CIK: 0000942257
Total reported value
$296.8M
Reporting period: 2023-09-30 · Number of holdings: 65
INTERNATIONAL BIOTECHNOLOGY TRUST PLC disclosed 65 holdings in its latest 13F filing for the period ending 2023-09-30, with total reported value of $296.8M and a quarterly turnover rate of 0.0%.
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International Biotechnology Trust PLC's disclosed holdings carry a Herfindahl concentration index of 0.033 — mathematically equivalent to about 30 equally-sized positions, well below its 65 actual disclosed holdings. That gap points to a strategy built around a small core of high-conviction bets rather than broad diversification.
Position sizes are fairly uniform across the portfolio (a coefficient of variation of 1.09), suggesting a disciplined, rules-based approach to how much capital goes into each idea.
No strong tilt toward either adding to existing winners or initiating outsized new positions was observed in the latest reported quarter.
Sector classification currently covers about 56% of this portfolio's disclosed value; the remainder includes holdings (e.g. unmapped tickers, options, or other security types) not yet covered by our sector mapping.
No holding changes this quarter
| # | Ticker | Issuer | Asset Subclass | Weight | Weight Change | Shares Change | 4Q Trend |
|---|---|---|---|---|---|---|---|
| 1 | AMGN | Amgen INC | Stock-Healthcare | 7.17% | — | -32.41% | |
| 2 | INCY | Incyte CORP | Stock-Healthcare | 6.97% | — | — | |
| 3 | GILD | Gilead Sciences INC | Stock-Healthcare | 5.90% | — | +61.56% | |
| 4 | ITCIEUR | Intra-cellular Therapies INC | Stock-Other | 5.57% | — | +79.73% | |
| 5 | BMRN | Biomarin Pharmaceutical INC | Stock-Healthcare | 4.58% | — | +161.96% | |
| 6 | SUPN | Supernus Pharmaceuticals INC | Stock-Healthcare | 3.96% | — | -18.53% | |
| 7 | VERA | Vera Therapeutics INC | Stock-Other | 3.50% | — | -22.24% | |
| 8 | BIIB | Biogen INC | Stock-Healthcare | 3.48% | — | +265.45% | |
| 9 | HRMY | Harmony Biosciences Holdings | Stock-Other | 3.47% | — | -44.87% | |
| 10 | MRTXEUR | Mirati Therapeutics INC | Stock-Other | 3.17% | — | -16.92% | |
| 11 | RARE | Ultragenyx Pharmaceutical In | Stock-Other | 3.00% | — | +212.36% | |
| 12 | QURE | uniQure N.V. | Stock-Other | 2.81% | — | +7909.68% | |
| 13 | AUPH | Aurinia Pharmaceuticals INC | Stock-Other | 2.72% | — | +81.43% | |
| 14 | UTHR | United Therapeutics CORP | Stock-Healthcare | 2.58% | — | -35.63% | |
| 15 | VRTX | Vertex Pharmaceuticals INC | Stock-Healthcare | 2.46% | — | — | |
| 16 | REGN | Regeneron Pharmaceuticals | Stock-Healthcare | 2.45% | — | -67.23% | |
| 17 | ILMN | Illumina INC | Stock-Healthcare | 2.34% | — | — | |
