Sphera Funds Management LTD.

Diversified strategySector-focusedMomentum follower

Total reported value

$629.7M

Reporting period: 2026-03-31 · Number of holdings: 97

SPHERA FUNDS MANAGEMENT LTD. disclosed 97 holdings in its latest 13F filing for the period ending 2026-03-31, with total reported value of $629.7M and a quarterly turnover rate of 58.2%.

Personality snowflake

Concentration: 8.59
Portfolio Stability: 58.21
Momentum/Contrarian: 100
Sector conviction: 100
Diversification: 100
Sizing Uniformity: 89.74

Recent moves

Add MLYS
+198.4%　$20.0M
Add XBI
+185.7%　$17.0M
Add CYTK
+226.1%　$13.9M
Add BBIO
+127.6%　$10.0M
Add TSEM
+19.0%　$11.2M
Trim NICE
-89.9%　-$5.7M

Holdings Map

New buyAddUnchangedTrim

Top 10 holdings by weight

Full holdings list this quarter

Showing top 95 holdings (of 97 total)

#	Ticker	Issuer	Asset Subclass	Weight	Weight Change	Shares Change
1	MLYS	Mineralys Therapeutics INC	Stock-Other	5.76%	+2.61%	+198.43%
2	TEVA	Teva Pharmaceutical-sp Adr	Stock-Healthcare	5.44%	—	+1.20%
3	TSEM	Tower Semiconductor Ltd.	Stock-Tech	4.06%	+1.28%	+18.95%
4	XBI	Ss Spdr S&p Biotech ETF	ETF-Tech	4.06%	+2.41%	+185.71%
5	NVMI	Nova Ltd.	Stock-Other	3.68%	+0.64%	+11.54%
6	CYTK	Cytokinetics INC	Stock-Healthcare	3.13%	+2.00%	+226.13%
7	BBIO	Bridgebio Pharma INC	Stock-Healthcare	2.89%	+1.30%	+127.61%
8	BIIB	Biogen INC	Stock-Healthcare	2.69%	—	-2.33%
9	RARE	Ultragenyx Pharmaceutical In	Stock-Other	2.69%	—	+24.39%
10	SNDX	Syndax Pharmaceuticals INC	Stock-Other	2.69%	—	-4.98%
11	COGT	Cogent Biosciences INC	Stock-Other	2.54%	-0.06%	+10.00%
12	SNY	Sanofi-adr	Stock-Healthcare	2.06%	—	+12.53%
13	AZN	AstraZeneca PLC	Stock-Healthcare	1.96%	+1.96%	NEW
14	AM6	Amicus Therapeutics INC	Stock-Other	1.39%	—	-8.35%
15	CLBT	Cellebrite DI Ltd.	Stock-Other	1.38%	+1.38%	NEW
16	APLSUSD	Apellis Pharmaceuticals INC	Stock-Other	1.37%	+0.15%	-14.36%
17	PANW	Palo Alto Networks INC	Stock-Tech	1.34%	+1.34%	NEW
18	LLY	Eli Lilly & Co	Stock-Healthcare	1.32%	—	—
19	BCRX	Biocryst Pharmaceuticals INC	Stock-Other	1.31%	—	+3.41%
20	CAMT	Camtek Ltd.	Stock-Other	1.28%	+0.47%	+34.23%
21	BMRN	Biomarin Pharmaceutical INC	Stock-Healthcare	1.26%	—	-4.83%
22	CLDX	Celldex Therapeutics INC	Stock-Other	1.23%	—	+1.59%
23	ORA	Ormat Technologies INC	Stock-Utilities	1.21%	+1.21%	NEW
24	XENE	Xenon Pharmaceuticals INC	Stock-Other	1.17%	+1.17%	NEW
25	SLNOEUR	Soleno Therapeutics INC	Stock-Other	1.15%	—	+58.66%
26	TNGX	Tango Therapeutics INC	Stock-Other	1.14%	+0.21%	-36.91%
27	JNJ	Johnson & Johnson	Stock-Healthcare	1.12%	—	-19.54%
28	SEDG 2.25 07-01-29	Solar Edge Technologies	Stock-Tech	1.10%	+0.19%	—
29	✓	Immatics NV	Stock-Other	1.09%	-0.66%	-19.16%
30	TRVI	Trevi Therapeutics INC	Stock-Other	1.09%	—	-4.09%
31	ORIC	Oric Pharmaceuticals INC	Stock-Other	1.08%	—	-46.47%
32	MAZE	Maze Therapeutics INC	Stock-Other	1.08%	+0.50%	+216.44%
33	GSK	Gsk Plc-spon Adr	Stock-Healthcare	1.07%	—	—
34	AMZN	Amazon.com INC	Stock-Consumer Disc	1.06%	+1.06%	NEW
35	ABBV	Abbvie INC	Stock-Healthcare	1.05%	—	+19.80%
36	AAOI	Applied Optoelectronics INC	Stock-Tech	0.99%	+0.99%	NEW
37	ELVN	Enliven Therapeutics INC	Stock-Other	0.95%	+0.27%	-32.41%
38	MRK	Merck & Co. INC.	Stock-Healthcare	0.93%	—	—
39	VOR	Vor Biopharma INC	Stock-Other	0.91%	—	-21.56%
40	ACAD	Acadia Pharmaceuticals INC	Stock-Healthcare	0.91%	—	+20.73%
41	NVS	Novartis Ag-sponsored Adr	Stock-Healthcare	0.90%	—	—
42	ELDN	Eledon Pharmaceuticals INC	Stock-Other	0.87%	+0.25%	-16.88%
43	ENPH	Enphase Energy INC	Stock-Tech	0.86%	—	-23.64%
44	RVMD	Revolution Medicines INC	Stock-Healthcare	0.85%	—	+4.97%
45	PFE	Pfizer INC	Stock-Healthcare	0.83%	+0.42%	+116.28%
46	BHVN	Biohaven Ltd.	Stock-Other	0.80%	+0.80%	NEW
47	FBRX	Forte Biosciences INC	Stock-Other	0.76%	—	-0.48%
48	HELP	Cybin INC	Stock-Other	0.75%	—	+19.56%
49	MDGL	Madrigal Pharmaceuticals INC	Stock-Healthcare	0.75%	+0.38%	+173.94%
50	SRRK	Scholar Rock Holding CORP	Stock-Other	0.74%	-0.61%	-40.44%

