| Frazier Life Sciences Management, L.P. | $399.2M | 10.27% |
| T. Rowe Price Investment Management, Inc. | $344.0M | 0.24% |
| BlackRock, Inc. | $326.0M | 0.01% |
| Venrock Adviser, LLC | $265.1M | 9.89% |
| RTW INVESTMENTS, LP | $261.4M | 2.60% |
| Vivo Capital, LLC | $196.6M | 16.34% |
| VANGUARD CAPITAL MANAGEMENT LLC | $182.0M | 0.00% |
| Siren, L.L.C. | $181.9M | 5.04% |
| Logos Global Management LP | $180.4M | 9.01% |
| Paradigm Biocapital Advisors LP | $168.2M | 3.44% |
| STATE STREET CORP | $150.5M | 0.01% |
| ARCH Venture Management, LLC | $114.7M | 16.95% |
| GEODE CAPITAL MANAGEMENT, LLC | $97.0M | 0.01% |
| Cormorant Asset Management, LP | $93.8M | 4.71% |
| Affinity Asset Advisors, LLC | $86.6M | 4.47% |
| Balyasny Asset Management L.P. | $83.2M | 0.11% |
| GOLDMAN SACHS GROUP INC | $78.9M | 0.01% |
| JANUS HENDERSON GROUP PLC | $60.0M | 0.03% |
| 5AM Venture Management, LLC | $56.4M | 15.66% |
| SUVRETTA CAPITAL MANAGEMENT, LLC | $55.6M | 1.42% |
| Commodore Capital LP | $51.4M | 2.97% |
| BANK OF AMERICA CORP /DE/ | $49.4M | 0.00% |
| a16z Capital Management, L.L.C. | $46.3M | 3.59% |
| Woodline Partners LP | $45.8M | 0.17% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | $34.0M | 0.05% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $30.7M | 0.00% |
| SILVERARC CAPITAL MANAGEMENT, LLC | $30.0M | 3.06% |
| UBS Group AG | $29.9M | 0.00% |
| PRICE T ROWE ASSOCIATES INC /MD/ | $29.4M | 0.00% |
| DIMENSIONAL FUND ADVISORS LP | $28.9M | 0.01% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $28.7M | 0.00% |
| NORTHERN TRUST CORP | $27.5M | 0.00% |
| VICTORY CAPITAL MANAGEMENT INC | $26.8M | 0.02% |
| VANGUARD FIDUCIARY TRUST CO | $24.9M | 0.01% |
| FMR LLC | $24.1M | 0.00% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $23.9M | 0.00% |
| RENAISSANCE TECHNOLOGIES LLC | $22.6M | 0.04% |
| D. E. Shaw & Co., Inc. | $19.7M | 0.01% |
| Rock Springs Capital Management LP | $17.9M | 1.05% |
| MORGAN STANLEY | $16.0M | 0.00% |
| EcoR1 Capital, LLC | $14.6M | 0.62% |
| First Turn Management, LLC | $14.0M | 1.57% |
| JPMORGAN CHASE & CO | $13.8M | 0.00% |
| CITADEL ADVISORS LLC | $12.3M | 0.00% |
| Holocene Advisors, LP | $12.3M | 0.03% |
| Invesco Ltd. | $12.3M | 0.00% |
| Integral Health Asset Management, LLC | $11.3M | 0.54% |
| Point72 Asset Management, L.P. | $11.2M | 0.01% |
| AQR CAPITAL MANAGEMENT LLC | $11.2M | 0.01% |
| AMERIPRISE FINANCIAL INC | $10.9M | 0.00% |
| JANE STREET GROUP, LLC | $10.0M | 0.00% |
| Caption Management, LLC | $9.9M | 0.06% |
| ALLIANCEBERNSTEIN L.P. | $9.8M | 0.00% |
| WELLINGTON MANAGEMENT GROUP LLP | $9.6M | 0.00% |
| MILLENNIUM MANAGEMENT LLC | $9.3M | 0.00% |
| ExodusPoint Capital Management, LP | $9.3M | 0.08% |
| Bank of New York Mellon Corp | $9.1M | 0.00% |
| Nuveen, LLC | $8.8M | 0.00% |
| Ensign Peak Advisors, Inc | $8.1M | 0.02% |
| MARSHALL WACE, LLP | $6.9M | 0.01% |
| Spruce Street Capital LP | $6.8M | 1.64% |
| Creative Planning | $6.8M | 0.00% |
| PRUDENTIAL FINANCIAL INC | $6.7M | 0.01% |
| Parkman Healthcare Partners LLC | $6.6M | 0.68% |
| TD Asset Management Inc | $6.4M | 0.01% |
| AMERICAN CENTURY COMPANIES INC | $6.2M | 0.00% |
| Polymer Capital Management (HK) LTD | $5.8M | 0.50% |
| ACUTA CAPITAL PARTNERS, LLC | $5.7M | 4.08% |
| Atom Investors LP | $5.6M | 0.40% |
| KVP Capital Advisors, LP | $5.5M | 4.11% |
| Swiss National Bank | $5.4M | 0.00% |
| Trexquant Investment LP | $4.9M | 0.04% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | $4.2M | 0.00% |
| VOYA INVESTMENT MANAGEMENT LLC | $4.1M | 0.00% |
| SIMPLEX TRADING, LLC | $4.1M | 0.00% |
| Rafferty Asset Management, LLC | $4.1M | 0.02% |
| RHUMBLINE ADVISERS | $3.9M | 0.00% |
