| BlackRock, Inc. | $504.5M | 0.01% |
| MORGAN STANLEY | $340.0M | 0.02% |
| Avoro Capital Advisors LLC | $300.2M | 2.95% |
| VANGUARD CAPITAL MANAGEMENT LLC | $229.6M | 0.01% |
| Holocene Advisors, LP | $217.0M | 0.52% |
| Balyasny Asset Management L.P. | $204.9M | 0.27% |
| CITADEL ADVISORS LLC | $197.6M | 0.03% |
| MILLENNIUM MANAGEMENT LLC | $178.9M | 0.07% |
| HBK INVESTMENTS L P | $155.5M | 1.58% |
| JPMORGAN CHASE & CO | $151.8M | 0.01% |
| LORD, ABBETT & CO. LLC | $148.3M | 0.48% |
| Ikarian Capital, LLC | $140.0M | 11.37% |
| FRANKLIN RESOURCES INC | $127.0M | 0.03% |
| GEODE CAPITAL MANAGEMENT, LLC | $122.2M | 0.01% |
| GLAZER CAPITAL, LLC | $121.0M | 2.57% |
| Paradigm Biocapital Advisors LP | $116.9M | 2.39% |
| Nearwater Capital Markets, Ltd | $113.4M | 2.67% |
| STATE STREET CORP | $112.8M | 0.00% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $112.6M | 0.01% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | $112.0M | 0.17% |
| Logos Global Management LP | $105.4M | 5.26% |
| CAPITOLIS LIQUID GLOBAL MARKETS LLC | $104.2M | 0.66% |
| ACORN CAPITAL ADVISORS, LLC | $92.1M | 26.17% |
| Pictet Asset Management Holding SA | $87.3M | 0.09% |
| Verition Fund Management LLC | $81.8M | 0.53% |
| WHITEBOX ADVISORS LLC | $79.1M | 0.97% |
| JANUS HENDERSON GROUP PLC | $77.5M | 0.04% |
| Capital International Investors | $75.1M | 0.02% |
| Vivo Capital, LLC | $70.4M | 5.85% |
| DIMENSIONAL FUND ADVISORS LP | $65.8M | 0.01% |
| UBS Group AG | $64.8M | 0.01% |
| Caption Management, LLC | $64.7M | 0.38% |
| LMR Partners LLP | $63.9M | 0.14% |
| GOLDMAN SACHS GROUP INC | $63.6M | 0.01% |
| ADAR1 Capital Management, LLC | $58.8M | 3.46% |
| Fort Baker Capital Management LP | $57.8M | 4.54% |
| Deep Track Capital, LP | $56.6M | 0.92% |
| Vestal Point Capital, LP | $52.7M | 1.47% |
| MARSHALL WACE, LLP | $48.9M | 0.05% |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | $48.7M | 0.08% |
| NEXPOINT ASSET MANAGEMENT, L.P. | $47.7M | 3.20% |
| First Trust Capital Management L.P. | $47.7M | 2.50% |
| BOOTHBAY FUND MANAGEMENT, LLC | $44.3M | 0.58% |
| BANK OF AMERICA CORP /DE/ | $42.8M | 0.00% |
| TUDOR INVESTMENT CORP ET AL | $42.7M | 0.08% |
| NORTHERN TRUST CORP | $42.5M | 0.01% |
| TORONTO DOMINION BANK | $41.7M | 0.06% |
| ALLIANCEBERNSTEIN L.P. | $41.7M | 0.01% |
| Nuveen, LLC | $40.7M | 0.01% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $39.4M | 0.01% |
| Polar Asset Management Partners Inc. | $38.2M | 0.76% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $38.1M | 0.00% |
| Fiera Capital Corp | $37.5M | 0.13% |
| BARCLAYS PLC | $35.3M | 0.01% |
| PRICE T ROWE ASSOCIATES INC /MD/ | $33.5M | 0.00% |
| Candriam S.C.A. | $33.3M | 0.17% |
| Hudson Bay Capital Management LP | $32.6M | 0.11% |
| NEXTBio Capital Management LP | $31.9M | 14.80% |
| VANGUARD FIDUCIARY TRUST CO | $30.3M | 0.01% |
| Affinity Asset Advisors, LLC | $29.7M | 1.53% |
| Mariner, LLC | $29.4M | 0.03% |
| Qube Research & Technologies Ltd | $28.4M | 0.03% |
| Octagon Capital Advisors LP | $27.9M | 3.09% |
| Jones Hill Capital LP | $27.5M | 5.89% |
| TIG Advisors, LLC | $26.9M | 1.25% |
| Melqart Asset Management (UK) Ltd | $26.7M | 2.64% |
| JENNISON ASSOCIATES LLC | $26.4M | 0.02% |
| ACUTA CAPITAL PARTNERS, LLC | $26.1M | 18.59% |
| NEUBERGER BERMAN GROUP LLC | $25.3M | 0.02% |
| Beryl Capital Management LLC | $25.2M | 23.00% |
| SAMLYN CAPITAL, LLC | $24.9M | 0.42% |
| KVP Capital Advisors, LP | $23.2M | 17.32% |
| JANE STREET GROUP, LLC | $22.8M | 0.00% |
| Slotnik Capital, LLC | $22.2M | 6.49% |
