| FMR LLC | $847.7M | 0.04% |
| Siren, L.L.C. | $532.2M | 14.75% |
| Redmile Group, LLC | $445.7M | 29.51% |
| BlackRock, Inc. | $367.2M | 0.01% |
| SAMSARA BIOCAPITAL, LLC | $339.1M | 32.95% |
| WELLINGTON MANAGEMENT GROUP LLP | $330.2M | 0.06% |
| PRICE T ROWE ASSOCIATES INC /MD/ | $305.1M | 0.04% |
| Orbis Allan Gray Ltd | $205.5M | 0.87% |
| STATE STREET CORP | $198.2M | 0.01% |
| VANGUARD CAPITAL MANAGEMENT LLC | $191.3M | 0.00% |
| Bellevue Group AG | $176.2M | 4.19% |
| JENNISON ASSOCIATES LLC | $164.2M | 0.11% |
| JANUS HENDERSON GROUP PLC | $109.9M | 0.05% |
| EVENTIDE ASSET MANAGEMENT, LLC | $107.9M | 1.78% |
| GEODE CAPITAL MANAGEMENT, LLC | $105.7M | 0.01% |
| Hood River Capital Management LLC | $100.8M | 1.01% |
| Polar Capital Holdings Plc | $97.5M | 0.35% |
| Driehaus Capital Management LLC | $94.4M | 0.69% |
| Holocene Advisors, LP | $93.0M | 0.22% |
| Woodline Partners LP | $73.8M | 0.28% |
| GOLDMAN SACHS GROUP INC | $69.4M | 0.01% |
| BANK OF AMERICA CORP /DE/ | $65.7M | 0.00% |
| Vestal Point Capital, LP | $65.1M | 1.82% |
| Paradigm Biocapital Advisors LP | $60.3M | 1.23% |
| Capital World Investors | $55.5M | 0.01% |
| MARSHALL WACE, LLP | $52.1M | 0.05% |
| STEMPOINT CAPITAL LP | $51.5M | 9.86% |
| CITADEL ADVISORS LLC | $48.5M | 0.01% |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | $48.3M | 0.06% |
| Pictet Asset Management Holding SA | $43.0M | 0.05% |
| FEDERATED HERMES, INC. | $39.2M | 0.06% |
| NORTHERN TRUST CORP | $37.5M | 0.00% |
| Rock Springs Capital Management LP | $36.4M | 2.14% |
| VOYA INVESTMENT MANAGEMENT LLC | $35.7M | 0.04% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | $35.5M | 0.00% |
| Ensign Peak Advisors, Inc | $35.3M | 0.07% |
| AMERICAN CENTURY COMPANIES INC | $34.8M | 0.02% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | $34.5M | 0.01% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | $34.4M | 0.05% |
| JANE STREET GROUP, LLC | $34.2M | 0.00% |
| Clearbridge Investments, LLC | $34.0M | 0.03% |
| UBS Group AG | $33.4M | 0.01% |
| LOOMIS SAYLES & CO L P | $31.4M | 0.04% |
| VANGUARD FIDUCIARY TRUST CO | $29.0M | 0.01% |
| Nuveen, LLC | $28.6M | 0.01% |
| Integral Health Asset Management, LLC | $24.6M | 1.18% |
| Eagle Health Investments LP | $24.3M | 4.25% |
| Fisher Asset Management, LLC | $22.5M | 0.01% |
| First Turn Management, LLC | $21.9M | 2.45% |
| ADAR1 Capital Management, LLC | $20.0M | 1.18% |
| Casdin Capital, LLC | $17.2M | 1.30% |
| SILVERARC CAPITAL MANAGEMENT, LLC | $16.7M | 1.70% |
| ARMISTICE CAPITAL, LLC | $16.6M | 0.29% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | $14.9M | 0.00% |
| NAN FUNG TRINITY (HK) LTD | $14.0M | 1.54% |
| RAYMOND JAMES FINANCIAL INC | $12.5M | 0.00% |
| DEUTSCHE BANK AG\ | $11.9M | 0.00% |
| Caption Management, LLC | $11.8M | 0.07% |
| Bank of New York Mellon Corp | $11.4M | 0.00% |
| Candriam S.C.A. | $11.1M | 0.06% |
| TD Asset Management Inc | $11.0M | 0.01% |
| MORGAN STANLEY | $10.8M | 0.00% |
| AQR CAPITAL MANAGEMENT LLC | $10.4M | 0.00% |
| BARCLAYS PLC | $9.5M | 0.00% |
| TWO SIGMA INVESTMENTS, LP | $8.8M | 0.01% |
| Universal- Beteiligungs- und Servicegesellschaft mbH | $8.7M | 0.02% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | $8.5M | 0.01% |
| Cinctive Capital Management LP | $8.5M | 0.55% |
| Granahan Investment Management, LLC | $7.7M | 0.37% |
| JPMORGAN CHASE & CO | $7.5M | 0.00% |
| Balyasny Asset Management L.P. | $7.4M | 0.01% |
| PEREGRINE CAPITAL MANAGEMENT LLC | $7.2M | 0.27% |
| SEI INVESTMENTS CO | $7.0M | 0.01% |
| GordonMD Global Investments LP | $6.5M | 4.54% |
| iA Global Asset Management Inc. | $6.1M | 0.09% |
| Swiss National Bank | $6.1M | 0.00% |
| Invesco Ltd. | $5.9M | 0.00% |
