CIK: 0001789778
Total reported value
$124.7M
Reporting period: 2026-03-31 · Number of holdings: 10
Blue Water Life Science Advisors, LP disclosed 10 holdings in its latest 13F filing for the period ending 2026-03-31, with total reported value of $124.7M and a quarterly turnover rate of 72.6%.
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Blue Water Life Science Advisors, LP's disclosed holdings carry a Herfindahl concentration index of 0.127 — mathematically equivalent to about 8 equally-sized positions, close to its 10 actual disclosed holdings. Value is spread relatively evenly across the portfolio rather than concentrated in a handful of names.
Position sizes are fairly uniform across the portfolio (a coefficient of variation of 0.55), suggesting a disciplined, rules-based approach to how much capital goes into each idea.
Recent activity leans toward initiating meaningfully larger new positions than it adds to existing ones (a 4.0 percentage-point tilt) — a pattern consistent with a more contrarian, new-idea-driven approach.
Sector classification currently covers about 31% of this portfolio's disclosed value; the remainder includes holdings (e.g. unmapped tickers, options, or other security types) not yet covered by our sector mapping.
Trim NTRA
-68.3% -$23.5M
Add CDNA
+83.3% $6.6M
Trim ADPT
-42.8% -$14.6M
Trim GH
-31.8% -$13.9M
Add TWST
-27.9% $966.8K
Add TEM
+81.0% $2.0M
| # | Ticker | Issuer | Asset Subclass | Weight | Weight Change | Shares Change | 4Q Trend |
|---|---|---|---|---|---|---|---|
| 1 | TXG | 10x Genomics Inc-class A | Stock-Other | 18.56% | +18.56% | NEW | |
| 2 | GH | Guardant Health INC | Stock-Healthcare | 17.94% | -4.82% | -31.77% | |
| 3 | CDNA | Caredx INC | Stock-Other | 13.02% | +6.99% | +83.33% | |
| 4 | ADPT | Adaptive Biotechnologies | Stock-Other | 11.24% | -6.75% | -42.77% | |
| 5 | TWST | Twist Bioscience CORP | Stock-Other | 10.52% | +2.90% | -27.94% | |
| 6 | PSNL | Personalis INC | Stock-Other | 8.56% | +0.19% | — | |
| 7 | NTRA | Natera INC | Stock-Healthcare | 7.18% | -13.16% | -68.34% | |
| 8 | QTRX | Quanterix CORP | Stock-Other | 6.05% | -2.30% | +2.39% | |
| 9 | TEM | Tempus Ai Inc-cl A | Stock-Healthcare | 5.67% | +2.47% | +81.01% | |
| 10 | BLLN | Billiontoone INC Cl A | Stock-Other | 1.27% | +1.27% | NEW |
Performance for Q3 2026
+73.7%
Performance Last 4 Quarters
+174.3%
| Period | Holdings | Total value | Stability | Top holdings |
|---|---|---|---|---|
| 2026-03-31 | 10 | $124.7M | 73 | |
| 2025-12-31 | 9 | $159.3M | 43 | |
| 2025-09-30 | 7 | $109.6M | 46 | |
| 2025-06-30 | 8 | $126.3M | 0 | |
| 2025-03-31 | 7 | $100.9M | 100 | |
| 2024-12-31 | 9 | $112.9M | 0 | |
| 2024-09-30 | 8 | $113.7M | 0 | |
| 2024-06-30 | 8 | $102.8M | 0 | |
| 2024-03-31 | 8 | $106.3M | 0 | |
| 2023-12-31 | 9 | $114.2M | 0 | |
| 2023-09-30 | 7 | $105.9M | 0 | |
| 2023-06-30 | 7 | $148.2M | 0 | |
| 2023-03-31 | 8 | $151.2M | 0 | |
| 2022-12-31 | 8 | $148.9M | 0 | |
| 2022-09-30 | 9 | $247.8M | 0 | |
| 2022-06-30 | 9 | $184.1M | 0 | |
| 2022-03-31 | 10 | $210.7M | 0 | |
| 2021-12-31 | 13 | $326.9M | 0 | |
| 2021-09-30 | 24 | $307.4M | 0 | |
| 2021-06-30 | 22 | $265.8M | 87 | |
| 2021-03-31 | 24 | $204.7M | 49 | |
| 2020-12-31 | 21 | $170.4M | 0 |
Blue Water Life Science Advisors, LP's most significant position changes for 2026-03-31: New buy: 10x Genomics Inc-class A (TXG); Sold out: Grail INC (GRAL); New buy: Billiontoone INC Cl A (BLLN); Trim: Natera INC (NTRA) — shares -68.34%; Add: Caredx INC (CDNA) — shares +83.33%.
