CIK: 0001055951
Total reported value
$5.0B
| # | Ticker | Issuer | Asset Subclass | Weight | Weight Change | Shares Change | 4Q Trend |
|---|---|---|---|---|---|---|---|
| 1 | PRLD | Prelude Therapeutics INC | Stock-Other | 5.91% | — | — | |
| 2 | SWTXUSD | Springworks Therapeutics INC | Stock-Other | 4.44% | — | — | |
| 3 | ALXN | Alexion Pharmaceuticals INC | Stock-Other | 3.32% | — | +2.37% | |
| 4 | PMVP | Pmv Pharmaceuticals INC | Stock-Other | 3.27% | — | — | |
| 5 | TPB | Turning Point Brands, Inc. | Stock-Other | 3.01% | — | — | |
| 6 | ✓ | Horizon Therapeutics PLC | Stock-Other | 2.94% | — | +4.91% | |
| 7 | IOVA | Iovance Biotherapeutics INC | Stock-Other | 2.75% | — | — | |
| 8 | MRTXEUR | Mirati Therapeutics INC | Stock-Other | 2.75% | — | -0.54% | |
| 9 | MRK | Merck & Co. INC. | Stock-Healthcare | 2.70% | +1.58% | NEW | |
| 10 | BMY | Bristol-myers Squibb Co | Stock-Healthcare | 2.69% | — | +23.14% | |
| 11 | BIIB | Biogen INC | Stock-Healthcare | 2.55% | — | — | |
| 12 | BSX | Boston Scientific CORP | Stock-Healthcare | 2.33% | -1.75% | — | |
| 13 | VRTX | Vertex Pharmaceuticals INC | Stock-Healthcare | 2.28% | — | — | |
| 14 | AFIB | Acutus Medical INC | Stock-Other | 2.05% | — | — | |
| 15 | NTRA | Natera INC | Stock-Healthcare | 1.92% | -0.67% | -34.87% | |
| 16 | ✓ | Prevail Therapeutics INC | Stock-Other | 1.77% | — | — | |
| 17 | ARQT | Arcutis Biotherapeutics INC | Stock-Other | 1.72% | — | — | |
| 18 | NBIX | Neurocrine Biosciences INC | Stock-Healthcare | 1.57% | -0.91% | EXIT | |
| 19 | BNR | Burning Rock Biotech Ltd-adr | Stock-Other | 1.50% | — | +0.00% | |
| 20 | HUM | Humana INC | Stock-Healthcare | 1.46% | — | — | |
| 21 | ASND | Ascendis Pharma A/S | Stock-Other | 1.42% | — | -53.01% | |
| 22 | RPTX | Repare Therapeutics INC | Stock-Other | 1.33% | — | — | |
| 23 | ETNBGBP | 89bio INC | Stock-Other | 1.20% | — | -6.87% | |
| 24 | DXCM | Dexcom INC | Stock-Healthcare | 1.17% | — | — | |
| 25 | TBPH | Theravance Biopharma, Inc. | Stock-Other | 1.16% | — | +143.46% | |
| 26 | ✓ | Passage Bio INC | Stock-Other | 1.15% | — | — | |
| 27 | 1T7 | Tricida INC | Stock-Other | 1.09% | — | — | |
| 28 | ISRG | Intuitive Surgical INC | Stock-Healthcare | 1.01% | -1.13% | — | |
| 29 | TORCEUR | Adicet Bio INC | Stock-Other | 1.00% | — | — | |
| 30 | CNC | Centene CORP | Stock-Healthcare | 0.98% | — | — | |
| 31 | AGIO | Agios Pharmaceuticals INC | Stock-Other | 0.97% | — | +20.72% | |
| 32 | SRPT | Sarepta Therapeutics INC | Stock-Healthcare | 0.95% | — | -3.68% | |
| 33 | ORIC | Oric Pharmaceuticals INC | Stock-Other | 0.92% | — | — | |
| 34 | AUPH | Aurinia Pharmaceuticals INC | Stock-Other | 0.88% | — | +297.38% | |
| 35 | XLRN | Acceleron Pharma INC | Stock-Other | 0.85% | — | +371.42% | |
| 36 | KROS | Keros Therapeutics INC | Stock-Other | 0.81% | — | — | |
| 37 | EXEL | Exelixis INC | Stock-Healthcare | 0.74% | — | — | |
| 38 | LOGCUSD | Logicbio Therapeutics INC | Stock-Other | 0.74% | — | — | |
| 39 | DCPHEUR | Deciphera Pharmaceuticals In | Stock-Other | 0.73% | — | — | |
| 40 | ✓ | Graybug Vision INC Com | Stock-Other | 0.72% | — | — | |
| 41 | EW | Edwards Lifesciences CORP | Stock-Healthcare | 0.71% | -1.52% | +33.20% | |
| 42 | ✓ | Imara INC | Stock-Other | 0.70% | — | — | |
| 43 | TKAIEUR | Novus Therapeutics INC | Stock-Other | 0.68% | — | — | |
| 44 | NSTGEUR | Nanostring Technologies INC | Stock-Other | 0.66% | — | -0.78% | |
