CIK: 0001493215
Total reported value
$10.0B
Reporting period: 2026-03-31 · Number of holdings: 88
RTW INVESTMENTS, LP disclosed 88 holdings in its latest 13F filing for the period ending 2026-03-31, with total reported value of $10.0B and a quarterly turnover rate of 36.5%.
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Rtw Investments, LP's disclosed holdings carry a Herfindahl concentration index of 0.037 — mathematically equivalent to about 27 equally-sized positions, well below its 88 actual disclosed holdings. That gap points to a strategy built around a small core of high-conviction bets rather than broad diversification.
Position sizes vary widely across the portfolio (a coefficient of variation of 1.52), with a handful of outsized bets alongside many smaller positions.
No strong tilt toward either adding to existing winners or initiating outsized new positions was observed in the latest reported quarter.
Sector classification currently covers about 45% of this portfolio's disclosed value; the remainder includes holdings (e.g. unmapped tickers, options, or other security types) not yet covered by our sector mapping.
Add CGON
+247.1% $389.2M
Add CELC
+452.5% $292.1M
Add TNGX
+791.9% $265.0M
Add ERAS
+10917.4% $260.9M
Trim MDGL
0.0% -$117.4M
Trim NTRA
-16.7% -$93.6M
| # | Ticker | Issuer | Asset Subclass | Weight | Weight Change | Shares Change | 4Q Trend |
|---|---|---|---|---|---|---|---|
| 1 | MDGL | Madrigal Pharmaceuticals INC | Stock-Healthcare | 10.38% | -1.25% | — | |
| 2 | INSM | Insmed INC | Stock-Healthcare | 7.88% | -0.56% | — | |
| 3 | PTGX | Protagonist Therapeutics INC | Stock-Other | 5.31% | +0.88% | — | |
| 4 | PTCT | Ptc Therapeutics INC | Stock-Healthcare | 5.25% | -0.64% | — | |
| 5 | ARGX | Argenx Se - Adr | Stock-Healthcare | 5.16% | -0.51% | +5.34% | |
| 6 | CGON | Cg Oncology INC | Stock-Other | 4.70% | +3.86% | +247.14% | |
| 7 | CELC | Celcuity INC | Stock-Other | 3.45% | +2.90% | +452.50% | |
| 8 | TNGX | Tango Therapeutics INC | Stock-Other | 2.77% | +2.64% | +791.92% | |
| 9 | ERAS | Erasca INC | Stock-Other | 2.60% | +2.59% | +10917.43% | |
| 10 | NTRA | Natera INC | Stock-Healthcare | 2.49% | -0.95% | -16.67% | |
| 11 | RDNT | Radnet INC | Stock-Healthcare | 2.38% | -0.43% | +8.80% | |
| 12 | TARS | Tarsus Pharmaceuticals INC | Stock-Other | 2.34% | -0.40% | +0.32% | |
| 13 | APGE | Apogee Therapeutics INC | Stock-Other | 2.33% | +0.28% | +2.58% | |
| 14 | SYRE | Spyre Therapeutics INC | Stock-Other | 2.09% | +0.72% | — | |
| 15 | COGT | Cogent Biosciences INC | Stock-Other | 2.09% | -0.61% | -28.10% | |
| 16 | IRTC | Irhythm Holdings INC | Stock-Healthcare | 1.96% | -0.14% | +41.16% | |