| STEMPOINT CAPITAL LP | $3.9M | 0.74% |
| FRED ALGER MANAGEMENT, LLC | $3.8M | 0.02% |
| Tidal Investments LLC | $3.7M | 0.01% |
| Tema ETFs LLC | $3.7M | 0.25% |
| Seven Fleet Capital Management LP | $3.6M | 1.14% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | $3.5M | 0.00% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | $3.3M | 0.00% |
| TANG CAPITAL MANAGEMENT LLC | $3.2M | 0.16% |
| Pictet Asset Management Holding SA | $3.1M | 0.00% |
| HighVista Strategies LLC | $2.9M | 0.81% |
| Cinctive Capital Management LP | $2.8M | 0.18% |
| Longaeva Partners L.P. | $2.8M | 0.10% |
| DEUTSCHE BANK AG\ | $2.6M | 0.00% |
| NATIXIS | $2.6M | 0.01% |
| XTX Topco Ltd | $2.4M | 0.04% |
| NOMURA HOLDINGS INC | $2.2M | 0.01% |
| Informed Momentum Co LLC | $2.2M | 0.26% |
| Legal & General Group Plc | $2.2M | 0.00% |
| Vanguard Global Advisers, LLC | $1.8M | 0.00% |
| PROFUND ADVISORS LLC | $1.8M | 0.07% |
| VANGUARD ASSET MANAGEMENT, Ltd | $1.8M | 0.00% |
| WELLS FARGO & COMPANY/MN | $1.7M | 0.00% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | $1.7M | 0.00% |
| MetLife Investment Management, LLC | $1.7M | 0.01% |
| FRANKLIN RESOURCES INC | $1.6M | 0.00% |
| Burkehill Global Management, LP | $1.6M | 0.08% |
| SEVEN GRAND MANAGERS, LLC | $1.6M | 0.11% |
| STATE OF WISCONSIN INVESTMENT BOARD | $1.6M | 0.00% |
| J. Goldman & Co LP | $1.6M | 0.05% |
| Squarepoint Ops LLC | $1.5M | 0.00% |
| ALGERT GLOBAL LLC | $1.4M | 0.02% |
| RAYMOND JAMES FINANCIAL INC | $1.3M | 0.00% |
| Cresset Asset Management, LLC | $1.3M | 0.01% |
| ArrowMark Colorado Holdings LLC | $1.3M | 0.03% |
| Virtus Investment Advisers, LLC | $1.2M | 0.34% |
| Harvest Investment Services, LLC | $1.2M | 0.22% |
| Schonfeld Strategic Advisors LLC | $1.1M | 0.01% |
| Hudson Bay Capital Management LP | $1.1M | 0.00% |
| Susquehanna Portfolio Strategies, LLC | $956.0K | 0.01% |
| State of New Jersey Common Pension Fund D | $941.3K | 0.00% |
| INTECH INVESTMENT MANAGEMENT LLC | $930.9K | 0.01% |
| GILDER GAGNON HOWE & CO LLC | $915.7K | 0.01% |
| Cerity Partners LLC | $902.2K | 0.00% |
| Brevan Howard Capital Management LP | $891.6K | 0.01% |
| China Universal Asset Management Co., Ltd. | $888.9K | 0.07% |
| NEW YORK STATE COMMON RETIREMENT FUND | $886.0K | 0.00% |
| Police & Firemen's Retirement System of New Jersey | $832.8K | 0.01% |
| CITIGROUP INC | $794.6K | 0.00% |
| Zurcher Kantonalbank (Zurich Cantonalbank) | $775.3K | 0.00% |
| Vanguard Personalized Indexing Management, LLC | $758.8K | 0.01% |
| ARIZONA STATE RETIREMENT SYSTEM | $756.5K | 0.00% |
| Connor, Clark & Lunn Investment Management Ltd. | $733.6K | 0.00% |
| BARCLAYS PLC | $729.4K | 0.00% |
| SG Americas Securities, LLC | $723.0K | 0.00% |
| Vanguard Investments Australia, Ltd. | $716.8K | 0.00% |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | $685.1K | 0.00% |
| ProShare Advisors LLC | $669.0K | 0.00% |
| KLP KAPITALFORVALTNING AS | $606.8K | 0.00% |
| Verdad Advisers, LP | $535.1K | 0.60% |
| STRS OHIO | $533.9K | 0.00% |
| CWM, LLC | $530.0K | 0.00% |
| E Fund Management Co., Ltd. | $527.5K | 0.02% |
| Tower Research Capital LLC (TRC) | $522.7K | 0.01% |
| SEI INVESTMENTS CO | $513.9K | 0.00% |
| Marks Group Wealth Management, Inc | $483.4K | 0.05% |
| Persistent Asset Partners Ltd | $457.4K | 0.17% |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | $449.4K | 0.00% |
| FORA Capital, LLC | $433.5K | 0.03% |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | $416.6K | 0.00% |
| Arrowpoint Investment Partners (Singapore) Pte. Ltd. | $402.0K | 0.36% |
| Quantbot Technologies LP | $375.8K | 0.02% |
| TEACHER RETIREMENT SYSTEM OF TEXAS | $357.2K | 0.00% |
| Quadrature Capital Ltd | $350.9K | 0.00% |