holdings2021-09-30 1.PRTA 2.MORFUSD 3.ANAB 4.RCUS 5.XNCR 6.NUVB 7.ALEC 8.MRTXEUR 9.LKFT 10.STTK
2021-06-30	72	$2.7B	91	1PRTA 2MORFUSD 3ANAB Top holdings2021-06-30 1.PRTA 2.MORFUSD 3.ANAB 4.XNCR 5.RLAY 6.NUVB 7.STTK 8.RCUS 9.ALEC 10.SPRY
2021-03-31	71	$2.3B	57	1PRTA 2XNCR 3MORFUSD Top holdings2021-03-31 1.PRTA 2.XNCR 3.MORFUSD 4.ANAB 5.NUVB 6.RLAY 7.SPRY 8.KURA 9.MRTXEUR 10.ORIC
2020-12-31	67	$1.9B	61	1XNCR 2RLAY 3STTK Top holdings2020-12-31 1.XNCR 2.RLAY 3.STTK 4.SPRY 5.PRTA 6.ORIC 7.MRTXEUR 8.MORFUSD 9.ANAB 10.BIIB
2020-09-30	50	$1.4B	62	1XNCR 2KURA 3RLAY Top holdings2020-09-30 1.XNCR 2.KURA 3.RLAY 4.PRTA 5.MORFUSD 6.MRTXEUR 7.ORIC 8.RNAGBP 9.ANAB 10.64049K
2020-06-30	49	$1.4B	98	1XNCR 2PRTA 3ORIC Top holdings2020-06-30 1.XNCR 2.PRTA 3.ORIC 4.MORFUSD 5.KURA 6.ASMB 7.DRNAUSD 8.ANAB 9.RNAGBP 10.64049K
2020-03-31	51	$957.2M	59	1PRTA 2XNCR 3ARVN Top holdings2020-03-31 1.PRTA 2.XNCR 3.ARVN 4.DRNAUSD 5.FATE 6.IRWD 7.ANAB 8.64049K 9.MORFUSD 10.ASMB
2019-12-31	44	$1.1B	76	1PRTA 2FGENEUR 3XNCR Top holdings2019-12-31 1.PRTA 2.FGENEUR 3.XNCR 4.DRNAUSD 5.KURA 6.IRWD 7.ARVN 8.ASMB 9.64049K 10.MORFUSD
2019-09-30	41	$791.9M	59	1XNCR 2PRTA 3FGENEUR Top holdings2019-09-30 1.XNCR 2.PRTA 3.FGENEUR 4.ONCEEUR 5.KURA 6.ARGX 7.DRNAUSD 8.IRWD 9.MORFUSD 10.SLDB
2019-06-30	40	$989.6M	65	1KURA 2XNCR 3ARGX Top holdings2019-06-30 1.KURA 2.XNCR 3.ARGX 4.FGENEUR 5.CRSP 6.ONCEEUR 7.MRTXEUR 8.DRNAUSD 9.IRWD 10.MORFUSD
2019-03-31	41	$1.1B	79	1ARGX 2KURA 3MRTXEUR Top holdings2019-03-31 1.ARGX 2.KURA 3.MRTXEUR 4.CRSP 5.XNCR 6.ONCEEUR 7.IRWD 8.31572Q 9.DRNAUSD 10.ASND
2018-12-31	54	$999.4M	75	1ARGX 2KURA 3FGENEUR Top holdings2018-12-31 1.ARGX 2.KURA 3.FGENEUR 4.IRWD 5.ASMB 6.ONCEEUR 7.ASND 8.IONS 9.31572Q 10.XNCR
2018-09-30	51	$1.1B	48	1FGENEUR 2ASMB 3IRWD Top holdings2018-09-30 1.FGENEUR 2.ASMB 3.IRWD 4.ASND 5.KURA 6.SRRK 7.DRNAUSD 8.ONCEEUR 9.MGNX 10.RCUS
2018-06-30	35	$1.1B	69	1FGENEUR 2IRWD 3ASMB Top holdings2018-06-30 1.FGENEUR 2.IRWD 3.ASMB 4.ASND 5.KURA 6.MDGL 7.151020 8.SRRK 9.DRNAUSD 10.MGNX
2018-03-31	32	$997.0M	48	1ASMB 2ASND 3FGENEUR Top holdings2018-03-31 1.ASMB 2.ASND 3.FGENEUR 4.IRWD 5.KURA 6.WVE 7.ARRYEUR 8.DRNAUSD 9.MGNX 10.RCUS
