CIK: 0001224962
Total reported value
$5.1B
| # | Ticker | Issuer | Asset Subclass | Weight | Weight Change | Shares Change | 4Q Trend |
|---|---|---|---|---|---|---|---|
| 1 | NBIX | Neurocrine Biosciences INC | Stock-Healthcare | 15.71% | -0.67% | +1.31% | |
| 2 | AM6 | Amicus Therapeutics INC | Stock-Other | 6.69% | -1.62% | EXIT | |
| 3 | GBTUSD | Global Blood Therapeutics In | Stock-Other | 5.23% | — | +6.63% | |
| 4 | ZGNXEUR | Zogenix INC | Stock-Other | 5.05% | — | -4.10% | |
| 5 | ✓ | Solid Biosciences INC | Stock-Other | 4.96% | — | +0.05% | |
| 6 | ALNY | Alnylam Pharmaceuticals INC | Stock-Healthcare | 2.80% | — | -35.14% | |
| 7 | XLRN | Acceleron Pharma INC | Stock-Other | 2.34% | — | — | |
| 8 | LJPC | La Jolla Pharmaceutical Co | Stock-Other | 2.32% | — | — | |
| 9 | IOVA | Iovance Biotherapeutics INC | Stock-Other | 2.19% | — | +24.57% | |
| 10 | ASND | Ascendis Pharma A/S | Stock-Other | 2.03% | +2.73% | — | |
| 11 | CRNX | Crinetics Pharmaceuticals In | Stock-Other | 1.98% | — | — | |
| 12 | 2655787D | Blueprint Medicines CORP | Stock-Other | 1.96% | — | -2.08% | |
| 13 | MYOKEUR | Myokardia INC | Stock-Other | 1.90% | — | — | |
| 14 | ✓ | Stock-Other | 1.81% | — | +42.78% | ||
| 15 | ✓ | Quotient LTD | Stock-Other | 1.77% | — | +35.57% | |
| 16 | DOVA | Dova Pharmaceuticals INC | Stock-Other | 1.75% | — | — | |
| 17 | MGTX | MeiraGTx Holdings plc | Stock-Other | 1.71% | — | — | |
| 18 | ARNAEUR | Arena Pharmaceuticals INC | Stock-Other | 1.68% | — | +62.35% | |
| 19 | MMSI | Merit Medical Systems INC | Stock-Healthcare | 1.63% | — | -8.12% | |
| 20 | RTRXEUR | Retrophin INC | Stock-Other | 1.62% | — | — | |
| 21 | ✓ | Corium Intl INC | Stock-Other | 1.62% | — | — | |
| 22 | BDQM | Albireo Pharma INC | Stock-Other | 1.50% | — | — | |
| 23 | ✓ | Verrica Pharmaceuticals INC | Stock-Other | 1.48% | — | — | |
| 24 | CTMX | Cytomx Therapeutics INC | Stock-Other | 1.32% | — | +38.51% | |
| 25 | ATNXEUR | Athenex INC | Stock-Other | 1.19% | — | +1410.28% | |
| 26 | KDMN | Kadmon Holdings INC | Stock-Other | 1.18% | — | — | |
| 27 | ✓ | Endocyte INC | Stock-Other | 1.16% | — | +27.06% | |
| 28 | ALDX | Aldeyra Therapeutics INC | Stock-Other | 1.14% | -0.39% | EXIT | |
| 29 | ARGX | Argenx Se - Adr | Stock-Healthcare | 1.14% | — | +5.93% | |
| 30 | ISRG | Intuitive Surgical INC | Stock-Healthcare | 1.11% | — | -27.50% | |
| 31 | ADMA | Adma Biologics INC | Stock-Healthcare | 1.08% | — | — | |
| 32 | BHVN | Biohaven Ltd. | Stock-Other | 0.99% | — | -63.88% | |
| 33 | RGNX | Regenxbio INC | Stock-Other | 0.95% | — | -45.72% | |
| 34 | QURE | uniQure N.V. | Stock-Other | 0.95% | — | -32.66% | |
| 35 | VRAYQ | Viewray INC | Stock-Other | 0.93% | — | +4833.33% | |
| 36 | NEPTGBP | Neptune Wellness Solutions I | Stock-Other | 0.92% | — | — | |
| 37 | XNCR | Xencor INC | Stock-Other | 0.86% | — | -22.47% | |
| 38 | NVTA1EUR | Invitae CORP | Stock-Other | 0.83% | — | -7.92% | |
| 39 | CBAYUSD | Cymabay Therapeutics INC | Stock-Other | 0.81% | — | — | |
| 40 | VAC2USD | Vbi Vaccines INC | Stock-Other | 0.63% | — | — | |
| 41 | AKBA | Akebia Therapeutics INC | Stock-Other | 0.58% | — | +10.57% | |
| 42 | AQST | Aquestive Therapeutics INC | Stock-Other | 0.54% | — | — | |
| 43 | RYTM | Rhythm Pharmaceuticals INC | Stock-Other | 0.52% | -0.83% | -17.05% | |
| 44 | ✓ | Foamix Pharmaceuticals LTD | Stock-Other | 0.48% | — | +178.11% | |
| 45 | ZYMEUSD | Zymeworks INC | Stock-Other | 0.45% | — | — | |