| # | Ticker | Issuer | Weight Change | Shares Change | Action |
|---|---|---|---|---|---|
| 1 | CDNA | Caredx INC | +7% | +83.33% | Add |
| 2 | TWST | Twist Bioscience CORP | +2.9% | -27.94% | Trim |
| 3 | TEM | Tempus Ai Inc-cl A | +2.5% | +81.01% | Add |
| 4 | PSNL | Personalis INC | +0.2% | — | Unchanged |
| 5 | QTRX | Quanterix CORP | -2.3% | +2.39% | Add |
| 6 | GH | Guardant Health INC | -4.8% | -31.77% | Trim |
| 7 | ADPT | Adaptive Biotechnologies | -6.8% | -42.77% | Trim |
| 8 | NTRA | Natera INC | -13.2% | -68.34% | Trim |
| 9 | TXG | 10x Genomics Inc-class A | — | NEW | New buy |
| 10 | GRAL | Grail INC | — | EXIT | Sold out |
| 11 | BLLN | Billiontoone INC Cl A | — | NEW | New buy |
| Period | Filed | Type | EDGAR |
|---|---|---|---|
| 2026-03-31 | 2026-05-14 | 13F-HR | View on EDGAR |
| 2025-12-31 | 2026-02-17 | 13F-HR | View on EDGAR |
| 2025-09-30 | 2025-11-14 | 13F-HR | View on EDGAR |
| 2025-06-30 | 2025-08-14 | 13F-HR | View on EDGAR |
| 2025-03-31 | 2025-05-15 | 13F-HR | View on EDGAR |
| 2024-12-31 | 2025-02-13 | 13F-HR | View on EDGAR |
| 2024-09-30 | 2024-11-14 | 13F-HR | View on EDGAR |
| 2024-06-30 | 2024-08-09 | 13F-HR | View on EDGAR |
| 2024-03-31 | 2024-05-15 | 13F-HR | View on EDGAR |
| 2023-12-31 | 2024-02-14 | 13F-HR | View on EDGAR |
| 2023-09-30 | 2023-11-14 | 13F-HR | View on EDGAR |
| 2023-06-30 | 2023-08-14 | 13F-HR | View on EDGAR |
| 2023-03-31 | 2023-05-15 | 13F-HR | View on EDGAR |
| 2022-12-31 | 2023-02-14 | 13F-HR | View on EDGAR |
| 2022-09-30 | 2022-11-14 | 13F-HR | View on EDGAR |
| 2022-06-30 | 2022-08-15 | 13F-HR | View on EDGAR |
| 2022-03-31 | 2022-05-18 | 13F-HR | View on EDGAR |
| 2021-12-31 | 2022-02-14 | 13F-HR | View on EDGAR |
| 2021-09-30 | 2021-11-15 | 13F-HR | View on EDGAR |
| 2021-06-30 | 2021-08-13 | 13F-HR | View on EDGAR |
| 2021-03-31 | 2021-05-14 | 13F-HR | View on EDGAR |
| 2020-12-31 | 2021-05-14 | Amendment | View on EDGAR |
| 2020-12-31 | 2021-02-16 | 13F-HR | View on EDGAR |
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