| BANK OF AMERICA CORP /DE/ | $1.9B | 0.14% |
| GOLDMAN SACHS GROUP INC | $1.8B | 0.21% |
| MORGAN STANLEY | $1.6B | 0.09% |
| CITIGROUP INC | $1.4B | 0.59% |
| Deep Track Capital, LP | $1.3B | 20.86% |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | $1.2B | 2.00% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $1.1B | 0.12% |
| JANE STREET GROUP, LLC | $933.0M | 0.12% |
| JPMORGAN CHASE & CO | $740.2M | 0.05% |
| CITADEL ADVISORS LLC | $578.6M | 0.09% |
| UBS Group AG | $510.5M | 0.08% |
| BARCLAYS PLC | $422.3M | 0.10% |
| WELLS FARGO & COMPANY/MN | $350.8M | 0.07% |
| Jefferies Financial Group Inc. | $298.9M | 2.05% |
| Jain Global LLC | $276.3M | 1.14% |
| Squarepoint Ops LLC | $267.3M | 0.31% |
| Two Seas Capital LP | $246.3M | 3.44% |
| BESSEMER GROUP INC | $230.6M | 0.36% |
| CANADA PENSION PLAN INVESTMENT BOARD | $224.5M | 0.14% |
| PEAK6 LLC | $216.3M | 0.51% |
| Caption Management, LLC | $199.0M | 1.16% |
| MILLENNIUM MANAGEMENT LLC | $197.1M | 0.08% |
| D. E. Shaw & Co., Inc. | $174.7M | 0.11% |
| Balyasny Asset Management L.P. | $166.7M | 0.22% |
| HSBC HOLDINGS PLC | $142.3M | 0.07% |
| Walleye Trading LLC | $141.3M | 0.24% |
| Sofinnova Investments, Inc. | $134.1M | 5.10% |
| BANK OF MONTREAL /CAN/ | $106.6M | 0.04% |
| MEITAV INVESTMENT HOUSE LTD | $103.4M | 1.13% |
| AMERIPRISE FINANCIAL INC | $102.4M | 0.02% |
| Ikarian Capital, LLC | $102.2M | 8.30% |
| Stonepine Capital Management, LLC | $102.2M | 40.92% |
| LPL Financial LLC | $101.2M | 0.03% |
| Eagle Health Investments LP | $93.2M | 16.31% |
| Employees Retirement System of Texas | $87.9M | 0.77% |
| Rokos Capital Management LLP | $84.3M | 0.64% |
| Greenhouse Funds LLLP | $83.1M | 3.72% |
| TUDOR INVESTMENT CORP ET AL | $79.7M | 0.15% |
| ASSETMARK, INC | $79.6M | 0.16% |
| CAPITAL FUND MANAGEMENT S.A. | $74.7M | 0.34% |
| Main Street Research LLC | $72.5M | 4.22% |
| ROYAL BANK OF CANADA | $66.7M | 0.01% |
| NATIXIS | $62.4M | 0.22% |
| Clal Insurance Enterprises Holdings Ltd | $61.9M | 0.37% |
| Quadrature Capital Ltd | $61.8M | 0.73% |
| PFM Health Sciences, LP | $58.2M | 5.30% |
| Migdal Insurance & Financial Holdings Ltd. | $57.5M | 0.50% |
| RAYMOND JAMES FINANCIAL INC | $55.3M | 0.02% |
| Clearbridge Investments, LLC | $53.3M | 0.05% |
| Investure, LLC | $52.7M | 2.58% |
| STRS OHIO | $52.4M | 0.21% |
| SG Americas Securities, LLC | $50.0M | 0.05% |
| Point72 Asset Management, L.P. | $47.7M | 0.06% |
| TWO SIGMA INVESTMENTS, LP | $43.6M | 0.04% |
| DAFNA Capital Management LLC | $40.7M | 9.25% |
| Nantahala Capital Management, LLC | $38.3M | 1.41% |
| Hudson Bay Capital Management LP | $37.4M | 0.13% |
| STIFEL FINANCIAL CORP | $37.2M | 0.03% |
| PSP Research LLC | $36.4M | 25.75% |
| Aptus Capital Advisors, LLC | $34.6M | 0.27% |
| LMR Partners LLP | $34.6M | 0.08% |
| CREDIT INDUSTRIEL ET COMMERCIAL | $33.9M | 2.64% |
| GENDELL JEFFREY L | $33.5M | 0.46% |
| WHITTIER TRUST CO | $33.2M | 0.37% |
| Annex Advisory Services, LLC | $31.6M | 0.59% |
| NEUBERGER BERMAN GROUP LLC | $30.5M | 0.02% |
| Rockefeller Capital Management L.P. | $30.1M | 0.05% |
| CREDIT AGRICOLE S A | $29.5M | 0.08% |
| BNP PARIBAS FINANCIAL MARKETS | $27.1M | 1.31% |
| SPHERA FUNDS MANAGEMENT LTD. | $25.5M | 4.06% |
| Williams Jones Wealth Management, LLC. | $25.5M | 0.31% |
| Qube Research & Technologies Ltd | $24.4M | 0.03% |
| Centiva Capital, LP | $24.2M | 0.18% |
| J. Goldman & Co LP | $24.2M | 0.70% |
| STATE OF WISCONSIN INVESTMENT BOARD | $24.0M | 0.05% |
| GenTrust, LLC | $22.4M | 0.96% |
| OSBORNE PARTNERS CAPITAL MANAGEMENT, LLC | $21.8M | 1.15% |