2017-12-31	31	$888.1M	72	1ASMB 2FGENEUR3151020 Top holdings2017-12-31 1.ASMB 2.FGENEUR 3.151020 4.IRWD 5.ASND 6.KURA 7.DRNAUSD 8.ARRYEUR 9.WVE 10.MYOKEUR
2017-09-30	40	$750.3M	88	1ASMB 2FGENEUR 3IRWD Top holdings2017-09-30 1.ASMB 2.FGENEUR 3.IRWD 4.ASND 5.KURA 6.IMMU 7.MYOKEUR 8.LKFT 9.MRNSUSD 10.LIFEUSD
2017-06-30	36	$563.2M	75	10153512IRWD 3ASMB Top holdings2017-06-30 1.015351 2.IRWD 3.ASMB 4.FGENEUR 5.LKFT 6.ASND 7.GILD 8.SGMOQ 9.KURA 10.888846
2017-03-31	33	$395.6M	84	1ASMB 2IRWD 3LKFT Top holdings2017-03-31 1.ASMB 2.IRWD 3.LKFT 4.GILD 5.ASND 6.KURA 7.TBPH 3.25 11-01-23 8.ACRS 9.CTMX 10.14740B
2016-12-31	30	$299.4M	87	1IRWD 2LKFT 3ASMB Top holdings2016-12-31 1.IRWD 2.LKFT 3.ASMB 4.ALXN 5.ASND 6.TBPH 3.25 11-01-23 7.ARDX 8.KURA 9.FPRX 10.ACRS
2016-09-30	31	$325.9M	88	1IRWD 2LKFT 3BMY Top holdings2016-09-30 1.IRWD 2.LKFT 3.BMY 4.ASMB 5.DERMEUR 6.ARDX 7.KURA 8.FPRX 9.FGENEUR 10.GILD
2016-06-30	32	$253.6M	87	1IRWD 2LKFT 3RTRXEUR Top holdings2016-06-30 1.IRWD 2.LKFT 3.RTRXEUR 4.CYTK 5.ASMB 6.FGENEUR 7.XLRN 8.GILD 9.G0177J 10.ITCIEUR
2016-03-31	37	$286.2M	82	1IRWD 2FPRX 3EPZMEUR Top holdings2016-03-31 1.IRWD 2.FPRX 3.EPZMEUR 4.FGENEUR 5.ARRY 3 06-01-20 6.RTRXEUR 7.78464A 8.CYTK 9.GILD 10.ASMB
2015-12-31	31	$318.4M	78	1FGENEUR 2FPRX3G50871 Top holdings2015-12-31 1.FGENEUR 2.FPRX 3.G50871 4.RTRXEUR 5.ARRY 3 06-01-20 6.KURA 7.ASMB 8.CYTK 9.91911K 10.COLL
2015-09-30	25	$219.7M	56	1FGENEUR 2ATRAGBX 3ARRY 3 06-01-20 Top holdings2015-09-30 1.FGENEUR 2.ATRAGBX 3.ARRY 3 06-01-20 4.RTRXEUR 5.EPZMEUR 6.ASMB 7.KRG 8.33938A 9.COLL 10.LIFEUSD
2015-06-30	27	$299.9M	69	1ATRAGBX 2EPZMEUR 3ASMB Top holdings2015-06-30 1.ATRAGBX 2.EPZMEUR 3.ASMB 4.FGENEUR 5.ARRY 3 06-01-20 6.KRG 7.33938A 8.LIFEUSD 9.RTRXEUR 10.KIN1USD
2015-03-31	24	$300.1M	85	1ATRAGBX 2EPZMEUR3756207 Top holdings2015-03-31 1.ATRAGBX 2.EPZMEUR 3.756207 4.IRWD 5.ARRY 3 06-01-20 6.ASMB 7.189464 8.CLVSEUR 9.KRG 10.33938A
2014-12-31	22	$197.6M	0	1KRG 2CLVSEUR3756207 Top holdings2014-12-31 1.KRG 2.CLVSEUR 3.756207 4.ARRY 3 06-01-20 5.MGNX 6.IRWD 7.FGENEUR 8.ATRAGBX 9.KIN1USD 10.SG7