1–50 of 95

Portfolio Performance

Performance for Q3 2026

+5.9%

Performance Last 4 Quarters

+85.2%

Based on 64% of reported portfolio value with available pricing

Stdev: +22.9%
Beta: +0.85
Alpha: +0.9%
Max Drawdown: -30.5%
Annualized Perf: +13.3%
Batting Avg vs S&P: +46.7%
Sortino: +1.14
Stutzer: +0.19
Treynor: +0.18
Sterling: +0.52
Calmar: +0.44
Information Ratio: -0.08
Tracking Error: +20.5%
Stdev Down: +13.2%
Winning Months %: +60%
Losing Months %: +40%
Best 12 Months: +97.4%
Worst 12 Months: -29.4%
Efficiency Ratio: +0.24
Sharpe: +0.66
Stdev Sectors: +28.9%
Skewness: +0.28
Kurtosis: +0.49
Upside Potential: +2.92

Reported value over time

Sector allocation

Sector allocation over time

Quarterly history

Period	Holdings	Total value	Stability	Top holdings
2026-03-31	97	$629.7M	58	1MLYS 2TEVA 3TSEM Top holdings2026-03-31 1.MLYS 2.TEVA 3.TSEM 4.XBI 5.NVMI 6.CYTK 7.BBIO 8.BIIB 9.RARE 10.SNDX
2025-12-31	100	$517.3M	70	1TEVA 2BIIB 3MLYS Top holdings2025-12-31 1.TEVA 2.BIIB 3.MLYS 4.SNDX 5.NVMI 6.RARE 7.TSEM 8.COGT 9.AZNN 10.PRAX
2025-09-30	115	$474.1M	86	1TEVA 2NICE 3TSEM Top holdings2025-09-30 1.TEVA 2.NICE 3.TSEM 4.CDTX 5.N5749R 6.NVMI 7.QQQ 8.BIIB 9.RARE 10.AZNN
2025-06-30	111	$426.1M	0	1TEVA 2NVMI 3XBI Top holdings2025-06-30 1.TEVA 2.NVMI 3.XBI 4.SNDX 5.TSEM 6.CYTK 7.SNY 8.BIIB 9.RARE 10.AZNN
2025-03-31	116	$434.3M	100	1TEVA 2TLT 3SNDX Top holdings2025-03-31 1.TEVA 2.TLT 3.SNDX 4.SNY 5.NVMI 6.AZNN 7.BBIO 8.RARE 9.SRPT 10.LLY
2024-12-31	108	$553.1M	0	1TEVA 2BBIO 3SNY Top holdings2024-12-31 1.TEVA 2.BBIO 3.SNY 4.SNDX 5.AZNN 6.AMZN 7.PRAX 8.NVMI 9.META 10.SRPT
2024-09-30	116	$628.4M	0	1TEVA 2SNY 3BBIO Top holdings2024-09-30 1.TEVA 2.SNY 3.BBIO 4.SNDX 5.AMZN 6.NICE 7.META 8.SRPT 9.AZNN 10.CYTK
2024-06-30	119	$733.2M	0	1TEVA 2SMH 3BBIO Top holdings2024-06-30 1.TEVA 2.SMH 3.BBIO 4.SNY 5.CYTK 6.AMZN 7.NICE 8.SNDX 9.META 10.SRPT