| 17 | STOK | Stoke Therapeutics INC | Stock-Other | 1.82% | — | +1.38% | |
| 18 | CYTK | Cytokinetics INC | Stock-Healthcare | 1.78% | — | — | |
| 19 | ACAD | Acadia Pharmaceuticals INC | Stock-Healthcare | 1.58% | -0.33% | — | |
| 20 | ✓ | Establishment Labs Hldgs INC | Stock-Other | 1.50% | -0.39% | +2.58% | |
| 21 | APLSUSD | Apellis Pharmaceuticals INC | Stock-Other | 1.48% | -0.45% | -51.93% | |
| 22 | IMCR | Immunocore Holdings Plc-adr | Stock-Other | 1.46% | -0.23% | — | |
| 23 | RGEN | Repligen CORP | Stock-Healthcare | 1.41% | -0.34% | +13.35% | |
| 24 | NBIX | Neurocrine Biosciences INC | Stock-Healthcare | 1.39% | — | — | |
| 25 | GH | Guardant Health INC | Stock-Healthcare | 1.36% | -0.16% | — | |
| 26 | ✓ | Immatics NV | Stock-Other | 1.26% | — | +12.56% | |
| 27 | ZLAB | Zai Lab Ltd-adr | Stock-Other | 1.23% | — | -5.53% | |
| 28 | BLTE | Belite Bio INC - Adr | Stock-Other | 1.13% | — | — | |
| 29 | ISRG | Intuitive Surgical INC | Stock-Healthcare | 1.01% | +0.44% | +117.33% | |
| 30 | ORKA | Oruka Therapeutics INC | Stock-Other | 1.00% | +0.38% | — | |
| 31 | GHRS | GH Research PLC | Stock-Other | 0.83% | — | — | |
| 32 | XNCR | Xencor INC | Stock-Other | 0.81% | -0.23% | — | |
| 33 | URGN | UroGen Pharma Ltd. | Stock-Other | 0.81% | -0.26% | — | |
| 34 | 260 | Centessa Pharmaceuticals-adr | Stock-Other | 0.81% | +0.36% | +14.70% | |
| 35 | IMVT | Immunovant INC | Stock-Other | 0.79% | — | — | |
| 36 | RARE | Ultragenyx Pharmaceutical In | Stock-Other | 0.76% | — | +21.62% | |
| 37 | HNGE | Hinge Health Inc-a | Stock-Other | 0.74% | +0.58% | +445.97% | |
| 38 | CSTL | Castle Biosciences INC | Stock-Other | 0.67% | -0.15% | +30.40% | |
| 39 | RCKT | Rocket Pharmaceuticals INC | Stock-Other | 0.63% | — | — | |
| 40 | TSHA | Taysha Gene Therapies INC | Stock-Other | 0.61% | -0.29% | -16.58% | |
| 41 | ALKS | Alkermes plc | Stock-Healthcare | 0.59% | — | — | |
| 42 | CMPS | Compass Pathways PLC | Stock-Other | 0.59% | — | +21.41% | |
| 43 | KOD | Kodiak Sciences INC | Stock-Other | 0.56% | +0.14% | +0.00% | |
| 44 | REPL | Replimune Group INC | Stock-Other | 0.56% | -0.14% | +3.03% | |
| 45 | CRNX | Crinetics Pharmaceuticals In | Stock-Other | 0.52% | — | +7.40% | |
| 46 | QURE | uniQure N.V. | Stock-Other | 0.42% | -0.47% | -30.31% | |
| 47 | WAY | Waystar Holding CORP | Stock-Other | 0.39% | +0.39% | NEW | |
| 48 | ARWR | Arrowhead Pharmaceuticals In | Stock-Healthcare | 0.37% | — | +0.17% | |
| 49 | OBIO | Orchestra Biomed Holdings In | Stock-Other | 0.35% | — | — | |
| 50 | VSTM | Verastem INC | Stock-Other | 0.35% | -0.16% | — |
Performance for Q3 2026
+17%
Performance Last 4 Quarters
+61.2%