Holding changes this quarter

Position changes disclosed by EcoR1 Capital, LLC for the quarter ending 2026-03-31, including ticker, issuer, weight change, shares change, and action
#	Ticker	Issuer	Weight Change	Shares Change	Action
1	260	Centessa Pharmaceuticals-adr	+7.3%	+105.80%	Add
2	ANAB	Anaptysbio INC	+1.2%	—	Unchanged
3	CGON	Cg Oncology INC	+1.2%	+3.49%	Add
4	ORIC	Oric Pharmaceuticals INC	+1.1%	—	Unchanged
5	ETON	Eton Pharmaceuticals INC	+0.7%	+6.96%	Add
6	JAZZ	Jazz Pharmaceuticals plc	+0.5%	—	Unchanged
7	MREO	Mereo Biopharma Group Pl-adr	0%	+70.16%	Add
8	SRZNW	Surrozen Inc-cw25	0%	—	Unchanged
9	IBIO	Ibio INC	-0.1%	-28.95%	Trim
10	NGNE	Neurogene INC	-0.1%	—	Unchanged
11	LKFT	Lakefront Biotherapeutic-adr	-0.4%	—	Unchanged
12	ATRA	Atara Biotherapeutics INC	-0.5%	-82.62%	Trim
13	CRSP	CRISPR Therapeutics AG	-0.5%	—	Unchanged
14	BBOT	Bridgebio Oncology Therapeut	-0.5%	—	Unchanged
15	ZBIO	Zenas Biopharma INC	-0.6%	—	Unchanged
16	XNCR	Xencor INC	-1.2%	-34.22%	Trim
17	MBX	Mbx Biosciences INC	-2.1%	-63.41%	Trim
18	CRNX	Crinetics Pharmaceuticals In	-2.5%	—	Unchanged
19	ZYME	Zymeworks INC	-3%	—	Unchanged
20	AKTS	Aktis Oncology INC	—	NEW	New buy
21	IMNM	Immunome INC	—	EXIT	Sold out
22	GPCR	Structure Therapeutics INC	—	EXIT	Sold out
23	PCVX	Vaxcyte INC	—	EXIT	Sold out
24	RLAY	Relay Therapeutics INC	—	NEW	New buy
25	AQST	Aquestive Therapeutics INC	—	EXIT	Sold out
26	VYGR	Voyager Therapeutics INC	—	EXIT	Sold out
27	ERAS	Erasca INC	—	NEW	New buy
28	MNKD	Mannkind CORP	—	EXIT	Sold out
29	NUVB-WS	Nuvation Bio INC -cw27	—	EXIT	Sold out
30	EIKN	Eikon Therapeutics INC	—	NEW	New buy
31	REPL	Replimune Group INC	—	NEW	New buy
32	✓	Zura Bio LTD	—	NEW	New buy
33	PHAT	Phathom Pharmaceuticals INC	—	NEW	New buy
34	EOLS	Evolus INC	—	EXIT	Sold out
35	STOK	Stoke Therapeutics INC	—	NEW	New buy
36	PRLD	Prelude Therapeutics INC	—	NEW	New buy
37	✓	Helix Acquisition CORP Iii	—	NEW	New buy
38	CAMP	Camp4 Therapeutics CORP	—	EXIT	Sold out

Filing History

Period	Filed	Type	EDGAR
2026-03-31	2026-05-15	13F-HR	View on EDGAR
2025-12-31	2026-02-17	13F-HR	View on EDGAR
2025-09-30	2025-11-14	13F-HR	View on EDGAR