2024-03-31	105	$711.7M	0	1TEVA 2XBI 3SNY Top holdings2024-03-31 1.TEVA 2.XBI 3.SNY 4.NICE 5.CYTK 6.BBIO 7.SNDX 8.BIIB 9.JSPR 10.ISREUR
2023-12-31	100	$621.3M	0	1XBI 2TEVA 3SNY Top holdings2023-12-31 1.XBI 2.TEVA 3.SNY 4.CYTK 5.NVMI 6.CLDX 7.SNDX 8.TSEM 9.NICE 10.MRK
2023-09-30	83	$549.0M	0	1TEVA246090E3SNY Top holdings2023-09-30 1.TEVA 2.46090E 3.SNY 4.NICE 5.AZNN 6.ENPH 0 03-01-28 7.JNJ 8.MRK 9.AMZN 10.TSEM
2023-06-30	88	$640.4M	0	1TEVA 2QQQ 3SNY Top holdings2023-06-30 1.TEVA 2.QQQ 3.SNY 4.NICE 5.AZNN 6.JNJ 7.MSFT 8.TSEM 9.AMZN 10.SNDX
2023-03-31	81	$598.4M	0	1IWM 2TEVA 3SPY Top holdings2023-03-31 1.IWM 2.TEVA 3.SPY 4.SNY 5.NICE 6.AZNN 7.JNJ 8.MSFT 9.SNDX 10.MRK
2022-12-31	64	$465.9M	0	146090E246090E3AZNN Top holdings2022-12-31 1.46090E 2.46090E 3.AZNN 4.SNY 5.TEVA 6.JNJ 7.SNDX 8.MRK 9.CRNX 10.BDQM
2022-09-30	75	$720.5M	0	146090E2AZNN 3LLY Top holdings2022-09-30 1.46090E 2.AZNN 3.LLY 4.SNY 5.JNJ 6.MRK 7.NVO 8.ABBV 9.VOO 10.SNDX
2022-06-30	57	$934.9M	0	1QQQ 2SPY 3AZNN Top holdings2022-06-30 1.QQQ 2.SPY 3.AZNN 4.JNJ 5.XBI 6.LLY 7.SNY 8.TEVA 9.ABBV 10.NVO
2022-03-31	66	$707.6M	0	1AZNN 2JNJ 3SNY Top holdings2022-03-31 1.AZNN 2.JNJ 3.SNY 4.QQQ 5.SWTXUSD 6.ABBV 7.FIVN 8.TEVA 9.PFE 10.NVO
2021-12-31	90	$909.6M	0	1ABBV 2AZNN 3SNY Top holdings2021-12-31 1.ABBV 2.AZNN 3.SNY 4.LLY 5.FIVN 6.MRK 7.JNJ 8.SNDX 9.XBI 10.SWTXUSD
2021-09-30	116	$1.2B	0	1LLY 2AZNN 3ABBV Top holdings2021-09-30 1.LLY 2.AZNN 3.ABBV 4.XBI 5.PFE 6.IWM 7.SNY 8.JNJ 9.BMY 10.GNRC
2021-06-30	134	$1.5B	73	1MRK 2XBI 3AZNN Top holdings2021-06-30 1.MRK 2.XBI 3.AZNN 4.JNJ 5.XENE 6.SNY 7.GNRC 8.ENPH 9.LLY 10.ABBV
2021-03-31	170	$1.3B	95	1JNJ 2LLY 3ABBV Top holdings2021-03-31 1.JNJ 2.LLY 3.ABBV 4.MRK 5.SNY 6.AZNN 7.IWM 8.ENPH 9.GNRC 10.IGV
2020-12-31	110	$1.1B	79	1SRPT 2MRK 3LLY Top holdings2020-12-31 1.SRPT 2.MRK 3.LLY 4.ABBV 5.JNJ 6.NVS 7.XBI 8.BMY 9.AZNN 10.68236R
