CIK: 0001055951
Total reported value
$5.0B
| # | Ticker | Issuer | Asset Subclass | Weight | Weight Change | Shares Change | 4Q Trend |
|---|---|---|---|---|---|---|---|
| 1 | ASND | Ascendis Pharma A/S | Stock-Other | 6.64% | — | -10.11% | |
| 2 | ✓ | Synthorx INC | Stock-Other | 5.30% | — | — | |
| 3 | 1T7 | Tricida INC | Stock-Other | 5.18% | — | -13.50% | |
| 4 | SWTXUSD | Springworks Therapeutics INC | Stock-Other | 4.07% | — | — | |
| 5 | ✓ | Prevail Therapeutics INC | Stock-Other | 3.12% | — | — | |
| 6 | BSX | Boston Scientific CORP | Stock-Healthcare | 3.02% | -1.75% | -11.27% | |
| 7 | ALEC | Alector INC | Stock-Other | 2.70% | — | -12.32% | |
| 8 | ALXN | Alexion Pharmaceuticals INC | Stock-Other | 2.57% | — | -0.04% | |
| 9 | MRK | Merck & Co. INC. | Stock-Healthcare | 2.54% | +1.58% | NEW | |
| 10 | MRTXEUR | Mirati Therapeutics INC | Stock-Other | 2.47% | — | +150.51% | |
| 11 | VRTX | Vertex Pharmaceuticals INC | Stock-Healthcare | 2.45% | — | -7.48% | |
| 12 | TPB | Turning Point Brands, Inc. | Stock-Other | 2.44% | — | — | |
| 13 | IOVA | Iovance Biotherapeutics INC | Stock-Other | 2.19% | — | — | |
| 14 | NXTCEUR | Nextcure INC | Stock-Other | 2.18% | — | — | |
| 15 | HUM | Humana INC | Stock-Healthcare | 2.05% | — | +115.57% | |
| 16 | BMY | Bristol-myers Squibb Co | Stock-Healthcare | 1.56% | — | — | |
| 17 | EHTH | Ehealth INC | Stock-Other | 1.53% | — | -8.67% | |
| 18 | ETNBGBP | 89bio INC | Stock-Other | 1.50% | — | — | |
| 19 | EW | Edwards Lifesciences CORP | Stock-Healthcare | 1.45% | -1.52% | -14.36% | |
| 20 | NBIX | Neurocrine Biosciences INC | Stock-Healthcare | 1.44% | -0.91% | EXIT | |
| 21 | CI | THE Cigna Group | Stock-Healthcare | 1.43% | -1.15% | EXIT | |
| 22 | INSP | Inspire Medical Systems INC | Stock-Healthcare | 1.43% | — | -8.43% | |
| 23 | ARQLUSD | Arqule INC | Stock-Other | 1.42% | — | +35.09% | |
| 24 | ISRG | Intuitive Surgical INC | Stock-Healthcare | 1.42% | -1.13% | -18.39% | |
| 25 | SRPT | Sarepta Therapeutics INC | Stock-Healthcare | 1.41% | — | -13.67% | |
| 26 | DHR | Danaher CORP | Stock-Healthcare | 1.40% | -0.40% | — | |
| 27 | BHC | Bausch Health Cos INC | Stock-Healthcare | 1.36% | — | -3.90% | |
| 28 | DCPHEUR | Deciphera Pharmaceuticals In | Stock-Other | 1.35% | — | -38.46% | |
| 29 | GKOS | Glaukos CORP | Stock-Healthcare | 1.20% | — | — | |
| 30 | PTCT | Ptc Therapeutics INC | Stock-Healthcare | 1.19% | — | -11.73% | |
| 31 | NTRA | Natera INC | Stock-Healthcare | 1.17% | -0.67% | -18.65% | |
| 32 | REGN | Regeneron Pharmaceuticals | Stock-Healthcare | 1.12% | — | -8.24% | |
| 33 | ARVN | Arvinas INC | Stock-Other | 1.11% | — | -9.38% | |
| 34 | QURE | uniQure N.V. | Stock-Other | 1.11% | +0.33% | +28.84% | |
| 35 | TMO | Thermo Fisher Scientific INC | Stock-Healthcare | 1.02% | — | -37.34% | |
| 36 | MGTX | MeiraGTx Holdings plc | Stock-Other | 0.99% | — | +3.10% | |
| 37 | TNDM | Tandem Diabetes Care INC | Stock-Other | 0.97% | — | +71.80% | |
| 38 | EXEL | Exelixis INC | Stock-Healthcare | 0.94% | — | -4.07% | |
| 39 | ABT | Abbott Laboratories | Stock-Healthcare | 0.89% | — | -13.05% | |
| 40 | ✓ | Horizon Therapeutics PLC | Stock-Other | 0.82% | — | — | |
| 41 | KRYS | Krystal Biotech INC | Stock-Healthcare | 0.79% | — | +65.26% | |
| 42 | BLU | Bellus Health INC | Stock-Other | 0.76% | — | — | |
| 43 | DXCM | Dexcom INC | Stock-Healthcare | 0.73% | — | -38.83% | |
| 44 | CRNX | Crinetics Pharmaceuticals In | Stock-Other | 0.73% | — | — | |
