| FMR LLC | $405.0M | 0.02% |
| WELLINGTON MANAGEMENT GROUP LLP | $349.9M | 0.07% |
| Avoro Capital Advisors LLC | $316.0M | 3.11% |
| JANUS HENDERSON GROUP PLC | $258.3M | 0.12% |
| Deep Track Capital, LP | $206.3M | 3.37% |
| BVF INC/IL | $166.7M | 5.31% |
| MORGAN STANLEY | $111.1M | 0.01% |
| PRICE T ROWE ASSOCIATES INC /MD/ | $96.4M | 0.01% |
| PRINCIPAL FINANCIAL GROUP INC | $84.5M | 0.05% |
| Driehaus Capital Management LLC | $76.0M | 0.56% |
| ORBIMED ADVISORS LLC | $71.1M | 1.46% |
| AMERICAN CENTURY COMPANIES INC | $69.3M | 0.04% |
| BAKER BROS. ADVISORS LP | $69.0M | 0.40% |
| Siren, L.L.C. | $64.0M | 1.78% |
| Casdin Capital, LLC | $56.6M | 4.29% |
| CAPITOLIS LIQUID GLOBAL MARKETS LLC | $55.5M | 0.35% |
| ALLIANCEBERNSTEIN L.P. | $44.4M | 0.01% |
| DEERFIELD MANAGEMENT COMPANY, L.P. | $37.0M | 0.44% |
| Pacific Heights Asset Management LLC | $36.2M | 1.21% |
| Rock Springs Capital Management LP | $30.9M | 1.82% |
| Paradigm Biocapital Advisors LP | $26.3M | 0.54% |
| FRANKLIN RESOURCES INC | $25.6M | 0.01% |
| Logos Global Management LP | $24.1M | 1.20% |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | $22.5M | 0.04% |
| BlackRock, Inc. | $21.3M | 0.00% |
| GOLDMAN SACHS GROUP INC | $20.9M | 0.00% |
| Aberdeen Group plc | $18.9M | 0.03% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $18.3M | 0.00% |
| DEUTSCHE BANK AG\ | $16.0M | 0.01% |
| NATIONAL BANK OF CANADA /FI/ | $14.7M | 0.01% |
| Balyasny Asset Management L.P. | $14.7M | 0.02% |
| Catalio Capital Management, LP | $12.3M | 2.57% |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | $12.3M | 0.05% |
| SEB Asset Management AB | $11.8M | 0.05% |
| Pentwater Capital Management LP | $11.8M | 0.06% |
| Parkman Healthcare Partners LLC | $11.2M | 1.15% |
| BANK OF AMERICA CORP /DE/ | $10.9M | 0.00% |
| AMERIPRISE FINANCIAL INC | $10.6M | 0.00% |
| UBS Group AG | $10.3M | 0.00% |
| Sio Capital Management, LLC | $10.1M | 1.45% |
| D. E. Shaw & Co., Inc. | $9.9M | 0.01% |
| TD Asset Management Inc | $9.9M | 0.01% |
| STEMPOINT CAPITAL LP | $9.7M | 1.85% |
| DIADEMA PARTNERS LP | $9.6M | 1.64% |
| JPMORGAN CHASE & CO | $9.4M | 0.00% |
| Woodline Partners LP | $9.2M | 0.03% |
| ArrowMark Colorado Holdings LLC | $9.1M | 0.24% |
| TWO SIGMA INVESTMENTS, LP | $8.7M | 0.01% |
| Cormorant Asset Management, LP | $8.4M | 0.42% |
| MILLENNIUM MANAGEMENT LLC | $8.1M | 0.00% |
| Schonfeld Strategic Advisors LLC | $8.0M | 0.06% |
| Holocene Advisors, LP | $7.7M | 0.02% |
| TCG Crossover Management, LLC | $6.8M | 0.19% |
| Eversept Partners, LP | $6.7M | 0.35% |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | $6.5M | 0.01% |
| NEXTBio Capital Management LP | $6.4M | 2.98% |
| HSG Holding Ltd | $6.2M | 0.38% |
| Rhenman & Partners Asset Management AB | $6.2M | 0.76% |
| B Group, Inc. | $6.1M | 4.56% |
| Davern Capital Partners, LP | $6.1M | 1.67% |
| PFM Health Sciences, LP | $6.1M | 0.56% |
| HighVista Strategies LLC | $6.0M | 1.65% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | $5.5M | 0.00% |
| CITADEL ADVISORS LLC | $5.5M | 0.00% |
| Universal- Beteiligungs- und Servicegesellschaft mbH | $5.3M | 0.01% |
| Trexquant Investment LP | $5.2M | 0.04% |
| Jump Financial, LLC | $5.2M | 0.07% |
| Jones Hill Capital LP | $4.8M | 1.04% |
| Birchview Capital, LP | $4.8M | 2.74% |
| PEREGRINE CAPITAL MANAGEMENT LLC | $4.7M | 0.17% |
| JANE STREET GROUP, LLC | $4.3M | 0.00% |
| Soleus Capital Management, L.P. | $3.9M | 0.16% |
| TUDOR INVESTMENT CORP ET AL | $3.6M | 0.01% |
| Boxer Capital Management, LLC | $3.6M | 0.47% |