2020-09-30	97	$1.0B	74	1ABBV 2MRK 3SRPT Top holdings2020-09-30 1.ABBV 2.MRK 3.SRPT 4.QQQ 5.JNJ 6.SNY 7.LLY 8.AZNN 9.AMGN 10.NVS
2020-06-30	87	$1.1B	82	1XBI 2ABBV 3MRK Top holdings2020-06-30 1.XBI 2.ABBV 3.MRK 4.SPY 5.SNY 6.AZNN 7.JNJ 8.BMY 9.QQQ 10.PFE
2020-03-31	78	$799.5M	100	1IWM 2MRK 3SPY Top holdings2020-03-31 1.IWM 2.MRK 3.SPY 4.JNJ 5.BMY 6.SNY 7.XBI 8.NVO 9.AZNN 10.SRPT
2019-12-31	86	$1.2B	88	1XBI 2IBB 3JNJ Top holdings2019-12-31 1.XBI 2.IBB 3.JNJ 4.BMY 5.SNY 6.MRK 7.NVO 8.GILD 9.SGENEUR 10.AM6
2019-09-30	80	$647.3M	76	1BMY 2JNJ 3GILD Top holdings2019-09-30 1.BMY 2.JNJ 3.GILD 4.MRK 5.SNY 6.CELG 7.AM6 8.NVO 9.SRPT 10.ALXN
2019-06-30	90	$731.0M	100	1JNJ 2ALXN 3BMY Top holdings2019-06-30 1.JNJ 2.ALXN 3.BMY 4.MRK 5.AZNN 6.AM6 7.TEVA 8.QURE 9.SRPT 10.VTY
2019-03-31	102	$1.1B	0	1XBI 2CELG 3BMY Top holdings2019-03-31 1.XBI 2.CELG 3.BMY 4.JNJ 5.AM6 6.ALXN 7.MRK 8.GILD 9.N59465 10.AZNN
2018-12-31	100	$887.2M	73	1XBI2N594653MRK Top holdings2018-12-31 1.XBI 2.N59465 3.MRK 4.BMY 5.CELG 6.CSTE 7.VTY 8.AM6 9.GILD 10.AZNN
2018-09-30	113	$871.1M	89	1XBI 2MRK3N59465 Top holdings2018-09-30 1.XBI 2.MRK 3.N59465 4.JNJ 5.GSK 6.BMY 7.GILD 8.AM6 9.ALXN 10.ALDX
2018-06-30	110	$725.4M	90	178464A2MRK3N59465 Top holdings2018-06-30 1.78464A 2.MRK 3.N59465 4.GSK 5.GILD 6.464287 7.82481R 8.ALXN 9.ALNY 10.SRPT
2018-03-31	108	$658.7M	81	1XBI 2MRK382481R Top holdings2018-03-31 1.XBI 2.MRK 3.82481R 4.CELG 5.AM6 6.N59465 7.PFE 8.GSK 9.SRPT 10.BIIB
2017-12-31	137	$852.2M	60	1XBI 2IBB3N59465 Top holdings2017-12-31 1.XBI 2.IBB 3.N59465 4.CELG 5.MRK 6.BIIB 7.SRPT 8.GSK 9.AM6 10.ALXN
2017-09-30	131	$700.9M	83	1XBI 2CELG 3BIIB Top holdings2017-09-30 1.XBI 2.CELG 3.BIIB 4.MRK 5.SRPT 6.GILD 7.GSK 8.M2196U 9.PFE 10.82481R
2017-06-30	128	$588.6M	69	178464A2CELG 3BIIB Top holdings2017-06-30 1.78464A 2.CELG 3.BIIB 4.MRK 5.GSK 6.73935A 7.GILD 8.NVS 9.BIIB 10.BMY
2017-03-31	112	$511.5M	85	178464A2CELG378462F Top holdings2017-03-31 1.78464A 2.CELG 3.78462F 4.BIIB 5.NVS 6.MRK 7.82481R 8.151020 9.SRPT 10.PFE