| 18 | ALNY | Alnylam Pharmaceuticals INC | Stock-Healthcare | 2.20% | — | -54.90% | |
| 19 | AMLX | Amylyx Pharmaceuticals INC | Stock-Other | 1.82% | — | +1080.00% | |
| 20 | KRYS | Krystal Biotech INC | Stock-Healthcare | 1.80% | — | +0.32% | |
| 21 | ✓ | Stock-Other | 1.74% | — | +18.68% | ||
| 22 | AXSM | Axsome Therapeutics INC | Stock-Healthcare | 1.37% | — | — | |
| 23 | ERAS | Erasca INC | Stock-Other | 1.28% | — | +35.06% | |
| 24 | ACAD | Acadia Pharmaceuticals INC | Stock-Healthcare | 1.26% | — | +19.01% | |
| 25 | RVNCEUR | Revance Therapeutics INC | Stock-Other | 1.11% | — | — | |
| 26 | NBIX | Neurocrine Biosciences INC | Stock-Healthcare | 1.09% | — | -58.07% | |
| 27 | SRPT | Sarepta Therapeutics INC | Stock-Healthcare | 1.09% | — | +42.02% | |
| 28 | RCKT | Rocket Pharmaceuticals INC | Stock-Other | 1.08% | — | — | |
| 29 | DNLI | Denali Therapeutics INC | Stock-Other | 1.07% | — | -18.09% | |
| 30 | AZNN | Astrazeneca Plc-spons Adr | Stock-Other | 1.06% | — | — | |
| 31 | XENE | Xenon Pharmaceuticals INC | Stock-Other | 1.05% | — | +258.82% | |
| 32 | CRSP | CRISPR Therapeutics AG | Stock-Healthcare | 0.96% | — | — | |
| 33 | MDGL | Madrigal Pharmaceuticals INC | Stock-Healthcare | 0.90% | — | — | |
| 34 | LEGN | Legend Biotech Corp-adr | Stock-Other | 0.86% | — | — | |
| 35 | HALO | Halozyme Therapeutics INC | Stock-Healthcare | 0.80% | — | -34.87% | |
| 36 | MRNS* | Marinus Pharmaceuticals INC | Stock-Other | 0.79% | — | +222.22% | |
| 37 | ONC | Beone Medicines Ltd-adr | Stock-Other | 0.77% | — | +45.98% | |
| 38 | JAZZ | Jazz Pharmaceuticals plc | Stock-Healthcare | 0.75% | — | — | |
| 39 | MIRM | Mirum Pharmaceuticals INC | Stock-Other | 0.72% | — | — | |
| 40 | IOVA | Iovance Biotherapeutics INC | Stock-Other | 0.68% | — | +584.62% | |
| 41 | IONS | Ionis Pharmaceuticals INC | Stock-Healthcare | 0.66% | — | — | |
| 42 | ZLAB | Zai Lab Ltd-adr | Stock-Other | 0.65% | — | — | |
| 43 | GMAB | Genmab A/s -sp Adr | Stock-Other | 0.53% | — | — | |
| 44 | CLDX | Celldex Therapeutics INC | Stock-Other | 0.45% | — | — | |
| 45 | COGT | Cogent Biosciences INC | Stock-Other | 0.44% | — | — | |
| 46 | DYN | Dyne Therapeutics INC | Stock-Other | 0.41% | — | -54.20% | |
| 47 | NVCR | NovoCure Limited | Stock-Healthcare | 0.40% | — | +131.25% | |
| 48 | AM6 | Amicus Therapeutics INC | Stock-Other | 0.37% | — | — | |
| 49 | CYTK | Cytokinetics INC | Stock-Healthcare | 0.37% | — | — | |
| 50 | GH | Guardant Health INC | Stock-Healthcare | 0.36% | — | — |
Performance for Q3 2026
+23.8%
Performance Last 4 Quarters
+78.3%
Based on 65% of reported portfolio value with available pricing
| Period | Holdings | Total value | Stability | Top holdings |
|---|---|---|---|---|
| 2023-09-30 | 65 | $296.8M | 0 | |