Based on 81% of reported portfolio value with available pricing
| Period | Holdings | Total value | Stability | Top holdings |
|---|---|---|---|---|
| 2026-03-31 | 88 | $10.0B | 37 | |
| 2025-12-31 | 91 | $10.0B | 55 | |
| 2025-09-30 | 74 | $8.1B | 48 | |
| 2025-06-30 | 73 | $7.0B | 0 | |
| 2025-03-31 | 68 | $6.5B | 100 | |
| 2024-12-31 | 72 | $6.6B | 0 | |
| 2024-09-30 | 68 | $6.9B | 0 | |
| 2024-06-30 | 68 | $6.5B | 0 | |
| 2024-03-31 | 69 | $6.8B | 0 | |
| 2023-12-31 | 64 | $6.4B | 0 | |
| 2023-09-30 | 67 | $4.7B | 0 | |
| 2023-06-30 | 62 | $5.3B | 0 | |
| 2023-03-31 | 60 | $4.8B | 0 | |
| 2022-12-31 | 77 | $4.9B | 0 | |
| 2022-09-30 | 86 | $4.3B | 0 | |
| 2022-06-30 | 107 | $3.9B | 0 | |
| 2022-03-31 | 106 | $4.8B | 0 | |
| 2021-12-31 | 124 | $6.8B | 0 | |
| 2021-09-30 | 120 | $6.6B | 0 | |
| 2021-06-30 | 113 | $6.6B | 98 | |
| 2021-03-31 | 111 | $6.4B | 42 | |
| 2020-12-31 | 102 | $6.0B | 56 | |
| 2020-09-30 | 90 | $4.2B | 38 | |
| 2020-06-30 | 77 | $3.6B | 61 | |
| 2020-03-31 | 65 | $2.3B | 100 | |
| 2019-12-31 | 60 | $2.6B | 0 | |
| 2019-09-30 | 60 | $1.7B | 38 | |
| 2019-06-30 | 52 | $1.9B | 49 | |
| 2019-03-31 | 50 | $1.5B | 48 | |
| 2018-12-31 | 47 | $1.1B | 71 | |
| 2018-09-30 | 46 | $1.7B | 40 | |
| 2018-06-30 | 40 | $1.4B | 53 | |
| 2018-03-31 | 38 | $1.1B | 76 | |
| 2017-12-31 | 32 | $599.1M | 37 | |
| 2017-09-30 | 27 | $574.2M | 31 | |
| 2017-06-30 | 28 | $474.4M | 49 | |
| 2017-03-31 | 28 | $379.9M | 46 | |
| 2016-12-31 | 32 | $265.7M | 75 | |
| 2016-09-30 | 36 | $330.9M | 73 | |
| 2016-06-30 | 35 | $292.7M | 42 | |
| 2016-03-31 | 34 | $275.4M | 100 | |
| 2015-12-31 | 29 | $302.8M | 0 | |
| 2015-09-30 | 44 | $321.8M | 66 | |
| 2015-06-30 | 35 | $343.5M | 74 | |
| 2015-03-31 | 24 | $221.5M | 61 | |
| 2014-12-31 | 21 | $270.3M | 0 |
Rtw Investments, LP's most significant position changes for 2026-03-31: Sold out: Penumbra INC (PEN); Sold out: Axsome Therapeutics INC (AXSM); Sold out: Insulet CORP (PODD); Sold out: Masimo CORP (MASI*); Sold out: Rapt Therapeutics INC (RAPT).
| # | Ticker | Issuer | Weight Change | Shares Change | Action |
|---|---|---|---|---|---|
| 1 | CGON | Cg Oncology INC | +3.9% | +247.14% | Add |
| 2 | CELC | Celcuity INC | +2.9% | +452.50% | Add |
| 3 | TNGX | Tango Therapeutics INC | +2.6% | +791.92% | Add |
| 4 | ERAS | Erasca INC | +2.6% | +10917.43% | Add |
| 5 | PTGX | Protagonist Therapeutics INC | +0.9% | — | Unchanged |
| 6 | SYRE | Spyre Therapeutics INC | +0.7% | — | Unchanged |
| 7 | HNGE | Hinge Health Inc-a | +0.6% | +445.97% | Add |
| 8 | ISRG | Intuitive Surgical INC | +0.4% | +117.33% | Add |
| 9 | ORKA | Oruka Therapeutics INC | +0.4% | — | Unchanged |
| 10 | 260 | Centessa Pharmaceuticals-adr | +0.4% | +14.70% | Add |