| Qube Research & Technologies Ltd | $3.5M | 0.00% |
| MARSHALL WACE, LLP | $3.3M | 0.00% |
| GEODE CAPITAL MANAGEMENT, LLC | $3.3M | 0.00% |
| PLATINUM INVESTMENT MANAGEMENT LTD | $3.2M | 0.81% |
| Jefferies Financial Group Inc. | $3.0M | 0.02% |
| Susquehanna Portfolio Strategies, LLC | $2.9M | 0.04% |
| Burkehill Global Management, LP | $2.9M | 0.14% |
| ALPS ADVISORS INC | $2.8M | 0.01% |
| RENAISSANCE TECHNOLOGIES LLC | $2.7M | 0.00% |
| SPHERA FUNDS MANAGEMENT LTD. | $2.4M | 0.39% |
| SEVEN GRAND MANAGERS, LLC | $2.4M | 0.16% |
| Buckland Partners Management Co LLC | $2.4M | 1.46% |
| Monashee Investment Management LLC | $2.4M | 1.31% |
| BANQUE PICTET & CIE SA | $2.4M | 0.02% |
| STATE STREET CORP | $2.3M | 0.00% |
| Pier Capital, LLC | $2.3M | 0.38% |
| DAFNA Capital Management LLC | $2.2M | 0.51% |
| Walleye Capital LLC | $2.2M | 0.01% |
| Brevan Howard Capital Management LP | $2.2M | 0.02% |
| ANTIPODES PARTNERS Ltd | $2.2M | 0.04% |
| RAYMOND JAMES FINANCIAL INC | $2.2M | 0.00% |
| OSAIC HOLDINGS, INC. | $2.1M | 0.00% |
| VOYA INVESTMENT MANAGEMENT LLC | $2.1M | 0.00% |
| BANK OF MONTREAL /CAN/ | $1.9M | 0.00% |
| Headlands Technologies LLC | $1.8M | 0.20% |
| FLAX POND CAPITAL, LLC | $1.7M | 1.40% |
| PSquared Asset Management AG | $1.7M | 0.59% |
| Mariner, LLC | $1.7M | 0.00% |
| TrueMark Investments, LLC | $1.7M | 0.32% |
| NOMURA ASSET MANAGEMENT CO LTD | $1.6M | 0.00% |
| CAPITAL FUND MANAGEMENT S.A. | $1.6M | 0.01% |
| XTX Topco Ltd | $1.5M | 0.03% |
| Avidity Partners Management LP | $1.4M | 0.29% |
| Verition Fund Management LLC | $1.4M | 0.01% |
| DCF Advisers, LLC | $1.3M | 0.35% |
| EXCHANGE TRADED CONCEPTS, LLC | $1.2M | 0.01% |
| Squarepoint Ops LLC | $1.1M | 0.00% |
| CenterBook Partners LP | $1.0M | 0.05% |
| CITIGROUP INC | $987.8K | 0.00% |
| BARCLAYS PLC | $924.9K | 0.00% |
| Persistent Asset Partners Ltd | $922.9K | 0.34% |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | $834.0K | 0.01% |
| Walleye Trading LLC | $766.4K | 0.00% |
| Aquatic Capital Management LLC | $714.0K | 0.02% |
| SECTORAL ASSET MANAGEMENT INC | $710.8K | 0.59% |
| SEI INVESTMENTS CO | $674.3K | 0.00% |
| MML INVESTORS SERVICES, LLC | $669.4K | 0.00% |
| China Universal Asset Management Co., Ltd. | $666.3K | 0.05% |
| GSA CAPITAL PARTNERS LLP | $666.0K | 0.04% |
| WEXFORD CAPITAL LP | $660.8K | 0.10% |
| BRANDYWINE MANAGERS, LLC | $643.8K | 0.38% |
| ENVESTNET ASSET MANAGEMENT INC | $548.4K | 0.00% |
| STIFEL FINANCIAL CORP | $546.7K | 0.00% |
| Verdad Advisers, LP | $546.3K | 0.62% |
| Russell Investments Group, Ltd. | $515.8K | 0.00% |
| Quinn Opportunity Partners LLC | $482.0K | 0.03% |
| HighTower Advisors, LLC | $463.7K | 0.00% |
| LPL Financial LLC | $446.3K | 0.00% |
| Gilbert & Cook, Inc. | $443.1K | 0.06% |
| SmartHarvest Portfolios, LLC | $436.5K | 0.18% |
| Seven Fleet Capital Management LP | $433.8K | 0.14% |
| Cinctive Capital Management LP | $420.0K | 0.03% |
| Allianz Asset Management GmbH | $414.5K | 0.00% |
| DNB Asset Management AS | $394.7K | 0.00% |
| AXQ CAPITAL, LP | $381.6K | 0.05% |
| WELLS FARGO & COMPANY/MN | $376.8K | 0.00% |
| Cetera Investment Advisers | $372.1K | 0.00% |
| MISSION WEALTH MANAGEMENT, LP | $365.5K | 0.01% |
| Vestmark Advisory Solutions, Inc. | $363.1K | 0.00% |
| Independent Advisor Alliance | $358.8K | 0.00% |
| Parallel Advisors, LLC | $354.4K | 0.01% |
| Scientech Research LLC | $335.4K | 0.28% |
| Janney Montgomery Scott LLC | $329.0K | 0.00% |
| Bellevue Group AG | $327.9K | 0.01% |
| Mirae Asset Global Investments Co., Ltd. | $309.0K | 0.00% |
| PEAK6 LLC | $291.9K | 0.00% |