| 2023-06-30 | 61 | $328.5M | 0 | |
| 2023-03-31 | 64 | $358.4M | 0 | |
| 2022-12-31 | 63 | $323.8M | 0 | |
| 2022-09-30 | 66 | $311.9M | 0 | |
| 2022-06-30 | 78 | $9.6M | 0 | |
| 2022-03-31 | 70 | $443.4M | 0 | |
| 2021-12-31 | 73 | $448.9M | 0 | |
| 2021-09-30 | 69 | $414.6M | 0 | |
| 2021-06-30 | 67 | $378.8M | 100 | |
| 2021-03-31 | 56 | $378.1M | 63 | |
| 2020-12-31 | 52 | $366.1M | 53 | |
| 2020-09-30 | 53 | $309.8M | 35 | |
| 2020-06-30 | 53 | $300.8M | 44 | |
| 2020-03-31 | 57 | $219.4M | 53 | |
| 2019-12-31 | 64 | $277.6M | 53 | |
| 2019-09-30 | 58 | $216.4M | 38 | |
| 2019-06-30 | 64 | $269.7M | 57 | |
| 2019-03-31 | 62 | $270.7M | 72 | |
| 2018-12-31 | 45 | $161.1M | 60 | |
| 2018-09-30 | 51 | $210.4M | 41 | |
| 2018-06-30 | 54 | $260.4M | 45 | |
| 2018-03-31 | 63 | $256.3M | 57 | |
| 2017-12-31 | 65 | $283.6M | 44 | |
| 2017-09-30 | 56 | $256.9M | 56 | |
| 2017-06-30 | 60 | $263.2M | 51 | |
| 2017-03-31 | 60 | $261.2M | 57 | |
| 2016-12-31 | 49 | $222.0M | 0 |
| # | Ticker | Issuer | Weight Change | Shares Change | Action |
|---|
| Period | Filed | Type | EDGAR |
|---|---|---|---|
| 2023-09-30 | 2023-11-14 | 13F-HR | View on EDGAR |
| 2023-06-30 | 2023-08-08 | 13F-HR | View on EDGAR |
| 2023-03-31 | 2023-05-18 | 13F-HR | View on EDGAR |
| 2022-12-31 | 2023-02-01 | 13F-HR | View on EDGAR |
| 2022-09-30 | 2022-11-08 | 13F-HR | View on EDGAR |
| 2022-06-30 | 2022-08-16 | 13F-HR | View on EDGAR |
| 2022-03-31 | 2022-05-20 | 13F-HR | View on EDGAR |
| 2021-12-31 | 2022-02-15 | 13F-HR | View on EDGAR |
| 2021-09-30 | 2021-11-12 | 13F-HR | View on EDGAR |
| 2021-06-30 | 2021-08-11 | 13F-HR | View on EDGAR |
| 2021-03-31 | 2021-05-17 | 13F-HR | View on EDGAR |
| 2020-12-31 | 2021-02-19 | 13F-HR | View on EDGAR |
| 2020-09-30 | 2020-12-01 | 13F-HR | View on EDGAR |
| 2020-06-30 | 2020-07-14 | 13F-HR | View on EDGAR |
| 2020-03-31 | 2020-05-18 | 13F-HR | View on EDGAR |
| 2019-12-31 | 2020-05-18 | 13F-HR | View on EDGAR |
| 2019-09-30 | 2019-11-14 | 13F-HR | View on EDGAR |
| 2019-06-30 | 2019-08-14 | 13F-HR | View on EDGAR |
| 2019-03-31 | 2019-05-14 | 13F-HR | View on EDGAR |
| 2018-12-31 | 2019-02-14 | 13F-HR | View on EDGAR |
| 2018-09-30 | 2018-11-14 | Amendment | View on EDGAR |
| 2018-09-30 | 2018-11-13 | 13F-HR | View on EDGAR |
| 2018-06-30 | 2018-08-13 | 13F-HR | View on EDGAR |
| 2018-03-31 | 2018-05-15 | 13F-HR | View on EDGAR |
| 2017-12-31 | 2018-03-02 | 13F-HR | View on EDGAR |
| 2017-09-30 | 2018-03-02 | 13F-HR | View on EDGAR |
| 2017-06-30 | 2018-03-02 | 13F-HR | View on EDGAR |
| 2017-03-31 | 2018-03-02 | 13F-HR | View on EDGAR |
| 2016-12-31 | 2018-03-02 | 13F-HR | View on EDGAR |
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