| EFG International AG | $5.5M | 0.12% |
| RHUMBLINE ADVISERS | $5.5M | 0.00% |
| Rafferty Asset Management, LLC | $5.1M | 0.02% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | $5.1M | 0.00% |
| XTX Topco Ltd | $4.9M | 0.09% |
| FIDEURAM - INTESA SANPAOLO PRIVATE BANKING S.P.A. | $4.9M | 0.17% |
| Artia Global Partners LP | $4.7M | 0.95% |
| SPHERA FUNDS MANAGEMENT LTD. | $4.6M | 0.74% |
| ALLIANCEBERNSTEIN L.P. | $4.4M | 0.00% |
| Hudson Bay Capital Management LP | $4.1M | 0.01% |
| Nicholas Investment Partners, LP | $4.1M | 0.29% |
| Aisling Capital Management LP | $3.8M | 0.80% |
| Trexquant Investment LP | $3.8M | 0.03% |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | $3.7M | 0.00% |
| StoneCrest Wealth Management, Inc. | $3.5M | 1.47% |
| ExodusPoint Capital Management, LP | $3.3M | 0.03% |
| VANGUARD ASSET MANAGEMENT, Ltd | $3.2M | 0.00% |
| Man Group plc | $3.1M | 0.01% |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | $3.0M | 0.00% |
| Moody Aldrich Partners LLC | $3.0M | 0.53% |
| NOMURA HOLDINGS INC | $2.9M | 0.01% |
| Ishara Investments LP | $2.8M | 2.67% |
| POLEN CAPITAL MANAGEMENT LLC | $2.6M | 0.02% |
| Squarepoint Ops LLC | $2.5M | 0.00% |
| Legal & General Group Plc | $2.5M | 0.00% |
| Susquehanna Portfolio Strategies, LLC | $2.4M | 0.04% |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | $2.4M | 0.00% |
| MetLife Investment Management, LLC | $2.3M | 0.01% |
| PROFUND ADVISORS LLC | $2.3M | 0.08% |
| KVP Capital Advisors, LP | $2.2M | 1.65% |
| SCHRODER INVESTMENT MANAGEMENT GROUP | $2.2M | 0.00% |
| Jasper Ridge Partners, L.P. | $2.1M | 0.05% |
| NEW YORK STATE COMMON RETIREMENT FUND | $1.9M | 0.00% |
| CITIGROUP INC | $1.9M | 0.00% |
| AMERIPRISE FINANCIAL INC | $1.9M | 0.00% |
| STATE OF WISCONSIN INVESTMENT BOARD | $1.9M | 0.00% |
| KENNEDY CAPITAL MANAGEMENT LLC | $1.8M | 0.04% |
| GUGGENHEIM CAPITAL LLC | $1.8M | 0.01% |
| Vanguard Global Advisers, LLC | $1.7M | 0.00% |
| WELLS FARGO & COMPANY/MN | $1.6M | 0.00% |
| TUDOR INVESTMENT CORP ET AL | $1.5M | 0.00% |
| Creative Planning | $1.4M | 0.00% |
| Zurcher Kantonalbank (Zurich Cantonalbank) | $1.4M | 0.00% |
| HRT FINANCIAL LP | $1.4M | 0.00% |
| Shay Capital LLC | $1.4M | 0.11% |
| FRANKLIN RESOURCES INC | $1.3M | 0.00% |
| Scientech Research LLC | $1.3M | 1.08% |
| Clearstead Advisors, LLC | $1.3M | 0.01% |
| VICTORY CAPITAL MANAGEMENT INC | $1.3M | 0.00% |
| INTECH INVESTMENT MANAGEMENT LLC | $1.3M | 0.01% |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | $1.2M | 0.01% |
| MILLENNIUM MANAGEMENT LLC | $1.2M | 0.00% |
| D.A. DAVIDSON & CO. | $1.2M | 0.01% |
| Police & Firemen's Retirement System of New Jersey | $1.2M | 0.01% |
| Handelsbanken Fonder AB | $1.2M | 0.00% |
| E. Ohman J:or Asset Management AB | $1.1M | 0.03% |
| DNB Asset Management AS | $1.1M | 0.00% |
| State of New Jersey Common Pension Fund D | $1.0M | 0.00% |
| GSA CAPITAL PARTNERS LLP | $1.0M | 0.06% |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | $970.8K | 0.00% |
| ENVESTNET ASSET MANAGEMENT INC | $957.7K | 0.00% |
| Values First Advisors, Inc. | $926.7K | 0.48% |
| Caitong International Asset Management Co., Ltd | $893.4K | 0.17% |
| China Universal Asset Management Co., Ltd. | $889.9K | 0.07% |
| ProShare Advisors LLC | $846.4K | 0.00% |
| ARIZONA STATE RETIREMENT SYSTEM | $843.7K | 0.00% |
| LPL Financial LLC | $834.0K | 0.00% |
| Virtu Financial LLC | $813.0K | 0.03% |
| Erste Asset Management GmbH | $801.3K | 0.01% |
| DARK FOREST CAPITAL MANAGEMENT LP | $797.6K | 0.07% |
| 683 Capital Management, LLC | $796.4K | 0.04% |
| Vanguard Investments Australia, Ltd. | $772.5K | 0.00% |
| Point72 Asset Management, L.P. | $747.2K | 0.00% |