| 11 | APGE | Apogee Therapeutics INC | +0.3% | +2.58% | Add |
| 12 | KOD | Kodiak Sciences INC | +0.1% | +0.00% | Add |
| 13 | EVMN | Evommune INC | +0.1% | +17.03% | Add |
| 14 | WVE | Wave Life Sciences Ltd. | -0.1% | — | Unchanged |
| 15 | JBIO | Jade Biosciences INC | -0.1% | -60.45% | Trim |
| 16 | REPL | Replimune Group INC | -0.1% | +3.03% | Add |
| 17 | IRTC | Irhythm Holdings INC | -0.1% | +41.16% | Add |
| 18 | CSTL | Castle Biosciences INC | -0.2% | +30.40% | Add |
| 19 | VSTM | Verastem INC | -0.2% | — | Unchanged |
| 20 | GH | Guardant Health INC | -0.2% | — | Unchanged |
| 21 | IMCR | Immunocore Holdings Plc-adr | -0.2% | — | Unchanged |
| 22 | XNCR | Xencor INC | -0.2% | — | Unchanged |
| 23 | URGN | UroGen Pharma Ltd. | -0.3% | — | Unchanged |
| 24 | TSHA | Taysha Gene Therapies INC | -0.3% | -16.58% | Trim |
| 25 | ACAD | Acadia Pharmaceuticals INC | -0.3% | — | Unchanged |
| 26 | RGEN | Repligen CORP | -0.3% | +13.35% | Add |
| 27 | ✓ | Establishment Labs Hldgs INC | -0.4% | +2.58% | Add |
| 28 | TARS | Tarsus Pharmaceuticals INC | -0.4% | +0.32% | Add |
| 29 | RDNT | Radnet INC | -0.4% | +8.80% | Add |
| 30 | APLSUSD | Apellis Pharmaceuticals INC | -0.5% | -51.93% | Trim |
| 31 | QURE | uniQure N.V. | -0.5% | -30.31% | Trim |
| 32 | ARGX | Argenx Se - Adr | -0.5% | +5.34% | Add |
| 33 | SYK | Stryker CORP | -0.5% | -59.18% | Trim |
| 34 | BBNX | Beta Bionics INC | -0.6% | -20.00% | Trim |
| 35 | INSM | Insmed INC | -0.6% | — | Add |
| 36 | COGT | Cogent Biosciences INC | -0.6% | -28.10% | Trim |
| 37 | PTCT | Ptc Therapeutics INC | -0.6% | — | Unchanged |
| 38 | NTRA | Natera INC | -1% | -16.67% | Trim |
| 39 | MDGL | Madrigal Pharmaceuticals INC | -1.3% | — | Unchanged |
| 40 | PEN | Penumbra INC | — | EXIT | Sold out |
| 41 | AXSM | Axsome Therapeutics INC | — | EXIT | Sold out |
| 42 | PODD | Insulet CORP | — | EXIT | Sold out |
| 43 | MASI* | Masimo CORP | — | EXIT | Sold out |
| 44 | RAPT | Rapt Therapeutics INC | — | EXIT | Sold out |
| 45 | WAY | Waystar Holding CORP | — | NEW | New buy |
| 46 | CADL | Candel Therapeutics INC | — | NEW | New buy |
| 47 | AKTS | Aktis Oncology INC | — | NEW | New buy |
| 48 | DNTH | Dianthus Therapeutics INC | — | NEW | New buy |
| 49 | IPSC | Century Therapeutics INC | — | NEW | New buy |
| 50 | AVTX | Avalo Therapeutics INC | — | NEW | New buy |
| Period | Filed | Type | EDGAR |
|---|---|---|---|
| 2026-03-31 | 2026-05-15 | 13F-HR | View on EDGAR |
| 2025-12-31 | 2026-02-17 | 13F-HR | View on EDGAR |
| 2025-09-30 | 2025-11-14 | 13F-HR | View on EDGAR |
| 2025-06-30 | 2025-08-14 | 13F-HR | View on EDGAR |
| 2025-03-31 | 2025-05-15 | 13F-HR | View on EDGAR |