| Eagle Health Investments LP | $21.7M | 3.80% |
| Catalio Capital Management, LP | $21.6M | 4.50% |
| Connor, Clark & Lunn Investment Management Ltd. | $20.3M | 0.05% |
| Sculptor Capital LP | $20.0M | 0.21% |
| FMR LLC | $19.8M | 0.00% |
| WELLINGTON MANAGEMENT GROUP LLP | $19.8M | 0.00% |
| Boxer Capital Management, LLC | $19.8M | 2.60% |
| Maven Securities LTD | $19.8M | 0.38% |
| First Turn Management, LLC | $17.2M | 1.92% |
| SOROS FUND MANAGEMENT LLC | $17.0M | 0.19% |
| Centiva Capital, LP | $16.6M | 0.12% |
| SummitTX Capital, L.P. | $16.5M | 0.51% |
| Davidson Kempner Capital Management LP | $16.4M | 0.22% |
| Invesco Ltd. | $16.1M | 0.00% |
| Atika Capital Management LLC | $15.9M | 2.50% |
| Monashee Investment Management LLC | $15.8M | 8.60% |
| Cormorant Asset Management, LP | $15.8M | 0.79% |
| Ensign Peak Advisors, Inc | $15.8M | 0.03% |
| Man Group plc | $15.0M | 0.03% |
| Bank of New York Mellon Corp | $14.8M | 0.00% |
| Magnetar Financial LLC | $14.8M | 0.15% |
| Squarepoint Ops LLC | $14.5M | 0.02% |
| GABELLI FUNDS LLC | $14.3M | 0.10% |
| HARVEST MANAGEMENT LLC | $13.6M | 6.58% |
| Russell Investments Group, Ltd. | $12.9M | 0.01% |
| ExodusPoint Capital Management, LP | $12.3M | 0.10% |
| Blackstone Inc. | $12.2M | 0.05% |
| Absolute Gestao de Investimentos Ltda. | $12.1M | 1.38% |
| EQUITEC PROPRIETARY MARKETS, LLC | $11.7M | 6.26% |
| Schonfeld Strategic Advisors LLC | $11.4M | 0.08% |
| GABELLI & Co INVESTMENT ADVISERS, INC. | $10.8M | 1.61% |
| Prosight Management, LP | $10.7M | 1.75% |
| D. E. Shaw & Co., Inc. | $10.6M | 0.01% |
| WATER ISLAND CAPITAL LLC | $9.9M | 1.11% |
| DIADEMA PARTNERS LP | $9.6M | 1.63% |
| AQR CAPITAL MANAGEMENT LLC | $9.3M | 0.00% |
| PFM Health Sciences, LP | $9.1M | 0.83% |
| AQR Arbitrage LLC | $9.0M | 0.15% |
| RENAISSANCE TECHNOLOGIES LLC | $8.9M | 0.01% |
| VOYA INVESTMENT MANAGEMENT LLC | $8.7M | 0.01% |
| Arnhold LLC | $8.6M | 0.63% |
| NEW YORK STATE COMMON RETIREMENT FUND | $8.5M | 0.01% |
| CIBRA Capital Ltd | $8.0M | 3.85% |
| METEORA CAPITAL, LLC | $7.9M | 0.58% |
| DEUTSCHE BANK AG\ | $7.9M | 0.00% |
| ALPINE ASSOCIATES MANAGEMENT INC. | $7.5M | 0.44% |
| RHUMBLINE ADVISERS | $6.5M | 0.01% |
| Capula Management Ltd | $6.4M | 0.05% |
| Groupe la Francaise | $6.2M | 0.09% |
| AMERIPRISE FINANCIAL INC | $6.2M | 0.00% |
| Twin Securities, Inc. | $6.1M | 2.97% |
| HighVista Strategies LLC | $6.0M | 1.66% |
| Rock Springs Capital Management LP | $6.0M | 0.35% |
| Swiss National Bank | $5.9M | 0.00% |
| PLATINUM INVESTMENT MANAGEMENT LTD | $5.8M | 1.47% |
| Artia Global Partners LP | $5.5M | 1.11% |
| Vestcor Inc | $5.3M | 0.15% |
| PICTON MAHONEY ASSET MANAGEMENT | $5.3M | 0.04% |
| Stonepine Capital Management, LLC | $5.3M | 2.11% |
| Alyeska Investment Group, L.P. | $5.3M | 0.01% |
| Informed Momentum Co LLC | $5.2M | 0.60% |
| Chicago Capital Management, LLC | $5.1M | 4.26% |
| PRUDENTIAL FINANCIAL INC | $5.1M | 0.01% |
| CAXTON ASSOCIATES LLP | $5.0M | 0.11% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | $5.0M | 0.00% |
| CREDIT INDUSTRIEL ET COMMERCIAL | $4.8M | 0.37% |
| TD Asset Management Inc | $4.7M | 0.00% |
| Brevan Howard Capital Management LP | $4.7M | 0.04% |
| Sand Grove Capital Management LLP | $4.3M | 0.97% |
| J. Goldman & Co LP | $4.3M | 0.12% |
| WELLS FARGO & COMPANY/MN | $4.2M | 0.00% |
| ROYAL BANK OF CANADA | $4.2M | 0.00% |
| Virtu Financial LLC | $3.7M | 0.15% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | $3.7M | 0.00% |
| ABC ARBITRAGE SA | $3.4M | 0.45% |
| VICTORY CAPITAL MANAGEMENT INC | $3.3M | 0.00% |