| 45 | CRSP | CRISPR Therapeutics AG | Stock-Healthcare | 0.66% | — | -9.68% | |
| 46 | EHTH | Ehealth INC | Stock-Other | 0.63% | — | — | |
| 47 | TELA | Tela Bio INC | Stock-Other | 0.63% | — | — | |
| 48 | PGNY | Progyny INC | Stock-Other | 0.62% | — | +391.34% | |
| 49 | MGTX | MeiraGTx Holdings plc | Stock-Other | 0.62% | — | — | |
| 50 | ATRC | Atricure INC | Stock-Other | 0.62% | — | — |
| # | Ticker | Issuer | Weight Change | Shares Change | Action |
|---|---|---|---|---|---|
| 1 | ✓ | Horizon Therapeutics PLC | +0.7% | +4.91% | Add |
| 2 | XLRN | Acceleron Pharma INC | +0.7% | +371.42% | Add |
| 3 | TKAIEUR | Novus Therapeutics INC | +0.7% | — | Unchanged |
| 4 | MRTXEUR | Mirati Therapeutics INC | +0.6% | -0.54% | Trim |
| 5 | AUPH | Aurinia Pharmaceuticals INC | +0.6% | +297.38% | Add |
| 6 | TPB | Turning Point Brands, Inc. | +0.5% | — | Unchanged |
| 7 | PGNY | Progyny INC | +0.5% | +391.34% | Add |
| 8 | TBPH | Theravance Biopharma, Inc. | +0.4% | +143.46% | Add |
| 9 | VRNA | Verona Pharma PLC - Adr | +0.4% | +355.44% | Add |
| 10 | BMY | Bristol-myers Squibb Co | +0.3% | +23.14% | Add |
| 11 | EW | Edwards Lifesciences CORP | +0.2% | +33.20% | Add |
| 12 | IOVA | Iovance Biotherapeutics INC | +0.2% | — | Unchanged |
| 13 | NSTGEUR | Nanostring Technologies INC | +0.2% | -0.78% | Trim |
| 14 | ETNBGBP | 89bio INC | +0.1% | -6.87% | Trim |
| 15 | SWTXUSD | Springworks Therapeutics INC | +0.1% | — | Unchanged |
| 16 | ✓ | Kala Bio INC Com New | -0.3% | +1.15% | Add |
| 17 | ✓ | Fusion Pharmaceuticals INC | -0.3% | — | Unchanged |
| 18 | ✓ | Mersana Therapeutics INC | -0.3% | -30.43% | Trim |
| 19 | ✓ | Imara INC | -0.4% | — | Unchanged |
| 20 | ADVMCHF | Adverum Biotechnologies INC | -0.4% | +39.31% | Add |
| 21 | AGIO | Agios Pharmaceuticals INC | -0.4% | +20.72% | Add |
| 22 | ORIC | Oric Pharmaceuticals INC | -0.5% | — | Unchanged |
| 23 | NBIX | Neurocrine Biosciences INC | -0.5% | +9.76% | Add |
| 24 | NXTCEUR | Nextcure INC | -0.5% | — | Unchanged |
| 25 | BLU | Bellus Health INC | -0.6% | — | Unchanged |
| 26 | ✓ | Prevail Therapeutics INC | -1.1% | — | Unchanged |
| 27 | ✓ | Passage Bio INC | -1.5% | — | Unchanged |
| 28 | ALEC | Alector INC | -1.7% | -54.39% | Trim |
| 29 | ASND | Ascendis Pharma A/S | -1.8% | -53.01% | Trim |
| 30 | 1T7 | Tricida INC | -2.6% | — | Unchanged |
| 31 | PRLD | Prelude Therapeutics INC | — | NEW | New buy |
| 32 | PMVP | Pmv Pharmaceuticals INC | — | NEW | New buy |
| 33 | AFIB | Acutus Medical INC | — | NEW | New buy |
| 34 | CI | THE Cigna Group | — | EXIT | Sold out |
| 35 | TORCEUR | Adicet Bio INC | — | NEW | New buy |
| 36 | ✓ | Graybug Vision INC Com | — | NEW | New buy |
| 37 | SYK | Stryker CORP | — | NEW | New buy |
| 38 | GKOS | Glaukos CORP | — | EXIT | Sold out |
| 39 | CHNGUSD | Change Healthcare INC | — | NEW | New buy |
| 40 | SLQT | Selectquote INC | — | EXIT | Sold out |
| 41 | INSP | Inspire Medical Systems INC | — | EXIT | Sold out |
| 42 | NBP | Novabridge Biosciences | — | NEW | New buy |
| 43 | PFE | Pfizer INC | — | NEW | New buy |
| 44 | IMMU | Immunomedics INC | — | EXIT | Sold out |
| 45 | IQV | Iqvia Holdings INC | — | EXIT | Sold out |
| 46 | HIIQEUR | Benefytt Technologies INC | — | EXIT | Sold out |
| 47 | REGN | Regeneron Pharmaceuticals | — | EXIT | Sold out |
| 48 | OSH3USD | Oak Street Health INC | — | NEW | New buy |
| 49 | GH | Guardant Health INC | — | NEW | New buy |
| 50 | PAND | Pandion Therapeutics INC | — | NEW | New buy |