2016-12-31	104	$395.1M	90	178464A2MRK 3CELG Top holdings2016-12-31 1.78464A 2.MRK 3.CELG 4.TEVA 5.ALXN 6.464287 7.IYK 8.19716T 9.SRPT 10.M6158M
2016-09-30	107	$614.2M	100	178464A2TLT 3MRK Top holdings2016-09-30 1.78464A 2.TLT 3.MRK 4.TEVA 5.SRPT 6.G0177J 7.LLY 8.BIIB 9.19716T 10.PFE
2016-06-30	91	$385.2M	97	1TEVA2G0177J382481R Top holdings2016-06-30 1.TEVA 2.G0177J 3.82481R 4.GILD 5.LLY 6.CELG 7.PFE 8.AMGN 9.BIIB 10.N59465
2016-03-31	91	$461.4M	100	181369Y2PFE 3TEVA Top holdings2016-03-31 1.81369Y 2.PFE 3.TEVA 4.BIIB 5.464287 6.G0177J 7.82481R 8.GILD 9.N59465 10.ORA
2015-12-31	119	$683.0M	76	178462F2TEVA 3ORA Top holdings2015-12-31 1.78462F 2.TEVA 3.ORA 4.PFE 5.BIIB 6.G0177J 7.78464A 8.ABBV 9.CELG 10.N59465
2015-09-30	128	$783.8M	95	181369Y2G0177J378462F Top holdings2015-09-30 1.81369Y 2.G0177J 3.78462F 4.TEVA 5.78464A 6.TLT 7.ESLT 8.BIIB 9.PFE 10.ABBV
2015-06-30	133	$1.0B	81	14642872G0177J378464A Top holdings2015-06-30 1.464287 2.G0177J 3.78464A 4.TEVA 5.GILD 6.PFE 7.TLT 8.ABBV 9.BIIB 10.MRK
2015-03-31	148	$960.5M	100	1464287278462F3G0083B Top holdings2015-03-31 1.464287 2.78462F 3.G0083B 4.PFE 5.78464A 6.GILD 7.TEVA 8.ABBV 9.TEVA 10.MRK
2014-12-31	128	$587.0M	90	1NVS2G0083B3PFE Top holdings2014-12-31 1.NVS 2.G0083B 3.PFE 4.TEVA 5.795435 6.GILD 7.82481R 8.VALE 9.BIIB 10.ISRLEUR
2014-09-30	132	$809.5M	100	1NVS278464A3PFE Top holdings2014-09-30 1.NVS 2.78464A 3.PFE 4.TEVA 5.81369Y 6.G0083B 7.MRK 8.ABBV 9.184901 10.82481R
2014-06-30	104	$405.8M	86	1NVS 2MRK 3TEVA Top holdings2014-06-30 1.NVS 2.MRK 3.TEVA 4.JNJ 5.PFE 6.GSK 7.82481R 8.SNY 9.SGENEUR 10.BMRN
2014-03-31	114	$438.1M	100	1NVS 2GSK 3SNY Top holdings2014-03-31 1.NVS 2.GSK 3.SNY 4.MRK 5.PFE 6.JNJ 7.LLY 8.XLF 9.XLV 10.AMGN
2013-12-31	96	$359.0M	0	1JNJ 2GSK 3PFE Top holdings2013-12-31 1.JNJ 2.GSK 3.PFE 4.PFE 5.XLF 6.MRK 7.MRK 8.82481R 9.GILD 10.AMGN