2025-06-30	2025-08-14	13F-HR	View on EDGAR
2025-03-31	2025-05-15	13F-HR	View on EDGAR
2024-12-31	2025-02-14	13F-HR	View on EDGAR
2024-09-30	2024-11-14	13F-HR	View on EDGAR
2024-06-30	2024-08-14	13F-HR	View on EDGAR
2024-03-31	2024-05-15	13F-HR	View on EDGAR
2023-12-31	2024-02-14	13F-HR	View on EDGAR
2023-09-30	2023-11-14	13F-HR	View on EDGAR
2023-06-30	2023-08-14	13F-HR	View on EDGAR
2023-03-31	2023-05-15	13F-HR	View on EDGAR
2022-12-31	2023-02-14	13F-HR	View on EDGAR
2022-09-30	2022-11-14	13F-HR	View on EDGAR
2022-06-30	2022-08-15	13F-HR	View on EDGAR
2022-03-31	2022-05-16	13F-HR	View on EDGAR
2021-12-31	2022-02-14	13F-HR	View on EDGAR
2021-09-30	2021-11-22	Amendment	View on EDGAR
2021-09-30	2021-11-15	13F-HR	View on EDGAR
2021-06-30	2021-08-16	13F-HR	View on EDGAR
2021-03-31	2021-05-17	13F-HR	View on EDGAR
2020-12-31	2021-02-16	13F-HR	View on EDGAR
2020-09-30	2020-11-16	13F-HR	View on EDGAR
2020-06-30	2020-08-14	13F-HR	View on EDGAR
2020-03-31	2020-05-15	13F-HR	View on EDGAR
2019-12-31	2020-02-18	Amendment	View on EDGAR
2019-12-31	2020-02-14	13F-HR	View on EDGAR
2019-09-30	2019-11-14	13F-HR	View on EDGAR
2019-06-30	2019-08-14	13F-HR	View on EDGAR
2019-03-31	2019-05-15	13F-HR	View on EDGAR
2018-12-31	2019-02-14	13F-HR	View on EDGAR
2018-09-30	2018-11-14	13F-HR	View on EDGAR
2018-06-30	2018-08-14	13F-HR	View on EDGAR
2018-03-31	2018-05-15	13F-HR	View on EDGAR
2017-12-31	2018-02-14	13F-HR	View on EDGAR
2017-09-30	2017-11-14	13F-HR	View on EDGAR
2017-06-30	2017-08-14	13F-HR	View on EDGAR
2017-03-31	2017-05-19	Amendment	View on EDGAR
2017-03-31	2017-05-15	13F-HR	View on EDGAR
2016-12-31	2017-02-15	Amendment	View on EDGAR
2016-12-31	2017-02-15	Amendment	View on EDGAR
2016-12-31	2017-02-14	13F-HR	View on EDGAR
2016-09-30	2016-11-14	13F-HR	View on EDGAR
2016-06-30	2016-08-15	13F-HR	View on EDGAR
2016-03-31	2016-05-16	13F-HR	View on EDGAR
2015-12-31	2016-02-16	13F-HR	View on EDGAR
2015-09-30	2015-11-16	13F-HR	View on EDGAR
2015-06-30	2015-08-14	13F-HR	View on EDGAR
2015-03-31	2015-05-18	Amendment	View on EDGAR
2015-03-31	2015-05-15	13F-HR	View on EDGAR
2014-12-31	2015-02-17	13F-HR	View on EDGAR