| Cetera Investment Advisers | $20.9M | 0.02% |
| Royal Fund Management, LLC | $20.8M | 1.98% |
| CAPSTONE INVESTMENT ADVISORS, LLC | $20.3M | 0.04% |
| WEATHERLY ASSET MANAGEMENT L. P. | $20.2M | 1.63% |
| Sivik Global Healthcare LLC | $19.2M | 14.55% |
| WS MANAGEMENT LLLP | $19.2M | 1.69% |
| BlackRock, Inc. | $19.0M | 0.00% |
| Curi Capital, LLC | $18.4M | 0.33% |
| United Capital Management of KS, Inc. | $18.1M | 2.74% |
| Nan Shan Life Insurance Co., Ltd. | $17.7M | 0.64% |
| L. Roy Papp & Associates, LLP | $17.1M | 1.97% |
| Madrona Financial Services, LLC | $16.9M | 3.69% |
| Mivtachim The Workers Social Insurance Fund Ltd. (Under Special Management) | $16.6M | 2.11% |
| OSAIC HOLDINGS, INC. | $16.6M | 0.02% |
| E Fund Management Co., Ltd. | $16.4M | 0.49% |
| Parallax Volatility Advisers, L.P. | $16.4M | 0.04% |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | $16.3M | 0.01% |
| WHITTIER TRUST CO OF NEVADA INC | $16.3M | 0.33% |
| Janney Montgomery Scott LLC | $15.4M | 0.04% |
| Quantitative Investment Management, LLC | $14.3M | 1.48% |
| Edge Wealth Management LLC | $14.2M | 2.43% |
| Riggs Asset Managment Co. Inc. | $13.8M | 2.83% |
| JBF Capital, Inc. | $13.4M | 1.98% |
| BANCO BILBAO VIZCAYA ARGENTARIA, S.A. | $13.4M | 0.09% |
| Yelin Lapidot Holdings Management Ltd. | $13.4M | 2.78% |
| ENVESTNET ASSET MANAGEMENT INC | $13.1M | 0.00% |
| MIRAE ASSET SECURITIES (USA) INC. | $12.8M | 0.47% |
| Lalia Capital, LLC | $12.8M | 8.07% |
| OXFORD ASSET MANAGEMENT LLP | $12.4M | 5.35% |
| Focus Partners Wealth | $12.3M | 0.01% |
| Thrivent Financial for Lutherans | $12.3M | 0.02% |
| NOMURA HOLDINGS INC | $12.1M | 0.03% |
| Lake Hills Wealth Management, LLC | $11.7M | 6.57% |
| INVESTMENT HOUSE LLC | $11.7M | 0.61% |
| Parkside Investments, LLC | $11.6M | 1.41% |
| Ilmarinen Mutual Pension Insurance Co | $11.5M | 0.09% |
| GROUP ONE TRADING LLC | $11.5M | 0.02% |
| Strategic Wealth Partners, Ltd. | $11.4M | 0.79% |
| Capula Management Ltd | $11.2M | 0.08% |
| HRT FINANCIAL LP | $11.1M | 0.03% |
| COMMONWEALTH EQUITY SERVICES, LLC | $10.8M | 0.02% |
| TOCQUEVILLE ASSET MANAGEMENT L.P. | $10.7M | 0.16% |
| Cambridge Investment Research Advisors, Inc. | $10.7M | 0.03% |
| HighTower Advisors, LLC | $10.5M | 0.01% |
| BLAIR WILLIAM & CO/IL | $10.4M | 0.03% |
| CASTLEARK MANAGEMENT LLC | $10.3M | 0.34% |
| Twin Tree Management, LP | $10.1M | 0.21% |
| FIFTH THIRD BANCORP | $9.9M | 0.02% |
| LHM, INC. | $9.4M | 3.71% |
| Allspring Global Investments Holdings, LLC | $9.2M | 0.02% |
| FIL Ltd | $9.2M | 0.01% |
| Tamar Securities, LLC | $8.8M | 0.95% |
| Spire Wealth Management | $8.8M | 0.30% |
| MONTAG A & ASSOCIATES INC | $8.7M | 0.40% |
| Marotta Asset Management | $8.5M | 1.56% |
| Crescent Grove Advisors, LLC | $8.2M | 0.79% |
| BANQUE PICTET & CIE SA | $8.2M | 0.06% |
| PNC FINANCIAL SERVICES GROUP, INC. | $8.2M | 0.00% |
| Baird Financial Group, Inc. | $7.7M | 0.01% |
| FLOW TRADERS U.S. LLC | $7.7M | 0.24% |
| Exome Asset Management LLC | $7.7M | 3.96% |
| OPPENHEIMER & CO INC | $7.3M | 0.09% |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | $7.2M | 0.01% |
| Fulcrum Capital LLC | $7.1M | 1.55% |
| NOMURA ASSET MANAGEMENT CO LTD | $6.9M | 0.02% |
| BROWN ADVISORY INC | $6.9M | 0.01% |
| PETREDIS INVESTMENT ADVISORS LLC | $6.9M | 0.56% |
| &PARTNERS | $6.5M | 0.03% |
| Carnegie Investment Counsel | $6.4M | 0.12% |
| Corient Private Wealth LLC | $6.3M | 0.01% |
| RH Tailwind Management, LLC | $6.3M | 0.80% |
| Verition Fund Management LLC | $6.1M | 0.04% |
| BOOTHBAY FUND MANAGEMENT, LLC | $5.6M | 0.07% |