| Darwin Global Management, Ltd. | $456.1M | 12.10% |
| Paradigm Biocapital Advisors LP | $177.7M | 3.63% |
| UBS Group AG | $122.5M | 0.02% |
| RTW INVESTMENTS, LP | $114.1M | 1.13% |
| MILLENNIUM MANAGEMENT LLC | $90.9M | 0.04% |
| Holocene Advisors, LP | $78.8M | 0.19% |
| EVENTIDE ASSET MANAGEMENT, LLC | $57.0M | 0.94% |
| DEERFIELD MANAGEMENT COMPANY, L.P. | $48.5M | 0.57% |
| PRICE T ROWE ASSOCIATES INC /MD/ | $44.9M | 0.01% |
| MORGAN STANLEY | $32.1M | 0.00% |
| PERCEPTIVE ADVISORS LLC | $24.2M | 0.47% |
| Patient Square Capital LP | $18.6M | 3.30% |
| Duquesne Family Office LLC | $16.9M | 0.50% |
| GOLDMAN SACHS GROUP INC | $16.8M | 0.00% |
| MPM BIOIMPACT LLC | $14.0M | 1.08% |
| Affinity Asset Advisors, LLC | $10.4M | 0.54% |
| FRED ALGER MANAGEMENT, LLC | $10.0M | 0.04% |
| PFM Health Sciences, LP | $9.5M | 0.86% |
| RENAISSANCE TECHNOLOGIES LLC | $8.3M | 0.01% |
| Longaeva Partners L.P. | $5.3M | 0.20% |
| TD Asset Management Inc | $5.3M | 0.00% |
| ADAR1 Capital Management, LLC | $4.3M | 0.25% |
| Artia Global Partners LP | $4.0M | 0.80% |
| Quadrature Capital Ltd | $3.8M | 0.04% |
| Aquatic Capital Management LLC | $3.2M | 0.09% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | $3.1M | 0.00% |
| Squarepoint Ops LLC | $2.7M | 0.00% |
| STATE STREET CORP | $2.6M | 0.00% |
| BANK OF MONTREAL /CAN/ | $2.5M | 0.00% |
| Trexquant Investment LP | $2.4M | 0.02% |
| XTX Topco Ltd | $2.4M | 0.04% |
| BALANCE CAPITAL PARTNERS L.P. | $2.3M | 2.63% |
| Verdad Advisers, LP | $2.2M | 2.48% |
| JANE STREET GROUP, LLC | $1.9M | 0.00% |
| HRT FINANCIAL LP | $1.7M | 0.00% |
| Blackstone Inc. | $1.7M | 0.01% |
| GEODE CAPITAL MANAGEMENT, LLC | $1.7M | 0.00% |
| HighVista Strategies LLC | $1.3M | 0.35% |
| Voleon Capital Management LP | $1.3M | 0.03% |
| BARCLAYS PLC | $1.1M | 0.00% |
| Arrowpoint Investment Partners (Singapore) Pte. Ltd. | $957.3K | 0.85% |
| Amundi | $671.2K | 0.00% |
| SmartHarvest Portfolios, LLC | $667.6K | 0.28% |
| BANK OF AMERICA CORP /DE/ | $602.4K | 0.00% |
| High Net Worth Advisory Group LLC | $558.0K | 0.13% |
| Convergence Financial, LLC | $473.2K | 0.05% |
| AMERIPRISE FINANCIAL INC | $441.2K | 0.00% |
| Engineers Gate Manager LP | $396.8K | 0.00% |
| AXQ CAPITAL, LP | $378.2K | 0.05% |
| ROYAL BANK OF CANADA | $360.0K | 0.00% |
| SG Americas Securities, LLC | $342.0K | 0.00% |
| CITADEL ADVISORS LLC | $320.2K | 0.00% |
| Virtus Investment Advisers, LLC | $307.6K | 0.08% |
| DYMON ASIA CAPITAL (SINGAPORE) PTE. LTD. | $302.9K | 0.03% |
| GAMMA Investing LLC | $272.2K | 0.01% |
| GSA CAPITAL PARTNERS LLP | $262.0K | 0.02% |
| EverSource Wealth Advisors, LLC | $256.4K | 0.01% |
| TUDOR INVESTMENT CORP ET AL | $254.5K | 0.00% |
| Merit Financial Group, LLC | $225.6K | 0.00% |
| Independent Advisor Alliance | $210.3K | 0.00% |
| FARALLON CAPITAL MANAGEMENT LLC | $207.3K | 0.00% |
| Mirae Asset Global Investments Co., Ltd. | $104.8K | 0.00% |
| Caitong International Asset Management Co., Ltd | $55.6K | 0.01% |
| BNP PARIBAS FINANCIAL MARKETS | $51.9K | 0.00% |
| WELLS FARGO & COMPANY/MN | $19.8K | 0.00% |
| E Fund Management (Hong Kong) Co., Ltd. | $13.2K | 0.01% |
| TD Waterhouse Canada Inc. | $11.7K | 0.00% |
| Rossby Financial, LCC | $9.2K | 0.00% |
| SBI Securities Co., Ltd. | $3.5K | 0.00% |
| Farther Finance Advisors, LLC | $2.5K | 0.00% |
| NISA INVESTMENT ADVISORS, LLC | $2.1K | 0.00% |
| JONES FINANCIAL COMPANIES LLLP | $912.0 | 0.00% |
| Bell Investment Advisors, Inc | $638.0 | 0.00% |
| JPMORGAN CHASE & CO | $448.0 | 0.00% |
| CITIGROUP INC | $159.0 | 0.00% |