| 45 | ADVMCHF | Adverum Biotechnologies INC | Stock-Other | 0.71% | — | +8.20% | |
| 46 | AUPH | Aurinia Pharmaceuticals INC | Stock-Other | 0.68% | — | -33.58% | |
| 47 | CRSP | CRISPR Therapeutics AG | Stock-Healthcare | 0.67% | — | +48.41% | |
| 48 | LOGCUSD | Logicbio Therapeutics INC | Stock-Other | 0.66% | — | — | |
| 49 | PRTA | Prothena Corporation plc | Stock-Other | 0.66% | — | -3.97% | |
| 50 | ATNXEUR | Athenex INC | Stock-Other | 0.60% | — | -16.22% |
| # | Ticker | Issuer | Weight Change | Shares Change | Action |
|---|---|---|---|---|---|
| 1 | ✓ | Synthorx INC | +3.7% | — | Unchanged |
| 2 | MRTXEUR | Mirati Therapeutics INC | +1.7% | +150.51% | Add |
| 3 | HUM | Humana INC | +1.2% | +115.57% | Add |
| 4 | SWTXUSD | Springworks Therapeutics INC | +1% | — | Unchanged |
| 5 | ARQLUSD | Arqule INC | +0.9% | +35.09% | Add |
| 6 | NXTCEUR | Nextcure INC | +0.6% | — | Unchanged |
| 7 | CI | THE Cigna Group | +0.6% | +67.94% | Add |
| 8 | TPB | Turning Point Brands, Inc. | +0.5% | — | Unchanged |
| 9 | QURE | uniQure N.V. | +0.5% | +28.84% | Add |
| 10 | KRYS | Krystal Biotech INC | +0.4% | +65.26% | Add |
| 11 | AUPH | Aurinia Pharmaceuticals INC | +0.3% | -33.58% | Trim |
| 12 | ADVMCHF | Adverum Biotechnologies INC | +0.3% | +8.20% | Add |
| 13 | IOVA | Iovance Biotherapeutics INC | +0.3% | — | Unchanged |
| 14 | CRSP | CRISPR Therapeutics AG | +0.3% | +48.41% | Add |
| 15 | ARVN | Arvinas INC | +0.3% | -9.38% | Trim |
| 16 | TNDM | Tandem Diabetes Care INC | +0.2% | +71.80% | Add |
| 17 | PRTA | Prothena Corporation plc | +0.2% | -3.97% | Trim |
| 18 | CRNX | Crinetics Pharmaceuticals In | +0.2% | — | Unchanged |
| 19 | SRPT | Sarepta Therapeutics INC | +0.1% | -13.67% | Trim |
| 20 | EHTH | Ehealth INC | 0% | -8.67% | Trim |
| 21 | BHC | Bausch Health Cos INC | 0% | -3.90% | Trim |
| 22 | ✓ | Prevail Therapeutics INC | -0.1% | — | Unchanged |
| 23 | ASND | Ascendis Pharma A/S | -0.2% | -10.11% | Trim |
| 24 | VRTX | Vertex Pharmaceuticals INC | -0.3% | -7.48% | Trim |
| 25 | LOGCUSD | Logicbio Therapeutics INC | -0.7% | — | Unchanged |
| 26 | ELV | Elevance Health INC | -0.7% | -58.13% | Trim |
| 27 | ✓ | Restorbio INC | -0.7% | — | Unchanged |
| 28 | MYOKEUR | Myokardia INC | -0.7% | -96.44% | Trim |
| 29 | TMO | Thermo Fisher Scientific INC | -0.9% | -37.34% | Trim |
| 30 | NBIX | Neurocrine Biosciences INC | -1.3% | -40.58% | Trim |
| 31 | 1T7 | Tricida INC | -1.3% | -13.50% | Trim |
| 32 | BMY | Bristol-myers Squibb Co | — | NEW | New buy |
| 33 | ETNBGBP | 89bio INC | — | NEW | New buy |
| 34 | DHR | Danaher CORP | — | NEW | New buy |
| 35 | 219 | Avedro INC | — | EXIT | Sold out |
| 36 | GKOS | Glaukos CORP | — | NEW | New buy |
| 37 | ✓ | Wright Medical Group NV | — | EXIT | Sold out |
| 38 | ✓ | Horizon Therapeutics PLC | — | NEW | New buy |
| 39 | PRNB | Principia Biopharma INC | — | EXIT | Sold out |
| 40 | BOLDEUR | Audentes Therapeutics INC | — | EXIT | Sold out |
| 41 | TELA | Tela Bio INC | — | NEW | New buy |
| 42 | RARE | Ultragenyx Pharmaceutical In | — | EXIT | Sold out |
| 43 | HCA | Hca Healthcare INC | — | NEW | New buy |
| 44 | APLT | Applied Therapeutics INC | — | NEW | New buy |
| 45 | ZBH | Zimmer Biomet Holdings INC | — | NEW | New buy |
| 46 | ONCEEUR | Spark Therapeutics INC | — | EXIT | Sold out |
| 47 | XBI | Ss Spdr S&p Biotech ETF | — | NEW | New buy |
| 48 | ✓ | Biomx INC | — | NEW | New buy |
| 49 | IBB | Ishares Biotechnology ETF | — | EXIT | Sold out |
| 50 | AVTR | Avantor INC | — | NEW | New buy |