| 2024-12-31 | 2025-02-14 | 13F-HR | View on EDGAR |
| 2024-09-30 | 2024-11-14 | 13F-HR | View on EDGAR |
| 2024-06-30 | 2024-08-14 | 13F-HR | View on EDGAR |
| 2024-03-31 | 2024-05-15 | 13F-HR | View on EDGAR |
| 2023-12-31 | 2024-02-14 | 13F-HR | View on EDGAR |
| 2023-09-30 | 2023-11-14 | 13F-HR | View on EDGAR |
| 2023-06-30 | 2023-08-14 | 13F-HR | View on EDGAR |
| 2023-03-31 | 2023-05-15 | 13F-HR | View on EDGAR |
| 2022-12-31 | 2023-02-14 | 13F-HR | View on EDGAR |
| 2022-09-30 | 2022-11-14 | 13F-HR | View on EDGAR |
| 2022-06-30 | 2022-08-15 | 13F-HR | View on EDGAR |
| 2022-03-31 | 2022-05-16 | 13F-HR | View on EDGAR |
| 2021-12-31 | 2022-02-14 | 13F-HR | View on EDGAR |
| 2021-09-30 | 2021-11-15 | 13F-HR | View on EDGAR |
| 2021-06-30 | 2021-08-13 | 13F-HR | View on EDGAR |
| 2021-03-31 | 2021-05-14 | 13F-HR | View on EDGAR |
| 2020-12-31 | 2021-02-16 | 13F-HR | View on EDGAR |
| 2020-09-30 | 2020-11-16 | 13F-HR | View on EDGAR |
| 2020-06-30 | 2020-08-14 | 13F-HR | View on EDGAR |
| 2020-03-31 | 2020-05-15 | 13F-HR | View on EDGAR |
| 2019-12-31 | 2020-02-14 | 13F-HR | View on EDGAR |
| 2019-12-31 | 2020-02-14 | Amendment | View on EDGAR |
| 2019-09-30 | 2019-11-14 | 13F-HR | View on EDGAR |
| 2019-06-30 | 2019-08-14 | 13F-HR | View on EDGAR |
| 2019-03-31 | 2019-05-15 | 13F-HR | View on EDGAR |
| 2018-12-31 | 2019-02-15 | Amendment | View on EDGAR |
| 2018-12-31 | 2019-02-15 | Amendment | View on EDGAR |
| 2018-12-31 | 2019-02-14 | 13F-HR | View on EDGAR |
| 2018-09-30 | 2018-11-14 | 13F-HR | View on EDGAR |
| 2018-06-30 | 2018-08-14 | 13F-HR | View on EDGAR |
| 2018-03-31 | 2018-05-14 | 13F-HR | View on EDGAR |
| 2017-12-31 | 2018-02-28 | Amendment | View on EDGAR |
| 2017-12-31 | 2018-02-14 | 13F-HR | View on EDGAR |
| 2017-09-30 | 2017-11-14 | 13F-HR | View on EDGAR |
| 2017-06-30 | 2017-08-14 | 13F-HR | View on EDGAR |
| 2017-03-31 | 2017-05-15 | 13F-HR | View on EDGAR |
| 2016-12-31 | 2017-02-15 | 13F-HR | View on EDGAR |
| 2016-09-30 | 2016-11-18 | Amendment | View on EDGAR |
| 2016-09-30 | 2016-11-14 | 13F-HR | View on EDGAR |
| 2016-06-30 | 2016-08-15 | 13F-HR | View on EDGAR |
| 2016-03-31 | 2016-05-11 | 13F-HR | View on EDGAR |
| 2015-12-31 | 2016-05-24 | Amendment | View on EDGAR |
| 2015-12-31 | 2016-05-24 | Amendment | View on EDGAR |
| 2015-12-31 | 2016-02-16 | 13F-HR | View on EDGAR |
| 2015-09-30 | 2016-05-24 | Amendment | View on EDGAR |
| 2015-09-30 | 2015-11-13 | 13F-HR | View on EDGAR |
| 2015-06-30 | 2015-08-14 | 13F-HR | View on EDGAR |
| 2015-03-31 | 2015-05-21 | 13F-HR | View on EDGAR |
| 2014-12-31 | 2015-02-17 | 13F-HR | View on EDGAR |
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