Holding changes this quarter

Sphera Funds Management LTD.'s most significant position changes for 2026-03-31: Sold out: Astrazeneca Plc-spons Adr (AZNN); New buy: AstraZeneca PLC (AZN); Sold out: Praxis Precision Medicines I (PRAX); New buy: Cellebrite DI Ltd. (CLBT); New buy: Palo Alto Networks INC (PANW).

Position changes disclosed by Sphera Funds Management LTD. for the quarter ending 2026-03-31, including ticker, issuer, weight change, shares change, and action
#	Ticker	Issuer	Weight Change	Shares Change	Action
1	MLYS	Mineralys Therapeutics INC	+2.6%	+198.43%	Add
2	XBI	Ss Spdr S&p Biotech ETF	+2.4%	+185.71%	Add
3	CYTK	Cytokinetics INC	+2%	+226.13%	Add
4	BBIO	Bridgebio Pharma INC	+1.3%	+127.61%	Add
5	TSEM	Tower Semiconductor Ltd.	+1.3%	+18.95%	Add
6	NVMI	Nova Ltd.	+0.6%	+11.54%	Add
7	PMN	Promis Neurosciences INC	+0.6%	+2657.61%	Add
8	MAZE	Maze Therapeutics INC	+0.5%	+216.44%	Add
9	CAMT	Camtek Ltd.	+0.5%	+34.23%	Add
10	PFE	Pfizer INC	+0.4%	+116.28%	Add
11	PALI	Palisade Bio INC	+0.4%	+841.59%	Add
12	MDGL	Madrigal Pharmaceuticals INC	+0.4%	+173.94%	Add
13	ELVN	Enliven Therapeutics INC	+0.3%	-32.41%	Trim
14	ELDN	Eledon Pharmaceuticals INC	+0.3%	-16.88%	Trim
15	TNGX	Tango Therapeutics INC	+0.2%	-36.91%	Trim
16	SEDG 2.25 07-01-29	Solar Edge Technologies	+0.2%	—	Unchanged
17	APLSUSD	Apellis Pharmaceuticals INC	+0.2%	-14.36%	Trim
18	COGT	Cogent Biosciences INC	-0.1%	+10.00%	Add
19	SRRK	Scholar Rock Holding CORP	-0.6%	-40.44%	Trim
20	✓	Immatics NV	-0.7%	-19.16%	Trim
21	SEDG	Solaredge Technologies INC	-0.7%	-73.12%	Trim
22	WVE	Wave Life Sciences Ltd.	-0.7%	+34.33%	Add
23	SVRA	Savara INC	-0.7%	-37.26%	Trim
24	DYN	Dyne Therapeutics INC	-1%	-59.13%	Trim
25	NICE	Nice LTD - Spon Adr	-1.1%	-89.93%	Trim
26	AZNN	Astrazeneca Plc-spons Adr	—	EXIT	Sold out
27	AZN	AstraZeneca PLC	—	NEW	New buy
28	PRAX	Praxis Precision Medicines I	—	EXIT	Sold out
29	CLBT	Cellebrite DI Ltd.	—	NEW	New buy
30	PANW	Palo Alto Networks INC	—	NEW	New buy
31	ORA	Ormat Technologies INC	—	NEW	New buy
32	XENE	Xenon Pharmaceuticals INC	—	NEW	New buy
33	AMZN	Amazon.com INC	—	NEW	New buy
34	ANNX	Annexon INC	—	EXIT	Sold out
35	AAOI	Applied Optoelectronics INC	—	NEW	New buy
36	BHVN	Biohaven Ltd.	—	NEW	New buy
37	CATBUSD	Astria Therapeutics INC	—	EXIT	Sold out
38	ZBIO	Zenas Biopharma INC	—	NEW	New buy
39	RLAY	Relay Therapeutics INC	—	NEW	New buy
40	AMD	Advanced Micro Devices	—	EXIT	Sold out
41	OVID	Ovid Therapeutics INC	—	NEW	New buy
42	TARA	Protara Therapeutic INC	—	EXIT	Sold out
43	IRON	Disc Medicine INC	—	NEW	New buy
44	AVGO	Broadcom INC	—	EXIT	Sold out
45	UPB	Upstream Bio INC	—	NEW	New buy
46	ESLT	Elbit Systems Ltd.	—	EXIT	Sold out
47	MSLE	Satellos Bioscience INC	—	NEW	New buy
48	NRIX	Nurix Therapeutics INC	—	EXIT	Sold out
49	GENB	Generate Biomedicines INC	—	NEW	New buy
50	JANX	Janux Therapeutics INC	—	EXIT	Sold out