| 46 | IRTC | Irhythm Holdings INC | Stock-Healthcare | 0.43% | — | -45.15% | |
| 47 | ✓ | Establishment Labs Hldgs INC | Stock-Other | 0.41% | — | — | |
| 48 | ✓ | Proqr Thrapeutics N V | Stock-Other | 0.39% | — | — | |
| 49 | ✓ | Motus Gi Hldgs INC | Stock-Other | 0.38% | — | — | |
| 50 | LIVN | LivaNova PLC | Stock-Other | 0.37% | — | — |
| # | Ticker | Issuer | Weight Change | Shares Change | Action |
|---|---|---|---|---|---|
| 1 | NBIX | Neurocrine Biosciences INC | +3.6% | +1.31% | Add |
| 2 | ✓ | Solid Biosciences INC | +1.3% | +0.05% | Add |
| 3 | ATNXEUR | Athenex INC | +1.1% | +1410.28% | Add |
| 4 | VRAYQ | Viewray INC | +0.9% | +4833.33% | Add |
| 5 | ✓ | +0.7% | +42.78% | Add | |
| 6 | ARNAEUR | Arena Pharmaceuticals INC | +0.7% | +62.35% | Add |
| 7 | ALDX | Aldeyra Therapeutics INC | +0.5% | — | Unchanged |
| 8 | MYOKEUR | Myokardia INC | +0.5% | — | Unchanged |
| 9 | ✓ | Endocyte INC | +0.5% | +27.06% | Add |
| 10 | ZGNXEUR | Zogenix INC | +0.5% | -4.10% | Trim |
| 11 | NVTA1EUR | Invitae CORP | +0.4% | -7.92% | Trim |
| 12 | ✓ | Quotient LTD | +0.4% | +35.57% | Add |
| 13 | XLRN | Acceleron Pharma INC | +0.4% | — | Unchanged |
| 14 | 2655787D | Blueprint Medicines CORP | +0.4% | -2.08% | Trim |
| 15 | ✓ | Foamix Pharmaceuticals LTD | +0.3% | +178.11% | Add |
| 16 | ADMA | Adma Biologics INC | +0.3% | — | Unchanged |
| 17 | MGTX | MeiraGTx Holdings plc | +0.3% | — | Unchanged |
| 18 | ✓ | Corium Intl INC | +0.3% | — | Unchanged |
| 19 | IRTC | Irhythm Holdings INC | -0.2% | -45.15% | Trim |
| 20 | ✓ | Verrica Pharmaceuticals INC | -0.3% | — | Unchanged |
| 21 | QURE | uniQure N.V. | -0.5% | -32.66% | Trim |
| 22 | GBTUSD | Global Blood Therapeutics In | -0.5% | +6.63% | Add |
| 23 | ADMSEUR | Adamas Pharmaceuticals INC | -0.5% | -61.07% | Trim |
| 24 | RGNX | Regenxbio INC | -0.7% | -45.72% | Trim |
| 25 | DOVA | Dova Pharmaceuticals INC | -0.7% | — | Unchanged |
| 26 | HUM | Humana INC | -0.8% | -76.39% | Trim |
| 27 | LJPC | La Jolla Pharmaceutical Co | -1% | — | Unchanged |
| 28 | AM6 | Amicus Therapeutics INC | -1.5% | +3.35% | Add |
| 29 | BHVN | Biohaven Ltd. | -1.8% | -63.88% | Trim |
| 30 | ALNY | Alnylam Pharmaceuticals INC | -2% | -35.14% | Trim |
| 31 | CRNX | Crinetics Pharmaceuticals In | — | NEW | New buy |
| 32 | ALXN | Alexion Pharmaceuticals INC | — | EXIT | Sold out |
| 33 | MRTXEUR | Mirati Therapeutics INC | — | EXIT | Sold out |
| 34 | NEPTGBP | Neptune Wellness Solutions I | — | NEW | New buy |
| 35 | PBYI | Puma Biotechnology INC | — | EXIT | Sold out |
| 36 | BOLDEUR | Audentes Therapeutics INC | — | EXIT | Sold out |
| 37 | ✓ | Athenahealth INC | — | EXIT | Sold out |
| 38 | ✓ | Gtx INC Del | — | EXIT | Sold out |
| 39 | ✓ | Neptune Technologies Bioreso | — | EXIT | Sold out |
| 40 | AQST | Aquestive Therapeutics INC | — | NEW | New buy |
| 41 | ✓ | Establishment Labs Hldgs INC | — | NEW | New buy |
| 42 | ✓ | Proqr Thrapeutics N V | — | NEW | New buy |
| 43 | LKFT | Lakefront Biotherapeutic-adr | — | EXIT | Sold out |
| 44 | LIVN | LivaNova PLC | — | NEW | New buy |
| 45 | VRTX | Vertex Pharmaceuticals INC | — | EXIT | Sold out |
| 46 | TDOC | Teladoc Health INC | — | EXIT | Sold out |
| 47 | ✓ | Protagonist Therapeutics INC | — | NEW | New buy |
| 48 | MNLOUSD | Menlo Therapeutics INC | — | EXIT | Sold out |
| 49 | ✓ | Amarin Corp PLC | — | NEW | New buy |
| 50 | TXMDEUR | Therapeuticsmd INC | — | NEW | New buy |