| FRANKLIN RESOURCES INC | US$530.5万 | 0.00% |
| Siren, L.L.C. | US$502.2万 | 0.14% |
| Vivo Capital, LLC | US$458.1万 | 0.38% |
| Point72 Asset Management, L.P. | US$388.9万 | 0.00% |
| Woodline Partners LP | US$281.7万 | 0.01% |
| SPHERA FUNDS MANAGEMENT LTD. | US$275.4万 | 0.44% |
| SUVRETTA CAPITAL MANAGEMENT, LLC | US$267.4万 | 0.07% |
| Soleus Capital Management, L.P. | US$233.3万 | 0.09% |
| Avidity Partners Management LP | US$218.3万 | 0.44% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | US$214.1万 | 0.00% |
| Saturn V Capital Management LP | US$197.1万 | 0.36% |
| MILLENNIUM MANAGEMENT LLC | US$168.0万 | 0.00% |
| 683 Capital Management, LLC | US$130.0万 | 0.07% |
| Empery Asset Management, LP | US$129.5万 | 1.56% |
| ADAR1 Capital Management, LLC | US$125.3万 | 0.07% |
| Stonepine Capital Management, LLC | US$56.3万 | 0.23% |
| CITADEL ADVISORS LLC | US$23.9万 | 0.00% |
| HRT FINANCIAL LP | US$17.1万 | 0.00% |
| MORGAN STANLEY | US$11.9万 | 0.00% |
| JANE STREET GROUP, LLC | US$11.0万 | 0.00% |
| ROYAL BANK OF CANADA | US$9.1万 | 0.00% |
| Monashee Investment Management LLC | US$6.8万 | 0.04% |
| GEODE CAPITAL MANAGEMENT, LLC | US$6.7万 | 0.00% |
| Propel Bio Management, LLC | US$5.7万 | 0.04% |
| AXQ CAPITAL, LP | US$5.7万 | 0.01% |
| China Universal Asset Management Co., Ltd. | US$3.6万 | 0.00% |
| NATIONAL BANK OF CANADA /FI/ | US$1.2万 | 0.00% |
| MAI Capital Management | US$789.0 | 0.00% |
| UBS Group AG | US$158.0 | 0.00% |
| Federation des caisses Desjardins du Quebec | US$106.0 | 0.00% |
| Caitong International Asset Management Co., Ltd | US$6.0 | 0.00% |