| T. Rowe Price Investment Management, Inc. | $63.4M | 0.04% |
| ORBIMED ADVISORS LLC | $40.5M | 0.83% |
| Redmile Group, LLC | $35.6M | 2.36% |
| Prosight Management, LP | $32.2M | 5.28% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | $29.9M | 0.05% |
| NEXTBio Capital Management LP | $20.3M | 9.40% |
| VANGUARD CAPITAL MANAGEMENT LLC | $14.6M | 0.00% |
| PRICE T ROWE ASSOCIATES INC /MD/ | $11.5M | 0.00% |
| CLARK ESTATES INC/NY | $9.5M | 2.28% |
| PINNACLE ASSOCIATES LTD | $8.8M | 0.11% |
| Aberdeen Group plc | $7.5M | 0.01% |
| Point72 Asset Management, L.P. | $6.6M | 0.01% |
| AMERIPRISE FINANCIAL INC | $5.8M | 0.00% |
| 683 Capital Management, LLC | $5.1M | 0.27% |
| MILLENNIUM MANAGEMENT LLC | $4.9M | 0.00% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $4.6M | 0.00% |
| GEODE CAPITAL MANAGEMENT, LLC | $4.2M | 0.00% |
| RENAISSANCE TECHNOLOGIES LLC | $3.9M | 0.01% |
| MARSHALL WACE, LLP | $3.7M | 0.00% |
| BlackRock, Inc. | $3.3M | 0.00% |
| S&G Foundation | $2.8M | 0.15% |
| JANE STREET GROUP, LLC | $2.7M | 0.00% |
| FMR LLC | $2.5M | 0.00% |
| TD Asset Management Inc | $2.5M | 0.00% |
| VANGUARD FIDUCIARY TRUST CO | $2.1M | 0.00% |
| TWO SIGMA INVESTMENTS, LP | $2.0M | 0.00% |
| DIADEMA PARTNERS LP | $1.9M | 0.32% |
| ALGERT GLOBAL LLC | $1.8M | 0.03% |
| SPHERA FUNDS MANAGEMENT LTD. | $1.8M | 0.29% |
| STATE STREET CORP | $1.7M | 0.00% |
| Hudson Bay Capital Management LP | $1.5M | 0.01% |
| MORGAN STANLEY | $1.3M | 0.00% |
| DEUTSCHE BANK AG\ | $1.3M | 0.00% |
| GOLDMAN SACHS GROUP INC | $1.2M | 0.00% |
| ACADIAN ASSET MANAGEMENT LLC | $1.2M | 0.00% |
| DIMENSIONAL FUND ADVISORS LP | $1.0M | 0.00% |
| CITADEL ADVISORS LLC | $951.8K | 0.00% |
| XTX Topco Ltd | $916.1K | 0.02% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | $915.0K | 0.00% |
| Connor, Clark & Lunn Investment Management Ltd. | $895.7K | 0.00% |
| Qube Research & Technologies Ltd | $815.3K | 0.00% |
| NORTHERN TRUST CORP | $810.6K | 0.00% |
| BARCLAYS PLC | $770.8K | 0.00% |
| HRT FINANCIAL LP | $583.0K | 0.00% |
| Bank of New York Mellon Corp | $577.2K | 0.00% |
| BANK OF AMERICA CORP /DE/ | $513.9K | 0.00% |
| Brevan Howard Capital Management LP | $511.0K | 0.00% |
| LBJ Family Wealth Advisors, Ltd. | $490.0K | 0.29% |
| CITIGROUP INC | $482.3K | 0.00% |
| Persistent Asset Partners Ltd | $477.3K | 0.18% |
| Pathstone Holdings, LLC | $475.5K | 0.00% |
| Hillsdale Investment Management Inc. | $420.5K | 0.01% |
| Davis Asset Management, L.P. | $310.4K | 0.01% |
| AMERICAN CENTURY COMPANIES INC | $309.5K | 0.00% |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | $272.0K | 0.01% |
| HSBC HOLDINGS PLC | $268.7K | 0.00% |
| EP Wealth Advisors, LLC | $264.7K | 0.00% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $262.9K | 0.00% |
| PIPER SANDLER & CO. | $253.8K | 0.00% |
| Invesco Ltd. | $237.5K | 0.00% |
| UBS Group AG | $233.3K | 0.00% |
| OMERS ADMINISTRATION Corp | $214.1K | 0.00% |
| Squarepoint Ops LLC | $200.4K | 0.00% |
| Dynamic Technology Lab Private Ltd | $190.3K | 0.03% |
| Vanguard Global Advisers, LLC | $169.1K | 0.00% |
| RITHOLTZ WEALTH MANAGEMENT | $167.2K | 0.00% |
| Jump Financial, LLC | $158.7K | 0.00% |
| BENJAMIN EDWARDS INC | $150.5K | 0.00% |
| Mallini Complete Financial Planning LLC | $145.5K | 0.12% |
| CHOREO, LLC | $130.2K | 0.00% |
| Diametric Capital, LP | $118.5K | 0.03% |
| Catalyst Funds Management Pty Ltd | $115.1K | 0.02% |
| Engineers Gate Manager LP | $103.4K | 0.00% |
| Verdad Advisers, LP | $86.0K | 0.10% |
| Creative Planning | $79.3K | 0.00% |
| Quadrature Capital Ltd | $78.0K | 0.00% |
| Schonfeld Strategic Advisors LLC | $74.2K | 0.00% |
| US BANCORP \DE\ | $51.5K | 0.00% |
| JPMORGAN CHASE & CO | $1.5K | 0.00% |
| Optiver Holding B.V. | $424.0 | 0.00% |
| BNP PARIBAS FINANCIAL MARKETS | $362.7 | 0.00% |
| SBI Securities Co., Ltd. | $322.0 | 0.00% |
| CWM, LLC | $251.0 | 0.00% |
| ROYAL BANK OF CANADA | $0.0 | 0.00% |