FAQ

What is Sphera Funds Management LTD. and what type of investor is it?

Sphera Funds Management LTD. is a investment manager that files SEC Form 13F quarterly, disclosing its U.S. public equity holdings to regulators. As of the most recent reporting period (2026-03-31), the firm manages a tracked equity portfolio valued at approximately $629.7M, spread across 97 disclosed positions.

What are Sphera Funds Management LTD.'s largest equity positions?

Based on the latest 13F filing, Sphera Funds Management LTD.'s top holdings by market value are: 1. Mineralys Therapeutics INC (MLYS) — $36.3M (5.8%) 2. Teva Pharmaceutical-sp Adr (TEVA) — $34.2M (5.4%) 3. Tower Semiconductor Ltd. (TSEM) — $25.6M (4.1%) 4. Ss Spdr S&p Biotech ETF (XBI) — $25.5M (4.1%) 5. Nova Ltd. (NVMI) — $23.2M (3.7%)

What changes did Sphera Funds Management LTD. make in its most recent portfolio filing?

In the latest reported quarter, Sphera Funds Management LTD. made 49 notable position adjustments: 15 new positions were initiated, 14 existing holdings were added to, 10 positions were partially reduced, and 10 were completely exited. The largest of these moves: Sold out: Astrazeneca Plc-spons Adr (AZNN); New buy: AstraZeneca PLC (AZN); Sold out: Praxis Precision Medicines I (PRAX); New buy: Cellebrite DI Ltd. (CLBT); New buy: Palo Alto Networks INC (PANW)

What sectors does Sphera Funds Management LTD. focus on?

Sphera Funds Management LTD. is concentrated in the following sectors based on its current disclosed equity portfolio: • Health Care: 73.2% • Information Technology: 21.3% • Utilities: 2.9% • Consumer Discretionary: 2.5%